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Protein
Submitted name:

Mucin-4

Gene

Muc4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Mucin-4Imported
Gene namesi
Name:Muc4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2153525 Muc4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3429 – 3452HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324579929 – 3470Sequence analysisAdd BLAST3442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3202 ↔ 3211PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiE9Q7Q0
PaxDbiE9Q7Q0
PeptideAtlasiE9Q7Q0
PRIDEiE9Q7Q0

PTM databases

iPTMnetiE9Q7Q0
PhosphoSitePlusiE9Q7Q0

Expressioni

Gene expression databases

BgeeiENSMUSG00000079620 Expressed in 191 organ(s), highest expression level in cornea
ExpressionAtlasiE9Q7Q0 baseline and differential
GenevisibleiE9Q7Q0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093813

Structurei

3D structure databases

SMRiE9Q7Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2458 – 2613NIDOInterPro annotationAdd BLAST156
Domaini2614 – 2726AMOPInterPro annotationAdd BLAST113
Domaini2739 – 2973VWFDInterPro annotationAdd BLAST235
Domaini3173 – 3212EGF-likeInterPro annotationAdd BLAST40
Domaini3382 – 3421EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IHUZ Eukaryota
ENOG4111F6U LUCA
GeneTreeiENSGT00730000110943
KOiK22017
OMAiLPQSQHT
OrthoDBiEOG091G01CZ
TreeFamiTF330652

