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Protein

2'-5'-oligoadenylate synthase 2

Gene

Oas2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:12396720, PubMed:29117179). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:29117179). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:21142819). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (PubMed:29117179). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (PubMed:29117179).1 Publication3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Produced as a latent enzyme which is activated by double stranded RNA (dsRNA) generated during the course of viral infection (PubMed:29117179). The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated (By similarity). ssRNA or dsDNA do not act as activators (By similarity). Strongly inhibited by copper, iron and zinc ions (By similarity). Partially inhibited by cobalt and nickel ions (By similarity).By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat is 6.4 sec(-1) for ATP.1 Publication
  1. KM=1.9 mM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei436ATPBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi448Magnesium; catalyticSequence analysis1
    Metal bindingi450Magnesium; catalyticSequence analysis1
    Metal bindingi519Magnesium; catalyticSequence analysis1
    Binding sitei582ATPBy similarity1
    Binding sitei585ATPBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • defense response to virus Source: UniProtKB
    • regulation of lactation Source: UniProtKB
    • regulation of ribonuclease activity Source: GO_Central
    • response to bacterium Source: MGI
    • response to virus Source: UniProtKB
    • RNA catabolic process Source: MGI
    • type I interferon signaling pathway Source: UniProtKB

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionNucleotidyltransferase, RNA-binding, Transferase
    Biological processAntiviral defense, Immunity, Innate immunity
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    2'-5'-oligoadenylate synthase 2 (EC:2.7.7.842 Publications)
    Short name:
    (2-5')oligo(A) synthase 2
    Short name:
    2-5A synthase 2
    Alternative name(s):
    2',5'-oligoadenylate synthetase-like 111 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Oas2Imported
    Synonyms:oasl111 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2180852 Oas2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi405I → N: Mice display postpartum failure of lactation and strongly reduced milk protein synthesis. Otherwise, mice develop normally and mammary glands are normal. The mutation causes an activation of the OAS2 pathway, characterized by a strong increase of Ribonuclease L (RNASEL) activity. 1 Publication1
    Mutagenesisi444K → A or G: Strongly reduced 2'-5'-oligoadenylate synthase activity. 1 Publication1
    Mutagenesisi509S → L: Abolished 2'-5'-oligoadenylate synthase activity. 1 Publication1
    Mutagenesisi538P → L: Strongly reduced 2'-5'-oligoadenylate synthase activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004186282 – 7422'-5'-oligoadenylate synthase 2Add BLAST741

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei417N6-acetyllysineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Myristoylation is not essential for its activity.By similarity
    Glycosylated. Glycosylation is essential for its activity.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Lipoprotein, Myristate

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    E9Q9A9

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    E9Q9A9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    E9Q9A9

    PeptideAtlas

    More...
    PeptideAtlasi
    E9Q9A9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    E9Q9A9

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    E9Q9A9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    E9Q9A9

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    E9Q9A9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in the uterus (PubMed:12396720). Expressed in mammary glands: expressed at low level before the establishment of lactation, then expression strongly increases, and subsequently decreases during early involution (PubMed:29117179).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000032690 Expressed in 120 organ(s), highest expression level in bone marrow macrophage

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    E9Q9A9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    E9Q9A9 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000060082

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    E9Q9A9

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    E9Q9A9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 374OAS domain 1Add BLAST315
    Regioni382 – 721OAS domain 2Add BLAST340

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the 2-5A synthase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0001 Eukaryota
    COG5272 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00510000046406

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000013200

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG007855

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    E9Q9A9

    KEGG Orthology (KO)

    More...
    KOi
    K14216

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KSYTSQK

    Database of Orthologous Groups

    More...
    OrthoDBi
    611234at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329749

