UniProtKB - E9QE31 (E9QE31_DANRE)
Protein
Calpain-3
Gene
capn3b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Calcium-regulated non-lysosomal thiol-protease.UniRule annotationARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 607 – 618 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
- calcium ion binding Source: InterPro
GO - Biological processi
- calcium-dependent self proteolysis Source: UniProtKB
- negative regulation of apoptotic process Source: GO_Central
- protein catabolic process Source: ZFIN
- proteolysis Source: GO_Central
- sarcomere organization Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotationARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1474228, Degradation of the extracellular matrix |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041001-149, capn3b |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000043035, Expressed in muscle tissue and 16 other tissues |
ExpressionAtlasi | E9QE31, baseline |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 360 | Calpain catalyticInterPro annotationAdd BLAST | 296 | |
Domaini | 551 – 585 | EF-handInterPro annotationAdd BLAST | 35 | |
Domaini | 594 – 620 | EF-handInterPro annotationAdd BLAST | 27 | |
Domaini | 624 – 659 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 689 – 723 | EF-handInterPro annotationAdd BLAST | 35 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 572 – 592 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156092 |
HOGENOMi | CLU_010982_0_1_1 |
OMAi | IACLTVN |
OrthoDBi | 704215at2759 |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029531, CAPN3 IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF329, PTHR10183:SF329, 3 hits |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF13833, EF-hand_8, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS50222, EF_HAND_2, 4 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E9QE31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEEQKFSET SVQLTEAAPQ TVGSGFTAPG NIYSAILSRN EAVKDARRLK
60 70 80 90 100
DFQELRDKYV RKKVLFEDPL FPAQDSSLFY SEKFPLKLEW KRPMEICKNP
110 120 130 140 150
QFILGGANRT DICQGDLGDC WLLAAIACLT LNDVILKRVV PHDQSFTENY
160 170 180 190 200
AGIFHFQFWR YGEWVDVVID DRLPTYKNKL VFTRSGQNNE FWSALMEKAY
210 220 230 240 250
AKLHGSYEAL KGGNSLEAME DFTGGVTEFY EITEAPKELY NIMRKALKRG
260 270 280 290 300
SLMGCAIDTL VPTAQRTKTA SGLVRGHAYS VTGVEQGKRK DGKDLMIRLV
310 320 330 340 350
RVRDPWGVAP PPACKSNDWV ELAKTEQDKQ RLQPGEQGEF WMCFEEFQKN
360 370 380 390 400
FTKLEICNLT PDTLEDDQMF KWNVTVHEGR WVKGCSAGGC RNFPDTYWTN
410 420 430 440 450
PQFRLVLLEA DAKEKTCTVV VALMQKGRRV ERCSGATLHN IGFAIYEVPK
460 470 480 490 500
EMKGNQQQQL SKDFFLYNAS TARSKSYVNI REVTERFCLK PGEYVIIPST
510 520 530 540 550
FDPHKESEFL LRVFSENRST SKVIDAEIEA EPMQVDNVKK KIKPFEEEET
560 570 580 590 600
EEEKQFRAIF QQIAGDDMEI NANELRTVLN RVVAKHKELK TEGFSLESCR
610 620 630 640 650
SMIALLDTDG TGHLNLQEFK HLWNKIKQWK LVFTRFDTDK SSTISSFEMR
660 670 680 690 700
NALTEAGFQL NNQLYDIICM RYANEHMELD FDSYISCLVR LEGMFRAFRA
710 720
FDKDGDGLIK LNVFEWLQLT MYA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1R632 | F1R632_DANRE | Calpain-3 | capn3b si:dkey-12h9.9 | 719 | Annotation score: | ||
A0A2R8Q1U8 | A0A2R8Q1U8_DANRE | Calpain-3 | capn3b | 715 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954831 Genomic DNA No translation available. |
RefSeqi | NP_001230250.1, NM_001243321.1 |
Genome annotation databases
Ensembli | ENSDART00000063177; ENSDARP00000063176; ENSDARG00000043035 |
GeneIDi | 100034405 |
KEGGi | dre:100034405 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL954831 Genomic DNA No translation available. |
RefSeqi | NP_001230250.1, NM_001243321.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E9QE31 |
Genome annotation databases
Ensembli | ENSDART00000063177; ENSDARP00000063176; ENSDARG00000043035 |
GeneIDi | 100034405 |
KEGGi | dre:100034405 |
Organism-specific databases
CTDi | 100034405 |
ZFINi | ZDB-GENE-041001-149, capn3b |
Phylogenomic databases
GeneTreei | ENSGT00940000156092 |
HOGENOMi | CLU_010982_0_1_1 |
OMAi | IACLTVN |
OrthoDBi | 704215at2759 |
Enzyme and pathway databases
Reactomei | R-DRE-1474228, Degradation of the extracellular matrix |
Gene expression databases
Bgeei | ENSDARG00000043035, Expressed in muscle tissue and 16 other tissues |
ExpressionAtlasi | E9QE31, baseline |
Family and domain databases
CDDi | cd00214, Calpain_III, 1 hit cd00044, CysPc, 1 hit |
InterProi | View protein in InterPro IPR033883, C2_III IPR022684, Calpain_cysteine_protease IPR022682, Calpain_domain_III IPR022683, Calpain_III IPR036213, Calpain_III_sf IPR029531, CAPN3 IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR001300, Peptidase_C2_calpain_cat |
PANTHERi | PTHR10183:SF329, PTHR10183:SF329, 3 hits |
Pfami | View protein in Pfam PF01067, Calpain_III, 1 hit PF13833, EF-hand_8, 1 hit PF00648, Peptidase_C2, 1 hit |
PRINTSi | PR00704, CALPAIN |
SMARTi | View protein in SMART SM00720, calpain_III, 1 hit SM00230, CysPc, 1 hit SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49758, SSF49758, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS50203, CALPAIN_CAT, 1 hit PS50222, EF_HAND_2, 4 hits PS00139, THIOL_PROTEASE_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9QE31_DANRE | |
Accessioni | E9QE31Primary (citable) accession number: E9QE31 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | January 20, 2016 | |
Last modified: | February 10, 2021 | |
This is version 72 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |