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Protein
Submitted name:

TATA-box-binding protein-associated factor 4

Gene

Taf4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: MGI
  • DNA binding Source: MGI
  • DNA-binding transcription factor activity Source: Ensembl
  • protein heterodimerization activity Source: InterPro
  • transcription factor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Submitted name:
TATA-box-binding protein-associated factor 4Imported
Gene namesi
Name:Taf4Imported
Synonyms:Taf4aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2152346 Taf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9QAP7
PaxDbiE9QAP7
PeptideAtlasiE9QAP7
PRIDEiE9QAP7

PTM databases

iPTMnetiE9QAP7
PhosphoSitePlusiE9QAP7

Expressioni

Gene expression databases

BgeeiENSMUSG00000039117 Expressed in 271 organ(s), highest expression level in secondary oocyte
GenevisibleiE9QAP7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-932 General transcription factor complex TFIID
IntActiE9QAP7, 4 interactors
MINTiE9QAP7
STRINGi10090.ENSMUSP00000038610

Structurei

3D structure databases

ProteinModelPortaliE9QAP7
SMRiE9QAP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini548 – 645TAFHInterPro annotationAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili939 – 959Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2341 Eukaryota
ENOG410XQS6 LUCA
GeneTreeiENSGT00390000011620
InParanoidiE9QAP7
KOiK03129
OMAiSRQFMRQ
OrthoDBiEOG091G0GOS
TreeFamiTF316520

Family and domain databases

CDDicd08045 TAF4, 1 hit
Gene3Di1.10.20.10, 1 hit
1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007900 TAF4
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
PfamiView protein in Pfam
PF05236 TAF4, 1 hit
PF07531 TAFH, 1 hit
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
SSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9QAP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGSDLLDE VFFNSEVDEK VVSDLVGSLE SQLAASAAHH HHLAPRTPEL
60 70 80 90 100
RAAAAGALGN HVVSGSPAGA AGAGPAASAE GAPAAAPEPP PAGRARPAGG
110 120 130 140 150
GPRRPGSSSP RRLLVPAGPA PAPAKLRPLP EASAGPCPAA AAAAAATAAA
160 170 180 190 200
VAGPDPAAAA PPAGPGASKP GPPGPPGPGA AQTLNGSAAP PTAPHAAPAV
210 220 230 240 250
SPVNNGPAPP PAAGSVIQAA PAPAAPSPPA APAPAAPPPP APPAPVAPAR
260 270 280 290 300
PPGHPAAPAP PVSPAAAAAA AAAAAAAQNG AAPAPAAASG GAAGLGQPGA
310 320 330 340 350
GAQGAKAEAP KPGPGPGPGP AAAAAAAGVA GGGAAGSVLL GPAMPGALPG
360 370 380 390 400
PAPGTPAGLA KGAAAATPSL PRTPAATTGA IRATLTPTVL APRLPQPPQN
410 420 430 440 450
PTNIQNFQLP PGMVLVRSEN GQLLMIPQQA LAQMQAHAQA QPQSTMAPRP
460 470 480 490 500
ATPTGAPPVQ ISTVQAPGTP IIARQVTPTT IIKQVSQAQT TVQPTTTLQR
510 520 530 540 550
SPGVQPQLVL GGSAQPASLG TATAVQTGTP QRTVPGASTT STAATETMEN
560 570 580 590 600
VKKCKSFLST LIKLASSGKQ STETAANVKD LVQNLLDGKI EAEDFTSRLY
610 620 630 640 650
RELNSSPQPY LVPFLKRSLP ALRQLTPDSA AFIQQSQQQQ PPASQATTAL
660 670 680 690 700
TAVVLSSSVQ RTAGKTAASV TSALQPPVIS LTQPTQVGVG KQAPPTPLVI
710 720 730 740 750
QQPPKPGALI RPPQVTLTQT PMVALRQPHN RIMLTTPQQI QLNQLQPVPV
760 770 780 790 800
VKPTVLPGTK ALSTVSAQAA AAQKNKLKEP GGGSFRDDDD INDVASMAGV
810 820 830 840 850
NLSEESARIL ATNSELVGTL TRSCKDDTFL LPAPLQRRIL EIGKKHGITE
860 870 880 890 900
LHPDVVSYVS HATQQRLQNL VEKISETAQQ KNFSYKDDDR YEQASDVRAQ
910 920 930 940 950
LKFFEQLDQI EKQRKDEQER EILMRAAKSR SRQEDPEQLR LKQKAKEMQQ
960 970 980 990 1000
QELAQMRQRD ANLTALAAIG PRKKRKVDCT GPGSGAEGSG PGAAVPGGSG
1010 1020 1030 1040
VGTPRQFTRQ RITRVNLRDL IFCLENERET SHSLLLYKAF LK
Length:1,042
Mass (Da):105,307
Last modified:April 5, 2011 - v1
Checksum:iA27B050487DCAB2E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPN6A0A2I3BPN6_MOUSE
TATA-box-binding protein-associated...
Taf4
1,030Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663067 Genomic DNA No translation available.
RefSeqiNP_001074561.1, NM_001081092.1
UniGeneiMm.235542

Genome annotation databases

EnsembliENSMUST00000041618; ENSMUSP00000038610; ENSMUSG00000039117
GeneIDi228980
KEGGimmu:228980
UCSCiuc008ohw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663067 Genomic DNA No translation available.
RefSeqiNP_001074561.1, NM_001081092.1
UniGeneiMm.235542

3D structure databases

ProteinModelPortaliE9QAP7
SMRiE9QAP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-932 General transcription factor complex TFIID
IntActiE9QAP7, 4 interactors
MINTiE9QAP7
STRINGi10090.ENSMUSP00000038610

PTM databases

iPTMnetiE9QAP7
PhosphoSitePlusiE9QAP7

Proteomic databases

MaxQBiE9QAP7
PaxDbiE9QAP7
PeptideAtlasiE9QAP7
PRIDEiE9QAP7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041618; ENSMUSP00000038610; ENSMUSG00000039117
GeneIDi228980
KEGGimmu:228980
UCSCiuc008ohw.1 mouse

Organism-specific databases

CTDi6874
MGIiMGI:2152346 Taf4

Phylogenomic databases

eggNOGiKOG2341 Eukaryota
ENOG410XQS6 LUCA
GeneTreeiENSGT00390000011620
InParanoidiE9QAP7
KOiK03129
OMAiSRQFMRQ
OrthoDBiEOG091G0GOS
TreeFamiTF316520

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRSiTaf4 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039117 Expressed in 271 organ(s), highest expression level in secondary oocyte
GenevisibleiE9QAP7 MM

Family and domain databases

CDDicd08045 TAF4, 1 hit
Gene3Di1.10.20.10, 1 hit
1.20.120.1110, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007900 TAF4
IPR037249 TAFH/NHR1_dom_sf
IPR003894 TAFH_NHR1
PfamiView protein in Pfam
PF05236 TAF4, 1 hit
PF07531 TAFH, 1 hit
SMARTiView protein in SMART
SM00549 TAFH, 1 hit
SUPFAMiSSF158553 SSF158553, 1 hit
SSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51119 TAFH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QAP7_MOUSE
AccessioniPrimary (citable) accession number: E9QAP7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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