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Entry version 59 (08 May 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Protein transport protein Sec16A

Gene

Sec16a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17428803). Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (By similarity). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in adipocytes (PubMed:27354378).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-204005 COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec16A
Alternative name(s):
SEC16 homolog A
Short name:
p2501 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec16a
Synonyms:Kiaa0310, Sec16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139207 Sec16a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Microsome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004456961 – 2357Protein transport protein Sec16AAdd BLAST2357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei591PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei615PhosphothreonineBy similarity1
Modified residuei617PhosphoserineBy similarity1
Modified residuei1087PhosphoserineBy similarity1
Modified residuei1223PhosphoserineBy similarity1
Modified residuei1245PhosphoserineBy similarity1
Modified residuei1340PhosphothreonineBy similarity1
Modified residuei1342PhosphoserineBy similarity1
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1365PhosphoserineBy similarity1
Modified residuei1371PhosphoserineBy similarity1
Modified residuei1374PhosphoserineBy similarity1
Modified residuei1377PhosphoserineBy similarity1
Modified residuei1384PhosphoserineBy similarity1
Modified residuei1588PhosphoserineBy similarity1
Modified residuei1616PhosphoserineBy similarity1
Modified residuei1922PhosphothreonineBy similarity1
Modified residuei1951PhosphoserineBy similarity1
Modified residuei2043PhosphoserineBy similarity1
Modified residuei2063PhosphoserineBy similarity1
Modified residuei2077PhosphoserineBy similarity1
Modified residuei2094PhosphoserineBy similarity1
Modified residuei2291PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
E9QAT4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9QAT4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9QAT4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9QAT4

PeptideAtlas

More...
PeptideAtlasi
E9QAT4

PRoteomics IDEntifications database

More...
PRIDEi
E9QAT4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A2AIX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A2AIX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026924 Expressed in 273 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
E9QAT4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9QAT4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (By similarity). Interacts with SEC23A (PubMed:17428803). Interacts with RNF183, RNF152, MIA3 and SEC13 (By similarity). Interacts with GORASP2 in response to ER stress (By similarity). Interacts with LRRK2 (via ROC domain) (PubMed:25201882). Interacts with RAB10 (PubMed:27354378).By similarity3 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E9QAT4, 7 interactors

Molecular INTeraction database

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MINTi
E9QAT4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
E9QAT4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1037 – 1905Required for localization to endoplasmic reticulum exit sitesBy similarityAdd BLAST869
Regioni1118 – 1415Interaction with MIA3By similarityAdd BLAST298
Regioni1119 – 1420Required for endoplasmic reticulum localizationBy similarityAdd BLAST302
Regioni1449 – 1905Central conserved domain (CCD); mediates interaction with RNF183, LRRK2 and SEC13By similarityAdd BLAST457
Regioni2126 – 2357Required for interaction with SEC23ABy similarityAdd BLAST232

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMIQ Eukaryota
ENOG41100S8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231542

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A2AIX1

KEGG Orthology (KO)

