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Protein

Dynein heavy chain 1, axonemal

Gene

Dnah1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of cilia required for sperm flagellum motility (PubMed:11371505). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1566 – 1573ATPSequence analysis8
Nucleotide bindingi1847 – 1854ATPSequence analysis8
Nucleotide bindingi2212 – 2219ATPSequence analysis8
Nucleotide bindingi2571 – 2578ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, minus-end-directed Source: GO_Central
  • dynein intermediate chain binding Source: GO_Central
  • dynein light chain binding Source: GO_Central
  • dynein light intermediate chain binding Source: GO_Central
  • microtubule motor activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 1, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 1
Ciliary dynein heavy chain 1
mDHC71 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dnah1Imported
Synonyms:Dhc7, Dnahc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107721 Dnah1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and show no malformations; however, homozygous males are infertile, due to inability of spermatozoa to move from the uterus into the oviduct. Spermatozoa show decreased motility. In addition, tracheal beating frequency is reduced.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004424301 – 4250Dynein heavy chain 1, axonemalAdd BLAST4250

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q8T7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q8T7

PRoteomics IDEntifications database

More...
PRIDEi
E9Q8T7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q8T7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q8T7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019027 Expressed in 115 organ(s), highest expression level in cerebellum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q8T7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000043281

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q8T7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1527StemBy similarityAdd BLAST1527
Regioni1528 – 1749AAA 1By similarityAdd BLAST222
Regioni1809 – 2042AAA 2By similarityAdd BLAST234
Regioni2174 – 2434AAA 3By similarityAdd BLAST261
Regioni2532 – 2784AAA 4By similarityAdd BLAST253
Regioni2799 – 3097StalkBy similarityAdd BLAST299
Regioni3182 – 3412AAA 5By similarityAdd BLAST231
Regioni3625 – 3844AAA 6By similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3045 – 3128Sequence analysisAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1566 – 1573GPAGTGKT motif8
Motifi1616 – 1622CFDEFNR motif7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154791

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG104858

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q8T7

KEGG Orthology (KO)

