UniProtKB - E9Q7W0 (E9Q7W0_MOUSE)
Protein
Submitted name:
Recombining-binding protein suppressor of hairless
Gene
Rbpj
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Recombining-binding protein suppressor of hairlessImported |
Gene namesi | Name:RbpjImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96522, Rbpj |
Subcellular locationi
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000039191, Expressed in ureter smooth muscle and 307 other tissues |
Genevisiblei | E9Q7W0, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 163 | LAG1_DNAbindInterPro annotationAdd BLAST | 132 | |
Domaini | 164 – 313 | BTDInterPro annotationAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 450 – 485 | DisorderedSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the Su(H) family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000005197 |
OMAi | DMPHFGL |
OrthoDBi | 444988at2759 |
Family and domain databases
CDDi | cd01176, IPT_RBP-Jkappa, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1450, 1 hit |
InterProi | View protein in InterPro IPR015350, Beta-trefoil_DNA-bd_dom IPR036358, BTD_sf IPR040159, CLS_fam IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008967, p53-like_TF_DNA-bd IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd IPR037095, RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007, RBP-Jkappa_IPT |
PANTHERi | PTHR10665, PTHR10665, 1 hit |
Pfami | View protein in Pfam PF09270, BTD, 1 hit PF09271, LAG1-DNAbind, 1 hit |
SMARTi | View protein in SMART SM01268, BTD, 1 hit SM01267, LAG1_DNAbind, 1 hit |
SUPFAMi | SSF110217, SSF110217, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
E9Q7W0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAYRKFGER PPPKRLTREA MRNYLKERGD QTVLILHAKV AQKSYGNEKR
60 70 80 90 100
FFCPPPCVYL MGSGWKKKKE QMERDGCSEQ ESQPCAFIGI GNSDQEMQQL
110 120 130 140 150
NLEGKNYCTA KTLYISDSDK RKHFMLSVKM FYGNSDDIGV FLSKRIKVIS
160 170 180 190 200
KPSKKKQSLK NADLCIASGT KVALFNRLRS QTVSTRYLHV EGGNFHASSQ
210 220 230 240 250
QWGAFYIHLL DDDESEGEEF TVRDGYIHYG QTVKLVCSVT GMALPRLIIR
260 270 280 290 300
KVDKQTALLD ADDPVSQLHK CAFYLKDTER MYLCLSQERI IQFQATPCPK
310 320 330 340 350
EQNKEMINDG ASWTIISTDK AEYTFYEGMG PVLAPVTPVP VVESLQLNGG
360 370 380 390 400
GDVAMLELTG QNFTPNLRVW FGDVEAETMY RCGESMLCVV PDISAFREGW
410 420 430 440 450
RWVRQPVQVP VTLVRNDGVI YSTSLTFTYT PEPGPRPHCS AAGAILRANS
460 470 480
SQVPSNESNT NSEGNYTNAS TNSTSVTSST ATVVS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP31266 | SUH_MOUSE | Recombining binding protein suppres... | Rbpj Igkjrb1, Igkrsbp, Rbpsuh | 526 | Annotation score: | ||
Q3U6F1 | Q3U6F1_MOUSE | Recombining-binding protein suppres... | Rbpj Rbpsuh | 465 | Annotation score: | ||
A0A0J9YTV5 | A0A0J9YTV5_MOUSE | Recombining-binding protein suppres... | Rbpj | 507 | Annotation score: | ||
A0A0J9YVE0 | A0A0J9YVE0_MOUSE | Recombining-binding protein suppres... | Rbpj | 180 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084054 Genomic DNA No translation available. AC105072 Genomic DNA No translation available. |
RefSeqi | NP_001074397.1, NM_001080928.1 |
Genome annotation databases
Ensembli | ENSMUST00000087360; ENSMUSP00000084618; ENSMUSG00000039191 |
GeneIDi | 19664 |
UCSCi | uc008xlh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084054 Genomic DNA No translation available. AC105072 Genomic DNA No translation available. |
RefSeqi | NP_001074397.1, NM_001080928.1 |
3D structure databases
SMRi | E9Q7W0 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E9Q7W0 |
PeptideAtlasi | E9Q7W0 |
PRIDEi | E9Q7W0 |
Protocols and materials databases
Antibodypediai | 10265, 351 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000087360; ENSMUSP00000084618; ENSMUSG00000039191 |
GeneIDi | 19664 |
UCSCi | uc008xlh.1, mouse |
Organism-specific databases
CTDi | 3516 |
MGIi | MGI:96522, Rbpj |
Phylogenomic databases
GeneTreei | ENSGT00390000005197 |
OMAi | DMPHFGL |
OrthoDBi | 444988at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19664, 1 hit in 15 CRISPR screens |
ChiTaRSi | Rbpj, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039191, Expressed in ureter smooth muscle and 307 other tissues |
Genevisiblei | E9Q7W0, MM |
Family and domain databases
CDDi | cd01176, IPT_RBP-Jkappa, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.1450, 1 hit |
InterProi | View protein in InterPro IPR015350, Beta-trefoil_DNA-bd_dom IPR036358, BTD_sf IPR040159, CLS_fam IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR008967, p53-like_TF_DNA-bd IPR015351, RBP-J/Cbf11/Cbf12_DNA-bd IPR037095, RBP-J/Cbf11/Cbf12_DNA-bd_sf IPR038007, RBP-Jkappa_IPT |
PANTHERi | PTHR10665, PTHR10665, 1 hit |
Pfami | View protein in Pfam PF09270, BTD, 1 hit PF09271, LAG1-DNAbind, 1 hit |
SMARTi | View protein in SMART SM01268, BTD, 1 hit SM01267, LAG1_DNAbind, 1 hit |
SUPFAMi | SSF110217, SSF110217, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E9Q7W0_MOUSE | |
Accessioni | E9Q7W0Primary (citable) accession number: E9Q7W0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |