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Protein

Adenylate cyclase type 10

Gene

Adcy10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO2 levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.UniRule annotation

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processcAMP biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 10UniRule annotation (EC:4.6.1.1UniRule annotation)
Gene namesi
Name:Adcy10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2660854 Adcy10

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSMUSG00000026567 Expressed in 27 organ(s), highest expression level in testis

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 179Guanylate cyclaseInterPro annotationAdd BLAST138
Domaini341 – 418Guanylate cyclaseInterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili571 – 591Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IEPA Eukaryota
ENOG410ZFMC LUCA
GeneTreeiENSGT00390000001322

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR016577 Adenylate_cyclase_typ10
IPR029787 Nucleotide_cyclase
IPR027417 P-loop_NTPase
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF011131 Soluble_adenylyl_cyclase, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
SSF52540 SSF52540, 1 hit
SSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q9T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSARRQELQD RAIVKIAAHL PDLIVYGDFS PERPSVKCFD GVLMFVDISG
60 70 80 90 100
FTAMTEKFST AMYMDRGAEQ LVEILNYYIS AIVEKVLIFG GDILKFAGDA
110 120 130 140 150
LLALWKVERK QLKNIITVVI KCSLEIHGLF EAKEAEEGLD IRVKIGLAAG
160 170 180 190 200
HITMLVFGDE TRNYFLVIGQ AVDDVRLAQN MAQMNDVILS PNCWQLCDRS
210 220 230 240 250
MIEIERIPDQ RAVKVSFLKP PPTFNFDEFF TKCMGFMDYY PSGDHKNFLR
260 270 280 290 300
LACMLESDPE LELSLQKYVM EIILKQIDDK QLRGYLSELR PVTIVFVNLM
310 320 330 340 350
FKEQDKVEVI GSAIQAACVH ITSVLKVFRG QINKVFMFDK GCSFLCVFGF
360 370 380 390 400
PGEKAPDEIT HALESAVDIF DFCSQVHKIR TVSIGVASGI VFCGIVGHTV
410 420 430 440 450
RHEYTVIGQK VNIAARMMMY YPGIVSCDSV TYDGSNLPAY FFKELPKKVM
460 470 480 490 500
KGVADPGPVY QCLGLNEKVM FGMAYLICNR YEGYPLLGRV REIDYFMSTM
510 520 530 540 550
KDFLMTNCSR VLMYEGLPGY GKSQVLMEIE YLASQHENHR AVAIALTKIS
560 570 580 590 600
FHQNFYTIQI LMANVLGLDT CKHYKERQTN LQNRVKTLLD EKFHCLLNDI
610 620 630 640 650
FHVQFPVSRE MSRMSKIRKQ KQLEALFMKI LAQTVREERI IFIIDEAQFV
660 670 680 690 700
DGTSWAFIEK LIRSMPIFIV MSLAPFSEVP CAAANAIMKN RNTTYITLGT
710 720 730 740 750
MQPQEIRDKV CVDLSVSSIP RELDSYLVEG SCGIPYYCEE LLKNLDHHRV
760 770 780 790 800
LLFQQAETEQ KTNVTWNNMF KHSVRPTDDM QLFTSISEGQ KEVCYLVSGV
810 820 830 840 850
RLNNLSPPAS LKEISLVQLD SMSLSHQMLV RCAAIIGLTF TTELLFEILP
860 870 880 890 900
CWNMKMMIKA LATLVESNVF NCFRSSKDLQ LALKQNVPTF EVHYRSLALK
910 920 930 940 950
LKEGLTYGEE EELREMEGEV VECRILRFCR PIMQKTAYEL WLKDQKKVLH
960 970 980 990 1000
LKCARFLEES AHRCNHCRNV DFIPYHHFIV DIRLNTLDMD TVKRMVTSQG
1010 1020 1030 1040 1050
FKIDEEEAIF SKSELPRKYK FPENLSITEI REKILHFFDN VILKMKSSPN
1060 1070 1080 1090 1100
DIIPLESCQC KELLQIVILP LAQHFVALEE NNKALYYFLE LASAYLILGD
1110 1120 1130 1140 1150
NYNAYMYLGE GERLLKSLTN EDSWSQTFEY ATFYSLKAEV CFNMGQMVLA
1160 1170 1180 1190 1200
KKMLRKALKL LNRMFPCNLL TLTFQMHVEK NRLSHFMNQH TQEGSVPGKK
1210 1220 1230 1240 1250
LAQLYLQASC FSLLWRIYSL NFFFHYKYYG HLAAMMEMNT SLETQNDFQI
1260 1270 1280 1290 1300
IKAYLDFSLY HHLAGYQGVW FKYEILVMEQ LLNLPLKGEA IEIMAYTADT
1310 1320 1330 1340 1350
LGHIKFLMGH LDLAIELGSR AHRMWSLLRN PNKYQMVLCR LSKPLFLKSR
1360 1370 1380 1390 1400
YKHLVQVLGW LWDLSVTEED IFSKAFFYFV CLDIMLYSGF IYRTFEECLE
1410 1420 1430 1440 1450
FIHHNEDNRI LKFQSGLLLG LYSCIAVWYA RLQEWDNFNK FSDRAKHLVT
1460 1470 1480 1490 1500
RRTPTVLYYE GISRYMEGQV LHLQKQIEEQ AENAQDSGVE ILKALETLVA
1510 1520 1530 1540 1550
QNTTGPVFYP RLYHLMAYVC ILMGDGHSCD FFLNTALELS ETHGNLLEKC
1560 1570 1580 1590 1600
WLSMSKEWWY SASELTGDQW LQTVLSLPSW DKIVSGKVTL QDVQKNKYLM

