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Entry version 71 (07 Oct 2020)
Sequence version 2 (21 Sep 2011)
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Protein

Phosphoinositide 5-phosphatase

Gene

synj1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation, RNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 5-phosphataseARBA annotation (EC:3.1.3.36ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:synj1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-9180, synj1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
E9QHF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000025011, Expressed in retina and 30 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 444SACInterPro annotationAdd BLAST326
Domaini899 – 975RRMInterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1032 – 1308DisorderedSequence analysisAdd BLAST277

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1048 – 1077Pro-richSequence analysisAdd BLAST30
Compositional biasi1095 – 1126Pro-richSequence analysisAdd BLAST32
Compositional biasi1150 – 1189Pro-richSequence analysisAdd BLAST40
Compositional biasi1196 – 1214Pro-richSequence analysisAdd BLAST19
Compositional biasi1222 – 1255Pro-richSequence analysisAdd BLAST34
Compositional biasi1294 – 1308PolarSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptojanin family.ARBA annotation
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157964

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003016_5_1_1

KEGG Orthology (KO)

More...
KOi
K20279

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVAIDCV

Database of Orthologous Groups

More...
OrthoDBi
359616at2759

TreeFam database of animal gene trees

More...
TreeFami
TF354311

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR002013, SAC_dom
IPR034972, SYNJ1

The PANTHER Classification System

More...
PANTHERi
PTHR11200:SF158, PTHR11200:SF158, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit
SSF56219, SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit
PS50275, SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9QHF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSKGYRIY HKLDPPPYSV IVETRNREEC LMFESGAVAV LSAAEKETIK
60 70 80 90 100
ASYTKMLDAY GILGVLRLNL GDSMLHSLVV VTGCSSVGKV QDSEVFRVTG
110 120 130 140 150
TDFVSLKNDP TDEDRIADVR KVLNSGNFYF AWSSTGVSLD LSLNAHRRIR
160 170 180 190 200
EDTSDNRFFW NQSLHLHLKH YGVNCDDWLL RLMCGGVEIR TIYAGHKQAK
210 220 230 240 250
ACVISRLSSE RAGTRFNVRG TNDDGQVANF VETEQIIFLD DKVSSFIQIR
260 270 280 290 300
GSIPLFWEQP GIQVGSHRVK LSRGFEANAP AFERHFSALK RLYGKQLIIN
310 320 330 340 350
LLGMKEGEHM LSKAFQSHLK ASEHSNAVKM LNFDYHQMVK GGKTEKLQTV
360 370 380 390 400
LKPQISKFVE DCDFFYYSGE TGIQRCQSGT IRSNCLDCLD RTNSVQAFIA
410 420 430 440 450
LEMLPKQLEA MGLTEKPQLV ARFQEVFRSM WSTNGDSISK IYAGTGALDG
460 470 480 490 500
KAKGGKLKDG ARSVTRTIQN NFFDSSKQEA IDILRLGSTL NSDLADKARA
510 520 530 540 550
LLTTSSLYVS EPILQSASPR VLLGMCQNHF KYTRPKKIRV CVGTWNVNGG
560 570 580 590 600
KQFRSIAFRN HTLNDWLLDA PKKAGHPEFQ DVKNNPVDIF AIGFEEMVEL
610 620 630 640 650
NAGNIVSAST TNQKLWAAEL QKNISRDQRY VLLASEQLVG VCLFVFIRPQ
660 670 680 690 700
HAPFIRDVAV DTVKTGMGGA TGNKGGVAIR MLFHTTSICF VCSHFAAGQS
710 720 730 740 750
QVKERNDDYN EIARKLSFPM GRLLYSHDYV FWCGDFNYRI NIPNEEVKEL
760 770 780 790 800
IRQQNWDALI GGDQLVEQKN AGQVFRGFIE GKLDFAPTYK YDLFSEDYDT
810 820 830 840 850
SEKCRTPAWT DRVLWKRRKW NFDKTAEELE LNVVGAPVNE EEQYPWSPGD
860 870 880 890 900
LKYYGRAELK TSDHRPVVAI IDVDILEVDP EARHQVYKEV IALQGPPDGT
910 920 930 940 950
ILVSLCSSGP DDYFDDALID DLLDKFANFG EVILIRFVEE KMWVTFLEGY
960 970 980 990 1000
SALAALSLSG STVNGKTIDI RLRSPGWIKS LEEEMSVERI CGSIPTSTSS
1010 1020 1030 1040 1050
TLLAENSDLG EEYDMEGDVD EEVEDILPQH LQPGAGMDLS ASPATSPRTS
1060 1070 1080 1090 1100
PCPSPTHGEP APPIRPSRAP PRTAGPPQGS PVDGQPAGAP FSQGLEPKRP
1110 1120 1130 1140 1150
PPPRPNAPPA RPAPPQRPPP PSGRGQATGP APGGIPRPIP PRAGVISVTP
1160 1170 1180 1190 1200
QARPPPPAHP GAPRPTAEVH PGAPRPSPDN HPGAPRPTAE PQSKPSELPL
1210 1220 1230 1240 1250
GPPLTLPGPV RPQMTSPMQP QSVSPVQPPV QPQLPPPIQS QLPPPMQPTL
1260 1270 1280 1290 1300
PAPLMPQQAP QTSAGAGAAA APQPGLASPK PPPRSRSSHA LPPESAPAPT

TQQEQSSG
Length:1,308
Mass (Da):143,771
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE000C5709F906883
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QHM1A0A2R8QHM1_DANRE
Phosphoinositide 5-phosphatase
synj1
1,354Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QA90A0A2R8QA90_DANRE
Phosphoinositide 5-phosphatase
synj1
1,304Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QIL9A0A2R8QIL9_DANRE
Phosphoinositide 5-phosphatase
synj1
1,306Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RW07A0A2R8RW07_DANRE
Phosphoinositide 5-phosphatase
synj1
1,352Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT027781 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001007031.2, NM_001007030.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000134276; ENSDARP00000122252; ENSDARG00000025011

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
337236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:337236

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT027781 Genomic DNA No translation available.
RefSeqiNP_001007031.2, NM_001007030.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiE9QHF3

Genome annotation databases

EnsembliENSDART00000134276; ENSDARP00000122252; ENSDARG00000025011
GeneIDi337236
KEGGidre:337236

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8867
ZFINiZDB-GENE-030131-9180, synj1

Phylogenomic databases

GeneTreeiENSGT00940000157964
HOGENOMiCLU_003016_5_1_1
KOiK20279
OMAiDVAIDCV
OrthoDBi359616at2759
TreeFamiTF354311

Gene expression databases

BgeeiENSDARG00000025011, Expressed in retina and 30 other tissues

Family and domain databases

Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047, DUF1866
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000300, IPPc
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR002013, SAC_dom
IPR034972, SYNJ1
PANTHERiPTHR11200:SF158, PTHR11200:SF158, 1 hit
PfamiView protein in Pfam
PF08952, DUF1866, 1 hit
PF03372, Exo_endo_phos, 1 hit
PF02383, Syja_N, 1 hit
SMARTiView protein in SMART
SM01165, DUF1866, 1 hit
SM00128, IPPc, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
SSF56219, SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit
PS50275, SAC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QHF3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QHF3
Secondary accession number(s): F1QU34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: September 21, 2011
Last modified: October 7, 2020
This is version 71 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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