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Entry version 55 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Cilia- and flagella-associated protein 43

Gene

Cfap43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Flagellar protein involved in sperm flagellum axoneme organization and function.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • sperm axoneme assembly Source: UniProtKB
  • sperm motility Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 431 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cfap431 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1289258 Cfap43

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and show no malformations. However, homozygous males exhibit complete male sterility due to severe defects in sperm mobility. Sperm from mutant mice exhibits teratozoospermia characterized by short, thick, and coiled flagella and sperm axonemal defects. Females are fertile and give litters of normal size.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455121 – 1682Cilia- and flagella-associated protein 43Add BLAST1682

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q7R9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7R9

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7R9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7R9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7R9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044948 Expressed in 180 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q7R9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q7R9 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati168 – 207WD 1Sequence analysisAdd BLAST40
Repeati262 – 305WD 2Sequence analysisAdd BLAST44
Repeati315 – 354WD 3Sequence analysisAdd BLAST40
Repeati358 – 397WD 4Sequence analysisAdd BLAST40
Repeati488 – 527WD 5Sequence analysisAdd BLAST40
Repeati697 – 738WD 6Sequence analysisAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili926 – 960Sequence analysisAdd BLAST35
Coiled coili1171 – 1223Sequence analysisAdd BLAST53

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP43 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEUP Eukaryota
ENOG410XSR0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064714

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q7R9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWQPEFE

Database of Orthologous Groups

More...
OrthoDBi
555110at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326434

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039692 CFAP43
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14885 PTHR14885, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50969 SSF50969, 1 hit
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q7R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDPERDDV TASATASASA SAPASASAHY SGSSLSVRWV QGFPSQNVHF
60 70 80 90 100
VNDQTICYPS GNFVIFINLE TKKKTVLQCI NGIVGVMATN VPSEVVAFSD
110 120 130 140 150
RRFKPVIYIY SFPSLTRKNK LKGDILLDYT LLCFSYCGTY LASYSSLPEF
160 170 180 190 200
ELALWNWEAS AILCKKSNPG MDVSQMSFNP MNWHQMCLSS SSAMSVWTIE
210 220 230 240 250
RSNQEHHFRI RSVKLPLEDA TFLNEPDMLF PTTLPKDLIY GPVLPLSAIA
260 270 280 290 300
GLVGEEAETF RPKDDIYPLL HPTMHCWTPS SDLYVGCEEG HLLMINTETL
310 320 330 340 350
KVTVLQKAEE FPLPDGAPLI NPLTLVYQKD GILASGIDGV IYSFIIKDSK
360 370 380 390 400
YQVKTFLEFD GPVTHLVFSP SYKMLLIQTD KGSVYIYTFG AEMPLDKLLD
410 420 430 440 450
ACDGKVQAVS FITPGTKYFL TLTSSGEVST VSLEDCNCTS RIFLKTQATA
460 470 480 490 500
LACSPSSPTA AVGTVDGYVY FLNILDVESP QMIHQAFLSQ SPVKIVTYDQ
510 520 530 540 550
RGIFLLVGTE EGNIFVIDAR PSKSFQIFGF TETGKDILQI STVSVMESDV
560 570 580 590 600
VEVLVLYPLP DMGRSRLEYF TLPVMLPEVV PENFSDERGR LKDDLTHKYL
610 620 630 640 650
YEVEHTLSSA VLGFTGSKIF GFCSQVPYIC SYVMPVKEHT GVLVLKPHQK
660 670 680 690 700
VQSKQYGSGT IYLSSHGLWL MTIAKCGILC IRDMFSMETF VRCRSHSHQG
710 720 730 740 750
RGIQNMKMSL DGQHILVNGK DDNTLVCLKW KRLGANIASE IFEHSRPLVL
760 770 780 790 800
HLSQTVESES VYLALSREST NEQQEETTES QKHLNSDSSE EEAVIDHKMI
810 820 830 840 850
PWIQQKMEEA IKKEVRIFSP RRKEIKRGIK ELAQVIAMMM EENEKVDIIA
860 870 880 890 900
KLDEQEFCLD ADELERLHDE CEEEVAKIRK DVEMHNLAQS YLTELIKEEC
910 920 930 940 950
WNSMAVKGRA LKCFHIPYVV DNFPMKERTE EELQELSKVM QQKKTEIECL
960 970 980 990 1000
KLRKEIVEVQ ATTTIAKKHH EEEEEEEEDE ERTIKTTSLP NYLLGSLSTD
1010 1020 1030 1040 1050
FGADTSLLTS QLDLHSREEK INQIILLKDI IYNIKRNFNS EFDAAYKQKE
1060 1070 1080 1090 1100
IEIARVKEKN VRIAEIISDL ELEETVWQPV FEDSEKPERA LVVEDDEISF
1110 1120 1130 1140 1150
KKYIAPWQRA KIKEVVSTYE MERLQQARIS DERQRGLMDM MGGVLEVKKE
1160 1170 1180 1190 1200
DILRMVIPQP PFMAKADALW SEDERKQFKE YEKKVKELNE ERDKYRKSLE
1210 1220 1230 1240 1250
AELKKLQNSI QESTQNFDDH LKRLFERRVK AEMVINQEEL KINNIIFSLL
1260 1270 1280 1290 1300
LDEELSSREQ FLNNYLLKKQ EEKTKTAEAI QKAREDLDVF KEHHDMLVAE
1310 1320 1330 1340 1350
DKILDRSFKK EFSDILGHQV DVLYKLFKRR PRVHKQKTQA DVTSLVPYGE
1360 1370 1380 1390 1400
RPGSAKLNKE NLAQLMKSMD ELDNINNMPE GLDPSVWEHF CSTRRAKVEN
1410 1420 1430 1440 1450
EYKVKQKAAC LLEMTTFLRK RMEEDDVVHH EIEKVFHELI RLQDEKVRFQ
1460 1470 1480 1490 1500
VNLTVQILLK QGQVELENFQ LMLEYSDAIL INKNIIEDLN SVIRTQGQKK
1510 1520 1530 1540 1550
VASMMESKEV HKGIYQIEWE HKKMEMEMED LNQRAWDIEM LFFSRDRQKY
1560 1570 1580 1590 1600
LNEPNYENVI AIQIGIMEQT ISVIDKTHKK NVENCKKLLK KLGKYSNQKD
1610 1620 1630 1640 1650
VANYTLSCNL REELVAVSER QDICNEIGSK LTCEKIARER YDNQLKQQKL
1660 1670 1680
LNISKQQAEQ ISILQAEVER LRMKTFPALI PM
Length:1,682
Mass (Da):193,426
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14A6C6A6835E7CA7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC126679 Genomic DNA No translation available.
AC131719 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57146.1

