Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disks large homolog 5

Gene

Dlg5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (By similarity). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin (PubMed:25232112). Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 5
Gene namesi
Name:Dlg5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1918478 Dlg5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004405561 – 1921Disks large homolog 5Add BLAST1921

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei900PhosphoserineBy similarity1
Modified residuei984PhosphothreonineCombined sources1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1011PhosphothreonineBy similarity1
Modified residuei1021PhosphoserineBy similarity1
Modified residuei1183PhosphothreonineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1263PhosphoserineCombined sources1
Modified residuei1334PhosphoserineBy similarity1
Modified residuei1669PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiE9Q9R9
PaxDbiE9Q9R9
PRIDEiE9Q9R9

PTM databases

iPTMnetiE9Q9R9
PhosphoSitePlusiE9Q9R9

Expressioni

Tissue specificityi

Brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta
ExpressionAtlasiE9Q9R9 baseline and differential
GenevisibleiE9Q9R9 MM

Interactioni

Subunit structurei

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (By similarity). Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714). Interacts with SCRIB (By similarity). Interacts with CTNB1 (PubMed:25232112). Interacts with SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (PubMed:25644602).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087879

Structurei

3D structure databases

ProteinModelPortaliE9Q9R9
SMRiE9Q9R9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90CARDPROSITE-ProRule annotationAdd BLAST90
Domaini620 – 710PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini705 – 796PDZ 2PROSITE-ProRule annotationAdd BLAST92
Domaini1350 – 1429PDZ 3PROSITE-ProRule annotationAdd BLAST80
Domaini1504 – 1585PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini1596 – 1664SH3PROSITE-ProRule annotationAdd BLAST69
Domaini1724 – 1907Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili139 – 601Sequence analysisAdd BLAST463

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 123Poly-SerSequence analysisAdd BLAST11
Compositional biasi285 – 288Poly-GlnSequence analysis4

Domaini

The guanylate kinase-like domain interacts with the SH3 domain.1 Publication

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000082455
HOVERGENiHBG081446
InParanoidiE9Q9R9
OrthoDBiEOG091G00NF
TreeFamiTF323171

