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Entry version 78 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Complement factor H

Gene

Cfh

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement factor HImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CfhImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88385, Cfh

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000026365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Sequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324313037 – 1252Sequence analysisAdd BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 159PROSITE-ProRule annotation
Disulfide bondi196 ↔ 223PROSITE-ProRule annotation
Disulfide bondi647 ↔ 690PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1055PROSITE-ProRule annotation
Disulfide bondi1071 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1132 ↔ 1175PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q8I0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q8I0

PeptideAtlas

More...
PeptideAtlasi
E9Q8I0

PRoteomics IDEntifications database

More...
PRIDEi
E9Q8I0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
355749

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q8I0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026365, Expressed in aorta and 317 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q8I0, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q8I0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 100SushiInterPro annotationAdd BLAST64
Domaini101 – 161SushiInterPro annotationAdd BLAST61
Domaini162 – 225SushiInterPro annotationAdd BLAST64
Domaini226 – 282SushiInterPro annotationAdd BLAST57
Domaini283 – 340SushiInterPro annotationAdd BLAST58
Domaini405 – 462SushiInterPro annotationAdd BLAST58
Domaini464 – 525SushiInterPro annotationAdd BLAST62
Domaini585 – 642SushiInterPro annotationAdd BLAST58
Domaini645 – 703SushiInterPro annotationAdd BLAST59
Domaini706 – 763SushiInterPro annotationAdd BLAST58
Domaini824 – 881SushiInterPro annotationAdd BLAST58
Domaini883 – 951SushiInterPro annotationAdd BLAST69
Domaini952 – 1009SushiInterPro annotationAdd BLAST58
Domaini1010 – 1068SushiInterPro annotationAdd BLAST59
Domaini1069 – 1127SushiInterPro annotationAdd BLAST59
Domaini1130 – 1188SushiInterPro annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni890 – 914DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi898 – 913Basic and acidic residuesSequence analysisAdd BLAST16

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164315

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSCHKGV

Database of Orthologous Groups

More...
OrthoDBi
296899at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q8I0

