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Protein

Cytochrome P450 2W1

Gene

Cyp2w1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2W1 (EC:1.14.14.-)
Gene namesi
Name:Cyp2w1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3616076 Cyp2w1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000043170524 – 493Cytochrome P450 2W1Sequence analysisAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiE9Q816
PaxDbiE9Q816
PRIDEiE9Q816

PTM databases

PhosphoSitePlusiE9Q816

Expressioni

Tissue specificityi

Detected in colon, ileum, and testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000029541 Expressed in 6 organ(s), highest expression level in zone of skin
ExpressionAtlasiE9Q816 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031521

Structurei

3D structure databases

ProteinModelPortaliE9Q816
SMRiE9Q816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
InParanoidiE9Q816
KOiK07423
OMAiFNIYPWL
OrthoDBiEOG091G0BT8
PhylomeDBiE9Q816
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q816-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLLLGVWG ILLLLGLWGL LQGCTRSPSL APRWPPGPRP LPFLGNLHLL
60 70 80 90 100
GVTQQDRALM ELSERYGPMF TIHLGSQKTV VLSGYEVVRE ALVGTGHELA
110 120 130 140 150
DRPPIPIFQH IQRGGGIFFS SGARWRAGRQ FTVRTLQSLG VQQPSMVGKV
160 170 180 190 200
LQELACLKGQ LDSYGGQPLP LALLGWAPCN ITFTLLFGQR FDYQDPVFVS
210 220 230 240 250
LLSLIDQVMV LLGSPGIQLF NTFPRLGAFL RLHRPVLSKI EEVRTILRTL
260 270 280 290 300
LETRRPPLPT GGPAQSYVEA LLQQGQEDDP EDMFGEANVL ACTLDMVMAG
310 320 330 340 350
TETTAATLQW AVFLMVKHPH VQGRVQEELD RVLGPGQLPQ PEHQRALPYT
360 370 380 390 400
SAVLHEVQRY ITLLPHVPRC TAADIQLGGY LLPKGTPVIP LLTSVLLDKT
410 420 430 440 450
QWETPSQFNP NHFLDAKGRF MKRGAFLPFS AGRRVCVGKS LARTELFLLF
460 470 480 490
AGLLQRYRLL PPPGLSPADL DLRPAPAFTM RPPAQTLCVV PRS
Length:493
Mass (Da):54,438
Last modified:April 5, 2011 - v1
Checksum:iBFD0F2958C443F62
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFE3A0A0G2JFE3_MOUSE
Cytochrome P450 2W1
Cyp2w1
200Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161058 Genomic DNA No translation available.
CCDSiCCDS51683.1
RefSeqiNP_001153737.1, NM_001160265.1
UniGeneiMm.482474

Genome annotation databases

EnsembliENSMUST00000031521; ENSMUSP00000031521; ENSMUSG00000029541
GeneIDi545817
KEGGimmu:545817
UCSCiuc012efv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161058 Genomic DNA No translation available.
CCDSiCCDS51683.1
RefSeqiNP_001153737.1, NM_001160265.1
UniGeneiMm.482474

3D structure databases

ProteinModelPortaliE9Q816
SMRiE9Q816
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031521

PTM databases

PhosphoSitePlusiE9Q816

Proteomic databases

MaxQBiE9Q816
PaxDbiE9Q816
PRIDEiE9Q816

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031521; ENSMUSP00000031521; ENSMUSG00000029541
GeneIDi545817
KEGGimmu:545817
UCSCiuc012efv.1 mouse

Organism-specific databases

CTDi54905
MGIiMGI:3616076 Cyp2w1

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140799
InParanoidiE9Q816
KOiK07423
OMAiFNIYPWL
OrthoDBiEOG091G0BT8
PhylomeDBiE9Q816
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics

Miscellaneous databases

PROiPR:E9Q816
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029541 Expressed in 6 organ(s), highest expression level in zone of skin
ExpressionAtlasiE9Q816 baseline and differential

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2W1_MOUSE
AccessioniPrimary (citable) accession number: E9Q816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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