Family and domain databases

InterProiView protein in InterPro
IPR005533 AMOP_dom
IPR000742 EGF-like_dom
IPR039898 Mucin_4
IPR003886 NIDO_dom
IPR001846 VWF_type-D
PANTHERiPTHR42668 PTHR42668, 12 hits
PfamiView protein in Pfam
PF06119 NIDO, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM00723 AMOP, 1 hit
SM00181 EGF, 3 hits
SM00539 NIDO, 1 hit
SM00216 VWD, 1 hit
PROSITEiView protein in PROSITE
PS50856 AMOP, 1 hit
PS50026 EGF_3, 2 hits
PS51220 NIDO, 1 hit
PS51233 VWFD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E9Q7Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGPHWRVPW LCLSCLYSCL LLLPDALATT STQTPMSLSS STRTSQMSSQ
60 70 80 90 100
ASTSSTSSDR RTSKTEQTST RDTPSSITTV SQSHHTTSME TSKPQTTTTT
110 120 130 140 150
EVTTSTPSAS SRDQIQTETS SQRTISPDGT TTSHAPSISS SAPSTTHMLT
160 170 180 190 200
TTSSTESTSV DSGHTTAITT QGLTPATAQV SLTPSSQNMS TVSTPITSTL
210 220 230 240 250
TQRQHTGSKQ TSSKSQVNIV TSTLSTSTSD STPAQTMSQV TSSSDKRTKP
260 270 280 290 300
STSGVSSTSL TTTEVLTQTS STDSAPGNTT LRITQNSTTH TTKVSTTSTP
310 320 330 340 350
QKLSPVSTLI NSSQKMSTLP QNQHTESMDT SRQPQTTTTI EVTTSTPSAS
360 370 380 390 400
SLHQIQTETN SPKTISPGET TTSHAPNMRS SPPKTSQILT TMPSTKSTSV
410 420 430 440 450
DTKQTKAITT KVSTPDTTQV SMTPSSQKLP THSTSTQELT SSYSQHIQSK
460 470 480 490 500
GTSSKSQTTT NTKVNTSTPS ASSRDKIQTE TSSQRTNSPG EKRTSHAPSM
510 520 530 540 550
SSSAPSTTHM LSTTSSNQST SVDTGQTTSV TAQGSTPAIT QTSLTPSSQN
560 570 580 590 600
TSTVSTPITS THKLSTLSQS QHTGSKGTSS NPQTTTTTEV TTSTPSATTH
610 620 630 640 650
DQIQTETSSQ NTISPGETTT SYAPIMSSSA PSTTHMLSTT SSTQSTSVDT
660 670 680 690 700
RHTTTLTNQG STPATTQVSP SSQNMSTVSA PITSTQILST FPQSQHTGSK
710 720 730 740 750
GTSSNPQTTT TPVVTTSNPS ATSRDQIQTE TSSQRTISPG ETTTSYASIM
760 770 780 790 800
SSSAPSTTHM LTTTSSTQST SVDTRHTIAV RTQGSTPATT QVSPSSQNMS
810 820 830 840 850
TVSTPITSTQ ILSTLPQSQH TGSKGTSSNP QTTTSPVVTT STPSGTSGDQ
860 870 880 890 900
IQTETSSQRT ISPGKTTTSH ALNINSSAPS TTHMLSTTSS TQSTSGDTRH
910 920 930 940 950
TTAGRTQGST PATTQVSPSS QNMSTVSAPI TSIQMLSTLP QSQHTESKST
960 970 980 990 1000
STNPQTTTTP EVTTSNPSAT SHDQIETETS SQRTISPGET TTSYAPIMSS
1010 1020 1030 1040 1050
SAPSTTHMLS TTSSTQSTSV DTRNTTTLTT QGSTPATTQV SPSSKNMSTV
1060 1070 1080 1090 1100
STPITSTHKL STLPQSQHTG SNGTSSSSST PATHRSHLHP NMSTVSTPIT
1110 1120 1130 1140 1150
TTHKLSTLSQ SQHTGSKGTS SNPQTTTTPV MTTSTPSATT HDQIQTETSS
1160 1170 1180 1190 1200
QRTISHGETT TSYAPIMSSS APSTTHMLST ASSTQITSVD TRHTTAITTQ
1210 1220 1230 1240 1250
GSTPATTQVS PSSQNMSTVS APITSIQILS TLPQSQHTGS KGTSTNPQTT
1260 1270 1280 1290 1300
TTPEVTTSTP SATSRDQIQT ETSSQRTISP GETTTSHAPI MSSSAPSTTH
1310 1320 1330 1340 1350
MLSTTSSTQS TSVDTRHTTA GRTQGSTPAT TQVSPSSQNM TTTSHALMSS
1360 1370 1380 1390 1400
SAPSTTHMLS TTSSTQSTSV DTRHTTTVTT QGSTPATTQV LPSSQNMSTV
1410 1420 1430 1440 1450
SAPITSTQIL STLPQSQHTG SKGTSTNPQT TTNAEVTTST PSATSHDQIE
1460 1470 1480 1490 1500
TETSSQRTIS PGETTTSHAP NMSSSAPSTT HMLSSTSSTQ ITSVDTGHTS
1510 1520 1530 1540 1550
AGRTQGSTPA TTQVSPSSQN MSTVSAPITS THILSTLPKS QHTGSKGTSS
1560 1570 1580 1590 1600
NPQTTITPVV TTSTPSASSR DQIQTETSFQ RTISPGETTT SHAPSMSSSA
1610 1620 1630 1640 1650
PSSTHMLSTA SSTQITSVDT RHTTAITTQG STPATTQVSP SSQNMSTVSA
1660 1670 1680 1690 1700
PITSIQMLST LPQSQHTESK STSTNPQTTT TPRVTTSTPS ASSRDQIQTE
1710 1720 1730 1740 1750
TSSQRTISPG KTTTSHVPNM NSSAPSTTHI LSTTSSIQST SGDTRHTTAV
