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UniProtKB - E9Q8T7 (DYH1_MOUSE)

Entry version 83 (10 Feb 2021)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
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Protein

Dynein heavy chain 1, axonemal

Gene

Dnah1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1566 – 1573ATPSequence analysis8
Nucleotide bindingi1847 – 1854ATPSequence analysis8
Nucleotide bindingi2212 – 2219ATPSequence analysis8
Nucleotide bindingi2571 – 2578ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 1, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
mDHC71 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah1Imported
Synonyms:Dhc7, Dnahc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107721, Dnah1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and show no malformations; however, homozygous males are infertile, due to inability of spermatozoa to move from the uterus into the oviduct. Spermatozoa show decreased motility. In addition, tracheal beating frequency is reduced.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004424301 – 4250Dynein heavy chain 1, axonemalAdd BLAST4250

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		E9Q8T7

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9Q8T7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9Q8T7

PRoteomics IDEntifications database

More...PRIDEi		E9Q8T7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9Q8T7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9Q8T7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000019027, Expressed in cerebellum and 138 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q8T7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000043281

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		E9Q8T7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q8T7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1527StemBy similarityAdd BLAST1527
Regioni1528 – 1749AAA 1By similarityAdd BLAST222
Regioni1809 – 2042AAA 2By similarityAdd BLAST234
Regioni2174 – 2434AAA 3By similarityAdd BLAST261
Regioni2532 – 2784AAA 4By similarityAdd BLAST253
Regioni2799 – 3097StalkBy similarityAdd BLAST299
Regioni3182 – 3412AAA 5By similarityAdd BLAST231
Regioni3625 – 3844AAA 6By similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3045 – 3128Sequence analysisAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1566 – 1573GPAGTGKT motif8
Motifi1616 – 1622CFDEFNR motif7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3595, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154791

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000038_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E9Q8T7

Identification of Orthologs from Complete Genome Data

More...OMAi		QTQDFID

Database of Orthologous Groups

More...OrthoDBi		3185at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E9Q8T7

