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Protein

DNA polymerase epsilon catalytic subunit

Gene

Pole

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA polymerase II participates in chromosomal DNA replication.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon catalytic subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:PoleImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1196391 Pole

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiE9QAP6
PeptideAtlasiE9QAP6
PRIDEiE9QAP6

Expressioni

Gene expression databases

BgeeiENSMUSG00000007080 Expressed in 177 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiE9QAP6 baseline and differential

Structurei

3D structure databases

SMRiE9QAP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 48DUF1744InterPro annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 85Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG1798 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00390000010194

Family and domain databases

InterProiView protein in InterPro
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
PANTHERiPTHR10670 PTHR10670, 1 hit
PfamiView protein in Pfam
PF08490 DUF1744, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9QAP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSLGDCLN PLEVHFIHSK EIFHSLTISF SRCWEFLLWM DPSNYGGIKG
60 70 80 90 100
KVPSSIHCGQ VKEQDSQARE ETDEEEEDKE KDEEEEGMGE SEVEDLLENN
110 120 130 140 150
WNILQFLPQA ASCQSYFLMI VSAYIVAVYQ SMKEELRHSA PGSTPVKRKG
160 170 180 190 200
ASQFSQESEG ATGSLPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN
210 220 230 240 250
TTEPSEMFPV LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL
260 270 280 290 300
LRLVDVGEFS EEAQFRDPCH SYVLPEVICH SCNFCRDLDL CKDSSFSQDG
310 320 330 340 350
AILPQWLCSN CQAPYDSSAI ESALVEALQR KLMAFTLQDL VCLKCRGMKE
360 370 380 390 400
THMPVYCSCA GDFTLTIRTE VFMEQIRIFQ NIAKYYSMSY LQETIEWLLQ

TSPVSNC
Length:407
Mass (Da):46,088
Last modified:April 5, 2011 - v1
Checksum:iE63DAADE1D76BA99
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9WVF7DPOE1_MOUSE
DNA polymerase epsilon catalytic su...
Pole Pole1
2,283Annotation score:
E9QAP5E9QAP5_MOUSE
DNA polymerase epsilon catalytic su...
Pole
193Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118260 Genomic DNA No translation available.
AC123699 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000112481; ENSMUSP00000108100; ENSMUSG00000007080
UCSCiuc008yqo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118260 Genomic DNA No translation available.
AC123699 Genomic DNA No translation available.

3D structure databases

SMRiE9QAP6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9QAP6
PeptideAtlasiE9QAP6
PRIDEiE9QAP6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112481; ENSMUSP00000108100; ENSMUSG00000007080
UCSCiuc008yqo.2 mouse

Organism-specific databases

MGIiMGI:1196391 Pole

Phylogenomic databases

eggNOGiKOG1798 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00390000010194

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007080 Expressed in 177 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiE9QAP6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
PANTHERiPTHR10670 PTHR10670, 1 hit
PfamiView protein in Pfam
PF08490 DUF1744, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9QAP6_MOUSE
AccessioniPrimary (citable) accession number: E9QAP6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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