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Entry version 55 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Protein HEG homolog 1

Gene

Heg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein HEG homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Heg1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924696 Heg1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 1204ExtracellularSequence analysisAdd BLAST1173
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1205 – 1225HelicalSequence analysisAdd BLAST21
Topological domaini1226 – 1337CytoplasmicSequence analysisAdd BLAST112

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Some mutant animals die in utero, but most die postnatally, about half before weaning as a result of pulmonary hemorrhage. Midgestation mutant embryos show cardiac defects characterized by invagination of the ventricular cavity into, and often through, the compact layer of ventricular myocardium. The septal myocardium is similarly honeycombed by endothelial-lined extensions from the ventricular cavity, a defect accompanied by the presence of ventricular septal defects in most late-gestation embryos. Neonatal mice also show defective cardiac integrity manifested by a blood-filled pericardial sac, due to the rupture of the low-pressure atrial chamber of the heart. Cardiac or pulmonary integrity defects are observed in half of the animals. About 10% of neonatal mutant mice exhibit dilated lymphatic vessel malformations.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041537732 – 1337Protein HEG homolog 1Add BLAST1306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi945 ↔ 956PROSITE-ProRule annotation
Disulfide bondi950 ↔ 967PROSITE-ProRule annotation
Disulfide bondi969 ↔ 978PROSITE-ProRule annotation
Disulfide bondi985 ↔ 996PROSITE-ProRule annotation
Disulfide bondi990 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi1007 ↔ 1018PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1093N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1315PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
E9Q7X6

MaxQB - The MaxQuant DataBase

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MaxQBi
E9Q7X6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7X6

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7X6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the endothelium of the developing heart and aorta and in the neural tube at 10.5 dpc, and in the arterial endothelium, smooth muscle, endocardium of the heart and brain vasculature at 14.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000075254 Expressed in 161 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
E9Q7X6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2.1 Publication

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
E9Q7X6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000119790

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
E9Q7X6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini941 – 979EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini981 – 1019EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi482 – 697Ser-richAdd BLAST216

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJZT Eukaryota
ENOG410Y1MK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00710000106813

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG070920

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q7X6

Identification of Orthologs from Complete Genome Data

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OMAi
GERSITG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR028720 HEG

The PANTHER Classification System

More...
PANTHERi
PTHR24037 PTHR24037, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: E9Q7X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATPRAPRWP PPSLLLLLLL PLLLLPPAAP GARGSLPSPA HRTLLPVAGP
60 70 80 90 100
LSPPGAGHTA PGPGVATRRG RSGRVPRGVS AAAARNRWLE SNNPEPHIGC
110 120 130 140 150
SPSYQSQEDH SGSRKGVTAQ NARMSHSSSE GPENPPLLPE TSAEWSNMAS
160 170 180 190 200
SHRADIAGLR RGPSPEITTA PTAHSSLLSL ESLPESPSSS RSQRRITPSQ
210 220 230 240 250
TESGTSLGFL ERTRELPEEG TVHTQVAGTW VSRQASHPAL EPGEPTVLSQ
260 270 280 290 300
KRNSSGQEHS GPPFSWSQSH PPPSDHPSSS GSIKNGNNFT ALQNPSVTQT
310 320 330 340 350
KSMLITDTYT NGVPRTLRSL PVGVDPADET EGFPEHSRLG ITSMSVRSSP
360 370 380 390 400
SVKDSRTNSG LTEHLGDGEG TELSTENGYG LPSIHWQSDA PSFGGRQLAS
410 420 430 440 450
SSEAGDGRAM PLTEAVFRSD PSIGGGESTG RWILTKKKTS TDAAESSALH
460 470 480 490 500
PEAGGAGGLT QSSHAAQQPR GGGEDSGMGG RSYAESSSSS SSTSSSESLD
510 520 530 540 550
SSAPLREHSL TGLSYTREHG SDAGQRTSSD HTDHGYVPST FTKGERTLLS
560 570 580 590 600
ITDNTSYSEA SESSTSSVKI SDSPSQAQPK QSSMSSDDDE PAQSSTESPV
610 620 630 640 650
LHTSNLPTYT STVNMPNTLV LDTGTKPVED PSDSRVPSTQ PSPSQPQPFS
660 670 680 690 700
SALPSTRSPG STSETTTSSP SPSPISLLVS TLAPYSVSQT TFPHPSSTLV
710 720 730 740 750
PHRPREPRVT SVQMSTAISA IALIPSNQTA NPKNQSTPQQ EKPITEAKSP
760 770 780 790 800
SLVSPPTDST KAVTVSLPPG APWSPALTGF STGPALPATS TSLAQMSPAL
810 820 830 840 850
TSAMPQTTHS PVTSPSTLSH VEALTSGAVV VHTTPKKPHL PTNPEILVPH
860 870 880 890 900
ISTEGAITTE GNREHTDPTT QPIPLTTSTT SAGERTTELG RAEESSPSHF
910 920 930 940 950
LTPSSPQTTD VSTAEMLTSR YITFAAQSTS QSPTALPPLT PVNSCTVNPC
960 970 980 990 1000
LHDGKCIVDL TGRGYRCVCP PAWQGENCSV DVNECLSSPC PPLATCNNTQ
1010 1020 1030 1040 1050
GSFTCRCPVG YQLEKGICNL VRTFVTEFKL KKTFLNTTAE NHSNTQELEN
1060 1070 1080 1090 1100
EIAQTLNVCF STLPGYIRTT AHVSREPSTV FISLKTTFAL ASNVTLFDLA
1110 1120 1130 1140 1150
DRIQKYVNSC RSSAEVCQLL GSQRRVFRAG SLCKRKSPEC DKETSICTDL
1160 1170 1180 1190 1200
DGVALCQCKS GYFQFNKMDH SCRACEDGYR LENETCMSCP FGLGGLNCGN
1210 1220 1230 1240 1250
PYQLITVVIA AAGGGLLLIL GVALIVTCCR KSKNDISKLI FKSGDFQMSP
1260 1270 1280 1290 1300
YTDVPKNPRS QEWGREAIEM HENGSTKNLL QMTDVYYSPT NVRNPELERN
1310 1320 1330
GLYPAYTGLP GSRHSCIFPG QYNPSFISDE SRRRDYF
Length:1,337
Mass (Da):141,899
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80D24CAAC1AD77BF
GO
Isoform 2 (identifier: E9Q7X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-179: Missing.