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1410.20, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006117 2-5-oligoadenylate_synth_CS
    IPR006116 2-5-oligoadenylate_synth_N
    IPR018952 2-5-oligoAdlate_synth_1_dom2/C
    IPR038121 2-5-oligoAdlate_synth_2_sf
    IPR026774 2-5A_synthase
    IPR002934 Polymerase_NTP_transf_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11258 PTHR11258, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01909 NTP_transf_2, 1 hit
    PF10421 OAS1_C, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00832 25A_SYNTH_1, 1 hit
    PS00833 25A_SYNTH_2, 2 hits
    PS50152 25A_SYNTH_3, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: E9Q9A9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MGNWLTGNWS SDRSSGYSSG WSPGGSSGVP SGPVHKLEKS IQANLTPNEN
    60 70 80 90 100
    CLKQIAVSSV PSQKLEGYIQ ENLKPNRESL KQIDQAVDAI WDLLRSQIPV
    110 120 130 140 150
    KEVAKGGSYG RETALRGCSD GTLVLFMDCF QQFQDQIKYQ DAYLDVIELW
    160 170 180 190 200
    LKIHEKKSVK HEHALVVQVS VPGQRILLQL LPVFNPLRSN ENPSSCVYVD
    210 220 230 240 250
    LKKSMDQVRA SPGEFSDCFT TLQQRFFKKY PQRLKDLILL VKHWYEQCQE
    260 270 280 290 300
    KWKTPPPQPL LYALELLTVY AWEQGCQAED FDMAQGVRTV LRLIQRPTEL
    310 320 330 340 350
    CVYWTVNYNF EDETVRNILL HQLRSQRPVI LDPTDPTNNV GKDDGFWELL
    360 370 380 390 400
    TEEAMAWLYS PSLNTESPAP YWDVLPMPLF VTPSHLLNKF IKDFLQPNKL
    410 420 430 440 450
    FLKQIKEAVD IICSFLKNVC FLNSDTKVLK TVKGGSTAKG TALKRGSDAD
    460 470 480 490 500
    IVVFLSSLES YDSLKTNRSQ FVQEIQKQLE EFVQAQEWEV TFEISKWKAP
    510 520 530 540 550
    RVLSFTLKSK TLNESVEFDV LPAYDALGQL RSDFTLRPEA YKDLIELCAS
    560 570 580 590 600
    QDIKEGEFSI CFTELQRNFI QTRPTKLKSL LRLIKHWYKQ YERKMKPKAS
    610 620 630 640 650
    LPPKYALELL TVYAWEQGSG TDDFDIAEGF RTVLDLVIKY RQLCIFWTVN
    660 670 680 690 700
    YNFEEEYMRK FLLTQIQKKR PVILDPADPT GDVGGGDRWC WHLLAEEAKE
    710 720 730 740
    WLSSPCFQVE QKGLVQPWKV PVMQTPGSCG GQIYPTVGGV TK
    Length:742
    Mass (Da):85,051
    Last modified:April 5, 2011 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8F21FB4BEF90C58
    GO
    Isoform 2 (identifier: E9Q9A9-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         723-742: MQTPGSCGGQIYPTVGGVTK → PRDLKTSDMVGVFTTGGILWQDQGFLSFV

    Show »
    Length:751
    Mass (Da):86,285
    Checksum:iB4E650AE78280C49
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F7CFL3F7CFL3_MOUSE
    2'-5'-oligoadenylate synthase 2
    Oas2
    236Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti270Y → C in BAB84135 (PubMed:12396720).Curated1
    Sequence conflicti630F → L in BAB84135 (PubMed:12396720).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti232Q → R in strain: C3H/He. 2 Publications1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044068723 – 742MQTPG…GGVTK → PRDLKTSDMVGVFTTGGILW QDQGFLSFV in isoform 2. 1 PublicationAdd BLAST20

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB067535 mRNA Translation: BAB84135.1
    AF418010 mRNA Translation: AAM54499.1
    AC115937 Genomic DNA No translation available.
    CH466529 Genomic DNA Translation: EDL19753.1

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS19625.2 [E9Q9A9-1]
    CCDS84949.1 [E9Q9A9-2]

