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Protein

Disks large homolog 5

Gene

Dlg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (By similarity). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin (PubMed:25232112). Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large homolog 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlg5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918478 Dlg5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004405561 – 1921Disks large homolog 5Add BLAST1921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei900PhosphoserineBy similarity1
Modified residuei984PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1011PhosphothreonineBy similarity1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1183PhosphothreonineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1263PhosphoserineCombined sources1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1669PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q9R9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q9R9

PRoteomics IDEntifications database

More...
PRIDEi
E9Q9R9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q9R9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q9R9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q9R9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q9R9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (By similarity). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (By similarity). Interacts with CTNB1 (PubMed:25232112). Interacts with SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (PubMed:25644602).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000087879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9Q9R9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q9R9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 90CARDPROSITE-ProRule annotationAdd BLAST90
Domaini620 – 710PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini705 – 796PDZ 2PROSITE-ProRule annotationAdd BLAST92
Domaini1350 – 1429PDZ 3PROSITE-ProRule annotationAdd BLAST80
Domaini1504 – 1585PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini1596 – 1664SH3PROSITE-ProRule annotationAdd BLAST69
Domaini1724 – 1907Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili139 – 601Sequence analysisAdd BLAST463

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi113 – 123Poly-SerSequence analysisAdd BLAST11
Compositional biasi285 – 288Poly-GlnSequence analysis4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The guanylate kinase-like domain interacts with the SH3 domain.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082455

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081446

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q9R9

Database of Orthologous Groups

More...
OrthoDBi
123652at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323171