TreeFam database of animal gene trees

More...TreeFami		TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: E9Q8T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEECNKEGPS SSSQGPGYCP VKVPESHDLE KILQESNYHP ERNPLNPDPK 
        60         70         80         90        100
TPPLPLTDLR QPRKSPLTGT DKKYPLMKQR GFYSDILSPG TLDKLGNVCC 
       110        120        130        140        150
GPYMSQNLIR QADLDKFTPK VDSFVIPEDF QERVEQQIIG ATTRLLTQTD 
       160        170        180        190        200
FPLQSYEPKV QVPFQVLPGQ CPRKIEIERR KQQYLRLDIE QLLTSEGIDS 
       210        220        230        240        250
NKLMPRHPDL QHPQTIEQGR DPLFPIYLPL KVFDNEEFDC RTPTEWLNMG 
       260        270        280        290        300
LEPGSQNRKP VPGKALLPTD DDLGHEDPKN QELDYRWCEV GVLDYDEEKK 
       310        320        330        340        350
LYLVQKTDKR GLVRDEMGMP ILNGGITPAG RPPLLATQYW VPRIQLLFCA 
       360        370        380        390        400
EDPRVFTQRV VQANALRKYT EALLMYNLYV DCMPTEGRRV INEQSLSKIK 
       410        420        430        440        450
QWALSTPRMR KGQSVLEHLS CLAREVNLDY ERSMNKINFD QIVSSNPETF 
       460        470        480        490        500
SYVTLPEKEE EKVPNQGLVS VPEYPFREQK EDFTFVSLLT RPEVITALSK 
       510        520        530        540        550
VRAECNKVTS MSLFHSSLSK YSRLEEFEQI QSQTFSQVQM FLKDSWISTL 
       560        570        580        590        600
KVAMRGSLRD MSKGWYNLYE TNWEVYLMSK LRKLMELIKY MLQDTLRFLV 
       610        620        630        640        650
QDSLGSFTQF IGDACCSVLE CVDDMDWGED LVNSPYKPRK NPLFIVDLVL 
       660        670        680        690        700
DNSGVHYSTP LEHFEMILLN LFDKGILATH AVPQLEKLVM EDIFISGDPL 
       710        720        730        740        750
LESVGLHEPL VEELRANITN AMHKAMMPLQ AYAKEYRKYL ELNNNDISTF 
       760        770        780        790        800
LKTYQTQCPS AEEVREVVIT HLKEKEILDN SLPSSIIIGP FYINVDNVKQ 
       810        820        830        840        850
SLSKKRKALA TSMLDILAKN LHKEVDSICE EFRSISRKIY EKPNSIEELA 
       860        870        880        890        900
ELRDWMKGIP EKLVFLEERI VKVMSDYEVM DEFFYNLTTD DFNDKWAANN 
       910        920        930        940        950
WPSKILGQID MVRQQHVEDE EKFRKIQLMD QNNFQEKLEG LQLVVAGFSI 
       960        970        980        990       1000
HVEIARAHEI ANEVRRVKKQ LKDCQQLAML YNNRERIFGL PITNYDKLSR 
      1010       1020       1030       1040       1050
MVKEFQPYLD LWTTASDWLR WSESWMNDPL SAIDAEQLEK NVIESFKTMH 
      1060       1070       1080       1090       1100
KCVKQFKDIP ACQEVALDIR TRIEEFKPYI PLIQGLRNPG MRNRHWEVLS 
      1110       1120       1130       1140       1150
NEININVRPK ANLTFARCLE MNLQDHIESI SKVAEVAGKE YAIEQALDKM 
      1160       1170       1180       1190       1200
EKEWSSILFN VLPYKETDTY ILKSPDEASQ LLDDHIVMTQ SMSFSPYKKP 
      1210       1220       1230       1240       1250
FEQRINSWET KLKLTQEVLE EWLNCQRAWL YLEPIFSSED ITRQLPVESK 
      1260       1270       1280       1290       1300
RYQTMERIWR KIMKNAYENR EVINVCSDQR LLDSLRDCNK LLDLVQKGLS 
      1310       1320       1330       1340       1350
EYLETKRTAF PRFYFLSDDE LLEILSQTKD PTAVQPHLRK CFENIARLLF 
      1360       1370       1380       1390       1400
QEDLEITHMY SAEGEEVKLS FSIYPSSNVE DWLLEVERSM KASVHDIIEM 
      1410       1420       1430       1440       1450