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KOi
K20353

Identification of Orthologs from Complete Genome Data

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OMAi
LKKWVNK

Database of Orthologous Groups

More...
OrthoDBi
235062at2759

TreeFam database of animal gene trees

More...
TreeFami
TF316276

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09233 ACE1-Sec16-like, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: E9QAT4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPQAVPS GVAGPPPAGN PRSMFWANSP YRKPANNAPV APITRPLQPV
60 70 80 90 100
TDPFAFNRQT LQNTPVGSSS KSSLPNLPGP ALSVFSQWPG LPVTPTNAGD
110 120 130 140 150
SSTGLHEPLS GTLSQPRADA SLFPPASTPS SLPGLEVSRN AEADPSSGHE
160 170 180 190 200
VQMLPHSAHY IPGVGPEQPL GGQMNDSGSG PDQPMNRHAP HDGAVTHAAS
210 220 230 240 250
PFLPQPQMPG QWGPAQGGPQ PSYQHHSPYL EGPVQNMGLQ AASLPHFPPP
260 270 280 290 300
SSLHQGPGHE SHAPQTFTPA SLASGEGNEI VHQQSKNHPL SSFPPKHTFE
310 320 330 340 350
QNSRIGNMWA SPELKQNPGV NKEHLLDPAH VNPFTQGNSP ENQAHHPPVA
360 370 380 390 400
ATNHALQEAA SGALSMFFQG EETENEENLS SEKAGLDKRL NLDSFSSTSR
410 420 430 440 450
LGHPPPPGAS GVYQAFPRGP SSEAAQEGDA QPYFSQSVGV RLDKQSTVPP
460 470 480 490 500
ANDAWGDVPG TGTRCASGPQ CENVENLEFV QNQEVLPRET LSVDPFPLSD
510 520 530 540 550
QIRYGPLPGP AASRPATVGL TRGGGLNLEA PDTPLHPTRP DSVSSSYSSH
560 570 580 590 600
SHRSPPGSAR PQELVGTFIQ QEVGKLEDDT SGSFFKQIDS SPVGGETDEV
610 620 630 640 650
TGSQNCCSSL SQPSTPSPPK PTGVFQTSAN SSFEPVKSHL VGVKPVEADR
660 670 680 690 700
ANMVVEVRGT QYCPKKRRAA VAPPDATSGN LEQPPDNMET PCAPQACPLP
710 720 730 740 750
LSTTGEAGQL VSNTAGTPLD TVRPVPDKRP SARAQGPVKC ESPATTLWAQ
760 770 780 790 800
NELPDFGGNV LLAPAAPALY VPVKPKPSEV VHHPEKGMSG QKAWKQGSVP
810 820 830 840 850
PLQNQDPPGA SENLENPPKV GEEEALPVQA SSGYASLLSS PPTESLHNQP
860 870 880 890 900
VLIAQPDQSY NLAQPINFSV SLLNPNEKNQ SWGDAVVGER SIVSNNWALG
910 920 930 940 950
GDPEERAALS GVPASAVTGA SLPSSIPQNC APQGSGSSEM IASQSASWLV
960 970 980 990 1000
QQLSPQTPQS PHPNAEKGPS EFVSSPAGNT SVMLVPPASS TLVPNSNKAK
1010 1020 1030 1040 1050
HSSNQEEAVG ALDFTLNRTL ENPVRMYSPS PSDGPASQQP LPNHPRQSGP
1060 1070 1080 1090 1100
GLHNQDHFYQ QVTKDAQDQH RLERAQPELV PPRPQNSPQV PQASCPEPSN
1110 1120 1130 1140 1150
PESPPTQGQS ESLAQPPASP ASVNTGQLLP QPPQASSASV TSTNSSQAAV
1160 1170 1180 1190 1200
RSEQLWLHPP PPNTFGPAPQ DLASYYYYRP LYDAYQSQYP SPYPSDPGTA
1210 1220 1230 1240 1250
SLYYQDMYGL YEPRYRPYDS SASAYAENHR YSEPERPSSR ASHYSDQLAP
1260 1270 1280 1290 1300
RQGYPEGYYN SKSGWSSHSD YYANYYSGQY DYGDPSRWDR YYGSRLRDPR
1310 1320 1330 1340 1350
TWDRRYWYDS EHDPYRKDHY AYSDRPEKCD DHWRYDPRFT GSFDDDAEIH
1360 1370 1380 1390 1400
RDPYGEEADR RSIHSEHSAR SLRSTHSLPS RRSSLSSHSH QSQIYRSHHV
1410 1420 1430 1440 1450
TGGSFEAPHA PGSFHGDYAY GTYASNFSGA HGFPEYSYPA DTSWPAVEQV
1460 1470 1480 1490 1500
PSRPTSPEKF TVPHVCARFG PGGQLLKVIP NLPSEGQPAL VEIHSLETLL
1510 1520 1530 1540 1550
QHTPEQEEMR SFPGPLGKDD THKVDVINFA QNKATKCLQN ESLIDKESAS
1560 1570 1580 1590 1600
LLWKFIILLC RQNGTVVGTD IAELLLRDHR TVWLPGKSPN EANLIDFTNE
1610 1620 1630 1640 1650
AVEQVEEEES GEAQLSFLTD SQTVTTSVLE KETERFRELL LYGRKKDALE
1660 1670 1680 1690 1700
SAMKNGLWGH ALLLASKMDS RTHARVMTRF ANSLPINDPL QTVYQLMSGR
1710 1720 1730 1740 1750
MPAASTCCGD EKWGDWRPHL AMVLSNLNNN MDVESRTMAT MGDTLASKGL
1760 1770 1780 1790 1800
LDAAHFCYLM AQVGFGVYTK KTTKLVLIGS NHSLPFLKFA TNEAIQRTEA
1810 1820 1830 1840 1850
YEYAQSLGAH TCSLPNFQVF KFIYLCRLAE MGLATQAFHY CEVIAKSVLT
1860 1870 1880 1890 1900
QPGAYSPVLI SQLTQMASQL RLFDPQLKEK PEEESFVEPA WLVQLQHVER
1910 1920 1930 1940 1950
QIQEGTVLWS QDGTEPQQCR ITSGSEVEQS DGPGLNQQAG PQADNPLLMP
1960 1970 1980 1990 2000
STEPLMHGVQ LLPTAPQTLP DGQPAHLSRV PMFPVPMSRG PLELSPAYGP
2010 2020 2030 2040 2050
PGSALGFPES SRSDPAVLHP GQALPPTTLS LQESGLPPQE AKSPDPEMVP
2060 2070 2080 2090 2100
RGSPVRHSPP ELSQEEFGES FADPGSSRTA QDLETSPVWD LGSSSLTRAP
2110 2120 2130 2140 2150
SLTSDSEGKK PAQAVKKEPK EPKKTESWFS RWLPGKKRTE AYLPDDKNKS
2160 2170 2180 2190 2200
IVWDEKKNQW VNLNEPEEEK KAPPPPPTSF PRVPQVAPTG PAGPPTASVN
2210 2220 2230 2240 2250
VFSRKAGGSR ARYVDVLNPS GTQRSEPALA PADFFAPLAP LPIPSNLFVP
2260 2270 2280 2290 2300
NPDAEEPQPA DGTGCRGQAP AGTQSKAEST LEPKVGSSTV SAPGPELLPS
2310 2320 2330 2340 2350
KPDGSQGGEA PGDHCPTGAP HGGSVPFYNP AQLVQASVTS GNSRPGRIGQ

