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Protein
Submitted name:

Inositol polyphosphate-5-phosphatase A

Gene

Inpp5a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Names & Taxonomyi

Protein namesi
Submitted name:
Inositol polyphosphate-5-phosphatase AImported
Gene namesi
Name:Inpp5aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2686961 Inpp5a

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiE9QAS7
PaxDbiE9QAS7
PeptideAtlasiE9QAS7
PRIDEiE9QAS7

Expressioni

Gene expression databases

BgeeiENSMUSG00000025477 Expressed in 301 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiE9QAS7 baseline and differential
GenevisibleiE9QAS7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026550

Structurei

3D structure databases

ProteinModelPortaliE9QAS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 400IPPcInterPro annotationAdd BLAST393

Phylogenomic databases

eggNOGiKOG1976 Eukaryota
ENOG410XNWI LUCA
GeneTreeiENSGT00390000015226
InParanoidiE9QAS7
OrthoDBiEOG091G0FF9
PhylomeDBiE9QAS7
TreeFamiTF314246

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR039737 INPP5A
IPR000300 IPPc
PANTHERiPTHR12997 PTHR12997, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9QAS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV LHTHKPHFMA
60 70 80 90 100
LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH
110 120 130 140 150
FTALGSFYFL HESLKNIYQF DFKAKKYKKV TGKEIYSDTL ESTPMLEKEK
160 170 180 190 200
FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS
210 220 230 240 250
VYSGVRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA
260 270 280 290 300
TMQTVRAADT NEVVKLIFRE SDNDRKVVLQ LEKKLFDYFN QDVFRDNNGT
310 320 330 340 350
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDSSQGEQYM NTRCPAWCDR
360 370 380 390 400
ILMSLSAKEL VLKSESEEKV ATYDHIGPNV CMGDHKPVFL AFRIAPGAGK
410 420
RCQRRERILE RPPCSSVSNS SS
Length:422
Mass (Da):48,812
Last modified:April 5, 2011 - v1
Checksum:i2B9BA725D3A2AA8A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TZT4Q3TZT4_MOUSE
Inositol polyphosphate-5-phosphatas...
Inpp5a
420Annotation score:
Q7TNC9Q7TNC9_MOUSE
Inositol polyphosphate-5-phosphatas...
Inpp5a
412Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112670 Genomic DNA No translation available.
AC118735 Genomic DNA No translation available.
RefSeqiNP_898967.2, NM_183144.3
UniGeneiMm.28308

Genome annotation databases

EnsembliENSMUST00000026550; ENSMUSP00000026550; ENSMUSG00000025477
GeneIDi212111
UCSCiuc009kfq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC112670 Genomic DNA No translation available.
AC118735 Genomic DNA No translation available.
RefSeqiNP_898967.2, NM_183144.3
UniGeneiMm.28308

3D structure databases

ProteinModelPortaliE9QAS7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026550

Proteomic databases

MaxQBiE9QAS7
PaxDbiE9QAS7
PeptideAtlasiE9QAS7
PRIDEiE9QAS7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026550; ENSMUSP00000026550; ENSMUSG00000025477
GeneIDi212111
UCSCiuc009kfq.2 mouse

Organism-specific databases

CTDi3632
MGIiMGI:2686961 Inpp5a

Phylogenomic databases

eggNOGiKOG1976 Eukaryota
ENOG410XNWI LUCA
GeneTreeiENSGT00390000015226
InParanoidiE9QAS7
OrthoDBiEOG091G0FF9
PhylomeDBiE9QAS7
TreeFamiTF314246

Enzyme and pathway databases

ReactomeiR-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol

Miscellaneous databases

ChiTaRSiInpp5a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025477 Expressed in 301 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiE9QAS7 baseline and differential
GenevisibleiE9QAS7 MM

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR039737 INPP5A
IPR000300 IPPc
PANTHERiPTHR12997 PTHR12997, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QAS7_MOUSE
AccessioniPrimary (citable) accession number: E9QAS7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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