NCBI Reference Sequences

More...
RefSeqi
NP_081835.2, NM_027559.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.29457
Mm.458438

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000160247; ENSMUSP00000125007; ENSMUSG00000044948

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100048534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100048534

UCSC genome browser

More...
UCSCi
uc012bnf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126679 Genomic DNA No translation available.
AC131719 Genomic DNA No translation available.
CCDSiCCDS57146.1
RefSeqiNP_081835.2, NM_027559.2
UniGeneiMm.29457
Mm.458438

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

PTM databases

iPTMnetiE9Q7R9
PhosphoSitePlusiE9Q7R9

Proteomic databases

MaxQBiE9Q7R9
PaxDbiE9Q7R9
PRIDEiE9Q7R9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160247; ENSMUSP00000125007; ENSMUSG00000044948
GeneIDi100048534
KEGGimmu:100048534
UCSCiuc012bnf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80217
MGIiMGI:1289258 Cfap43

Phylogenomic databases

eggNOGiENOG410IEUP Eukaryota
ENOG410XSR0 LUCA
GeneTreeiENSGT00530000064714
InParanoidiE9Q7R9
OMAiVWQPEFE
OrthoDBi555110at2759
TreeFamiTF326434

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044948 Expressed in 180 organ(s), highest expression level in testis
ExpressionAtlasiE9Q7R9 baseline and differential
GenevisibleiE9Q7R9 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR039692 CFAP43
IPR011044 Quino_amine_DH_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14885 PTHR14885, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50969 SSF50969, 1 hit
SSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA43_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7R9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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