1760 1770 1780 1790 1800
RTQGSTPATT QVSLAPSSQN MSTLSAPITS PQHFSTLPQN QHTGSMGTSS
1810 1820 1830 1840 1850
NPQSTTIPEV TTSTLSASSR DQVQTETSSQ RTISPGETTT SHASSLSSSA
1860 1870 1880 1890 1900
PSSTHMLSTA SSTEITSGDT RHTTAIVTQG STPATTQTTL TPSSQNMSTV
1910 1920 1930 1940 1950
STPITSTHKL SPLPQSQHTE NMGTSSNPQT TTTPEVTTST PSATSYDQIQ
1960 1970 1980 1990 2000
TETSFQRTIS PGETTTSHAP SMSNSAPSST HKLSTASSTE ITSVDTRHTI
2010 2020 2030 2040 2050
AITTQGSTLA TTQTSLTPSS QNMSTVSAPI TSSQILSTLR QSQHTGSKGT
2060 2070 2080 2090 2100
SSNHQTTTTP VVTTSTSSAT SRDQIQTETS SLRTISPDGT TTSHASSMSS
2110 2120 2130 2140 2150
SSPNTTHLLI TTSSTESTSV DTGYSTVITT HGSTLATTQV SLTPSSQNMS
2160 2170 2180 2190 2200
TVSMPSTSSQ ELTSLPQRQH TGNMETSSQP QNITPTVVTT STLLSFSRGS
2210 2220 2230 2240 2250
TELQTMSWGT SSSGTINTLS TPVRNTSPAS TSGILTSTLT TSGNTGYTGV
2260 2270 2280 2290 2300
TRSLGVITSR VTSTSLPGKS TVVHSTPAQP LSAHSQSHQT YGTGTPSMSQ
2310 2320 2330 2340 2350
TSILPDMTSE KRVASSPGPT VTESFSHVSS SSGLTTKTDN DRNTAVSATS
2360 2370 2380 2390 2400
STLTSPSPTT ASRSTVPLPS LLPDQGISLF PYGSEVGDQN LFARTVDFNS
2410 2420 2430 2440 2450
PIFKILIGFP LGSSLRDSFY VTDNGQIIFP ESDYDVFSYP NPPQRGFTGR
2460 2470 2480 2490 2500
ERVAMVAPFW ADADFSSSRG AIFYQEYVTF YNEHHQLIRE VETLINDFTS
2510 2520 2530 2540 2550
SWGYRAKWTL KVTWVNVPAY TAQESFGTNT YQAILSTDGS RSYALFLYQN
2560 2570 2580 2590 2600
SGMRWDVTQE PYNRVLMGFS SGDGYFENSP LTFRPAMEKY RPDRFLNSKL
2610 2620 2630 2640 2650
GIRGLQVYRL HREERPNYRL KCLQWLESQP QQPSWGWSSV SCPCSWQQGQ
2660 2670 2680 2690 2700
RDFRFRPINP GWWDRQLCSF SSGRGGVCCS YGAWGEFREG WRMHSPWQFD
2710 2720 2730 2740 2750
EEQEAQNWCC QWNDKPSFCV WYQLRRPRVS CAGYRPPRPA WTFGDPHITT
2760 2770 2780 2790 2800
LDNANFTFNG LGDFLLVQAQ DRNSSFLLEG RTAQTGTAKA TNFIAFAAQY
2810 2820 2830 2840 2850
NTSSLKSPIT VQWFLEPSDK IRVVYNNQTV AFNTRDTEVL PIFNTTGVLL
2860 2870 2880 2890 2900
TQNGSQVSAN FDGTVTISVI ARSNILHASS SLSEEYRNHT EGLLGVWNDN
2910 2920 2930 2940 2950
PEDDFRMPNG STIPSNSSEE TLFYYGMTWH VNGTGLLGIR ADPLPTKFTP
2960 2970 2980 2990 3000
IFLSQLLNQS ASGEDLASGC KGDRKCMFDI LATGNRTIGQ STNSILNEFQ
3010 3020 3030 3040 3050
HMNDTLNQYP PSINCSSKIQ AYKGQTVTTE ITSNSKDATL SLSKKCSGFK
3060 3070 3080 3090 3100
LFENGSLQWT PTSPEACTLE ILARDVRTNL SWVLQPKTVA CFCSKEEQCL
3110 3120 3130 3140 3150
YNETSKEGNS SLEVTSCKCD GDTFGRLCER SKDPCDEPCF PNVNCIPGKG
3160 3170 3180 3190 3200
CEACPPNTTG DGRHCAALED SCPNRSCPMN YCYNNGHCDI SEAPGCQPTC
3210 3220 3230 3240 3250
TCPPAFTDNR CFLAGNSFTP TISMELPLRT IVLSLREDEN ASAADVNASV
3260 3270 3280 3290 3300
ANILENLDMR AFFSNSLVEL IRTSPGAQPS SKSIHHWKVT SHFKYRPRGP
3310 3320 3330 3340 3350
LIHYLNNQLI GAVMEAFLLQ ARQERQKRSG EARKDVHFFP ISRADVQDQM
3360 3370 3380 3390 3400
ALNLSMLEEY FTCDGYKGYH LVYSPQDGVT CVSPCSEGYC HNGGQCKHLP
3410 3420 3430 3440 3450
DGPQCSCASF TIYSSSGEHC EHLSVKLGAF YGILFGTLGA LLLLGILAFM
3460 3470
IFHFCGCSKN KFSYPLDSEL
Length:3,470
Mass (Da):368,411
Last modified:April 5, 2011 - v1
Checksum:iE54B9CF74CCFA475
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8JZM8MUC4_MOUSE
Mucin-4
Muc4
3,443Annotation score:
F6R2G3F6R2G3_MOUSE
Mucin-4
Muc4
1,401Annotation score:
E9Q9U1E9Q9U1_MOUSE
Mucin-4
Muc4
293Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139244 Genomic DNA No translation available.
AC161755 Genomic DNA No translation available.
RefSeqiNP_536705.3, NM_080457.3
UniGeneiMm.214599

