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Protein
Submitted name:

B-TFIID TATA-box-binding protein-associated factor 1

Gene

Btaf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
B-TFIID TATA-box-binding protein-associated factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Btaf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2147538 Btaf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9QAE3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9QAE3

PeptideAtlas

More...
PeptideAtlasi
E9QAE3

PRoteomics IDEntifications database

More...
PRIDEi
E9QAE3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9QAE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9QAE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040565 Expressed in 245 organ(s), highest expression level in pes

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9QAE3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E9QAE3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097093

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1277 – 1452Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini1635 – 1789Helicase C-terminalInterPro annotationAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili827 – 847Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0387 Eukaryota
ENOG410XP4Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157500

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9QAE3

KEGG Orthology (KO)

More...
KOi
K15192

Identification of Orthologs from Complete Genome Data

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OMAi
ALIFCQM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00E4

TreeFam database of animal gene trees

More...
TreeFami
TF300546

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9QAE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSRLDRLF ILLDTGTTPV TRKAAAQQLG EVVKLHPHEL NNLLSKVLIY
60 70 80 90 100
LRSTNWDTRI AAGQAVEAIV KNVPEWNPVP RTKQEPTESS MEDSSTTDRL
110 120 130 140 150
NFDRFDICRL LQHGASLLGS AGAEFEVQDE KSGEVDPKER IARQRKLLQK
160 170 180 190 200
KLGLNMGEAI GMSTEELFND EDLDYTPTSA ALVNKQSTLQ AAELIDSEFR
210 220 230 240 250
AGMSNRQKNK AKRMAKLFAK QRSRDAVETN EKSNDSTDGE PEEKRRKVAN
260 270 280 290 300
VVINQTASDS KVLIDNVPES SSLIEETNEW PLESFCEELC NDLFNPSWEV
310 320 330 340 350
RHGAGTGLRE ILKAHGKSGG KMGDSTLEEM IQQHQEWLED LVIRLLCVFA
360 370 380 390 400
LDRFGDFVSD EVVAPVRETC AQTLGVVLKH MNETGVHKTV DVLLKLLTQE
410 420 430 440 450
QWEVRHGGLL GIKYALAVRQ DVINTLLPKV LTRIIEGLQD LDDDVRAVAA
460 470 480 490 500
ASLVPVVESL VYLQTQKVPS IINTLWDSLL ELDDLTASTN SIMTLLSSML
510 520 530 540 550
TYPQVQQCSI QQSLTVLVPR VWPFLHHTIS SVRRAALETL FTLLSTQDEN
560 570 580 590 600
SSSWLIPILS DMLRHIFQFC VLESSQEILD LIHKVWMELL SKASVQYLVA
610 620 630 640 650
AACPWMSAWL CLMMQPSHLP IDLNMLLEVK ARAKEKTGGK VRQGQIQNKE
660 670 680 690 700
VLQEYIAGAD TIMEDPATRD FVVMRARMMA AKLLGALCCY ICDPSVNMVN
710 720 730 740 750
QEIKPADSLG QLLLFYLNSK SALQRISVAL VICEWAALQK ECKAVTLAVQ
760 770 780 790 800
PRLLDILSEH LYYDEIAVPF TRMQNECKQF ISSLADAHIE VGNRVNNNVL
810 820 830 840 850
TIDQANDLVT TIFNEVTSTF DLNPQVLQQL DSKRHQVQMT VAETNQEWQV
860 870 880 890 900
LQLRVHTFAA CAVVSLQQLP EKLNPIIKPL METIKKEENT LVQNYAAQYI
910 920 930 940 950
AKLLQQCTTR TPCPNSKVIK NLCSSLCVDP YLTPCVTCPV PTQSGQENSK
