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Protein

Neurexin-2

Gene

Nrxn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.By similarity

GO - Molecular functioni

  • calcium channel regulator activity Source: MGI
  • cell adhesion molecule binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • neuroligin family protein binding Source: BHF-UCL
  • transmembrane signaling receptor activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexin-2Curated
Alternative name(s):
Neurexin II-alpha
Neurexin-2-alpha1 Publication
Gene namesi
Name:Nrxn2Combined sources
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1096362 Nrxn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 1634ExtracellularCuratedAdd BLAST1606
Transmembranei1635 – 1655HelicalSequence analysisAdd BLAST21
Topological domaini1656 – 1710CytoplasmicCuratedAdd BLAST55

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324449229 – 1710Neurexin-2Sequence analysisAdd BLAST1682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 219PROSITE-ProRule annotation
Disulfide bondi213 ↔ 229PROSITE-ProRule annotation
Disulfide bondi231 ↔ 241PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 486PROSITE-ProRule annotation
Disulfide bondi657 ↔ 686PROSITE-ProRule annotation
Disulfide bondi694 ↔ 705PROSITE-ProRule annotation
Disulfide bondi699 ↔ 714PROSITE-ProRule annotation
Disulfide bondi716 ↔ 726PROSITE-ProRule annotation
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1065 ↔ 1093PROSITE-ProRule annotation
Disulfide bondi1100 ↔ 1111PROSITE-ProRule annotation
Disulfide bondi1105 ↔ 1120PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1132PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiE9Q7X7
PRIDEiE9Q7X7

Expressioni

Gene expression databases

BgeeiENSMUSG00000033768 Expressed in 119 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9Q7X7 baseline and differential

Interactioni

Subunit structurei

The laminin G-like domain 1 binds to NXPH1. Interacts with PATJ (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (PubMed:22220752, PubMed:21410790). Isoforms alpha 2C bind to alpha-dystroglycan (By similarity). Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (PubMed:28864826).By similarity3 Publications

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9Q7X7
SMRiE9Q7X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 206Laminin G-like 1PROSITE-ProRule annotationAdd BLAST178
Domaini202 – 242EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini289 – 486Laminin G-like 2PROSITE-ProRule annotationAdd BLAST198
Domaini493 – 686Laminin G-like 3PROSITE-ProRule annotationAdd BLAST194
Domaini690 – 727EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini732 – 904Laminin G-like 4PROSITE-ProRule annotationAdd BLAST173
Domaini918 – 1093Laminin G-like 5PROSITE-ProRule annotationAdd BLAST176
Domaini1096 – 1133EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini1137 – 1345Laminin G-like 6PROSITE-ProRule annotationAdd BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1352 – 1393Thr-richPROSITE-ProRule annotationAdd BLAST42
Compositional biasi1433 – 1621Pro-richPROSITE-ProRule annotationAdd BLAST189

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
InParanoidiE9Q7X7
OrthoDBiEOG091G00KC

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

E9Q7X7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSRWQPP PQLPPLLLLL ALAAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA GVGSHSSTQR
560 570 580 590 600
ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGICREGWN RFVCDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPTAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM RLTVNLDCLR
810 820 830 840 850
VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD NVTVEGQMAG
860 870 880 890 900
AHTRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD
910 920 930 940 950
ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA
960 970 980 990 1000
PDGLLLFNSG NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ
1010 1020 1030 1040 1050
WHNVVVSRDP GNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGLSKNMFS
1060 1070 1080 1090 1100
NLPKLVASRD GFQGCLASVD LNGRLPDLIA DALHRIGQVE RGCDGPSTTC
1110 1120 1130 1140 1150
TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI FGKGGALITY
1160 1170 1180 1190 1200
TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV
1210 1220 1230 1240 1250
GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY
1260 1270 1280 1290 1300
PAGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR
1310 1320 1330 1340 1350
DQGRPFQGQV SGLYYNGLKV LALAAESDPN VRTEGHLRLV GEGPSVLLSA
1360 1370 1380 1390 1400
ETTATTLLAD MATTIMETTT TMATTTTRRG RSPTMRDSTT QNTDDLLVAS
1410 1420 1430 1440 1450
AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS PFVPPPPTFY
1460 1470 1480 1490 1500
PFLTGVGATQ DTLPPPAARR PSSGGPCQAE RDDSDCEEPV EASGFASGEV
1510 1520 1530 1540 1550
FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPRPNLRTDG ATGAPGVLFA
1560 1570 1580 1590 1600
PSAPAPNLPA GKMNHRDPLQ PLLENPPLGP GVPTAFEPRR PPPLRPGVTS
1610 1620 1630 1640 1650
APGFPRLPTA NPTGPGERGP PGAVEVIRES SSTTGMVVGI VAAAALCILI
1660 1670 1680 1690 1700
LLYAMYKYRN RDEGSYQVDQ SRNYISNSAQ SNGAVVKEKA PAAPKTPSKA
1710
KKNKDKEYYV
Length:1,710
Mass (Da):184,885
Last modified:April 5, 2011 - v1
Checksum:iFB3DB56946383587
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUM9E9PUM9_MOUSE
Neurexin-2
Nrxn2
1,703Annotation score:
E9Q5N7E9Q5N7_MOUSE
Neurexin-2
Nrxn2
1,503Annotation score:
E9PUN2E9PUN2_MOUSE
Neurexin-2
Nrxn2
660Annotation score:
E9PUN0E9PUN0_MOUSE
Neurexin-2
Nrxn2
1,640Annotation score:
E9PUN1E9PUN1_MOUSE
Neurexin-2
Nrxn2
353Annotation score:
F6WN33F6WN33_MOUSE
Neurexin-2
Nrxn2
206Annotation score:
F6Y027F6Y027_MOUSE
Neurexin-2
Nrxn2
216Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124394 Genomic DNA No translation available.
AC167245 Genomic DNA No translation available.
UniGeneiMm.329616
Mm.414022

Genome annotation databases

EnsembliENSMUST00000137166; ENSMUSP00000119762; ENSMUSG00000033768
ENSMUST00000202463; ENSMUSP00000144319; ENSMUSG00000107104

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124394 Genomic DNA No translation available.
AC167245 Genomic DNA No translation available.
UniGeneiMm.329616
Mm.414022

3D structure databases

ProteinModelPortaliE9Q7X7
SMRiE9Q7X7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9Q7X7
PRIDEiE9Q7X7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000137166; ENSMUSP00000119762; ENSMUSG00000033768
ENSMUST00000202463; ENSMUSP00000144319; ENSMUSG00000107104

Organism-specific databases

MGIiMGI:1096362 Nrxn2

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
InParanoidiE9Q7X7
OrthoDBiEOG091G00KC

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiNrxn2 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033768 Expressed in 119 organ(s), highest expression level in cerebellum
ExpressionAtlasiE9Q7X7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 6 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNRX2A_MOUSE
AccessioniPrimary (citable) accession number: E9Q7X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2018
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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