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Entry version 54 (26 Feb 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Granulin a

Gene

grna

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Granulin aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:grnaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-8434 grna

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324617817 – 1049Sequence analysisAdd BLAST1033

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9QI45

PeptideAtlas

More...
PeptideAtlasi
E9QI45

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000004954 Expressed in spleen and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9QI45 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000113859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 63GRANULINSInterPro annotationAdd BLAST14
Domaini139 – 152GRANULINSInterPro annotationAdd BLAST14
Domaini203 – 216GRANULINSInterPro annotationAdd BLAST14
Domaini322 – 335GRANULINSInterPro annotationAdd BLAST14
Domaini410 – 423GRANULINSInterPro annotationAdd BLAST14
Domaini495 – 508GRANULINSInterPro annotationAdd BLAST14
Domaini583 – 596GRANULINSInterPro annotationAdd BLAST14
Domaini671 – 684GRANULINSInterPro annotationAdd BLAST14
Domaini759 – 772GRANULINSInterPro annotationAdd BLAST14
Domaini839 – 852GRANULINSInterPro annotationAdd BLAST14
Domaini920 – 933GRANULINSInterPro annotationAdd BLAST14
Domaini1003 – 1016GRANULINSInterPro annotationAdd BLAST14

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni246 – 272DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi257 – 272PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4296 Eukaryota
ENOG410XR6S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00470000042293

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9QI45

Identification of Orthologs from Complete Genome Data

More...
OMAi
EGGWGCC

TreeFam database of animal gene trees

More...
TreeFami
TF319678

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.500, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000118 Granulin
IPR039036 Granulin_fam
IPR037277 Granulin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12274 PTHR12274, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00396 Granulin, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00277 GRAN, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00799 GRANULINS, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9QI45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLTVCLAV VTLVICSQCP NNEVCEAGQS CCQDPTGGFS CCPFHHGECC
60 70 80 90 100
EDHLHCCPEG MLCSVKDLTC TNATHTQPLA DRTLAKKPDL PKSFRMIFSM
110 120 130 140 150
PASESDITCP DGSSCPAEFS CLLMSTSYGC CPVAQGLACS DGKHCCPNDH
160 170 180 190 200
ECSTDSSLCV KRKVKVQTVL CGNGTSECPA DTTCCQADDG QWGCCPMPKA
210 220 230 240 250
VCCDDKIHCC PEDTVCDVKA LKCVSSTNQE LPMWDKFPAR LRAEWEDHKQ
260 270 280 290 300
KRPETQRTTA RPTGTTSTTT AANQMTTLPA EHQGVSSDVA CNDTAACPDG
310 320 330 340 350
STCCKTKDGG WACCPLPEAV CCEDFIHCCP HGKKCDVAAG SCEDPSGSVS
360 370 380 390 400
WVEKVPVRPI RKQKVAVTQV SSVSSDVPCN DTAACADGTT CCKTKEGDWA
410 420 430 440 450
CCPLPEAVCC EDFVHCCPKG KKCNIAAMKC EDPLCTEEPL VKQTPVQSTT
460 470 480 490 500
TPNVIGTQKS DVPCNDTAAC PDGSTCCKTK DGGWACCPLP EAVCCEDFIH
510 520 530 540 550
CCPHGKKCDV AAGSCEDPSG SVPWVEKVPV RPIRKQKVAV TTVSPVSSDI
560 570 580 590 600
ACNDTVACPD GSTCCKDKDG EWGCCPLPEA VCCEDFIHCC PHGKKCNVAA
610 620 630 640 650
GSCDDPSGSV PWMDKVPVRP IKKQKVAVTQ ASSASSDVPC NDTAACPDGS
660 670 680 690 700
TCCKTKDGGW ACCPLPEAVC CEDFIHCCPH GKKCDVAAGS CEDSSGSVPW
710 720 730 740 750
VEKVPVRPIR KQKVANTKVS PVSSDVACND TVACPDGSTC CKDKDGDWGC
760 770 780 790 800
CPLPEAVCCE DFIHCCPHGK KCNVAAGSCD DPSGSVPWVE KVPVHLRAGQ
810 820 830 840 850
RPSGKVKCNA THGCPESSTC CKNIAGEWGC CPFSQAVCCT DGEHCCPAHY
860 870 880 890 900
KCNLSSVSCI KGDVVIPWYN KIAAESTPAP KLDLGVVKCD EQSSCSADST
910 920 930 940 950
CCLLSKDETG CCPFPEAVCC PDQKHCCPEG YRCDLRRRSC VKTTRLYVEI
960 970 980 990 1000
TQLTHIRSNK PQPSVVVKDV QCGGGFSCHD GETCCLTSQT TWGCCPSPKA
1010 1020 1030 1040
VCCDDMQHCC PAGYKCGPGG TCISAGDLDW SNWVNWKLFF SKKKRALTL
Length:1,049
Mass (Da):111,492
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CFCFACFEFB56426
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QCA6E9QCA6_DANRE
Granulin a
grna
873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QNY0F1QNY0_DANRE
Granulin a
grna
873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3IST4I3IST4_DANRE
Granulin a
grna
147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3ISF3I3ISF3_DANRE
Granulin a
grna
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3ISQ5I3ISQ5_DANRE
Granulin a
grna
189Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3ITR0I3ITR0_DANRE
Granulin a
grna
182Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX901883 Genomic DNA No translation available.
CR384107 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005164026.1, XM_005163969.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000137973; ENSDARP00000113859; ENSDARG00000004954

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
791524

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX901883 Genomic DNA No translation available.
CR384107 Genomic DNA No translation available.
RefSeqiXP_005164026.1, XM_005163969.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000113859

Proteomic databases

PaxDbiE9QI45
PeptideAtlasiE9QI45

Genome annotation databases

EnsembliENSDART00000137973; ENSDARP00000113859; ENSDARG00000004954
GeneIDi791524

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
791524
ZFINiZDB-GENE-030131-8434 grna

Phylogenomic databases

eggNOGiKOG4296 Eukaryota
ENOG410XR6S LUCA
GeneTreeiENSGT00470000042293
InParanoidiE9QI45
OMAiEGGWGCC
TreeFamiTF319678

Enzyme and pathway databases

ReactomeiR-DRE-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSDARG00000004954 Expressed in spleen and 40 other tissues
ExpressionAtlasiE9QI45 baseline and differential

Family and domain databases

Gene3Di3.10.20.500, 12 hits
InterProiView protein in InterPro
IPR000118 Granulin
IPR039036 Granulin_fam
IPR037277 Granulin_sf
PANTHERiPTHR12274 PTHR12274, 4 hits
PfamiView protein in Pfam
PF00396 Granulin, 12 hits
SMARTiView protein in SMART
SM00277 GRAN, 12 hits
PROSITEiView protein in PROSITE
PS00799 GRANULINS, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QI45_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QI45
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 26, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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