Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leiomodin-3

Gene

Lmod3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25774500, PubMed:26035871). Increases the rate of actin polymerization (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-3
Gene namesi
Name:Lmod3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444169 Lmod3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice show severe muscle weakness and postnatal growth retardation. Skeletal muscles show the presence of nemaline bodies and have disorganized sarcomeric structures. Muscle atrophy is specific to the fast fibers.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004396461 – 571Leiomodin-3Add BLAST571

Post-translational modificationi

Ubiquitinated, leading to its degradation. Interaction with KLHL40 negatively regulates ubiquitination and degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiE9QA62
PaxDbiE9QA62
PRIDEiE9QA62

PTM databases

iPTMnetiE9QA62
PhosphoSitePlusiE9QA62

Expressioni

Tissue specificityi

Skeletal muscle and heart-specific (at protein level).1 Publication

Developmental stagei

Expressed by E15.5 in both skeletal muscle and heart. Expression is maintained throughout adulthood.1 Publication

Inductioni

Expression is regulated by SRF and MEF2.1 Publication

Gene expression databases

BgeeiENSMUSG00000044086 Expressed in 121 organ(s), highest expression level in quadriceps femoris
GenevisibleiE9QA62 MM

Interactioni

Subunit structurei

May interact with tropomyosin alpha (TPM1/2) N-terminus (By similarity). Interacts with KLHL40; leading to stabilization (PubMed:24960163).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093315

Structurei

3D structure databases

ProteinModelPortaliE9QA62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini545 – 564WH2PROSITE-ProRule annotationAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili397 – 436Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 184Glu-richPROSITE-ProRule annotationAdd BLAST43
Compositional biasi416 – 420Poly-GlnSequence analysis5

Sequence similaritiesi

Belongs to the tropomodulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG079700
InParanoidiE9QA62
KOiK22030
OMAiNKRESKG
OrthoDBiEOG091G0C3H
PhylomeDBiE9QA62
TreeFamiTF315841

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR030131 LMOD3
IPR032675 LRR_dom_sf
IPR004934 TMOD
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF3 PTHR10901:SF3, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit

Sequencei

Sequence statusi: Complete.

E9QA62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGHSRNSEQ EDTLSEELDE DELLANLSPE ELKELQSEME VMAPDPHLPV
60 70 80 90 100
GMIQKDQTDK APTGNFNHKS LVDYMYLQKA SRRMLEDERV PVSFVQSEKN
110 120 130 140 150
TQNQREVGDK GIKNMPQFLK EKLNSEILAK KRESNGSNNV QEAEDDDEDE
160 170 180 190 200
EEEEEDDEDE EEEEEDEEDD EGEEDEDGEQ ANREKNDAKE QIHNNPGTYQ
210 220 230 240 250
QLATKTAHEQ KDTSETKEKG EKKIAKLDPK KLALDTSFLK VSARPSGNQT
260 270 280 290 300
DLDGSLRRVR QNDPDMKELN LNNIENIPKE MLLDFVNAMK KNKHIKTFSL
310 320 330 340 350
ANVGADESVA FALANMLREN RSVTTLNIES NFITGKGIVA IMRCLQFNET
360 370 380 390 400
LTELRFHNQR HMLGHHAEME ISRLLKANTT LLKMGYHFEL PGPRMVVTNL
410 420 430 440 450
LTRNQDKRRQ KRQEEQQQQQ LKEQRKLIAM LENGLGLPPG MWERLGGPMP
460 470 480 490 500
DPRMQEFFQP ASGRPLDAQE VPFGSRKEMI KNPPQPPQCK TDPDSFRVVK
510 520 530 540 550
LKRIQRKSRM PEAREAQEKT NLKDVIKTLK PVPRNRPPPL VEITPRDQLL
560 570
NDIRHSNVAY LKPVQLPKEL E
Length:571
Mass (Da):65,689
Last modified:April 5, 2011 - v1
Checksum:i7DEEE7D4AE05D6F5
GO

Sequence cautioni

The sequence AAI17773 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93S → N in AAI27158 (PubMed:15489334).Curated1
Sequence conflicti150Missing in AAI27158 (PubMed:15489334).Curated1
Sequence conflicti199Y → C in AAI27158 (PubMed:15489334).Curated1
Sequence conflicti208H → D in AAI27158 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155724 Genomic DNA No translation available.
BC117772 mRNA Translation: AAI17773.1 Different initiation.
BC127157 mRNA Translation: AAI27158.1
CCDSiCCDS39576.1
RefSeqiNP_001074626.1, NM_001081157.1
XP_006506333.1, XM_006506270.3
XP_006506334.1, XM_006506271.3
UniGeneiMm.68163

Genome annotation databases

EnsembliENSMUST00000095655; ENSMUSP00000093315; ENSMUSG00000044086
GeneIDi320502
KEGGimmu:320502
UCSCiuc009das.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155724 Genomic DNA No translation available.
BC117772 mRNA Translation: AAI17773.1 Different initiation.
BC127157 mRNA Translation: AAI27158.1
CCDSiCCDS39576.1
RefSeqiNP_001074626.1, NM_001081157.1
XP_006506333.1, XM_006506270.3
XP_006506334.1, XM_006506271.3
UniGeneiMm.68163

3D structure databases

ProteinModelPortaliE9QA62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093315

PTM databases

iPTMnetiE9QA62
PhosphoSitePlusiE9QA62

Proteomic databases

MaxQBiE9QA62
PaxDbiE9QA62
PRIDEiE9QA62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095655; ENSMUSP00000093315; ENSMUSG00000044086
GeneIDi320502
KEGGimmu:320502
UCSCiuc009das.1 mouse

Organism-specific databases

CTDi56203
MGIiMGI:2444169 Lmod3

Phylogenomic databases

eggNOGiKOG3735 Eukaryota
ENOG410YAHM LUCA
GeneTreeiENSGT00760000119226
HOGENOMiHOG000261624
HOVERGENiHBG079700
InParanoidiE9QA62
KOiK22030
OMAiNKRESKG
OrthoDBiEOG091G0C3H
PhylomeDBiE9QA62
TreeFamiTF315841

Miscellaneous databases

PROiPR:E9QA62
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044086 Expressed in 121 organ(s), highest expression level in quadriceps femoris
GenevisibleiE9QA62 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR030131 LMOD3
IPR032675 LRR_dom_sf
IPR004934 TMOD
PANTHERiPTHR10901 PTHR10901, 1 hit
PTHR10901:SF3 PTHR10901:SF3, 1 hit
PfamiView protein in Pfam
PF03250 Tropomodulin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMOD3_MOUSE
AccessioniPrimary (citable) accession number: E9QA62
Secondary accession number(s): A0AUN8, A0JP45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again