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Entry version 71 (07 Apr 2021)
Sequence version 2 (21 Sep 2011)
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Protein
Submitted name:

Lysine (K)-specific demethylase 6B, b

Gene

kdm6bb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Lysine (K)-specific demethylase 6B, bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kdm6bbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040724-166, kdm6bb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9QG91

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000056929, Expressed in retina and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000073960

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1415 – 1578JmjCInterPro annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 586DisorderedSequence analysisAdd BLAST586
Regioni640 – 673DisorderedSequence analysisAdd BLAST34
Regioni785 – 961DisorderedSequence analysisAdd BLAST177
Regioni978 – 1068DisorderedSequence analysisAdd BLAST91
Regioni1312 – 1332DisorderedSequence analysisAdd BLAST21
Regioni1351 – 1396DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 57PolarSequence analysisAdd BLAST22
Compositional biasi70 – 87PolyampholyteSequence analysisAdd BLAST18
Compositional biasi90 – 164PolarSequence analysisAdd BLAST75
Compositional biasi227 – 248PolarSequence analysisAdd BLAST22
Compositional biasi258 – 279PolarSequence analysisAdd BLAST22
Compositional biasi285 – 299PolyampholyteSequence analysisAdd BLAST15
Compositional biasi312 – 376PolarSequence analysisAdd BLAST65
Compositional biasi409 – 432PolyampholyteSequence analysisAdd BLAST24
Compositional biasi452 – 467BasicSequence analysisAdd BLAST16
Compositional biasi469 – 484PolyampholyteSequence analysisAdd BLAST16
Compositional biasi496 – 520PolyampholyteSequence analysisAdd BLAST25
Compositional biasi521 – 545BasicSequence analysisAdd BLAST25
Compositional biasi546 – 562PolyampholyteSequence analysisAdd BLAST17
Compositional biasi563 – 577PolarSequence analysisAdd BLAST15
Compositional biasi640 – 659PolyampholyteSequence analysisAdd BLAST20
Compositional biasi808 – 838PolarSequence analysisAdd BLAST31
Compositional biasi897 – 943PolyampholyteSequence analysisAdd BLAST47
Compositional biasi978 – 992PolarSequence analysisAdd BLAST15
Compositional biasi993 – 1032PolyampholyteSequence analysisAdd BLAST40
Compositional biasi1377 – 1396PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1246, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160414

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001909_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHSHRTH

Database of Orthologous Groups

More...
OrthoDBi
268901at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003347, JmjC_dom
IPR029518, KDM6B

