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Protein

Cadherin-related family member 2

Gene

Cdhr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Differentiation
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 2Curated
Gene namesi
Name:Cdhr2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2687323 Cdhr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1152ExtracellularCuratedAdd BLAST1132
Transmembranei1153 – 1173HelicalSequence analysisAdd BLAST21
Topological domaini1174 – 1308CytoplasmicCuratedAdd BLAST135

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500324310721 – 1308Cadherin-related family member 2Sequence analysisAdd BLAST1288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1245PhosphoserineBy similarity1
Modified residuei1297PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiE9Q7P9
PaxDbiE9Q7P9
PRIDEiE9Q7P9

PTM databases

iPTMnetiE9Q7P9
PhosphoSitePlusiE9Q7P9

Expressioni

Gene expression databases

BgeeiENSMUSG00000034918 Expressed in 46 organ(s), highest expression level in intestine
GenevisibleiE9Q7P9 MM

Interactioni

Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with MAST2 (By similarity). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (Probable).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043596

Structurei

Secondary structure

11308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliE9Q7P9
SMRiE9Q7P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 124Cadherin 1PROSITE-ProRule annotationAdd BLAST92
Domaini125 – 241Cadherin 2PROSITE-ProRule annotationAdd BLAST117
Domaini242 – 353Cadherin 3PROSITE-ProRule annotationAdd BLAST112
Domaini368 – 480Cadherin 4PROSITE-ProRule annotationAdd BLAST113
Domaini481 – 586Cadherin 5PROSITE-ProRule annotationAdd BLAST106
Domaini586 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST110
Domaini695 – 807Cadherin 7PROSITE-ProRule annotationAdd BLAST113
Domaini809 – 927Cadherin 8PROSITE-ProRule annotationAdd BLAST119
Domaini929 – 1051Cadherin 9PROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1178 – 1308Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organizationBy similarityAdd BLAST131

Domaini

The cadherin 1 domain is required for binding to CDHR5.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000149083
HOGENOMiHOG000115467
HOVERGENiHBG053524
InParanoidiE9Q7P9
KOiK16502
OMAiNVICTKA
OrthoDBiEOG091G00MF
TreeFamiTF332908

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030276 CDHR2
PANTHERiPTHR44787 PTHR44787, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 7 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SUPFAMiSSF49313 SSF49313, 9 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9Q7P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWLWLLCAL LPAFMVSVTA NSPPSFGVNM TLVTLPEDLP VGAVAFWLVA
60 70 80 90 100
TDSDNDHLTY GISGPNASYF SVNANTGEVK LASPLDFETV PFFKITISTS
110 120 130 140 150
DGLNIRTAEM QVIVEDRNDN IPVFLNTEFS TSINETLPVG SVVFSVLAED
160 170 180 190 200
KDTGTAGLVQ YFIEKVIPST ANSNNLFRIL ENGSIVLNDT LSYNNKSAFY
210 220 230 240 250
QLELKACDSG GILDNKPKTQ CSQPVFVSIS VIDEPDLDPR FIREFYSASV
260 270 280 290 300
AEDATLGTSV LTVEAVDSDK GINDIVTYSV SNSTRPGWFD IREDGVIFVN
310 320 330 340 350
GSLDREQLLL ENEEVQIQVT ATEKNLNIYG QEAKASMWVT IRVTDVNDHK
360 370 380 390 400
PEFYNCSLPG CSFSPQEAQV NFIGYVDEHA SARISIDGLT MVAYDPDQGD
410 420 430 440 450
NGTFLLSLNG QDAEAFNVSP ERAAGSVSVQ VVVRNSEMVD YEKETVMVVE
460 470 480 490 500
VVATDSVSNN YSVATVTIHL RNINDHRPVF SQSLYELTVP EHCPTGYLVT
510 520 530 540 550
DKIQATDLDG DEWGPITYSL LPGNGADLFE VEPNSGNLTV KNGTLLDREK
560 570 580 590 600
QAVYYLTLQA TDGGNQSTTT ALEITLLDIN DNPPVVRGSY NVFVPEENGN
610 620 630 640 650
VSVTIQAYDD DQPDTNNSLL VFSLLPGPYS SNFSLDPNTG LLRNLGPLDR
660 670 680 690 700
EAIDPALEGR IVLTVIVADC GEPSLSTNVN VTITVEDIND NLPVFNQSYE
710 720 730 740 750
FSVWERVPGA WVGTVKAWDA DQTAANNRIS FSLSGTGANN FILQGNVLEQ
760 770 780 790 800
GWAEGSLWLL PDVRLDYETQ KFFHLTVSAE NPGPQGLDST ANVTVTVMDV
810 820 830 840 850
NDEPPTLDAA SLQAISVTEN GSEHGQVTRV IAQDVDTAAL LRIELVDVIC
860 870 880 890 900
TKAGVDVGSV CHGWFSVDGN GSVYINQSEA IDYEACHLVT LVVRAYDLNT
910 920 930 940 950
DPGFDAYSSN GSLLINIKDK NDNAPYFLPN NQTFVIIPEL VLPNQQVASV
960 970 980 990 1000
QARDEDSEDN GIIMFSILKA EFVRKDGTSN PVQVFRITRS VEAGLFTGSI
1010 1020 1030 1040 1050
ELVTNLDSTI QGTYQVTVQA QDQPTLGPAL ETQTTLNLFT VDQSYRVRLQ
1060 1070 1080 1090 1100
FSTSKEDVGA NMEEIKEALI QATRTSVYVV TIQNIDSTAR ARASSYMDAY
1110 1120 1130 1140 1150
FVFSNGTALT LTELNMMIRK DQDALRQLLQ LGLVVVSSQE SQEPDQQKLL
1160 1170 1180 1190 1200
TSVIIGLVVS LVLVLVILIT ALVCLRKSYH RKLRAMKAGK EARKTPIETT
1210 1220 1230 1240 1250
APTAAIPGTN MYNTDRANPV LDLPTKDLGL ECHSSSDLDY DSLNSLDENS
1260 1270 1280 1290 1300
VDLDMDSKEF KRKDLPGDPP EPDPEPLTAV LSGRSAGASE QQKKNLSFTN