RVNILDNPF
Length:1,609
Mass (Da):185,903
Last modified:April 5, 2011 - v1
Checksum:i50131B3B613F34FB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C0T9ADCYA_MOUSE
Adenylate cyclase type 10
Adcy10 Sac, Sacy
1,614Annotation score:
M0QWB5M0QWB5_MOUSE
Adenylate cyclase type 10
Adcy10
98Annotation score:
A0A0A6YXI1A0A0A6YXI1_MOUSE
Adenylate cyclase type 10
Adcy10
169Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102776 Genomic DNA No translation available.
AC162789 Genomic DNA No translation available.
RefSeqiXP_017176549.1, XM_017321060.1
UniGeneiMm.66952

Genome annotation databases

EnsembliENSMUST00000111439; ENSMUSP00000107066; ENSMUSG00000026567
ENSMUST00000111440; ENSMUSP00000107067; ENSMUSG00000026567
GeneIDi271639
UCSCiuc007dje.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102776 Genomic DNA No translation available.
AC162789 Genomic DNA No translation available.
RefSeqiXP_017176549.1, XM_017321060.1
UniGeneiMm.66952

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111439; ENSMUSP00000107066; ENSMUSG00000026567
ENSMUST00000111440; ENSMUSP00000107067; ENSMUSG00000026567
GeneIDi271639
UCSCiuc007dje.1 mouse

Organism-specific databases

CTDi55811
MGIiMGI:2660854 Adcy10

Phylogenomic databases

eggNOGiENOG410IEPA Eukaryota
ENOG410ZFMC LUCA
GeneTreeiENSGT00390000001322

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026567 Expressed in 27 organ(s), highest expression level in testis

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR016577 Adenylate_cyclase_typ10
IPR029787 Nucleotide_cyclase
IPR027417 P-loop_NTPase
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
PIRSFiPIRSF011131 Soluble_adenylyl_cyclase, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
SSF52540 SSF52540, 1 hit
SSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q9T4_MOUSE
AccessioniPrimary (citable) accession number: E9Q9T4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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