The PANTHER Classification System

More...
PANTHERi
PTHR14017:SF5, PTHR14017:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02373, JmjC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00558, JmjC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184, JMJC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9QG91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYHIAEQYSG RNSWDSFPSS GPNRAPWAPG NNRHWAPPSS GGNYQSPSQN
60 70 80 90 100
YMAGRSYPNK AYNNRPPGFS RDRLHAHPRD RGNGKEQRVP RSCGPTQNQH
110 120 130 140 150
HNPERSTLNY SSGYEGHLSS SNNHGNQPHR YGGPHQQQRS TGRPPQTQGE
160 170 180 190 200
KWTHSAQSRS FQGPSLKRPV PPHNLSQPLR EPSPSRDDCP SKRSRSINSH
210 220 230 240 250
QNFHPRDKYF INRPPPSHPP RPWSPAYKSS MSWSLSEKRS SPSRFQESSH
260 270 280 290 300
SVTRDHTYRP YSHSSPPSSV PNQGLHNRKL TKQGPAHHPV HDHPDSPPRG
310 320 330 340 350
AKGGWDCPSP ANLTVPYSQQ HQLPPPQRHT GPSSSPATSV PQPRSNTAQH
360 370 380 390 400
GWKTQNRSGK HSNSEMGRTT YELDSHQSVG GDRKRSSGSK HISRQRSPIQ
410 420 430 440 450
PYNSAEGRVR DCTEWRNPET GLKKHDQKDS DSPSEPTTQT SERGQRAQRS
460 470 480 490 500
EMKKSRHSKH QNKLKSTHKS ALSKLDSELL KHIQAKKRHK ERLRRKQKKE
510 520 530 540 550
EGELTEDTKE RIEKKIEERK KKKTREGRKG HDKKTIHKSG RKLGQVKKRA
560 570 580 590 600
KEERKQGDRK SETSISKTAS PNLGTLYPSD SDPLLDDLLA DPLHLSYIEE
610 620 630 640 650
ENEFSQHTSG FILPCKSPVN NNHCSPCQST LEINTKVLEV DEKSDSEPDH
660 670 680 690 700
VDTSDDDSVG THDVSGSNPS LLNTHVSEEE PIRCKEVVPG LHTAPDLLPA
710 720 730 740 750
HCTYSEELLR LDPPTSPPVL SWQGSPVLDL GDDDEDVKEE DMIGVLRRPV
760 770 780 790 800
LQPSPTHSSP LREAIEISTG VDYCHSDLAK LYGLPESSKA MDTEEEDEEK
810 820 830 840 850
TDGEQKDGSP DASGSSETNK PHLHQMDTFK SPSSAMASHR YTYRGGPFGR
860 870 880 890 900
PPPSALVGVK YSSSLSLGPE IHPPDQQSPP ASSPTTEIPD QVIHSLIQPT
910 920 930 940 950
DKDKESETEE EIMKTGAKED KIEVKGEETK VQKMDEQMEV KLAEPTKDPA
960 970 980 990 1000
STSLEEKESV MSPATVQAKL VHSCELLLNQ NSSPVSKVMK VSGSKSDQRE
1010 1020 1030 1040 1050
NEGDRQKDQL KTPRKAIRTM KEEEPETCVG RSIKAKHHKK GDRGENKKDI
1060 1070 1080 1090 1100
MKDKAETNSS SLSSEDAQKQ LVEIRTKQVV PENQQIEIKV GKTESHKIKR
1110 1120 1130 1140 1150
EKETDVKKDA IKEDAIKADS SATGCTSCTT NLQSSSTMTL FTRPPMLERV
1160 1170 1180 1190 1200
NLRNQHELSK IPLKELKICL VKIESRGRQT FRASEIEEKS IPLDAINIRN
1210 1220 1230 1240 1250
NAAEVIRACK GADIKNKFRE SYLLPSLSVK PDLSCRTPIP RDKLNPPTPS
1260 1270 1280 1290 1300
IYLESKRDAF SPVLLQFCTD SKNAVTVIRG LAGSLRLNLG LFSTKSLVEA
1310 1320 1330 1340 1350
NSEHAVEVRT QVQQPADENW NHSGSAQTWP CESSRSHTTI AKYAQYQASS
1360 1370 1380 1390 1400
FQESLQEEKD SEDEDEEDKS KEKNEAKSNS QNNIGTTSTT TSSKQKAVGK
1410 1420 1430 1440 1450
IIKFGTNIDL SDPKRWKAQL QELLKLPAFM RVSSTANMLS HVGHTILGMN
1460 1470 1480 1490 1500
TVQLYMKVPG SRTPGHQENN NFCSVNINIG PGDCEWFAVH EHYWKAISDF
1510 1520 1530 1540 1550
CEKHGVDYLT GSWWPVLEDL YRSNIPVYRF IQRPGDLVWI NAGTVHWVQA
1560 1570 1580 1590 1600
VGWCNNIAWN VGPLNAYQYQ LALERFEWNE VKKVKSIVPM IHVSWNVART
1610 1620 1630 1640 1650
IKITDPNTFK MIKHCLMQSI KHIQILRDQL VSAGKKISYQ SRVKDEPAYY
1660 1670 1680 1690 1700
CNECDLEVFD LLFVTSENSS RKTYVVHCED CARERSPGLN GVVVLEQYRI
1710
DELMNMYDNF TLSAVPCCR
Length:1,719
Mass (Da):193,329
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25711219E96582D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL807389 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001025349.2, NM_001030178.2
XP_005172678.1, XM_005172621.3
XP_005172680.1, XM_005172623.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000136123; ENSDARP00000120451; ENSDARG00000056929

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
563644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:563644

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807389 Genomic DNA No translation available.
RefSeqiNP_001025349.2, NM_001030178.2
XP_005172678.1, XM_005172621.3
XP_005172680.1, XM_005172623.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073960

Proteomic databases

PaxDbiE9QG91

Genome annotation databases

EnsembliENSDART00000136123; ENSDARP00000120451; ENSDARG00000056929
GeneIDi563644
KEGGidre:563644

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
563644
ZFINiZDB-GENE-040724-166, kdm6bb

Phylogenomic databases

eggNOGiKOG1246, Eukaryota
GeneTreeiENSGT00940000160414
HOGENOMiCLU_001909_0_0_1
OMAiDHSHRTH
OrthoDBi268901at2759
TreeFamiTF317405

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9QG91

Gene expression databases

BgeeiENSDARG00000056929, Expressed in retina and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR003347, JmjC_dom
IPR029518, KDM6B
PANTHERiPTHR14017:SF5, PTHR14017:SF5, 1 hit
PfamiView protein in Pfam
PF02373, JmjC, 1 hit
SMARTiView protein in SMART
SM00558, JmjC, 1 hit
PROSITEiView protein in PROSITE
PS51184, JMJC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QG91_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QG91
Secondary accession number(s): F1QQ03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: September 21, 2011
Last modified: April 7, 2021
This is version 71 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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