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Protein
Submitted name:

Kinesin-like protein KIF1A

Gene

Kif1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 104ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin-like protein KIF1AImported
Gene namesi
Name:Kif1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:108391 Kif1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiE9Q9G6
PeptideAtlasiE9Q9G6
PRIDEiE9Q9G6

Expressioni

Gene expression databases

BgeeiENSMUSG00000014602 Expressed in 192 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9Q9G6 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9Q9G6
SMRiE9Q9G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 354Kinesin motorInterPro annotationAdd BLAST350
Domaini516 – 572FHAInterPro annotationAdd BLAST57
Domaini1583 – 1681PHInterPro annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili430 – 457Sequence analysisAdd BLAST28
Coiled coili628 – 662Sequence analysisAdd BLAST35
Coiled coili802 – 822Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
TreeFamiTF105221

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E9Q9G6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF
60 70 80 90 100
SFDYSYWSHT SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGK QEKDQQGIIP QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYN DIQDLMDSGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK VSKISLVDLA
260 270 280 290 300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK
310 320 330 340 350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR
360 370 380 390 400
AKQIRCNAII NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDMTNALVG
410 420 430 440 450
MSPSSSLSAL SSRAASVSSL HERILFAPGS EEAIERLKET EKIIAELNET
460 470 480 490 500
WEEKLRRTEA IRMEREALLA EMGVAMREDG GTLGVFSPKK TPHLVNLNED
510 520 530 540 550
PLMSECLLYY IKDGVTRVGR EDAERRQDIV LSGHFIKEEH CIFRSDSRGG
560 570 580 590 600
GEAVVTLEPC EGADTYVNGK KVTEPSILRS GNRIIMGKSH VFRFNHPEQA
610 620 630 640 650
RQERERTPCA ETPAEPVDWA FAQRELLEKQ GIDMKQEMEQ RLQELEDQYR
660 670 680 690 700
REREEATYLL EQQRLDYESK LEALQKQMDS RYYPEVNEEE EEPEDEVQWT
710 720 730 740 750
ERECELALWA FRKWKWYQFT SLRDLLWGNA IFLKEANAIS VELKKKVQFQ
760 770 780 790 800
FVLLTDTLYS PLPPDLLPPE AAKDRETRPF PRTIVAVEVQ DQKNGATHYW
810 820 830 840 850
TLEKLRQRLD LMREMYDRAA EVPSSVVEDC DNVVTGGDPF YDRFPWFRLV
860 870 880 890 900
GRAFVYLSNL LYPVPLVHRV AIVSEKGEVK GFLRVAVQAI SADEEAPDYG
910 920 930 940 950
SGVRQSGTAK ISFDDQHFEK FQSESCPVVG MSRSGTSQEE LRIVEGQGQG
960 970 980 990 1000
ADAGPSADEV NNNTCSAVPP EGLMDSPEKA ALDGPLDTAL DHLRLGSTFT
1010 1020 1030 1040 1050
FRVTVLQASS ISAEYADIFC QFNFIHRHDE AFSTEPLKNT GRGPPLGFYH
1060 1070 1080 1090 1100
VQNIAVEVTK SFIEYIKSQP IVFEVFGHYQ QHPFPPLCKD VLSPLRPSRR
1110 1120 1130 1140 1150
HFPRVMPLSK PVPATKLSTM TRPSPGPCHC KYDLLVYFEI CELEANGDYI
1160 1170 1180 1190 1200
PAVVDHRGGM PCMGTFLLHQ GIQRRITVTL LHETGSHIRW KEVRELVVGR
1210 1220 1230 1240 1250
IRNTPETDEA LIDPNILSLN ILSSGYVHPA QDDRQFLDSD IPRTFYQFEA
1260 1270 1280 1290 1300
AWDSSMHNSL LLNRVTPYRE KIYMTLSAYI EMENCTQPAV ITKDFCMVFY
1310 1320 1330 1340 1350
SRDAKLPASR SIRNLFGSGS LRATEGNRVT GVYELSLCHV ADAGSPGMQR
1360 1370 1380 1390 1400
RRRRVLDTSV AYVRGEENLA GWRPRSDSLI LDHQWELEKL SLLQEVEKTR
1410 1420 1430 1440 1450
HYLLLREKLE TTQRPGPEVL SPASSEDSES RSSSGASSPL SAEGQPSPLE
1460 1470 1480 1490 1500
APNERQRELA VKCLRLLMHT FNREYTHSHV CISASESKLS EMSVTLMRDP
1510 1520 1530 1540 1550
SMSPLGAATL TPSSTCPSLI EGRYGATDVR TPQPCSRPAS PEPELLPELD
1560 1570 1580 1590 1600
SKKTPSPVRA TETEKEPQRL LVPDIQEIRV SPIVSKKGYL HFLEPHTAGW
1610 1620 1630 1640 1650
AKRFVVVRRP YAYMYNSDKD TVERFVLNLS TAQVEYSEDQ QAMLKTPNTF
1660 1670 1680 1690
AVCTEHRGIL LQANSDKDMH DWLYAFNPLL AGTIRSKLSR RRSAQMRV
Length:1,698
Mass (Da):192,048
Last modified:April 5, 2011 - v1
Checksum:iBDA9A773577475BC
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P33173KIF1A_MOUSE
Kinesin-like protein KIF1A
Kif1a Atsv, Kif1
1,695Annotation score:
E9QAN4E9QAN4_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,689Annotation score:
Q6TA13Q6TA13_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,698Annotation score:
A0A087WQE8A0A087WQE8_MOUSE
Kinesin-like protein KIF1A
Kif1a
1,791Annotation score:
G3UW47G3UW47_MOUSE
Kinesin family member 1A
Kif1a mCG_133020
1,697Annotation score:
A0A087WSU7A0A087WSU7_MOUSE
Kinesin-like protein KIF1A
Kif1a
109Annotation score:
A0A087WNM0A0A087WNM0_MOUSE
Kinesin-like protein KIF1A
Kif1a
78Annotation score:
A0A087WRJ3A0A087WRJ3_MOUSE
Kinesin-like protein KIF1A
Kif1a
46Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110247 Genomic DNA No translation available.
AC119846 Genomic DNA No translation available.
RefSeqiNP_001281078.1, NM_001294149.1
UniGeneiMm.276408

Genome annotation databases

EnsembliENSMUST00000112958; ENSMUSP00000108582; ENSMUSG00000014602
GeneIDi16560
UCSCiuc007cdh.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110247 Genomic DNA No translation available.
AC119846 Genomic DNA No translation available.
RefSeqiNP_001281078.1, NM_001294149.1
UniGeneiMm.276408

3D structure databases

ProteinModelPortaliE9Q9G6
SMRiE9Q9G6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9Q9G6
PeptideAtlasiE9Q9G6
PRIDEiE9Q9G6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112958; ENSMUSP00000108582; ENSMUSG00000014602
GeneIDi16560
UCSCiuc007cdh.3 mouse

Organism-specific databases

CTDi547
MGIiMGI:108391 Kif1a

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
TreeFamiTF105221

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSiKif1a mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014602 Expressed in 192 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9Q9G6 baseline and differential

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di2.30.29.30, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q9G6_MOUSE
AccessioniPrimary (citable) accession number: E9Q9G6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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