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Protein
Submitted name:

Kinase D-interacting substrate 220

Gene

Kidins220

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-170984 ARMS-mediated activation

Names & Taxonomyi

Protein namesi
Submitted name:
Kinase D-interacting substrate 220Imported
Gene namesi
Name:Kidins220Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1924730 Kidins220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Transmembranei524 – 546HelicalSequence analysisAdd BLAST23
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21
Transmembranei687 – 706HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiE9Q9B7
PaxDbiE9Q9B7
PRIDEiE9Q9B7

PTM databases

iPTMnetiE9Q9B7
PhosphoSitePlusiE9Q9B7

Expressioni

Gene expression databases

BgeeiENSMUSG00000036333 Expressed in 252 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiE9Q9B7 baseline and differential
GenevisibleiE9Q9B7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063999

Structurei

3D structure databases

ProteinModelPortaliE9Q9B7
SMRiE9Q9B7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 390ANK_REP_REGIONInterPro annotationAdd BLAST374
Repeati37 – 69ANKPROSITE-ProRule annotationAdd BLAST33
Repeati70 – 102ANKPROSITE-ProRule annotationAdd BLAST33
Repeati103 – 135ANKPROSITE-ProRule annotationAdd BLAST33
Repeati136 – 168ANKPROSITE-ProRule annotationAdd BLAST33
Repeati169 – 201ANKPROSITE-ProRule annotationAdd BLAST33
Repeati202 – 234ANKPROSITE-ProRule annotationAdd BLAST33
Repeati235 – 267ANKPROSITE-ProRule annotationAdd BLAST33
Repeati268 – 300ANKPROSITE-ProRule annotationAdd BLAST33
Repeati334 – 366ANKPROSITE-ProRule annotationAdd BLAST33
Repeati367 – 390ANKPROSITE-ProRule annotationAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili719 – 739Sequence analysisAdd BLAST21

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0502 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148967
InParanoidiE9Q9B7
KOiK12460
OrthoDBiEOG091G01EB
TreeFamiTF344032