AIKAYPTMLR TEWVLNWPGQ VTIAGCQTYW TMEVAEALEA GNISSKLFPQ 
      1460       1470       1480       1490       1500
LSKQLSDLVA LVRGKLSRMQ RMVLSALIVI EVHAKDVVSK LIDENVVSVH 
      1510       1520       1530       1540       1550
DFEWISQLRY YWTKDDLYIR AVNAEFIYGY EYLGNSGRLV ITPLTDRCYL 
      1560       1570       1580       1590       1600
TLTGALHLKF GGAPAGPAGT GKTETTKDLG KALAIQTVVF NCSDQLDFMA 
      1610       1620       1630       1640       1650
MGKFFKGLAS AGAWACFDEF NRIDIEVLSV VAQQITTIQK AQQQRVERFM 
      1660       1670       1680       1690       1700
FEGVEIPLVP SCAVFITMNP GYAGRTELPD NLKALFRPVA MMVPDYAMIA 
      1710       1720       1730       1740       1750
EISLYSFGFN EANVLAKKIT TTFKLSSEQL SSQDHYDFGM RAVKTVISAA 
      1760       1770       1780       1790       1800
GNLKRENPTM NEELICLRAI RDVNVPKFLQ EDLKLFSGIV SDLFPTIKEE 
      1810       1820       1830       1840       1850
ETDYGILDQA IRRSCEKNNL KDVEGFLIKC IQLYETTVVR HGLMLVGPTG 
      1860       1870       1880       1890       1900
SGKSNCYRVL AAAMTLLKGK PSISGGVYEA VNYYVLNPKS ITMGQLYGEF 
      1910       1920       1930       1940       1950
DLLTHEWTDG IFSSLIRAGA IASDTNKKWY MFDGPVDAVW IENMNTVLDD 
      1960       1970       1980       1990       2000
NKKLCLSSGE IIKLTEAMTM MFEVQDLAVA SPATVSRCGM VYLEPSILGL 
      2010       2020       2030       2040       2050
MPFVECWLKR LPAIIKPYEE QFKSLFTKYL ENSINFVRNT VKEVIASTNS 
      2060       2070       2080       2090       2100
NLTMSLLKLL DCFFRPFLPR EGLKKIPSEK LSHIPELIEP WFIFSLVWSV 
      2110       2120       2130       2140       2150
GATGDHTSRI SFSQWLRLKM RLEQVKLGFP EDGLVYDYRL DDAGISSTED 
      2160       2170       2180       2190       2200
DDEEEDENKQ VSWVKWMDYS APFTMMPDTN YCNIIVPTMD TVQMSYLLGM 
      2210       2220       2230       2240       2250
LLTNHKPVLC IGPTGTGKTL TVSNKLLKYL PLEYISHFLT FSARTSANQT 
      2260       2270       2280       2290       2300
QDLIDSKLDK RRKGVFGPPL GRNFIFFIDD LNMPALETYG AQPPIELLRQ 
      2310       2320       2330       2340       2350
WMDHGGWYDR KVIGAFKNLV DINFVCAMGP PGGGRNAITP RLTRHFNYLS 
      2360       2370       2380       2390       2400
FIEMDEVSKK RIFSIILECW MDGLLGEKSY REPVPGAPNI DDLTEPLVDA 
      2410       2420       2430       2440       2450
TINVYGIITS QLLPTPAKSH YTFNLRDLSK VFQGMLMAEP SKVEDKVQLL 
      2460       2470       2480       2490       2500
RLWYHENCRV FRDRLVNEED RSWFDELLEA QMEEFGVAFN KVCPFQPILY 
      2510       2520       2530       2540       2550
GDFMSPGSDV KSYELITSES KMMQVIEEYM EDYNQINTAK LRLVLFVDAM 
      2560       2570       2580       2590       2600
SHICRISRTL RQALGNALLL GVGGSGRSSL TRLASHMAEY ECFQIELSKN 
      2610       2620       2630       2640       2650
YGMSEWREDV KKVLLKAGLQ NLPITFLFSD TQIKNESFLE DINNVLNSGD 
      2660       2670       2680       2690       2700
IPNIYSADEQ DQIINTMRPY IQEQGLQPTK ANLMAAYTGR VRSNIHMVLC 
      2710       2720       2730       2740       2750
MSPIGEVFRA RLRQFPSLVN CCTIDWFNEW PAEALKSVAT TFLSEIPELE 
      2760       2770       2780       2790       2800
CSEEVIQGLI QVCVFIHQSV ASKCVEYLAE LARHNYVTPK SYLELLNIFS 
      2810       2820       2830       2840       2850
ILIGQKKMEL KTAKNRMKSG LDKLLRTSED VAKMQEELEI MRPLLEEAAK 
      2860       2870       2880       2890       2900
DTMLTMEQIK VDTAIAEETR KSVQAEEIKA NEKANKAQAI ADDAQKDLDE 