More...
KOi
K10408

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEWRDDV

Database of Orthologous Groups

More...
OrthoDBi
3185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q8T7

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035699 AAA_6
IPR035706 AAA_9
IPR026983 DHC_fam
IPR026975 DNAH1
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10676 PTHR10676, 1 hit
PTHR10676:SF358 PTHR10676:SF358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: E9Q8T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEECNKEGPS SSSQGPGYCP VKVPESHDLE KILQESNYHP ERNPLNPDPK
60 70 80 90 100
TPPLPLTDLR QPRKSPLTGT DKKYPLMKQR GFYSDILSPG TLDKLGNVCC
110 120 130 140 150
GPYMSQNLIR QADLDKFTPK VDSFVIPEDF QERVEQQIIG ATTRLLTQTD
160 170 180 190 200
FPLQSYEPKV QVPFQVLPGQ CPRKIEIERR KQQYLRLDIE QLLTSEGIDS
210 220 230 240 250
NKLMPRHPDL QHPQTIEQGR DPLFPIYLPL KVFDNEEFDC RTPTEWLNMG
260 270 280 290 300
LEPGSQNRKP VPGKALLPTD DDLGHEDPKN QELDYRWCEV GVLDYDEEKK
310 320 330 340 350
LYLVQKTDKR GLVRDEMGMP ILNGGITPAG RPPLLATQYW VPRIQLLFCA
360 370 380 390 400
EDPRVFTQRV VQANALRKYT EALLMYNLYV DCMPTEGRRV INEQSLSKIK
410 420 430 440 450
QWALSTPRMR KGQSVLEHLS CLAREVNLDY ERSMNKINFD QIVSSNPETF
460 470 480 490 500
SYVTLPEKEE EKVPNQGLVS VPEYPFREQK EDFTFVSLLT RPEVITALSK
510 520 530 540 550
VRAECNKVTS MSLFHSSLSK YSRLEEFEQI QSQTFSQVQM FLKDSWISTL
560 570 580 590 600
KVAMRGSLRD MSKGWYNLYE TNWEVYLMSK LRKLMELIKY MLQDTLRFLV
610 620 630 640 650
QDSLGSFTQF IGDACCSVLE CVDDMDWGED LVNSPYKPRK NPLFIVDLVL
660 670 680 690 700
DNSGVHYSTP LEHFEMILLN LFDKGILATH AVPQLEKLVM EDIFISGDPL
710 720 730 740 750
LESVGLHEPL VEELRANITN AMHKAMMPLQ AYAKEYRKYL ELNNNDISTF
760 770 780 790 800
LKTYQTQCPS AEEVREVVIT HLKEKEILDN SLPSSIIIGP FYINVDNVKQ
810 820 830 840 850
SLSKKRKALA TSMLDILAKN LHKEVDSICE EFRSISRKIY EKPNSIEELA
860 870 880 890 900
ELRDWMKGIP EKLVFLEERI VKVMSDYEVM DEFFYNLTTD DFNDKWAANN
910 920 930 940 950
WPSKILGQID MVRQQHVEDE EKFRKIQLMD QNNFQEKLEG LQLVVAGFSI
960 970 980 990 1000
HVEIARAHEI ANEVRRVKKQ LKDCQQLAML YNNRERIFGL PITNYDKLSR
1010 1020 1030 1040 1050
MVKEFQPYLD LWTTASDWLR WSESWMNDPL SAIDAEQLEK NVIESFKTMH
1060 1070 1080 1090 1100
KCVKQFKDIP ACQEVALDIR TRIEEFKPYI PLIQGLRNPG MRNRHWEVLS
1110 1120 1130 1140 1150
NEININVRPK ANLTFARCLE MNLQDHIESI SKVAEVAGKE YAIEQALDKM
1160 1170 1180 1190 1200
EKEWSSILFN VLPYKETDTY ILKSPDEASQ LLDDHIVMTQ SMSFSPYKKP
1210 1220 1230 1240 1250
FEQRINSWET KLKLTQEVLE EWLNCQRAWL YLEPIFSSED ITRQLPVESK
1260 1270 1280 1290 1300
RYQTMERIWR KIMKNAYENR EVINVCSDQR LLDSLRDCNK LLDLVQKGLS