RKYAALN
Length:2,357
Mass (Da):254,202
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF482E74AEFD7157
GO
Isoform 2 (identifier: E9QAT4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2309-2309: E → ELSRCSSLSSLSQEVSRHFHQ

Show »
Length:2,377
Mass (Da):256,473
Checksum:i3D97AFDDF97218BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BPW6F7BPW6_MOUSE
Protein transport protein sec16
Sec16a
907Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T8X6F6T8X6_MOUSE
Protein transport protein Sec16A
Sec16a
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2038P → L in AAH42603 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0599362309E → ELSRCSSLSSLSQEVSRHFH Q in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL732541 Genomic DNA No translation available.
BC042603 mRNA Translation: AAH42603.1
AK122242 mRNA Translation: BAC65524.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38085.1 [E9QAT4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_694765.2, NM_153125.2 [E9QAT4-1]
XP_006497974.1, XM_006497911.3 [E9QAT4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091252; ENSMUSP00000088796; ENSMUSG00000026924 [E9QAT4-1]
ENSMUST00000114082; ENSMUSP00000109716; ENSMUSG00000026924 [E9QAT4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
227648

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227648

UCSC genome browser

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UCSCi
uc008ivi.1 mouse [E9QAT4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732541 Genomic DNA No translation available.
BC042603 mRNA Translation: AAH42603.1
AK122242 mRNA Translation: BAC65524.3
CCDSiCCDS38085.1 [E9QAT4-1]
RefSeqiNP_694765.2, NM_153125.2 [E9QAT4-1]
XP_006497974.1, XM_006497911.3 [E9QAT4-2]

3D structure databases

SMRiE9QAT4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9QAT4, 7 interactors
MINTiE9QAT4
STRINGi10090.ENSMUSP00000109716

PTM databases

iPTMnetiA2AIX1
PhosphoSitePlusiA2AIX1

Proteomic databases

EPDiE9QAT4
jPOSTiE9QAT4
MaxQBiE9QAT4
PaxDbiE9QAT4
PeptideAtlasiE9QAT4
PRIDEiE9QAT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091252; ENSMUSP00000088796; ENSMUSG00000026924 [E9QAT4-1]
ENSMUST00000114082; ENSMUSP00000109716; ENSMUSG00000026924 [E9QAT4-2]
GeneIDi227648
KEGGimmu:227648
UCSCiuc008ivi.1 mouse [E9QAT4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9919
MGIiMGI:2139207 Sec16a

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IMIQ Eukaryota
ENOG41100S8 LUCA
GeneTreeiENSGT00940000159324
HOGENOMiHOG000231542
InParanoidiA2AIX1
KOiK20353
OMAiLKKWVNK
OrthoDBi235062at2759
TreeFamiTF316276

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sec16a mouse

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026924 Expressed in 273 organ(s), highest expression level in pituitary gland
ExpressionAtlasiE9QAT4 baseline and differential
GenevisibleiE9QAT4 MM

Family and domain databases

CDDicd09233 ACE1-Sec16-like, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD
PfamiView protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC16A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QAT4
Secondary accession number(s): A2AIX1, Q80U43, Q811L5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2018
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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