960 970 980 990 1000
GSNSEKDGMH HTVTKHRGII TLYRHQKAAF AITSRRGPIP KAIKAQIADL
1010 1020 1030 1040 1050
PAGSSGTILV ELDEGQKPYL VQRRGAEFAL TTIVKHFGAE MAVKLPHLWD
1060 1070 1080 1090 1100
AMVGPLKSMI DLNNFDGKSL LERGDVPAQE LVNSLQVFEI AAASMDSALH
1110 1120 1130 1140 1150
PLLVQHLPHL YMCLQYPSTA VRHMAARCIG VMSKIATMET MNIFLEKVLP
1160 1170 1180 1190 1200
WLGAIDDNVK QEGAIEALAC VMEQLDVGIV PYIVLLVVPV LGRMSDQTDS
1210 1220 1230 1240 1250
VRFMATQCFA TLIRLMPLEA GIPDPPNMSE ELIQLKAKER HFLEQLLDGK
1260 1270 1280 1290 1300
KLENYKIPVP INAELRKYQQ DGVNWLAFLN KYKLHGILCD DMGLGKTLQS
1310 1320 1330 1340 1350
ICILAGDHCQ RAQEYARSKL AECMPLPSLV VCPPTLTGHW VDEVGKFCSR
1360 1370 1380 1390 1400
EYLNPLHYTG PPTERIRLQH QVKRHNLIVA SYDVVRNDID FFRNIKFNYC
1410 1420 1430 1440 1450
ILDEGHVIKN GKTKLSKAVK QLTANYRIIL SGTPIQNNVL ELWSLFDFLM
1460 1470 1480 1490 1500
PGFLGTERQF AARYGKPILA SRDARSSSRE QEAGVLAMDA LHRQVLPFLL
1510 1520 1530 1540 1550
RRMKEDVLQD LPPKIIQDYY CTLSPLQVQL YEDFAKSRAK CDVDETVSSA
1560 1570 1580 1590 1600
ALSEETEKPK LKATGHVFQA LQYLRKLCNH PALVLTPQHP EFKSTTEKLT
1610 1620 1630 1640 1650
VQNSSLHDIQ HAPKLSALKQ LLLDCGLGNG SSTESGTESV VAQHRILIFC
1660 1670 1680 1690 1700
QLKSMLDIVE HDLLKPHLPS VTYLRLDGSI PPGQRHSIVS RFNNDPSIDV
1710 1720 1730 1740 1750
LLLTTHVGGL GLNLTGADTV VFVEHDWNPM RDLQAMDRAH RIGQKRVVNV
1760 1770 1780 1790 1800
YRLITRGTLE EKIMGLQKFK MNIANTVISQ ENSSLQSMGT DQLLDLFTLD
1810 1820 1830 1840
KDGKAEKADS STSGKASMKS VLENLSDLWD AEQYDSEYNL ETFMRSLE
Length:1,848
Mass (Da):207,052
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B9BA401216EB9D8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC118931 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074175.1, NM_001080706.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.295062

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000099494; ENSMUSP00000097093; ENSMUSG00000040565

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107182

UCSC genome browser

More...
UCSCi
uc008hhw.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118931 Genomic DNA No translation available.
RefSeqiNP_001074175.1, NM_001080706.1
UniGeneiMm.295062

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

IntActiE9QAE3, 1 interactor
STRINGi10090.ENSMUSP00000097093

PTM databases

iPTMnetiE9QAE3
PhosphoSitePlusiE9QAE3

Proteomic databases

MaxQBiE9QAE3
PaxDbiE9QAE3
PeptideAtlasiE9QAE3
PRIDEiE9QAE3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099494; ENSMUSP00000097093; ENSMUSG00000040565
GeneIDi107182
KEGGimmu:107182
UCSCiuc008hhw.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9044
MGIiMGI:2147538 Btaf1

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00940000157500
InParanoidiE9QAE3
KOiK15192
OMAiALIFCQM
OrthoDBiEOG091G00E4
TreeFamiTF300546

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Btaf1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040565 Expressed in 245 organ(s), highest expression level in pes
GenevisibleiE9QAE3 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.25.10.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9QAE3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9QAE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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