1310 1320 1330 1340 1350
EYLETKRTAF PRFYFLSDDE LLEILSQTKD PTAVQPHLRK CFENIARLLF
1360 1370 1380 1390 1400
QEDLEITHMY SAEGEEVKLS FSIYPSSNVE DWLLEVERSM KASVHDIIEM
1410 1420 1430 1440 1450
AIKAYPTMLR TEWVLNWPGQ VTIAGCQTYW TMEVAEALEA GNISSKLFPQ
1460 1470 1480 1490 1500
LSKQLSDLVA LVRGKLSRMQ RMVLSALIVI EVHAKDVVSK LIDENVVSVH
1510 1520 1530 1540 1550
DFEWISQLRY YWTKDDLYIR AVNAEFIYGY EYLGNSGRLV ITPLTDRCYL
1560 1570 1580 1590 1600
TLTGALHLKF GGAPAGPAGT GKTETTKDLG KALAIQTVVF NCSDQLDFMA
1610 1620 1630 1640 1650
MGKFFKGLAS AGAWACFDEF NRIDIEVLSV VAQQITTIQK AQQQRVERFM
1660 1670 1680 1690 1700
FEGVEIPLVP SCAVFITMNP GYAGRTELPD NLKALFRPVA MMVPDYAMIA
1710 1720 1730 1740 1750
EISLYSFGFN EANVLAKKIT TTFKLSSEQL SSQDHYDFGM RAVKTVISAA
1760 1770 1780 1790 1800
GNLKRENPTM NEELICLRAI RDVNVPKFLQ EDLKLFSGIV SDLFPTIKEE
1810 1820 1830 1840 1850
ETDYGILDQA IRRSCEKNNL KDVEGFLIKC IQLYETTVVR HGLMLVGPTG
1860 1870 1880 1890 1900
SGKSNCYRVL AAAMTLLKGK PSISGGVYEA VNYYVLNPKS ITMGQLYGEF
1910 1920 1930 1940 1950
DLLTHEWTDG IFSSLIRAGA IASDTNKKWY MFDGPVDAVW IENMNTVLDD
1960 1970 1980 1990 2000
NKKLCLSSGE IIKLTEAMTM MFEVQDLAVA SPATVSRCGM VYLEPSILGL
2010 2020 2030 2040 2050
MPFVECWLKR LPAIIKPYEE QFKSLFTKYL ENSINFVRNT VKEVIASTNS
2060 2070 2080 2090 2100
NLTMSLLKLL DCFFRPFLPR EGLKKIPSEK LSHIPELIEP WFIFSLVWSV
2110 2120 2130 2140 2150
GATGDHTSRI SFSQWLRLKM RLEQVKLGFP EDGLVYDYRL DDAGISSTED
2160 2170 2180 2190 2200
DDEEEDENKQ VSWVKWMDYS APFTMMPDTN YCNIIVPTMD TVQMSYLLGM
2210 2220 2230 2240 2250
LLTNHKPVLC IGPTGTGKTL TVSNKLLKYL PLEYISHFLT FSARTSANQT
2260 2270 2280 2290 2300
QDLIDSKLDK RRKGVFGPPL GRNFIFFIDD LNMPALETYG AQPPIELLRQ
2310 2320 2330 2340 2350
WMDHGGWYDR KVIGAFKNLV DINFVCAMGP PGGGRNAITP RLTRHFNYLS
2360 2370 2380 2390 2400
FIEMDEVSKK RIFSIILECW MDGLLGEKSY REPVPGAPNI DDLTEPLVDA
2410 2420 2430 2440 2450
TINVYGIITS QLLPTPAKSH YTFNLRDLSK VFQGMLMAEP SKVEDKVQLL
2460 2470 2480 2490 2500
RLWYHENCRV FRDRLVNEED RSWFDELLEA QMEEFGVAFN KVCPFQPILY
2510 2520 2530 2540 2550
GDFMSPGSDV KSYELITSES KMMQVIEEYM EDYNQINTAK LRLVLFVDAM
2560 2570 2580 2590 2600
SHICRISRTL RQALGNALLL GVGGSGRSSL TRLASHMAEY ECFQIELSKN
2610 2620 2630 2640 2650
YGMSEWREDV KKVLLKAGLQ NLPITFLFSD TQIKNESFLE DINNVLNSGD
2660 2670 2680 2690 2700
IPNIYSADEQ DQIINTMRPY IQEQGLQPTK ANLMAAYTGR VRSNIHMVLC
2710 2720 2730 2740 2750
MSPIGEVFRA RLRQFPSLVN CCTIDWFNEW PAEALKSVAT TFLSEIPELE
2760 2770 2780 2790 2800
CSEEVIQGLI QVCVFIHQSV ASKCVEYLAE LARHNYVTPK SYLELLNIFS
2810 2820 2830 2840 2850
ILIGQKKMEL KTAKNRMKSG LDKLLRTSED VAKMQEELEI MRPLLEEAAK
2860 2870 2880 2890 2900