      2910       2920       2930       2940       2950
ALPALDAALA SLRNLNKNDV TEVRAMQRPP PGVKLVIEAV CIMKGIKPKK 
      2960       2970       2980       2990       3000
VPGEKPGSKV DDYWEPGKGL LQDPGRFLES LFKFDKDNIG EAVIKAIQPY 
      3010       3020       3030       3040       3050
IDNEEFQPAA IAKVSKACTS ICQWVRAMHK YHFVAKAVEP KRQALREAQD 
      3060       3070       3080       3090       3100
DLEVTQRILE EAKHHLHEVE DGIATMQAKY RECVAKKEEL EMKCEQCEQR 
      3110       3120       3130       3140       3150
LGRADKLING LADEKVRWQE TVENLENMLD NIFGDVLVAA GFVAYLGPFT 
      3160       3170       3180       3190       3200
GQYRTTLYEY WVNQLTVHHV PHTSKPTLIT TLGNPVKIRS WQIAGLPNDT 
      3210       3220       3230       3240       3250
LSVENGVINQ FSQRWTHFID PQGQANKWIK NMERESGLDV FKLSDRDFLR 
      3260       3270       3280       3290       3300
SMENAIRFGK PCLLENVGEE LDPALEPVLL KQTYKQQGNI VLKLGDTVIP 
      3310       3320       3330       3340       3350
YHEDFRMYIT TKLPNPHYSP EISTKLTLIN FTLSPSGLED QLLGQVVAEE 
      3360       3370       3380       3390       3400
RPDLEEAKNQ LIVSNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL 
      3410       3420       3430       3440       3450
EASKMKAAEI QAKVRIAEQT EKDIDLTRME YIPVAVRTQI LFFCVSDLAN 
      3460       3470       3480       3490       3500
VDPMYQYSLE WFLNIFLSGI ANSERADNLK KRIVNINRYL TFSLYSNVCR 
      3510       3520       3530       3540       3550
SLFEKHKLMF AFLLCVRIMM NEGKINQAEW RYLLSGGSIQ TMFENPAPQW 
      3560       3570       3580       3590       3600
LSDRAWRDIL ALSNLPTFAT FSNDFVMYLS EFQAIFDSAE PHRELLPGIW 
      3610       3620       3630       3640       3650
NAYLDEFQKL LILRCLRGDK VTNAMQDFVA THLEPRFIEP QTANLSAVFK 
      3660       3670       3680       3690       3700
ESNSTTPLIF VLSPGTDPAA DLYKFAEEMK FSKKFSAISL GQGQGPRAEA 
      3710       3720       3730       3740       3750
MMRNSIERGK WVFFQNCHLA PSWMPALERL IEHINPDKVH RDFRLWLTSL 
      3760       3770       3780       3790       3800
PSNKFPVSIL QNGSKMTIEP PRGVKANLLK SYNSLSDDFL HSCQKVVEFK 
      3810       3820       3830       3840       3850
SLLLSLCLFH GNALERRKFG PLGFNIPYEF TDGDLRICIS QLKMFLDEYE 
      3860       3870       3880       3890       3900
DIPYKVLKYT AGEINYGGRV TDDWDRRCVM NILEDFYNPA VLSSEHSYSN 
      3910       3920       3930       3940       3950
SGIYHQIPPT YDLNGYLSYI KSLPLNDMPE IFGLHDNANI TFAQNETFAL 
      3960       3970       3980       3990       4000
FNAILQLQPK SSSMGGQSRE ELVEDVAENI LLQVPGPIEL QEVTKKFPVL 
      4010       4020       4030       4040       4050
YEESMNTVLV QEVIRYNKLL EVITQTLSDM LKAIKGLVVM SLELELMSIS 
      4060       4070       4080       4090       4100
LYNNTVPELW KSKAYPSLKP LASWIMDLLL RLDFMHSWIN DGIPPVFWIS 
      4110       4120       4130       4140       4150
GFFFPQAFLT GTLQNFARKF VISIDTITFD FKVLPEASSE IKERPQTGCY 
      4160       4170       4180       4190       4200
IHGLFLEGAR WDSMNFQLAE SRPKELYTEM AVIWLLPEAN RKVQNQDFYL 
      4210       4220       4230       4240       4250
CPIYKTLTRA GTLSTTGHST NYVIAVEIPS NQPQRHWIKR GVALICALDY
Length:4,250
Mass (Da):487,070
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27CA12B77EC9E3F9
GO
Isoform 2 (identifier: E9Q8T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-486: LVSVPEYPFREQKEDFTFV → ESHWTLAAHLASSPHLRLS
     487-4250: Missing.