    NCBI Reference Sequences

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    RefSeqi
    NP_001334377.1, NM_001347448.1 [E9Q9A9-2]
    NP_660262.2, NM_145227.3 [E9Q9A9-1]

    UniGene gene-oriented nucleotide sequence clusters

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    UniGenei
    Mm.260926

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000053909; ENSMUSP00000060082; ENSMUSG00000032690 [E9Q9A9-1]
    ENSMUST00000081491; ENSMUSP00000080209; ENSMUSG00000032690 [E9Q9A9-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    246728

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:246728

    UCSC genome browser

    More...
    UCSCi
    uc008zhw.2 mouse [E9Q9A9-2]
    uc008zhx.2 mouse [E9Q9A9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB067535 mRNA Translation: BAB84135.1
    AF418010 mRNA Translation: AAM54499.1
    AC115937 Genomic DNA No translation available.
    CH466529 Genomic DNA Translation: EDL19753.1
    CCDSiCCDS19625.2 [E9Q9A9-1]
    CCDS84949.1 [E9Q9A9-2]
    RefSeqiNP_001334377.1, NM_001347448.1 [E9Q9A9-2]
    NP_660262.2, NM_145227.3 [E9Q9A9-1]
    UniGeneiMm.260926

    3D structure databases

    ProteinModelPortaliE9Q9A9
    SMRiE9Q9A9
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000060082

    PTM databases

    iPTMnetiE9Q9A9
    PhosphoSitePlusiE9Q9A9
    SwissPalmiE9Q9A9

    Proteomic databases

    EPDiE9Q9A9
    MaxQBiE9Q9A9
    PaxDbiE9Q9A9
    PeptideAtlasiE9Q9A9
    PRIDEiE9Q9A9

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000053909; ENSMUSP00000060082; ENSMUSG00000032690 [E9Q9A9-1]
    ENSMUST00000081491; ENSMUSP00000080209; ENSMUSG00000032690 [E9Q9A9-2]
    GeneIDi246728
    KEGGimmu:246728
    UCSCiuc008zhw.2 mouse [E9Q9A9-2]
    uc008zhx.2 mouse [E9Q9A9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4939
    MGIiMGI:2180852 Oas2

    Phylogenomic databases

    eggNOGiKOG0001 Eukaryota
    COG5272 LUCA
    GeneTreeiENSGT00510000046406
    HOGENOMiHOG000013200
    HOVERGENiHBG007855
    InParanoidiE9Q9A9
    KOiK14216
    OMAiKSYTSQK
    OrthoDBi611234at2759
    TreeFamiTF329749

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Oas2 mouse

    Protein Ontology

    More...
    PROi
    PR:E9Q9A9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000032690 Expressed in 120 organ(s), highest expression level in bone marrow macrophage
    ExpressionAtlasiE9Q9A9 baseline and differential
    GenevisibleiE9Q9A9 MM

    Family and domain databases

    Gene3Di1.10.1410.20, 2 hits
    InterProiView protein in InterPro
    IPR006117 2-5-oligoadenylate_synth_CS
    IPR006116 2-5-oligoadenylate_synth_N
    IPR018952 2-5-oligoAdlate_synth_1_dom2/C
    IPR038121 2-5-oligoAdlate_synth_2_sf
    IPR026774 2-5A_synthase
    IPR002934 Polymerase_NTP_transf_dom
    PANTHERiPTHR11258 PTHR11258, 1 hit
    PfamiView protein in Pfam
    PF01909 NTP_transf_2, 1 hit
    PF10421 OAS1_C, 2 hits
    PROSITEiView protein in PROSITE
    PS00832 25A_SYNTH_1, 1 hit
    PS00833 25A_SYNTH_2, 2 hits
    PS50152 25A_SYNTH_3, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOAS2_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q9A9
    Secondary accession number(s): Q8K4E5, Q8VI92
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: April 5, 2011
    Last modified: January 16, 2019
    This is version 66 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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