DTMLTMEQIK VDTAIAEETR KSVQAEEIKA NEKANKAQAI ADDAQKDLDE
2910 2920 2930 2940 2950
ALPALDAALA SLRNLNKNDV TEVRAMQRPP PGVKLVIEAV CIMKGIKPKK
2960 2970 2980 2990 3000
VPGEKPGSKV DDYWEPGKGL LQDPGRFLES LFKFDKDNIG EAVIKAIQPY
3010 3020 3030 3040 3050
IDNEEFQPAA IAKVSKACTS ICQWVRAMHK YHFVAKAVEP KRQALREAQD
3060 3070 3080 3090 3100
DLEVTQRILE EAKHHLHEVE DGIATMQAKY RECVAKKEEL EMKCEQCEQR
3110 3120 3130 3140 3150
LGRADKLING LADEKVRWQE TVENLENMLD NIFGDVLVAA GFVAYLGPFT
3160 3170 3180 3190 3200
GQYRTTLYEY WVNQLTVHHV PHTSKPTLIT TLGNPVKIRS WQIAGLPNDT
3210 3220 3230 3240 3250
LSVENGVINQ FSQRWTHFID PQGQANKWIK NMERESGLDV FKLSDRDFLR
3260 3270 3280 3290 3300
SMENAIRFGK PCLLENVGEE LDPALEPVLL KQTYKQQGNI VLKLGDTVIP
3310 3320 3330 3340 3350
YHEDFRMYIT TKLPNPHYSP EISTKLTLIN FTLSPSGLED QLLGQVVAEE
3360 3370 3380 3390 3400
RPDLEEAKNQ LIVSNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL
3410 3420 3430 3440 3450
EASKMKAAEI QAKVRIAEQT EKDIDLTRME YIPVAVRTQI LFFCVSDLAN
3460 3470 3480 3490 3500
VDPMYQYSLE WFLNIFLSGI ANSERADNLK KRIVNINRYL TFSLYSNVCR
3510 3520 3530 3540 3550
SLFEKHKLMF AFLLCVRIMM NEGKINQAEW RYLLSGGSIQ TMFENPAPQW
3560 3570 3580 3590 3600
LSDRAWRDIL ALSNLPTFAT FSNDFVMYLS EFQAIFDSAE PHRELLPGIW
3610 3620 3630 3640 3650
NAYLDEFQKL LILRCLRGDK VTNAMQDFVA THLEPRFIEP QTANLSAVFK
3660 3670 3680 3690 3700
ESNSTTPLIF VLSPGTDPAA DLYKFAEEMK FSKKFSAISL GQGQGPRAEA
3710 3720 3730 3740 3750
MMRNSIERGK WVFFQNCHLA PSWMPALERL IEHINPDKVH RDFRLWLTSL
3760 3770 3780 3790 3800
PSNKFPVSIL QNGSKMTIEP PRGVKANLLK SYNSLSDDFL HSCQKVVEFK
3810 3820 3830 3840 3850
SLLLSLCLFH GNALERRKFG PLGFNIPYEF TDGDLRICIS QLKMFLDEYE
3860 3870 3880 3890 3900
DIPYKVLKYT AGEINYGGRV TDDWDRRCVM NILEDFYNPA VLSSEHSYSN
3910 3920 3930 3940 3950
SGIYHQIPPT YDLNGYLSYI KSLPLNDMPE IFGLHDNANI TFAQNETFAL
3960 3970 3980 3990 4000
FNAILQLQPK SSSMGGQSRE ELVEDVAENI LLQVPGPIEL QEVTKKFPVL
4010 4020 4030 4040 4050
YEESMNTVLV QEVIRYNKLL EVITQTLSDM LKAIKGLVVM SLELELMSIS
4060 4070 4080 4090 4100
LYNNTVPELW KSKAYPSLKP LASWIMDLLL RLDFMHSWIN DGIPPVFWIS
4110 4120 4130 4140 4150
GFFFPQAFLT GTLQNFARKF VISIDTITFD FKVLPEASSE IKERPQTGCY
4160 4170 4180 4190 4200
IHGLFLEGAR WDSMNFQLAE SRPKELYTEM AVIWLLPEAN RKVQNQDFYL
4210 4220 4230 4240 4250
CPIYKTLTRA GTLSTTGHST NYVIAVEIPS NQPQRHWIKR GVALICALDY
Length:4,250
Mass (Da):487,070
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27CA12B77EC9E3F9
GO
Isoform 2 (identifier: E9Q8T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-486: LVSVPEYPFREQKEDFTFV → ESHWTLAAHLASSPHLRLS
     487-4250: Missing.