Genome annotation databases

EnsembliENSMUST00000096106; ENSMUSP00000093813; ENSMUSG00000079620
GeneIDi140474
KEGGimmu:140474
UCSCiuc012aeq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139244 Genomic DNA No translation available.
AC161755 Genomic DNA No translation available.
RefSeqiNP_536705.3, NM_080457.3
UniGeneiMm.214599

3D structure databases

SMRiE9Q7Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093813

PTM databases

iPTMnetiE9Q7Q0
PhosphoSitePlusiE9Q7Q0

Proteomic databases

MaxQBiE9Q7Q0
PaxDbiE9Q7Q0
PeptideAtlasiE9Q7Q0
PRIDEiE9Q7Q0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096106; ENSMUSP00000093813; ENSMUSG00000079620
GeneIDi140474
KEGGimmu:140474
UCSCiuc012aeq.1 mouse

Organism-specific databases

CTDi4585
MGIiMGI:2153525 Muc4

Phylogenomic databases

eggNOGiENOG410IHUZ Eukaryota
ENOG4111F6U LUCA
GeneTreeiENSGT00730000110943
KOiK22017
OMAiLPQSQHT
OrthoDBiEOG091G01CZ
TreeFamiTF330652

Enzyme and pathway databases

ReactomeiR-MMU-913709 O-linked glycosylation of mucins
R-MMU-977068 Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRSiMuc4 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079620 Expressed in 191 organ(s), highest expression level in cornea
ExpressionAtlasiE9Q7Q0 baseline and differential
GenevisibleiE9Q7Q0 MM

Family and domain databases

InterProiView protein in InterPro
IPR005533 AMOP_dom
IPR000742 EGF-like_dom
IPR039898 Mucin_4
IPR003886 NIDO_dom
IPR001846 VWF_type-D
PANTHERiPTHR42668 PTHR42668, 12 hits
PfamiView protein in Pfam
PF06119 NIDO, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM00723 AMOP, 1 hit
SM00181 EGF, 3 hits
SM00539 NIDO, 1 hit
SM00216 VWD, 1 hit
PROSITEiView protein in PROSITE
PS50856 AMOP, 1 hit
PS50026 EGF_3, 2 hits
PS51220 NIDO, 1 hit
PS51233 VWFD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q7Q0_MOUSE
AccessioniPrimary (citable) accession number: E9Q7Q0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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