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Protein

DNA polymerase epsilon catalytic subunit

Gene

Pole

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA polymerase II participates in chromosomal DNA replication.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon catalytic subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:PoleImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1196391 Pole

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiE9QAP5
PeptideAtlasiE9QAP5
PRIDEiE9QAP5

Expressioni

Gene expression databases

BgeeiENSMUSG00000007080
ExpressionAtlasiE9QAP5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9QAP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 180DNA_pol_B_exo1InterPro annotationAdd BLAST94

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG1798 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00390000010194

Family and domain databases

InterProiView protein in InterPro
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR029703 POL2
IPR012337 RNaseH-like_sf
PANTHERiPTHR10670 PTHR10670, 1 hit
PfamiView protein in Pfam
PF03104 DNA_pol_B_exo1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

E9QAP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLRNSGRRH PEPGADGEGS RDDGPSSSVS ALKRLERSQW TDKMDLRFGF
60 70 80 90 100
ERLKEPGERT GWLINMHPTE ILDEDKRLVS AVDYYFIQDD GSRFKVALPY
110 120 130 140 150
MPYFYIAARK GCDREVSSFL SKKFQGKIAK LENVPKEDLD LPNHLVGLKR
160 170 180 190
SYIKLSFHTV EDLVKVRKEI SPAVKKNREQ DHASDEYTTM LSR
Length:193
Mass (Da):22,251
Last modified:April 5, 2011 - v1
Checksum:i208AA560402C04B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118260 Genomic DNA No translation available.
AC123699 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000112482; ENSMUSP00000108101; ENSMUSG00000007080
UCSCiuc008yqk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiE9QAP5_MOUSE
AccessioniPrimary (citable) accession number: E9QAP5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 18, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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