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Protein

PR domain zinc finger protein 15

Gene

Prdm15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming. Involved in early embryo development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri402 – 424C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 457C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri468 – 486C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri495 – 517C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 684C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri689 – 711C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 831C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri837 – 859C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri865 – 888C2H2-type 15PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PR domain zinc finger protein 15Curated (EC:2.1.1.-Curated)
Alternative name(s):
PR domain-containing protein 15Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prdm15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1930121 Prdm15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice die before birth and show early postimplantation developmental defect. Display reduced embryonic stem cells (ESCs) proliferation and self-renewal capacity. Show altered transcription of naive pluripotency and self-renewal modulator genes.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004447181 – 1174PR domain zinc finger protein 15Add BLAST1174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki552Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q8T2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q8T2

PRoteomics IDEntifications database

More...
PRIDEi
E9Q8T2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic stem cells (ESCs) (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000014039 Expressed in 248 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q8T2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q8T2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093533

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q8T2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 185SETPROSITE-ProRule annotationAdd BLAST111

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri402 – 424C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 457C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri468 – 486C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST19
Zinc fingeri495 – 517C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 684C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri689 – 711C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri809 – 831C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri837 – 859C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri865 – 888C2H2-type 15PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115685

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053669

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q8T2

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331419

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: E9Q8T2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCPPTIWEKG GQVGARWSLR APEVSAMAED GSEEIMFIWC EDCSQYHDSE
60 70 80 90 100
CPELGPVVMV KDSFVLSRAR SSLPSNLEIR RLDDGAEGVF AVTQLVKRTQ
110 120 130 140 150
FGPFESRRVA KWEKESAFPL KVFQKDGHPV CFDTSNEDDC NWMMLVRPAL
160 170 180 190 200
EPGHQNLTAY QHGSDVYFTT SKDIPAGTEL RVWYAAFYAK KMDKPMLKQA
210 220 230 240 250
CSSVQAAGTP EPSVSVEPER GQWVCKVCSN TFLELQLLNE HLLGHLEQAK
260 270 280 290 300
SLPAGGQQHE AASEKEPDAP RMEPPTAAES KSIQSVMVTK EPKKKPRRGR
310 320 330 340 350
KPKASKVEQP LVIIKDKEPS EHVAEIITEI PPDEPVSATP DERIMELVLG
360 370 380 390 400
KLAAPTNEAS SVPKFPHHPS STIALKRGLV LSSRHGVRRK LVRQLGEHKR
410 420 430 440 450
IHQCGTCSKV FQNSSNLSRH VRSHGECAHG DKLFKCEECS KLFSRKESLK
460 470 480 490 500
QHVSYKHSRN EVDGEYRYRC GSCGKTFRME SALEFHNCRT DDKTFQCEMC
510 520 530 540 550
FRFFSTNSNL SKHKKKHGDK KFACEVCSKM FYRKDVMLDH QRRHLDGVRR
560 570 580 590 600
VKREDLEASG ESLVRYKKEP SGCPVCGKVF SCRSNMNKHL LTHGDKKYTC
610 620 630 640 650
EICGRKFFRV DVLRDHIHVH FKDIALMDDH QREEFIGKIG ISSEENDDNS
660 670 680 690 700
DESADSEPHK YSCKRCQLTF GRGKEYLKHI MEVHKEKGHG CSICHRRFAL
710 720 730 740 750
KATYHAHMVI HRENLPDPNV QKYIHPCEIC GRIFNSIGNL ERHKLIHTGV
760 770 780 790 800
KSHACEQCGK SFARKDMLKE HMRVHDNIRE YLCAECGKGM KTKHALRHHM
810 820 830 840 850
KLHKGIKEYE CKECHRKFAQ KVNMLKHYKR HTGIKDFMCE LCGKTFSERN
860 870 880 890 900
TMETHKLIHT VGKQWTCSVC DKKYVTEYML QKHVQLTHDK VEAQSCQLCG
910 920 930 940 950
TKVSTRASMS RHMRRKHPEV LAVRIDDLDH LPETTTIDAS SIGIVQPALG
960 970 980 990 1000
LEQEELAEGK HGKAAKRSHK RKQKPEEEAG APVPEDTTFS EYPEKEPEFT
1010 1020 1030 1040 1050
GSVGDETNSA VQSIQQVVVT LGDPNVTAPS SSVGLTNITV TPITTAAGTQ
1060 1070 1080 1090 1100
FTNLQPVAVG HLTNPDRQLQ LDNSILTVTF DTVSGSAMLH NRQNDVQIHP
1110 1120 1130 1140 1150
QPEATNPQSV AHFINLTTLV NSITPLGNQL SEQHPLTWRA VPQTDVLQPP
1160 1170
QAPAAPQQAV QPQVQNEQQQ MYSY
Length:1,174
Mass (Da):132,870
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C12468F8E056D76
GO
Isoform 2 (identifier: E9Q8T2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.

Show »
Length:1,148
Mass (Da):130,061
Checksum:i1FF878205B7109D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIL7D6RIL7_MOUSE
PR domain zinc finger protein 15
Prdm15
474Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7Q9D3Z7Q9_MOUSE
PR domain zinc finger protein 15
Prdm15
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYH8D3YYH8_MOUSE
PR domain zinc finger protein 15
Prdm15
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298R → I in BAE26081 (PubMed:16141072).Curated1
Sequence conflicti609R → L in BAE26081 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0596471 – 26Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK144820 mRNA Translation: BAE26081.1
AC121560 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49926.1 [E9Q8T2-1]

NCBI Reference Sequences

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RefSeqi
NP_659038.2, NM_144789.2 [E9Q8T2-1]
XP_006522932.1, XM_006522869.3 [E9Q8T2-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.328741

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000095849; ENSMUSP00000093533; ENSMUSG00000014039 [E9Q8T2-1]
ENSMUST00000121584; ENSMUSP00000113791; ENSMUSG00000014039 [E9Q8T2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
114604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:114604

UCSC genome browser

More...
UCSCi
uc012ajc.1 mouse [E9Q8T2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144820 mRNA Translation: BAE26081.1
AC121560 Genomic DNA No translation available.
CCDSiCCDS49926.1 [E9Q8T2-1]
RefSeqiNP_659038.2, NM_144789.2 [E9Q8T2-1]
XP_006522932.1, XM_006522869.3 [E9Q8T2-2]
UniGeneiMm.328741

3D structure databases

SMRiE9Q8T2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093533

Proteomic databases

MaxQBiE9Q8T2
PaxDbiE9Q8T2
PRIDEiE9Q8T2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095849; ENSMUSP00000093533; ENSMUSG00000014039 [E9Q8T2-1]
ENSMUST00000121584; ENSMUSP00000113791; ENSMUSG00000014039 [E9Q8T2-2]
GeneIDi114604
KEGGimmu:114604
UCSCiuc012ajc.1 mouse [E9Q8T2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
63977
MGIiMGI:1930121 Prdm15

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157890
HOGENOMiHOG000115685
HOVERGENiHBG053669
InParanoidiE9Q8T2
OrthoDBi1318335at2759
TreeFamiTF331419

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000014039 Expressed in 248 organ(s), highest expression level in pituitary gland
ExpressionAtlasiE9Q8T2 baseline and differential
GenevisibleiE9Q8T2 MM

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRD15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q8T2
Secondary accession number(s): E9Q6A1, Q3UML7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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