TreeFam database of animal gene trees

More...
TreeFami
TF326157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084, Sushi, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535, SSF57535, 18 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923, SUSHI, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q8I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQHRFLLES VGPRKIQIMR LSARIIWLIL WTVCAAEDCK GPPPRENSEI
60 70 80 90 100
LSGSWSEQLY PEGTQATYKC RPGYRTLGTI VKVCKNGKWV ASNPSRICRK
110 120 130 140 150
KPCGHPGDTP FGSFRLAVGS QFEFGAKVVY TCDDGYQLLG EIDYRECGAD
160 170 180 190 200
GWINDIPLCE VVKCLPVTEL ENGRIVSGAA ETDQEYYFGQ VVRFECNSGF
210 220 230 240 250
KIEGHKEIHC SENGLWSNEK PRCVEILCTP PRVENGDGIN VKPVYKENER
260 270 280 290 300
YHYKCKHGYV PKERGDAVCT GSGWSSQPFC EEKRCSPPYI LNGIYTPHRI
310 320 330 340 350
IHRSDDEIRY ECNYGFYPVT GSTVSKCTPT GWIPVPRCTL KPCEFPQFKY
360 370 380 390 400
GRLYYEESLR PNFPVSIGNK YSYKCDNGFS PPSGYSWDYL RCTAQGWEPE
410 420 430 440 450
VPCVRKCVFH YVENGDSAYW EKVYVQGQSL KVQCYNGYSL QNGQDTMTCT
460 470 480 490 500
ENGWSPPPKC IRIKTCSASD IHIDNGFLSE SSSIYALNRE TSYRCKQGYV
510 520 530 540 550
TNTGEISGSI TCLQNGWSPQ PSCIKSCDMP VFENSITKNT RTWFKLNDKL
560 570 580 590 600
DYECLVGFEN EYKHTKGSIT CTYYGWSDTP SCYERECSVP TLDRKLVVSP
610 620 630 640 650
RKEKYRVGDL LEFSCHSGHR VGPDSVQCYH FGWSPGFPTC KGQVASCAPP
660 670 680 690 700
LEILNGEING AKKVEYSHGE VVKYDCKPRF LLKGPNKIQC VDGNWTTLPV
710 720 730 740 750
CIEEERTCGD IPELEHGSAK CSVPPYHHGD SVEFICEENF TMIGHGSVSC
760 770 780 790 800
ISGKWTQLPK CVATDQLEKC RVLKSTGIEA IKPKLTEFTH NSTMDYKCRD
810 820 830 840 850
KQEYERSICI NGKWDPEPNC TSKTSCPPPP QIPNTQVIET TVKYLDGEKL
860 870 880 890 900
SVLCQDNYLT QDSEEMVCKD GRWQSLPRCI EKIPCSQPPT IEHGSINLPR
910 920 930 940 950
SSEERRDSIE SSSHEHGTTF SYVCDDGFRI PEENRITCYM GKWSTPPRCV
960 970 980 990 1000
GLPCGPPPSI PLGTVSLELE SYQHGEEVTY HCSTGFGIDG PAFIICEGGK
1010 1020 1030 1040 1050
WSDPPKCIKT DCDVLPTVKN AIIRGKSKKS YRTGEQVTFR CQSPYQMNGS
1060 1070 1080 1090 1100
DTVTCVNSRW IGQPVCKDNS CVDPPHVPNA TIVTRTKNKY LHGDRVRYEC
1110 1120 1130 1140 1150
NKPLELFGQV EVMCENGIWT EKPKCRDSTG KCGPPPPIDN GDITSLSLPV
1160 1170 1180 1190 1200
YEPLSSVEYQ CQKYYLLKGK KTITCRNGKW SEPPTCLHAC VIPENIMESH
1210 1220 1230 1240 1250
NIILKWRHTE KIYSHSGEDI EFGCKYGYYK ARDSPPFRTK CINGTINYPT

CV
Length:1,252
Mass (Da):141,271
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8159C7F2A9E365E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P06909CFAH_MOUSE
Complement factor H
Cfh Hf1
1,234Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGQ0D6RGQ0_MOUSE
Complement factor H
Cfh
1,110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q8H9E9Q8H9_MOUSE
Complement factor H
Cfh
1,195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVP8A0A0A6YVP8_MOUSE
Complement factor H
Cfh
707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWP4A0A0A6YWP4_MOUSE
Complement factor H
Cfh
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_034018.2, NM_009888.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111976; ENSMUSP00000107607; ENSMUSG00000026365

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12628

UCSC genome browser

More...
UCSCi
uc007cws.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_034018.2, NM_009888.3

3D structure databases

SMRiE9Q8I0
ModBaseiSearch...

PTM databases

SwissPalmiE9Q8I0

Proteomic databases

jPOSTiE9Q8I0
MaxQBiE9Q8I0
PeptideAtlasiE9Q8I0
PRIDEiE9Q8I0
ProteomicsDBi355749

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
12628

Genome annotation databases

EnsembliENSMUST00000111976; ENSMUSP00000107607; ENSMUSG00000026365
GeneIDi12628
KEGGimmu:12628
UCSCiuc007cws.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3075
MGIiMGI:88385, Cfh
VEuPathDBiHostDB:ENSMUSG00000026365

Phylogenomic databases

GeneTreeiENSGT00940000164315
OMAiMSCHKGV
OrthoDBi296899at2759
PhylomeDBiE9Q8I0
TreeFamiTF326157

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
12628, 0 hits in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cfh, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026365, Expressed in aorta and 317 other tissues
GenevisibleiE9Q8I0, MM

Family and domain databases

CDDicd00033, CCP, 16 hits
InterProiView protein in InterPro
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084, Sushi, 16 hits
SMARTiView protein in SMART
SM00032, CCP, 20 hits
SUPFAMiSSF57535, SSF57535, 18 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q8I0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q8I0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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