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UniProtKB - E9Q9Q6 (E9Q9Q6_MOUSE)
Protein
Submitted name:
Cadherin 18
Gene
Cdh18
Organism
Mus musculus (Mouse)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins.
UniRule annotationGO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- adherens junction organization Source: GO_Central
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- cell morphogenesis Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesionUniRule annotationARBA annotation |
Ligand | CalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Names & Taxonomyi
Protein namesi | Submitted name: Cadherin 18Imported |
Gene namesi | Name:Cdh18Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1344366, Cdh18 |
VEuPathDBi | HostDB:ENSMUSG00000040420 |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- catenin complex Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 615 – 636 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5003245869 | 25 – 790 | Sequence analysisAdd BLAST | 766 |
Proteomic databases
PaxDbi | E9Q9Q6 |
ProteomicsDBi | 351273 |
PTM databases
GlyConnecti | 2168, 1 N-Linked glycan (1 site) |
GlyGeni | E9Q9Q6, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | E9Q9Q6 |
PhosphoSitePlusi | E9Q9Q6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040420, Expressed in cerebellum and 60 other tissues |
ExpressionAtlasi | E9Q9Q6, baseline and differential |
Genevisiblei | E9Q9Q6, MM |
Interactioni
GO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130851 |
Miscellaneous databases
RNActi | E9Q9Q6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 79 – 159 | CadherinInterPro annotationAdd BLAST | 81 | |
Domaini | 160 – 268 | CadherinInterPro annotationAdd BLAST | 109 | |
Domaini | 269 – 383 | CadherinInterPro annotationAdd BLAST | 115 | |
Domaini | 384 – 488 | CadherinInterPro annotationAdd BLAST | 105 | |
Domaini | 488 – 605 | CadherinInterPro annotationAdd BLAST | 118 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000157512 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | E9Q9Q6 |
OMAi | IRMCQGE |
OrthoDBi | 240489at2759 |
PhylomeDBi | E9Q9Q6 |
TreeFami | TF329887 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9Q9Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRITSTSCIC PVLVCLCFVQ RCYGTAHHSS IKVTRNQTKH TEGETEVHHR
60 70 80 90 100
PKRGWVWNQF FVLEEHMGPD PQYVGKLHSN SDKGDGSVKY ILTGEGAGTI
110 120 130 140 150
FIIDDTTGDI HSTKSLDREQ KTHYVLHAQA IDRRTNKPLE PESEFIIKVQ
160 170 180 190 200
DINDNAPKFT DGPYIVTVPE MSDMGTSVLQ VTATDADDPT YGNSARVVYS
210 220 230 240 250
ILQGQPYFSV DPKTGVIRTA LHNMDREARE HYSVVIQAKD MAGQVGGLSG
260 270 280 290 300
STTVNITLTD VNDNPPRFPQ KHYQLYVPES AQVGSAVGKI KANDADTGSN
310 320 330 340 350
ADMTYSITNG DGIGVFSIST DKDTREGILS LKKPLNYEKK KSYTLNIEGA
360 370 380 390 400
NTHLDFRFSH LGPFKDATML KVIVGDVDEP PLFSMPSYVM EVYENAKIGT
410 420 430 440 450
IVGTVLAQDP DSANSLVRYF INHSTEEERF FNIDANTGTI KTSKVLDREE
460 470 480 490 500
TPWYNITVTA SENDNPDLLS HVSVGIRVLD VNDNPPELAR EYDIVVCENS
510 520 530 540 550
KPGQVIHTIT ATDKDDFANG PRFHFFLDER LPMNPNFTLK DNEDNTASIL
560 570 580 590 600
TRRRRFSRTM QDVYYLPIMI SDGGIPSLSS SSTLTIRVCA CERDGRVRTC
610 620 630 640 650
HAEAFLSSAG LSTGALIAIL LCVVILLAIV VLFITLRRGK KEPLIISEED
660 670 680 690 700
VRENVVTYDD EGGGEEDTEA FDITALRNPA AAEEFTYRRD IRPEVKLTPR
710 720 730 740 750
HQTLSTLESI DVQEFIKQRL AEADLDPSVP PYDSLQTYAY EGQRSEAGSI
760 770 780 790
SSLDSATTQS DQDYHYLGDW GPEFKKLAEL YGEIESERTT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q941 | E9Q941_MOUSE | Cadherin 18 | Cdh18 | 574 | Annotation score: | ||
Q8BLB5 | Q8BLB5_MOUSE | Cadherin 18 | Cdh18 | 337 | Annotation score: | ||
A0A2I3BPS8 | A0A2I3BPS8_MOUSE | Cadherin 18 | Cdh18 | 575 | Annotation score: | ||
F6RSC2 | F6RSC2_MOUSE | Cadherin 18 | Cdh18 | 441 | Annotation score: |
Sequence databases
RefSeqi | NP_001074768.1, NM_001081299.1 XP_006520157.1, XM_006520094.3 XP_006520158.1, XM_006520095.3 XP_006520159.1, XM_006520096.3 XP_011243662.1, XM_011245360.2 |
Genome annotation databases
Ensembli | ENSMUST00000164787; ENSMUSP00000130851; ENSMUSG00000040420 |
GeneIDi | 320865 |
KEGGi | mmu:320865 |
UCSCi | uc007vis.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001074768.1, NM_001081299.1 XP_006520157.1, XM_006520094.3 XP_006520158.1, XM_006520095.3 XP_006520159.1, XM_006520096.3 XP_011243662.1, XM_011245360.2 |
3D structure databases
SMRi | E9Q9Q6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000130851 |
PTM databases
GlyConnecti | 2168, 1 N-Linked glycan (1 site) |
GlyGeni | E9Q9Q6, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | E9Q9Q6 |
PhosphoSitePlusi | E9Q9Q6 |
Proteomic databases
PaxDbi | E9Q9Q6 |
ProteomicsDBi | 351273 |
Protocols and materials databases
Antibodypediai | 2730, 179 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENSMUST00000164787; ENSMUSP00000130851; ENSMUSG00000040420 |
GeneIDi | 320865 |
KEGGi | mmu:320865 |
UCSCi | uc007vis.1, mouse |
Organism-specific databases
CTDi | 1016 |
MGIi | MGI:1344366, Cdh18 |
VEuPathDBi | HostDB:ENSMUSG00000040420 |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000157512 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | E9Q9Q6 |
OMAi | IRMCQGE |
OrthoDBi | 240489at2759 |
PhylomeDBi | E9Q9Q6 |
TreeFami | TF329887 |
Enzyme and pathway databases
Reactomei | R-MMU-418990, Adherens junctions interactions |
Miscellaneous databases
BioGRID-ORCSi | 320865, 1 hit in 64 CRISPR screens |
ChiTaRSi | Cdh18, mouse |
RNActi | E9Q9Q6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040420, Expressed in cerebellum and 60 other tissues |
ExpressionAtlasi | E9Q9Q6, baseline and differential |
Genevisiblei | E9Q9Q6, MM |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | E9Q9Q6_MOUSE | |
Accessioni | E9Q9Q6Primary (citable) accession number: E9Q9Q6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |