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Protein
Submitted name:

Disks large homolog 5

Gene

Dlg5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Disks large homolog 5Imported
Gene namesi
Name:Dlg5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1918478 Dlg5

PTM / Processingi

Proteomic databases

MaxQBiE9Q9I2
PeptideAtlasiE9Q9I2
PRIDEiE9Q9I2

Expressioni

Gene expression databases

BgeeiENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta
ExpressionAtlasiE9Q9I2 baseline and differential
GenevisibleiE9Q9I2 MM

Interactioni

Protein-protein interaction databases

IntActiE9Q9I2, 13 interactors

Structurei

3D structure databases

ProteinModelPortaliE9Q9I2
SMRiE9Q9I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90CARDInterPro annotationAdd BLAST90
Domaini597 – 687PDZInterPro annotationAdd BLAST91
Domaini682 – 773PDZInterPro annotationAdd BLAST92
Domaini1327 – 1406PDZInterPro annotationAdd BLAST80
Domaini1481 – 1562PDZInterPro annotationAdd BLAST82
Domaini1573 – 1641SH3InterPro annotationAdd BLAST69
Domaini1754 – 1884Guanylate kinase-likeInterPro annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 143Sequence analysisAdd BLAST28
Coiled coili165 – 199Sequence analysisAdd BLAST35
Coiled coili214 – 241Sequence analysisAdd BLAST28
Coiled coili280 – 335Sequence analysisAdd BLAST56
Coiled coili360 – 387Sequence analysisAdd BLAST28
Coiled coili409 – 457Sequence analysisAdd BLAST49
Coiled coili465 – 499Sequence analysisAdd BLAST35
Coiled coili521 – 576Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
OMAiEWAPYSP

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q9I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQRRELLA QCQQSLAQAM TEVEAVLGLL EAAGALSPGE RRQLDEEAGG
60 70 80 90 100
AKAELLLQLL LAKEQDHFQD LRAALEKTQP HLLPILYLNG VVGPPQSTEG
110 120 130 140 150
AGTTGKAPSP PPLLTEQQAN DTVENLSIQL RLMTRERNEL RKRLAFATHG
160 170 180 190 200
ATFDKRPYHR LNPDYERLKI QCVRAMSDLQ SLQNQHTNAL KRCEEVAKET
210 220 230 240 250
DFYHTLHSRL LSDQTQLKDD VDMLRRENGK LRRERNLLQQ SWEDMKRLRE
260 270 280 290 300
EDQKEIGDLR AQQQQVLKHN GSSEILNKLY DTAMDKLEVV KKDYDALRKR
310 320 330 340 350
YSEKVAMHNS DLSRLEQLGE ENQRLQKQTE MLTQQRDTAI QLQHQCALSL
360 370 380 390 400
RRFETIHHEL SKATAQNKDL QWEMELLQSE LTELRSKQVK TAKESEKYKE
410 420 430 440 450
ERDAVYSEYK LIMSERDQVI SELDKLQTEV ELAESKLKSS TSEKKAASEE
460 470 480 490 500
MEALRQIKDT VTMDAGRANK EVEILRKQCK ALCQELKEAL QEADVAKCRR
510 520 530 540 550
DWAFQERDKI VAERDSIRTL CDNLRRERDR AVSELAEALR SLDDTRKQKN
560 570 580 590 600
DVSRELKELK EQMECQLEKE ARFRQLMAHS SHDSAIDTDS MEWETEVVEF
610 620 630 640 650
ERETEDIDLK ALGFDMAEGV NEPCFPGDCG IFVTKVDKGS IADGRLRVND
660 670 680 690 700
WLLRINDVDL INKDKKQAIK ALLNGEGAIN MVVRRRKSLG GKVVTPLHIN
710 720 730 740 750
LSGQKDSGIS LENGVYAAAV VPGSPAAKEG SLAVGDRIVA INGIALDNKS
760 770 780 790 800
LNECESLLRS CQDSLTLSLL KVFPQSSSWS GQNIFENIKD SDRMLSCRAH
810 820 830 840 850
GPEVQAHNKR NLLQHNNSTQ TDIFYTDRLE DRKELGHSGG SSSFLHKPFS
860 870 880 890 900
GSSSPVSPQA CPSTSERSLN SFRSDTSAER GYGLVDMRSQ RPLLSFETEV
910 920 930 940 950
GPCGAVEVPL DKIDPEGSNS GGTWPKAVLG STSGPEKLSV YKKPKQRKSI
960 970 980 990 1000
FDPNTFKRPQ TPPKIDYLLP GPGLTHSPQP SKRVGSLTPP KPPRRSDSIK
1010 1020 1030 1040 1050
FQHRLETSSE SEATLVGSSP STSPPSAPPP SMDPSEPTHA SPPRKARVRI
1060 1070 1080 1090 1100
ASSYHSEGDG DTSYLPAKKP CDEDLTSQKV DELGQKRRRP KSAPSFRPKI
1110 1120 1130 1140 1150
SPVVIPAQCL EEQECVPAIG ELSPEGQEWS PYSPGHASRH GNPLLYPNRP
1160 1170 1180 1190 1200
SVGTVPRSMT PGTTVGSILR NPIYTVRSHR VLPCGSPPVP RDAGSQSLSP
1210 1220 1230 1240 1250
SVQHQGRLSL DLSHRACSDY SEMRASQGSN SLPSSARLGS SSNLQFKAER
1260 1270 1280 1290 1300
IKIPLTPRYP RSVMGSDRGS LSHSECSTPP RSPLNIDTLS SCSQPQTTAS
1310 1320 1330 1340 1350
TLPRIAVNPS SHGERRKDRP FVEEPRHVKV QKGSEPLGIS IVSGEKGGVY
1360 1370 1380 1390 1400
VSKVTLGSIA HQAGLEYGDQ LLEFNGINLR SATEQQARLI IGQQCDTITI
1410 1420 1430 1440 1450
LAQYNPHIHQ LNSHSRSSSH LDPAATPHST LQGSSAGTPE HPSVIDPLME
1460 1470 1480 1490 1500
QDEGPGTPPA KQSASSTRSV GDTTKKTPDP RIVFIKKSQL DLGVHLCGGN
1510 1520 1530 1540 1550
LHGVFVAEVE DDSPAKGPDG LVPGDLILEY GSLDMRSRTV EDVYVEMLKP
1560 1570 1580 1590 1600
KDSLRLKVQY RHEEFTRVKG LPGDSFYIRA LYDRLAEVEP ELSFKKDDIL
1610 1620 1630 1640 1650
YVDDTLPQGV FGSWMAWQLD ENAQKIQRGQ IPSKYVMDQE FSRRLSMSEV
1660 1670 1680 1690 1700
KDDNTAKTLS AAARRSFFRR KHKHKRSGSK DGKDLLALDT FSNDSIPLFE
1710 1720 1730 1740 1750
DSVSLAYQRV QKVDCTSLRP VLLLGPLLDV VKEMLVNEAP GKFCRCPLEV
1760 1770 1780 1790 1800
MKASQQAIER GVKDCLFVDY KRRSGHFDVT TVASIKEITE KNRHCLLDIA
1810 1820 1830 1840 1850
PHAIERLHHM HIYPIVIFIR YKSAKHIKEQ RDPVYLRDKV TQRHSKEQFE
1860 1870 1880 1890
TAQKIDQEYS RYFTGVVQGG ALSSICTQIL AMVSQEQSKV LWIPACPP
Length:1,898
Mass (Da):212,097
Last modified:April 5, 2011 - v1
Checksum:i705BEAA929D3DE23
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q9R9DLG5_MOUSE
Disks large homolog 5
Dlg5
1,921Annotation score:
F6YZU5F6YZU5_MOUSE
Disks large homolog 5
Dlg5
1,572Annotation score:
F6Z115F6Z115_MOUSE
Disks large homolog 5
Dlg5
205Annotation score:
F6VMK9F6VMK9_MOUSE
Disks large homolog 5
Dlg5
228Annotation score:
F7BYL0F7BYL0_MOUSE
Disks large homolog 5
Dlg5
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163638 Genomic DNA No translation available.
RefSeqiNP_082002.1, NM_027726.1
UniGeneiMm.68971

Genome annotation databases

EnsembliENSMUST00000073687; ENSMUSP00000073367; ENSMUSG00000021782
GeneIDi71228
UCSCiuc007sqh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163638 Genomic DNA No translation available.
RefSeqiNP_082002.1, NM_027726.1
UniGeneiMm.68971

3D structure databases

ProteinModelPortaliE9Q9I2
SMRiE9Q9I2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q9I2, 13 interactors

Proteomic databases

MaxQBiE9Q9I2
PeptideAtlasiE9Q9I2
PRIDEiE9Q9I2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073687; ENSMUSP00000073367; ENSMUSG00000021782
GeneIDi71228
UCSCiuc007sqh.1 mouse

Organism-specific databases

CTDi9231
MGIiMGI:1918478 Dlg5

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
GeneTreeiENSGT00760000118866
OMAiEWAPYSP

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021782 Expressed in 268 organ(s), highest expression level in placenta
ExpressionAtlasiE9Q9I2 baseline and differential
GenevisibleiE9Q9I2 MM

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR035537 DLG5_SH3
IPR006907 DUF622
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 3 hits
PF04822 Takusan, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q9I2_MOUSE
AccessioniPrimary (citable) accession number: E9Q9I2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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