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11860 SH3_DLG5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 1 hit
PF04822 Takusan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q9R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG
60 70 80 90 100
AKAELLLQLL LAKEQDHFQD LRAALEKTQP HLLPILYLNG VVGPPQSTEG
110 120 130 140 150
AGSTYSVLSI MPSDSESSSS LSSVGTTGKA PSPPPLLTEQ QANDTVENLS
160 170 180 190 200
IQLRLMTRER NELRKRLAFA THGATFDKRP YHRLNPDYER LKIQCVRAMS
210 220 230 240 250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTQL KDDVDMLRRE
260 270 280 290 300
NGKLRRERNL LQQSWEDMKR LREEDQKEIG DLRAQQQQVL KHNGSSEILN
310 320 330 340 350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAM HNSDLSRLEQ LGEENQRLQK
360 370 380 390 400
QTEMLTQQRD TAIQLQHQCA LSLRRFETIH HELSKATAQN KDLQWEMELL
410 420 430 440 450
QSELTELRSK QVKTAKESEK YKEERDAVYS EYKLIMSERD QVISELDKLQ
460 470 480 490 500
TEVELAESKL KSSTSEKKAA SEEMEALRQI KDTVTMDAGR ANKEVEILRK
510 520 530 540 550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE
560 570 580 590 600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMECQL EKEARFRQLM
610 620 630 640 650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG
660 670 680 690 700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG
710 720 730 740 750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVVPGSPAA
760 770 780 790 800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS
810 820 830 840 850
SWSGQNIFEN IKDSDRMLSC RAHGPEVQAH NKRNLLQHNN STQTDIFYTD
860 870 880 890 900
RLEDRKELGH SGGSSSFLHK PFSGSSSPVS PQACPSTSER SLNSFRSDTS
910 920 930 940 950
AERGYGLVDM RSQRPLLSFE TEVGPCGAVE VPLDKIDPEG SNSGGTWPKA
960 970 980 990 1000
VLGSTSGPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGLTHS
1010 1020 1030 1040 1050
PQPSKRVGSL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA
1060 1070 1080 1090 1100
PPPSMDPSEP THASPPRKAR VRIASSYHSE GDGDTSYLPA KKPCDEDLTS
1110 1120 1130 1140 1150
QKVDELGQKR RRPKSAPSFR PKISPVVIPA QCLEEQECVP AIGELSPEGQ
1160 1170 1180 1190 1200
EWSPYSPGHA SRHGNPLLYP NRPSVGTVPR SMTPGTTVGS ILRNPIYTVR
1210 1220 1230 1240 1250
SHRVLPCGSP PVPRDAGSQS LSPSVQHQGR LSLDLSHRAC SDYSEMRASQ
1260 1270 1280 1290 1300
GSNSLPSSAR LGSSSNLQFK AERIKIPLTP RYPRSVMGSD RGSLSHSECS
1310 1320 1330 1340 1350
TPPRSPLNID TLSSCSQPQT TASTLPRIAV NPSSHGERRK DRPFVEEPRH
1360 1370 1380 1390 1400
VKVQKGSEPL GISIVSGEKG GVYVSKVTLG SIAHQAGLEY GDQLLEFNGI
1410 1420 1430 1440 1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH IHQLNSHSRS SSHLDPAATP
1460 1470 1480 1490 1500
HSTLQGSSAG TPEHPSVIDP LMEQDEGPGT PPAKQSASST RSVGDTTKKT
1510 1520 1530 1540 1550
PDPRIVFIKK SQLDLGVHLC GGNLHGVFVA EVEDDSPAKG PDGLVPGDLI
1560 1570 1580 1590 1600
LEYGSLDMRS RTVEDVYVEM LKPKDSLRLK VQYRHEEFTR VKGLPGDSFY
1610 1620 1630 1640 1650
IRALYDRLAE VEPELSFKKD DILYVDDTLP QGVFGSWMAW QLDENAQKIQ
1660 1670 1680 1690 1700
RGQIPSKYVM DQEFSRRLSM SEVKDDNTAK TLSAAARRSF FRRKHKHKRS
1710 1720 1730 1740 1750
GSKDGKDLLA LDTFSNDSIP LFEDSVSLAY QRVQKVDCTS LRPVLLLGPL
1760 1770 1780 1790 1800
LDVVKEMLVN EAPGKFCRCP LEVMKASQQA IERGVKDCLF VDYKRRSGHF
1810 1820 1830 1840 1850
DVTTVASIKE ITEKNRHCLL DIAPHAIERL HHMHIYPIVI FIRYKSAKHI
1860 1870 1880 1890 1900
KEQRDPVYLR DKVTQRHSKE QFETAQKIDQ EYSRYFTGVV QGGALSSICT
1910 1920
QILAMVSQEQ SKVLWIPACP P
Length:1,921
Mass (Da):214,386
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B2C62F913B3B26E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9I2E9Q9I2_MOUSE
Disks large homolog 5
Dlg5
1,898Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YZU5F6YZU5_MOUSE
Disks large homolog 5
Dlg5
1,572Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z115F6Z115_MOUSE
Disks large homolog 5
Dlg5
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VMK9F6VMK9_MOUSE
Disks large homolog 5
Dlg5
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7BYL0F7BYL0_MOUSE
Disks large homolog 5
Dlg5
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti946T → P in BAE28082 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1642L → P in allele LP; loss of neuronal function and disruption of interactions between the SH3 and guanylate kinase-like domains. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK147699 mRNA Translation: BAE28082.1
AC163638 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS49417.1

NCBI Reference Sequences

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RefSeqi
NP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.68971

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000090398; ENSMUSP00000087879; ENSMUSG00000021782

Database of genes from NCBI RefSeq genomes

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GeneIDi
71228

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71228

UCSC genome browser

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UCSCi
uc007sqg.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147699 mRNA Translation: BAE28082.1
AC163638 Genomic DNA No translation available.
CCDSiCCDS49417.1
RefSeqiNP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1
UniGeneiMm.68971

3D structure databases

ProteinModelPortaliE9Q9R9
SMRiE9Q9R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087879

PTM databases

iPTMnetiE9Q9R9
PhosphoSitePlusiE9Q9R9

Proteomic databases

MaxQBiE9Q9R9
PaxDbiE9Q9R9
PRIDEiE9Q9R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090398; ENSMUSP00000087879; ENSMUSG00000021782
GeneIDi71228
KEGGimmu:71228
UCSCiuc007sqg.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9231
MGIiMGI:1918478 Dlg5

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00940000155303
HOGENOMiHOG000082455
HOVERGENiHBG081446
InParanoidiE9Q9R9
OrthoDBi123652at2759
TreeFamiTF323171

Miscellaneous databases

Protein Ontology

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PROi
PR:E9Q9R9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta
ExpressionAtlasiE9Q9R9 baseline and differential
GenevisibleiE9Q9R9 MM

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 1 hit
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLG5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q9R9
Secondary accession number(s): Q3UGX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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