Show »
Length:486
Mass (Da):55,763
Checksum:i13F2DE53D81572CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti839I → L in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti854D → V in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1111A → G in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1136V → M in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1302Y → S in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1389S → I in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1406P → L in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti1427Q → R in CAB06069 (PubMed:9373155).Curated1
Sequence conflicti2025 – 2046LFTKY…KEVIA → SLPSTWRIPSTCSEHSEGSD C in CAB06069 (PubMed:9373155).CuratedAdd BLAST22
Sequence conflicti2052L → V in CAB06069 (PubMed:9373155).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059235468 – 486LVSVP…DFTFV → ESHWTLAAHLASSPHLRLS in isoform 2. Add BLAST19
Alternative sequenceiVSP_059236487 – 4250Missing in isoform 2. Add BLAST3764

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK053204 mRNA Translation: BAC35309.1
AC108416 Genomic DNA No translation available.
CH466573 Genomic DNA Translation: EDL24805.1
BC023155 mRNA Translation: AAH23155.1
Z83815 mRNA Translation: CAB06069.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS49436.1 [E9Q8T7-1]

NCBI Reference Sequences

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RefSeqi
NP_001028840.1, NM_001033668.1 [E9Q8T7-1]
XP_017171287.1, XM_017315798.1 [E9Q8T7-1]
XP_017171288.1, XM_017315799.1 [E9Q8T7-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.101811

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000048603; ENSMUSP00000043281; ENSMUSG00000019027 [E9Q8T7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
110084

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:110084

UCSC genome browser

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UCSCi
uc007sxk.2 mouse [E9Q8T7-1]
uc007sxl.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053204 mRNA Translation: BAC35309.1
AC108416 Genomic DNA No translation available.
CH466573 Genomic DNA Translation: EDL24805.1
BC023155 mRNA Translation: AAH23155.1
Z83815 mRNA Translation: CAB06069.2
CCDSiCCDS49436.1 [E9Q8T7-1]
RefSeqiNP_001028840.1, NM_001033668.1 [E9Q8T7-1]
XP_017171287.1, XM_017315798.1 [E9Q8T7-1]
XP_017171288.1, XM_017315799.1 [E9Q8T7-1]
UniGeneiMm.101811

3D structure databases

SMRiE9Q8T7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043281

PTM databases

iPTMnetiE9Q8T7
PhosphoSitePlusiE9Q8T7

Proteomic databases

MaxQBiE9Q8T7
PaxDbiE9Q8T7
PRIDEiE9Q8T7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048603; ENSMUSP00000043281; ENSMUSG00000019027 [E9Q8T7-1]
GeneIDi110084
KEGGimmu:110084
UCSCiuc007sxk.2 mouse [E9Q8T7-1]
uc007sxl.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25981
MGIiMGI:107721 Dnah1

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000154791
HOVERGENiHBG104858
InParanoidiE9Q8T7
KOiK10408
OMAiTEWRDDV
OrthoDBi3185at2759
PhylomeDBiE9Q8T7
TreeFamiTF316836

Miscellaneous databases

Protein Ontology

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PROi
PR:E9Q8T7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019027 Expressed in 115 organ(s), highest expression level in cerebellum
GenevisibleiE9Q8T7 MM

Family and domain databases

InterProiView protein in InterPro
IPR035699 AAA_6
IPR035706 AAA_9
IPR026983 DHC_fam
IPR026975 DNAH1
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PTHR10676:SF358 PTHR10676:SF358, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q8T7
Secondary accession number(s): O08828, Q8R584
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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