Note: No experimental confirmation available.
Show »
Length:1,240
Mass (Da):131,544
Checksum:i45774F3CC51AAEA0
GO
Isoform 3 (identifier: E9Q7X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-179: Missing.
     510-550: LTGLSYTREH...FTKGERTLLS → REFLVHGNRH...YSQAIILLAD
     551-1337: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:453
Mass (Da):47,417
Checksum:iE2336B609C6E476E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q440E9Q440_MOUSE
Protein HEG homolog 1
Heg1
1,082Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6D4A0A338P6D4_MOUSE
Protein HEG homolog 1
Heg1
1,313Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BRS4Q8BRS4_MOUSE
Protein HEG homolog 1
Heg1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH72651 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04223483 – 179Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_042235510 – 550LTGLS…RTLLS → REFLVHGNRHRVLGCVWSFD LPKHTLGKEFHYSQAIILLA D in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_042236551 – 1337Missing in isoform 3. 1 PublicationAdd BLAST787

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK163128 mRNA Translation: BAE37205.1
AK028518 mRNA Translation: BAC25987.1
AC121570 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97850.1
BC072651 mRNA Translation: AAH72651.1 Different initiation.

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.245741

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000126532; ENSMUSP00000119790; ENSMUSG00000075254 [E9Q7X6-1]

UCSC genome browser

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UCSCi
uc007zah.1 mouse [E9Q7X6-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK163128 mRNA Translation: BAE37205.1
AK028518 mRNA Translation: BAC25987.1
AC121570 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97850.1
BC072651 mRNA Translation: AAH72651.1 Different initiation.
UniGeneiMm.245741

3D structure databases

ProteinModelPortaliE9Q7X6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiE9Q7X6
STRINGi10090.ENSMUSP00000119790

PTM databases

iPTMnetiE9Q7X6
PhosphoSitePlusiE9Q7X6

Proteomic databases

jPOSTiE9Q7X6
MaxQBiE9Q7X6
PaxDbiE9Q7X6
PRIDEiE9Q7X6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126532; ENSMUSP00000119790; ENSMUSG00000075254 [E9Q7X6-1]
UCSCiuc007zah.1 mouse [E9Q7X6-3]

Organism-specific databases

MGIiMGI:1924696 Heg1

Phylogenomic databases

eggNOGiENOG410IJZT Eukaryota
ENOG410Y1MK LUCA
GeneTreeiENSGT00710000106813
HOVERGENiHBG070920
InParanoidiE9Q7X6
OMAiGERSITG

Miscellaneous databases

Protein Ontology

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PROi
PR:E9Q7X6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000075254 Expressed in 161 organ(s), highest expression level in female gonad
ExpressionAtlasiE9Q7X6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR028720 HEG
PANTHERiPTHR24037 PTHR24037, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEG1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7X6
Secondary accession number(s): Q3TR26, Q6GQS6, Q8CED0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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