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011646 KAP_P-loop
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07693 KAP_NTPase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 10 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q9B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN
60 70 80 90 100
VEIVKELIKN GANCNLEDLD NWTALISASK EGHIHIVEEL LKCGANLEHR
110 120 130 140 150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA
160 170 180 190 200
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG
210 220 230 240 250
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHIE
260 270 280 290 300
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ
310 320 330 340 350
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV
360 370 380 390 400
VELLLDKGAR VSAVDKKGDT PLHVAIRGRS RRLAELLLRN PKDGRLLYRP
410 420 430 440 450
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI
460 470 480 490 500
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL
510 520 530 540 550
IVFLILLLCG GLGLVFAFTV DTNLAIAVSL SFLALLYIFF IVIYFGGRQE
560 570 580 590 600
GESWNWAWAL STRLARHIGY LELLFKLMFV NPPELPEQTT KALPVRFLFT
610 620 630 640 650
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDSQGKKK
660 670 680 690 700
WKKTCCLPSF IIFLFIVGCI IAGITLLAIF RVDPKHLTVN AILISIASIV
710 720 730 740 750
GLAFVLNCRT WWQVLDSLLN SQRKRLHSAA SKLHKLKSEG FMKVLKCEVE
760 770 780 790 800
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF
810 820 830 840 850
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS
860 870 880 890 900
NARKFLVTSA TNGDISCSEA TGVQEDADRR VSQNSLGEMT KLGSKTALNR
910 920 930 940 950
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG
960 970 980 990 1000
RLLRANQITF NWDRLASWIN LTEQWPYRTS WLILYLGETE GIPDQMTLKT
1010 1020 1030 1040 1050
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKTFLPC
1060 1070 1080 1090 1100
TVNLDPKLRE IIADVRAARE QINIGGLAYP PLPLHEAPPR PPSGYSQPAS
1110 1120 1130 1140 1150
VCSSSASFNG PFPGGVVSPQ PHSSYYSGLS GPQHPFYNRP FFAPYLYTPR
1160 1170 1180 1190 1200
YYPGGSQHLI SRSSVKTSLP RDQNNGLEVI KEDAAEGLPS PTASSREKSW
1210 1220 1230 1240 1250
TRKQLMELCD SGFNKQRQAS VPATGTSLLL SSMTVDIVCE KLRQIEGLDQ
1260 1270 1280 1290 1300
GMLPQYCTTI KKANINGRVL AQCNIDELKK EMAMNFGDWH LFRSMVLEMR
1310 1320 1330 1340 1350
SVENQVVPED PRFLNENSSA PVAHGESARR TSHSELPHTE LSSQTPYTLN
1360 1370 1380 1390 1400
FSFEELNTLG LDEGAPRHSN LSWQSQTRRT PSLSSLNSQD SSIEISKLTD
1410 1420 1430 1440 1450
KVQAEYRDAY REYIAQMSQL EGGTGSSTIS GRSSPHSTYY IGQSSSGGSI
1460 1470 1480 1490 1500
HSNLEQERGK ENELKQEEGR KSFLMKRGDV LDYSSSGVST NEASPLDPIT
1510 1520 1530 1540 1550
EEDEKSDQSG SKLLPGKKSS ERPSLFQTDL KLKGSGLRYQ KLPSDEDESG
1560 1570 1580 1590 1600
TEESDNTPLL KDDKDKKAEG KAERVAKSPE HSVEPIRTFI KAKEYLSDAL
1610 1620 1630 1640 1650
LDKKDSSDSG VRSNESSPNH SLHNEAADDS QLEKANLIEL EDEGHSGKRG
1660 1670 1680 1690 1700
MPHSLSGLQD PVIARMSICS EDKKSPSECS LIASSPEESW PSCQKAYNLN
1710 1720 1730 1740 1750
RTPSTVTLNN NTAPTNRANQ NFDEIEGVRE TSQVILRPGP SPNPTAVQNE
1760 1770 1780 1790
NLKSMAHKRS QRSSYTRLSK DASELHAASS DSTGFGEERE SIL
Length:1,793
Mass (Da):199,184
Last modified:April 5, 2011 - v1
Checksum:iBDC16F1BA7F870CB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VME9A0A1Y7VME9_MOUSE
Kinase D-interacting substrate 220
Kidins220
1,763Annotation score:
A0A1Y7VNF8A0A1Y7VNF8_MOUSE
Kinase D-interacting substrate 220
Kidins220
1,182Annotation score:
A0A1Y7VMH7A0A1Y7VMH7_MOUSE
Kinase D-interacting substrate 220
Kidins220
1,672Annotation score:
A0A1Y7VK25A0A1Y7VK25_MOUSE
Kinase D-interacting substrate 220
Kidins220
61Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159307 Genomic DNA No translation available.
CT010478 Genomic DNA No translation available.
RefSeqiNP_001074847.1, NM_001081378.1
UniGeneiMm.250641
Mm.475357

Genome annotation databases

EnsembliENSMUST00000066652; ENSMUSP00000063999; ENSMUSG00000036333
GeneIDi77480
KEGGimmu:77480
UCSCiuc007nfa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159307 Genomic DNA No translation available.
CT010478 Genomic DNA No translation available.
RefSeqiNP_001074847.1, NM_001081378.1
UniGeneiMm.250641
Mm.475357

3D structure databases

ProteinModelPortaliE9Q9B7
SMRiE9Q9B7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063999

PTM databases

iPTMnetiE9Q9B7
PhosphoSitePlusiE9Q9B7

Proteomic databases

MaxQBiE9Q9B7
PaxDbiE9Q9B7
PRIDEiE9Q9B7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066652; ENSMUSP00000063999; ENSMUSG00000036333
GeneIDi77480
KEGGimmu:77480
UCSCiuc007nfa.1 mouse

Organism-specific databases

CTDi57498
MGIiMGI:1924730 Kidins220

Phylogenomic databases

eggNOGiKOG0502 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00920000148967
InParanoidiE9Q9B7
KOiK12460
OrthoDBiEOG091G01EB
TreeFamiTF344032

Enzyme and pathway databases

ReactomeiR-MMU-170984 ARMS-mediated activation

Miscellaneous databases

ChiTaRSiKidins220 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036333 Expressed in 252 organ(s), highest expression level in vestibular membrane of cochlear duct
ExpressionAtlasiE9Q9B7 baseline and differential
GenevisibleiE9Q9B7 MM

Family and domain databases

CDDicd00204 ANK, 3 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011646 KAP_P-loop
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF12796 Ank_2, 4 hits
PF07693 KAP_NTPase, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q9B7_MOUSE
AccessioniPrimary (citable) accession number: E9Q9B7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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