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q9R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG
60 70 80 90 100
AKAELLLQLL LAKEQDHFQD LRAALEKTQP HLLPILYLNG VVGPPQSTEG
110 120 130 140 150
AGSTYSVLSI MPSDSESSSS LSSVGTTGKA PSPPPLLTEQ QANDTVENLS
160 170 180 190 200
IQLRLMTRER NELRKRLAFA THGATFDKRP YHRLNPDYER LKIQCVRAMS
210 220 230 240 250
DLQSLQNQHT NALKRCEEVA KETDFYHTLH SRLLSDQTQL KDDVDMLRRE
260 270 280 290 300
NGKLRRERNL LQQSWEDMKR LREEDQKEIG DLRAQQQQVL KHNGSSEILN
310 320 330 340 350
KLYDTAMDKL EVVKKDYDAL RKRYSEKVAM HNSDLSRLEQ LGEENQRLQK
360 370 380 390 400
QTEMLTQQRD TAIQLQHQCA LSLRRFETIH HELSKATAQN KDLQWEMELL
410 420 430 440 450
QSELTELRSK QVKTAKESEK YKEERDAVYS EYKLIMSERD QVISELDKLQ
460 470 480 490 500
TEVELAESKL KSSTSEKKAA SEEMEALRQI KDTVTMDAGR ANKEVEILRK
510 520 530 540 550
QCKALCQELK EALQEADVAK CRRDWAFQER DKIVAERDSI RTLCDNLRRE
560 570 580 590 600
RDRAVSELAE ALRSLDDTRK QKNDVSRELK ELKEQMECQL EKEARFRQLM
610 620 630 640 650
AHSSHDSAID TDSMEWETEV VEFERETEDI DLKALGFDMA EGVNEPCFPG
660 670 680 690 700
DCGIFVTKVD KGSIADGRLR VNDWLLRIND VDLINKDKKQ AIKALLNGEG
710 720 730 740 750
AINMVVRRRK SLGGKVVTPL HINLSGQKDS GISLENGVYA AAVVPGSPAA
760 770 780 790 800
KEGSLAVGDR IVAINGIALD NKSLNECESL LRSCQDSLTL SLLKVFPQSS
810 820 830 840 850
SWSGQNIFEN IKDSDRMLSC RAHGPEVQAH NKRNLLQHNN STQTDIFYTD
860 870 880 890 900
RLEDRKELGH SGGSSSFLHK PFSGSSSPVS PQACPSTSER SLNSFRSDTS
910 920 930 940 950
AERGYGLVDM RSQRPLLSFE TEVGPCGAVE VPLDKIDPEG SNSGGTWPKA
960 970 980 990 1000
VLGSTSGPEK LSVYKKPKQR KSIFDPNTFK RPQTPPKIDY LLPGPGLTHS
1010 1020 1030 1040 1050
PQPSKRVGSL TPPKPPRRSD SIKFQHRLET SSESEATLVG SSPSTSPPSA
1060 1070 1080 1090 1100
PPPSMDPSEP THASPPRKAR VRIASSYHSE GDGDTSYLPA KKPCDEDLTS
1110 1120 1130 1140 1150
QKVDELGQKR RRPKSAPSFR PKISPVVIPA QCLEEQECVP AIGELSPEGQ
1160 1170 1180 1190 1200
EWSPYSPGHA SRHGNPLLYP NRPSVGTVPR SMTPGTTVGS ILRNPIYTVR
1210 1220 1230 1240 1250
SHRVLPCGSP PVPRDAGSQS LSPSVQHQGR LSLDLSHRAC SDYSEMRASQ
1260 1270 1280 1290 1300
GSNSLPSSAR LGSSSNLQFK AERIKIPLTP RYPRSVMGSD RGSLSHSECS
1310 1320 1330 1340 1350
TPPRSPLNID TLSSCSQPQT TASTLPRIAV NPSSHGERRK DRPFVEEPRH
1360 1370 1380 1390 1400
VKVQKGSEPL GISIVSGEKG GVYVSKVTLG SIAHQAGLEY GDQLLEFNGI
1410 1420 1430 1440 1450
NLRSATEQQA RLIIGQQCDT ITILAQYNPH IHQLNSHSRS SSHLDPAATP
1460 1470 1480 1490 1500
HSTLQGSSAG TPEHPSVIDP LMEQDEGPGT PPAKQSASST RSVGDTTKKT
1510 1520 1530 1540 1550
PDPRIVFIKK SQLDLGVHLC GGNLHGVFVA EVEDDSPAKG PDGLVPGDLI
1560 1570 1580 1590 1600
LEYGSLDMRS RTVEDVYVEM LKPKDSLRLK VQYRHEEFTR VKGLPGDSFY
1610 1620 1630 1640 1650
IRALYDRLAE VEPELSFKKD DILYVDDTLP QGVFGSWMAW QLDENAQKIQ
1660 1670 1680 1690 1700
RGQIPSKYVM DQEFSRRLSM SEVKDDNTAK TLSAAARRSF FRRKHKHKRS
1710 1720 1730 1740 1750
GSKDGKDLLA LDTFSNDSIP LFEDSVSLAY QRVQKVDCTS LRPVLLLGPL
1760 1770 1780 1790 1800
LDVVKEMLVN EAPGKFCRCP LEVMKASQQA IERGVKDCLF VDYKRRSGHF
1810 1820 1830 1840 1850
DVTTVASIKE ITEKNRHCLL DIAPHAIERL HHMHIYPIVI FIRYKSAKHI
1860 1870 1880 1890 1900
KEQRDPVYLR DKVTQRHSKE QFETAQKIDQ EYSRYFTGVV QGGALSSICT
1910 1920
QILAMVSQEQ SKVLWIPACP P
Length:1,921
Mass (Da):214,386
Last modified:April 5, 2011 - v1
Checksum:i0B2C62F913B3B26E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9I2E9Q9I2_MOUSE
Disks large homolog 5
Dlg5
1,898Annotation score:
F6YZU5F6YZU5_MOUSE
Disks large homolog 5
Dlg5
1,572Annotation score:
F6Z115F6Z115_MOUSE
Disks large homolog 5
Dlg5
205Annotation score:
F6VMK9F6VMK9_MOUSE
Disks large homolog 5
Dlg5
228Annotation score:
F7BYL0F7BYL0_MOUSE
Disks large homolog 5
Dlg5
72Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti946T → P in BAE28082 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1642L → P in allele LP; loss of neuronal function and disruption of interactions between the SH3 and guanylate kinase-like domains. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147699 mRNA Translation: BAE28082.1
AC163638 Genomic DNA No translation available.
CCDSiCCDS49417.1
RefSeqiNP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1
UniGeneiMm.68971

Genome annotation databases

EnsembliENSMUST00000090398; ENSMUSP00000087879; ENSMUSG00000021782
GeneIDi71228
KEGGimmu:71228
UCSCiuc007sqg.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147699 mRNA Translation: BAE28082.1
AC163638 Genomic DNA No translation available.
CCDSiCCDS49417.1
RefSeqiNP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1
UniGeneiMm.68971

3D structure databases

ProteinModelPortaliE9Q9R9
SMRiE9Q9R9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087879

PTM databases

iPTMnetiE9Q9R9
PhosphoSitePlusiE9Q9R9

Proteomic databases

MaxQBiE9Q9R9
PaxDbiE9Q9R9
PRIDEiE9Q9R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090398; ENSMUSP00000087879; ENSMUSG00000021782
GeneIDi71228
KEGGimmu:71228
UCSCiuc007sqg.1 mouse

Organism-specific databases

CTDi9231
MGIiMGI:1918478 Dlg5

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000082455
HOVERGENiHBG081446
InParanoidiE9Q9R9
OrthoDBiEOG091G00NF
TreeFamiTF323171

Miscellaneous databases

PROiPR:E9Q9R9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta
ExpressionAtlasiE9Q9R9 baseline and differential
GenevisibleiE9Q9R9 MM

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLG5_MOUSE
AccessioniPrimary (citable) accession number: E9Q9R9
Secondary accession number(s): Q3UGX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again