PGLDTTDL
Length:1,308
Mass (Da):142,633
Last modified:April 5, 2011 - v1
Checksum:i9C1DD3E53E556A0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371N → D in BAE25870 (PubMed:16141072).Curated1
Sequence conflicti697Q → QS in AAI41302 (PubMed:15489334).Curated1
Sequence conflicti697Q → QS in AAI45625 (PubMed:15489334).Curated1
Sequence conflicti704W → C in AAI45625 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144400 mRNA Translation: BAE25870.1
AC162526 Genomic DNA No translation available.
BC141301 mRNA Translation: AAI41302.1
BC145624 mRNA Translation: AAI45625.1
CCDSiCCDS36669.1
RefSeqiNP_001028536.2, NM_001033364.3
UniGeneiMm.315382

Genome annotation databases

EnsembliENSMUST00000037145; ENSMUSP00000043596; ENSMUSG00000034918
GeneIDi268663
KEGGimmu:268663
UCSCiuc007qoz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144400 mRNA Translation: BAE25870.1
AC162526 Genomic DNA No translation available.
BC141301 mRNA Translation: AAI41302.1
BC145624 mRNA Translation: AAI45625.1
CCDSiCCDS36669.1
RefSeqiNP_001028536.2, NM_001033364.3
UniGeneiMm.315382

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CYXX-ray2.10A21-348[»]
ProteinModelPortaliE9Q7P9
SMRiE9Q7P9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043596

PTM databases

iPTMnetiE9Q7P9
PhosphoSitePlusiE9Q7P9

Proteomic databases

MaxQBiE9Q7P9
PaxDbiE9Q7P9
PRIDEiE9Q7P9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037145; ENSMUSP00000043596; ENSMUSG00000034918
GeneIDi268663
KEGGimmu:268663
UCSCiuc007qoz.2 mouse

Organism-specific databases

CTDi54825
MGIiMGI:2687323 Cdhr2

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00920000149083
HOGENOMiHOG000115467
HOVERGENiHBG053524
InParanoidiE9Q7P9
KOiK16502
OMAiNVICTKA
OrthoDBiEOG091G00MF
TreeFamiTF332908

Miscellaneous databases

PROiPR:E9Q7P9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034918 Expressed in 46 organ(s), highest expression level in intestine
GenevisibleiE9Q7P9 MM

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR030276 CDHR2
PANTHERiPTHR44787 PTHR44787, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 7 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SUPFAMiSSF49313 SSF49313, 9 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCDHR2_MOUSE
AccessioniPrimary (citable) accession number: E9Q7P9
Secondary accession number(s): B7ZP46, B9EJ32, Q3UN77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2016
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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