UniProtKB - E9Q8W9 (E9Q8W9_MOUSE)
Protein
Ubiquitin carboxyl-terminal hydrolase
Gene
Usp3
Organism
Mus musculus (Mouse)
Status
Functioni
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.UniRule annotation
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotationARBA annotation EC:3.4.19.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 104 | UBP-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- protein deubiquitination Source: UniProtKB-UniRule
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseUniRule annotationARBA annotation |
Biological process | Ubl conjugation pathwayUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolaseUniRule annotation (EC:3.4.19.12UniRule annotation) |
Gene namesi | Name:Usp3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2152450, Usp3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032376, Expressed in primary oocyte and 293 other tissues |
ExpressionAtlasi | E9Q8W9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 104 | UBP-typeInterPro annotationAdd BLAST | 78 | |
Domaini | 159 – 473 | USPInterPro annotationAdd BLAST | 315 |
Sequence similaritiesi
Belongs to the peptidase C19 family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 27 – 104 | UBP-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157850 |
OrthoDBi | 929408at2759 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom IPR013083, Znf_RING/FYVE/PHD IPR001607, Znf_UBP |
Pfami | View protein in Pfam PF00443, UCH, 1 hit PF02148, zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00290, ZnF_UBP, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit PS50271, ZF_UBP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E9Q8W9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG
60 70 80 90 100
RYVNGHAKKH YEDAQIPLLN HKRSEKQEKA QHTVCMDCSS YSTYCYRCDD
110 120 130 140 150
FVVNDTKLGL VQKVREHLQN LENSAFTADR HRKRKLLENS SLNSKLLKVN
160 170 180 190 200
GSTTAICATG LRNLGNTCFM NAILQSLRSL VEEFRKTLCA LWQGSQTAFS
210 220 230 240 250
PESLFYVVWK IMPNFRGYQQ QDAHEFMRYL LDHLHLELQG GFNGVSRSAI
260 270 280 290 300
LQENSTLSAS NKCCINGAST VVTAIFGGIL QNEVNCLICG TESRKFDPFL
310 320 330 340 350
DLSLDIPSQF RSKRSKNQEN GPVCSLRDCL RSFTDLEELD ETELYMCHKC
360 370 380 390 400
KKKQKSTKKF WIQKLPKALC LHLKRFHWTA YLRNKVDTYV QFPLRGLDMK
410 420 430 440 450
CYLLEPENSG PDSCLYDLAA VVVHHGSGVG SGHYTAYAVH EGRWFHFNDS
460 470 480
TVTVTDEETV GKAKAYILFY VERQARAGAE KL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ91W36 | UBP3_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Usp3 | 520 | Annotation score: | ||
G3UZF0 | G3UZF0_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Usp3 | 476 | Annotation score: | ||
D6RG67 | D6RG67_MOUSE | Ubiquitin carboxyl-terminal hydrola... | Usp3 | 49 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132087 Genomic DNA No translation available. AC166755 Genomic DNA No translation available. |
RefSeqi | NP_001289045.1, NM_001302116.1 |
Genome annotation databases
Ensembli | ENSMUST00000098613; ENSMUSP00000096213; ENSMUSG00000032376 |
GeneIDi | 235441 |
UCSCi | uc012gvp.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132087 Genomic DNA No translation available. AC166755 Genomic DNA No translation available. |
RefSeqi | NP_001289045.1, NM_001302116.1 |
3D structure databases
SMRi | E9Q8W9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9Q8W9 |
PeptideAtlasi | E9Q8W9 |
PRIDEi | E9Q8W9 |
Protocols and materials databases
Antibodypediai | 13304, 289 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098613; ENSMUSP00000096213; ENSMUSG00000032376 |
GeneIDi | 235441 |
UCSCi | uc012gvp.2, mouse |
Organism-specific databases
CTDi | 9960 |
MGIi | MGI:2152450, Usp3 |
Phylogenomic databases
GeneTreei | ENSGT00940000157850 |
OrthoDBi | 929408at2759 |
Miscellaneous databases
BioGRID-ORCSi | 235441, 2 hits in 17 CRISPR screens |
ChiTaRSi | Usp3, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032376, Expressed in primary oocyte and 293 other tissues |
ExpressionAtlasi | E9Q8W9, baseline and differential |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom IPR013083, Znf_RING/FYVE/PHD IPR001607, Znf_UBP |
Pfami | View protein in Pfam PF00443, UCH, 1 hit PF02148, zf-UBP, 1 hit |
SMARTi | View protein in SMART SM00290, ZnF_UBP, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit PS50271, ZF_UBP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9Q8W9_MOUSE | |
Accessioni | E9Q8W9Primary (citable) accession number: E9Q8W9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |