UniProtKB - E9QJG1 (E9QJG1_DANRE)
Protein
Submitted name:
Heart development protein with EGF-like domains 1
Gene
heg1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- cell-cell junction assembly Source: InterPro
- heart development Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Heart development protein with EGF-like domains 1Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040714-1, heg1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5003244774 | 28 – 841 | Sequence analysisAdd BLAST | 814 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 614 ↔ 623 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000018441, Expressed in heart and 30 other tissues |
ExpressionAtlasi | E9QJG1, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 587 – 624 | EGF-likeInterPro annotationAdd BLAST | 38 | |
Domaini | 626 – 665 | EGF-likeInterPro annotationAdd BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 119 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 200 – 390 | DisorderedSequence analysisAdd BLAST | 191 | |
Regioni | 404 – 479 | DisorderedSequence analysisAdd BLAST | 76 | |
Regioni | 496 – 556 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 90 – 119 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 200 – 384 | PolarSequence analysisAdd BLAST | 185 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00710000106813 |
OMAi | CPPLAMC |
Family and domain databases
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR028720, HEG |
PANTHERi | PTHR24037, PTHR24037, 2 hits |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9QJG1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMETCARRVL FTAALLVLST VIAETFSTDS DTDNPLSTET FYSRTSGLKQ
60 70 80 90 100
TSSWPGREAT ATAVDLSSGL GEMTEIPASV SITAAREGHS PKPLQTSTNA
110 120 130 140 150
ADWKTSMTSD ETTEHLQSDT ELTHNATAQW ESPSSASHSI TSHHPVTETR
160 170 180 190 200
TVRDVTDLID MDTTDSVSHT DSTYISTTNR VGERTLLSVI SNSTFAYTQN
210 220 230 240 250
SSISDAESQT SPWEEKTSGA TQVNEETEET VSTVSEQTDP TFEDRNITSA
260 270 280 290 300
TLETGRSTLF QGTESQTGQP SVTGQTAKEV TDIDNPNSTP PLTVTSRDVE
310 320 330 340 350
ETDATSVSSE TSYTQTSSDS ASSILPFTSS ERNVTSTSQE SHNSTLIYST
360 370 380 390 400
NTGGSTEFST GSVSSTAHEE TERSSTQIVD ETTLHDVTSA PPVLEDVATT
410 420 430 440 450
IDDSLSKFPS GQSPTIPKTD DQTNTQVVPT STHRPQVTDE ATDEVSTVYS
460 470 480 490 500
STTTLTTTTP SVTTRQLQPH HTTVETQTQH TTIVTTDIIQ VLRTTPSTAH
510 520 530 540 550
HVPTSTTSGP QAPSTADSSD VTTLHLETST ATPGNTTAHG GRATTPFSKS
560 570 580 590 600
SPSRTTVVVT TGHLTDKSTT ETGSATTQMP LRTSASPGHV CGPKTCANGG
610 620 630 640 650
HCVRSAEGSY YCQCLSAWTG PFCTEDVDEC VNSPCPQGSV CVNTGGSFSC
660 670 680 690 700
ECDLGFDLED GRSCTQVKTF LGTFTVNNSL HLRNLGLHEL HREIQQLLNA
710 720 730 740 750
SLSIFHGYRR FTLGKRDGQG VQIPVVSMFS LSSNVTSADV FNSIQMSLNN
760 770 780 790 800
CSRTYSHCPI KLQHQLSYHV ESLCMAQKTK CDVQYSDCSD ISGIPNCQCL
810 820 830 840
PGYFKRNPED MTCRDCGDGL KLVNGKCVEC MFGFGGFNCN N
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6R8J2 | HEG_DANRE | Protein HEG | heg | 977 | Annotation score: | ||
A9C3V5 | A9C3V5_DANRE | Heart development protein with EGF-... | heg1 heg | 977 | Annotation score: | ||
A9C3V6 | A9C3V6_DANRE | Heart development protein with EGF-... | heg1 heg | 935 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR933561 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000140325; ENSDARP00000115779; ENSDARG00000018441 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR933561 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000140325; ENSDARP00000115779; ENSDARG00000018441 |
Organism-specific databases
ZFINi | ZDB-GENE-040714-1, heg1 |
Phylogenomic databases
GeneTreei | ENSGT00710000106813 |
OMAi | CPPLAMC |
Gene expression databases
Bgeei | ENSDARG00000018441, Expressed in heart and 30 other tissues |
ExpressionAtlasi | E9QJG1, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR028720, HEG |
PANTHERi | PTHR24037, PTHR24037, 2 hits |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9QJG1_DANRE | |
Accessioni | E9QJG1Primary (citable) accession number: E9QJG1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | February 10, 2021 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |