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Entry version 58 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Protein furry homolog

Gene

Fry

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme inhibitor activity Source: HGNC

GO - Biological processi

  • cell morphogenesis Source: GO_Central
  • negative regulation of tubulin deacetylation Source: HGNC
  • neuron projection development Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein furry homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fry
Synonyms:Kiaa4143
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443895 Fry

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2516T → A: Loss of phosphorylation by CDK1. Loss of PLK1-binding. 1 Publication1
Mutagenesisi2516T → E: Loss of PLK1-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004203691 – 3020Protein furry homologAdd BLAST3020

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213PhosphotyrosineBy similarity1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1383PhosphoserineCombined sources1
Modified residuei1936PhosphoserineCombined sources1
Modified residuei1940PhosphoserineCombined sources1
Modified residuei2427PhosphoserineCombined sources1
Modified residuei2428PhosphoserineCombined sources1
Modified residuei2495PhosphoserineCombined sources1
Modified residuei2516Phosphothreonine; by CDK11 Publication1
Modified residuei2815PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by AURKA, CDK1 and PLK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q8I9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q8I9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q8I9

PeptideAtlas

More...
PeptideAtlasi
E9Q8I9

PRoteomics IDEntifications database

More...
PRIDEi
E9Q8I9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q8I9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q8I9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q8I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000056602 Expressed in 241 organ(s), highest expression level in ascending aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q8I9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q8I9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further FRY phosphorylation by PLK1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
235965, 1 interactor

Protein interaction database and analysis system

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IntActi
E9Q8I9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084454

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the furry protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1825 Eukaryota
ENOG410XSZS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00610000086058

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000146445

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067116

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q8I9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLPISVD

Database of Orthologous Groups

More...
OrthoDBi
11874at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313568

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR025614 Cell_morpho_N
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid

The PANTHER Classification System

More...
PANTHERi
PTHR12295 PTHR12295, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits
PF14222 MOR2-PAG1_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: E9Q8I9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASQQDSGFF EISIKYLLKS WSNASPVGNG YIKPPVPPAS GTHREKGPPA
60 70 80 90 100
MLPINVDPDS KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR
110 120 130 140 150
GEDPQFDQVI SSMSSLSEYC LPSILRTLFD WYKRQNGIED ESHEYRPRTS
160 170 180 190 200
NKSKSDEQQR DYLMERRDLA IDFIFSLVLI EVLKQIPLHP VIDSLIHDII
210 220 230 240 250
NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF PAVKKKFMAE
260 270 280 290 300
LKELRHKEQS PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY
310 320 330 340 350
FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE
360 370 380 390 400
LSSRKKHSLA LYPLVTCLLC VSQKQLFLNR WHVFLNNCLS NLKNKDPKMA
410 420 430 440 450
RVALESLYRL LWVYMIRIKC ESNTATQSRL ITITTTLFPK GSRGVVPRDM
460 470 480 490 500
PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC VGKPAKAFSL NPERMNIGLR
510 520 530 540 550
AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK TLTEEEAKMI
560 570 580 590 600
GMSLYYSQVR KAVGNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP
610 620 630 640 650
KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG
660 670 680 690 700
LLVDFSDWRE DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI
710 720 730 740 750
QTQGRAYEQA NKIRNSELIP NGSSHRMQSE RGPHCSVLHA VEGFALVLLC
760 770 780 790 800
SFQVATRKLS VLILKEIRAL FLALGQPEDD DRPMIDVMDQ LSSSILESFI
810 820 830 840 850
HVAVSDSATL PPTHNVDLQW LVEWNAVLVN SHYDVKSPSH VWIFAQSVKD
860 870 880 890 900
PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPVNAK
910 920 930 940 950
KTSTASSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG
960 970 980 990 1000
TVSYDNKAIG TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE
1010 1020 1030 1040 1050
LVEELHPLMK EALERRPENK KRRERRDLLR LQLLRIFELL ADAGVISDST
1060 1070 1080 1090 1100
NGALERDTLA LGALFLEYVD LTRMLLEAEN DKEVEILKDI RAHFSAMVAN
1110 1120 1130 1140 1150
LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP LDRYSDRNHQ
1160 1170 1180 1190 1200
ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ
1210 1220 1230 1240 1250
LGCEVVMLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGNRN
1260 1270 1280 1290 1300
YPFDIVTLLN LVLFKASDTN REIYEVSMQL MQILEAKLFV HSKKVAEQRP
1310 1320 1330 1340 1350
GSILYGTHGP LPPLYSVSLA LLSCELARMY PELTLPLFSE VSQRFPTTHP
1360 1370 1380 1390 1400
NGRQIMLTYL LPWLHNIELV DSRLLLPGSS PSSPEDEVKD REGEVTASHG
1410 1420 1430 1440 1450
LKGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGAEMENAWN ALANNEKWSN
1460 1470 1480 1490 1500
NLRVTLQFLI SLCGVSSDTI LLPYIKKVAT YLCRNNTIQT MEELLFELQQ
1510 1520 1530 1540 1550
TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQDSFPDPE
1560 1570 1580 1590 1600
ESKILKESDD RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL
1610 1620 1630 1640 1650
SITEAKQPQP LPMPCSGGCW APLVDYLPET ITPRGPLHRC NIAVIFMTEM
1660 1670 1680 1690 1700
VVDHSVREDW ALHLPLLLHA VFLGLDHYRP EVFEHSKKLL LHLLIALSCN
1710 1720 1730 1740 1750
SNFHAIASVL LQTREMGEAK TLTMQPAYQP EYLYTGGFDF LREDQSSPVP
1760 1770 1780 1790 1800
DSGLNSSSTS SSISLGGSSG NLPQMTQEVE DVEAATETDE KASKLIEFLT
1810 1820 1830 1840 1850
TRAFGPLWCH EDITPKNQNS KSAEQLSNFL RHVVSVFKDS RSGFHLEQHL
1860 1870 1880 1890 1900
SEVALQTALA SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH
1910 1920 1930 1940 1950
GDEIQGYVME ALLTLEAAVD NLSDCLKNSD LFTVLSRSSS PDLSSSSKLT
1960 1970 1980 1990 2000
ASRKSTGQLN VNPGTPGSGG GGGGSGNTTT AERSRHQRSF SVPKKFGVVD
2010 2020 2030 2040 2050
RSSDPPRSAT LDRIQACTQQ GLSSKTRSNS SLKESLTDPS HVSHPTNLLA
2060 2070 2080 2090 2100
TIFWVTVALM ESDFEFEYLM ALRLLNRLLA HMPLEKAENR EKLEKLQAQL
2110 2120 2130 2140 2150
KWADFPGLQQ LLLKGFTSLT TTDLTLQLFS LLTSVSKVPM VDSSQAIGFP
2160 2170 2180 2190 2200
LNVLCLLPQL IQHFENPNQF CKDIAERIAQ VCLEEKNPKL SNLAHVMTLY
2210 2220 2230 2240 2250
KTHSYTRDCA TWVNVVCRYL HEAYADITLN MVTYLAELLE KGLPSMQQPL
2260 2270 2280 2290 2300
LQVIYSLLSY MDLSVVPVKQ FNMEVLKTIE KYVQSIHWRE ALNILKLVVS
2310 2320 2330 2340 2350
RSASLVLPSY QHSDLSKIEL HRVWTSASKE LPGKTLDFHF DISETPIIGR
2360 2370 2380 2390 2400
RYDELQNSSG RDGKPRAMAV TRSASSTSSG SNSNVLVPVS WKRPQYSQKR
2410 2420 2430 2440 2450
TKEKLVHVLS LCGQEVGLSK NPSVIFSSCG DLDLPEHQTS LVSSEDGPRE
2460 2470 2480 2490 2500
QENMDDTNSE QQFRVFRDFD FLDVELEDGE GESMDNFNWG VRRRSLDSLD
2510 2520 2530 2540 2550
KCDMQILEER QLSRSTPSLN KMSHEDSDES SEEDLTASQI LEHSDLIMNL
2560 2570 2580 2590 2600
SPSEEANPME LLTSACDSAP ADPHSFNTRM ANFEASLPDI NNLQISEGSK
2610 2620 2630 2640 2650
AEAVPEEEDT TVHEDDLSSS INELPAAFEC SDSFSLDMTE AEEKGNRGLD
2660 2670 2680 2690 2700
QYTLASFGEG DRGVSPPPSP FFSAILAAFQ PAACDDAEEA WRSHINQLMC
2710 2720 2730 2740 2750
DSDGSCAVYT FHVFSSLFKN IQKRFCFLTC DAASYLGDNL RGIGSKFVSS
2760 2770 2780 2790 2800
SQMLTSCSEC PTLFVDAETL LSCGLLDKLK FSVLELQEYL DTYNNRKEAT
2810 2820 2830 2840 2850
LSWLANCKAT FAGGSRDGVI TCQPGDSEEK QLELCQRLYK LHFQLLLLYQ
2860 2870 2880 2890 2900
SYCKLIGQVH EVSSVPELLN MSRELSDLKR NLKEATAAIA TDPLYIEGAW
2910 2920 2930 2940 2950
SEPTFTSTEA AIQSMLECLK NNELGKALRQ IKECRSLWPN DIFGSSSDDE
2960 2970 2980 2990 3000
VQTLLNIYFR HQTLGQTGTY ALVGSNHSLT EICTKLMELN MEIRDMIRRA
3010 3020
QNYRVLTAFL PDSSVSGTSL
Length:3,020
Mass (Da):339,093
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB72299FB788ED9C
GO
Isoform 2 (identifier: E9Q8I9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2480-2480: E → EELQ
     2831-2831: Q → QMESLAQ

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:3,029
Mass (Da):340,123
Checksum:i8D347901D3CC8F75
GO
Isoform 3 (identifier: E9Q8I9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MASQQDSGFFEISIKYLLKSWSN → MEITTACWRRSCVISLIKGL
     808-817: ATLPPTHNVD → VSRRVVPNAI
     818-3020: Missing.

Note: No experimental confirmation available.
Show »
Length:814
Mass (Da):92,674
Checksum:iC539CD9BE71CC3F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVH0A0A0J9YVH0_MOUSE
Protein furry homolog
Fry
1,016Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTT8A0A0J9YTT8_MOUSE
Protein furry homolog
Fry
653Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUS4A0A0J9YUS4_MOUSE
Protein furry homolog
Fry
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUP4A0A0J9YUP4_MOUSE
Protein furry homolog
Fry
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVI5A0A0J9YVI5_MOUSE
Protein furry homolog
Fry
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC37538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti363P → Q in BAC39723 (PubMed:16141072).Curated1
Sequence conflicti2366 – 2368RAM → TRP in AAH42756 (PubMed:15489334).Curated3
Sequence conflicti2630C → G in BAD90515 (Ref. 3) Curated1
Sequence conflicti2687A → V in BAD90515 (Ref. 3) Curated1
Sequence conflicti2763L → P in AAH96532 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0444411 – 23MASQQ…KSWSN → MEITTACWRRSCVISLIKGL in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_044442808 – 817ATLPPTHNVD → VSRRVVPNAI in isoform 3. 1 Publication10
Alternative sequenceiVSP_044443818 – 3020Missing in isoform 3. 1 PublicationAdd BLAST2203
Alternative sequenceiVSP_0444442480E → EELQ in isoform 2. 3 Publications1
Alternative sequenceiVSP_0444452831Q → QMESLAQ in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK079097 mRNA Translation: BAC37538.1 Different initiation.
AK086708 mRNA Translation: BAC39723.1
AC084217 Genomic DNA No translation available.
AC154885 Genomic DNA No translation available.
AK220506 mRNA Translation: BAD90515.1
BC042756 mRNA Translation: AAH42756.1
BC096532 mRNA Translation: AAH96532.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS51708.1 [E9Q8I9-1]

NCBI Reference Sequences

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RefSeqi
NP_766475.2, NM_172887.2 [E9Q8I9-1]
XP_006504993.1, XM_006504930.3 [E9Q8I9-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.216590
Mm.412151
Mm.454348

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000087204; ENSMUSP00000084454; ENSMUSG00000056602 [E9Q8I9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
320365

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:320365

UCSC genome browser

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UCSCi
uc009att.1 mouse [E9Q8I9-3]
uc009atv.2 mouse [E9Q8I9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079097 mRNA Translation: BAC37538.1 Different initiation.
AK086708 mRNA Translation: BAC39723.1
AC084217 Genomic DNA No translation available.
AC154885 Genomic DNA No translation available.
AK220506 mRNA Translation: BAD90515.1
BC042756 mRNA Translation: AAH42756.1
BC096532 mRNA Translation: AAH96532.1
CCDSiCCDS51708.1 [E9Q8I9-1]
RefSeqiNP_766475.2, NM_172887.2 [E9Q8I9-1]
XP_006504993.1, XM_006504930.3 [E9Q8I9-2]
UniGeneiMm.216590
Mm.412151
Mm.454348

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protein-protein interaction databases

BioGridi235965, 1 interactor
IntActiE9Q8I9, 1 interactor
STRINGi10090.ENSMUSP00000084454

PTM databases

iPTMnetiE9Q8I9
PhosphoSitePlusiE9Q8I9
SwissPalmiE9Q8I9

Proteomic databases

jPOSTiE9Q8I9
MaxQBiE9Q8I9
PaxDbiE9Q8I9
PeptideAtlasiE9Q8I9
PRIDEiE9Q8I9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087204; ENSMUSP00000084454; ENSMUSG00000056602 [E9Q8I9-1]
GeneIDi320365
KEGGimmu:320365
UCSCiuc009att.1 mouse [E9Q8I9-3]
uc009atv.2 mouse [E9Q8I9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10129
MGIiMGI:2443895 Fry

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1825 Eukaryota
ENOG410XSZS LUCA
GeneTreeiENSGT00610000086058
HOGENOMiHOG000146445
HOVERGENiHBG067116
InParanoidiE9Q8I9
OMAiMLPISVD
OrthoDBi11874at2759
TreeFamiTF313568

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Fry mouse

Protein Ontology

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PROi
PR:E9Q8I9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000056602 Expressed in 241 organ(s), highest expression level in ascending aorta
ExpressionAtlasiE9Q8I9 baseline and differential
GenevisibleiE9Q8I9 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR025614 Cell_morpho_N
IPR025481 Cell_Morphogen_C
IPR039867 Furry/Tao3/Mor2
IPR029473 MOR2-PAG1_mid
PANTHERiPTHR12295 PTHR12295, 1 hit
PfamiView protein in Pfam
PF14225 MOR2-PAG1_C, 1 hit
PF14228 MOR2-PAG1_mid, 4 hits
PF14222 MOR2-PAG1_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFRY_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q8I9
Secondary accession number(s): Q4VA57
, Q5DTL4, Q8BIW6, Q8BUA0, Q8CG91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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