Show »
Length:486
Mass (Da):55,763
Checksum:i13F2DE53D81572CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti839I → L in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti854D → V in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1111A → G in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1136V → M in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1302Y → S in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1389S → I in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1406P → L in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1427Q → R in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti2025 – 2046LFTKY…KEVIA → SLPSTWRIPSTCSEHSEGSD C in CAB06069 (PubMed:9373155).CuratedAdd BLAST22
Sequence conflicti2052L → V in CAB06069 (PubMed:9373155).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059235468 – 486LVSVP…DFTFV → ESHWTLAAHLASSPHLRLS in isoform 2. Add BLAST19
Alternative sequenceiVSP_059236487 – 4250Missing in isoform 2. Add BLAST3764

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK053204 mRNA Translation: BAC35309.1
AC108416 Genomic DNA No translation available.
CH466573 Genomic DNA Translation: EDL24805.1
BC023155 mRNA Translation: AAH23155.1
Z83815 mRNA Translation: CAB06069.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS49436.1 [E9Q8T7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001028840.1, NM_001033668.1 [E9Q8T7-1]
XP_017171287.1, XM_017315798.1
XP_017171288.1, XM_017315799.1 [E9Q8T7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000048603; ENSMUSP00000043281; ENSMUSG00000019027 [E9Q8T7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		110084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:110084

UCSC genome browser

More...UCSCi		uc007sxk.2, mouse [E9Q8T7-1]
uc007sxl.1, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053204 mRNA Translation: BAC35309.1
AC108416 Genomic DNA No translation available.
CH466573 Genomic DNA Translation: EDL24805.1
BC023155 mRNA Translation: AAH23155.1
Z83815 mRNA Translation: CAB06069.2
CCDSiCCDS49436.1 [E9Q8T7-1]
RefSeqiNP_001028840.1, NM_001033668.1 [E9Q8T7-1]
XP_017171287.1, XM_017315798.1
XP_017171288.1, XM_017315799.1 [E9Q8T7-1]

3D structure databases

SMRiE9Q8T7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043281

PTM databases

iPTMnetiE9Q8T7
PhosphoSitePlusiE9Q8T7

Proteomic databases

jPOSTiE9Q8T7
MaxQBiE9Q8T7
PaxDbiE9Q8T7
PRIDEiE9Q8T7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48327, 47 antibodies

Genome annotation databases

EnsembliENSMUST00000048603; ENSMUSP00000043281; ENSMUSG00000019027 [E9Q8T7-1]
GeneIDi110084
KEGGimmu:110084
UCSCiuc007sxk.2, mouse [E9Q8T7-1]
uc007sxl.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25981
MGIiMGI:107721, Dnah1

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000154791
HOGENOMiCLU_000038_0_0_1
InParanoidiE9Q8T7
OMAiQTQDFID
OrthoDBi3185at2759
PhylomeDBiE9Q8T7
TreeFamiTF316836

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		110084, 1 hit in 17 CRISPR screens

Protein Ontology

More...PROi		PR:E9Q8T7
RNActiE9Q8T7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000019027, Expressed in cerebellum and 138 other tissues
GenevisibleiE9Q8T7, MM

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR041466, Dynein_AAA5_ext
IPR041228, Dynein_C
IPR043160, Dynein_C_barrel
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08393, DHC_N2, 1 hit
PF17852, Dynein_AAA_lid, 1 hit
PF18199, Dynein_C, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q8T7
Secondary accession number(s): O08828, Q8R584
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: February 10, 2021
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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