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Entry version 62 (22 Apr 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

TSC22 domain family, member 2

Gene

Tsc22d2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • response to osmotic stress Source: MGI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TSC22 domain family, member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tsc22d2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919283 Tsc22d2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q7M2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q7M2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7M2

PeptideAtlas

More...
PeptideAtlasi
E9Q7M2

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7M2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7M2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000027806 Expressed in cleaving embryo and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q7M2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q7M2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000096688

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q7M2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q7M2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 86DisorderedSequence analysisAdd BLAST67
Regioni224 – 292DisorderedSequence analysisAdd BLAST69
Regioni334 – 353DisorderedSequence analysisAdd BLAST20
Regioni520 – 563DisorderedSequence analysisAdd BLAST44
Regioni726 – 769DisorderedSequence analysisAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili691 – 725Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 258PolarSequence analysisAdd BLAST34
Compositional biasi726 – 753PolarSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4797 Eukaryota
ENOG410YCNM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160465

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020315_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q7M2

Database of Orthologous Groups

More...
OrthoDBi
1602203at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000580 TSC-22_Dip_Bun

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01166 TSC22, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01289 TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q7M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD
60 70 80 90 100
VSRATDYGPE EVCERSSSEE TLNNVGDAET PGTVSPNLIL DGQLAAASAA
110 120 130 140 150
PANGGGGGVS ARSVAGALAQ TLAAAAASVS TPGPSSATPS QPPATCSSRF
160 170 180 190 200
RVIKLDHGSG EPYRRGRWTC MEYYERDSDS SVLTRSGDCI RHSNTLEQTA
210 220 230 240 250
ERDSGLGATG GSVVVVVASM QGAHGLDSGT DSSLTAVSQL PPSEKMSQPT
260 270 280 290 300
LAQPQSFSVG QPQPPPPVGG AVAPSSASLP PFPGAATGPQ PMTAAVQPTQ
310 320 330 340 350
LQGAVAGGAL PGPVGQGLPP PPNVNLAQPV ALAAQPGPAG GSSLSQQFAY
360 370 380 390 400
PQPQIPPGHL LPMQPSGQSE YLPPHVALQP PSPAQPLSTS ASATSASAAS
410 420 430 440 450
FPLGSGQSVS SLGAQMMGAS AQPSEAVAPG PVPVGQAAPC QPAGVAPAAL
460 470 480 490 500
GGVVQPGSGL TGVGQPQPVQ PPQQMGGSGQ LPAVPGGPHT VVPGVPNVPA
510 520 530 540 550
AVPVPSVPSV PTTSVTMPNV PAPLGQSQQL SSHTPVSRSS SVIQQVGSPL
560 570 580 590 600
AQGTHSAPTS LPQSDLSQFQ TQTQPLVGQV DDTRRKSEPL PQAPLSLIAE
610 620 630 640 650
SKPVVKPPVA DALTNPLQLT PMNSLATSVF SIAIPVDGDE DRNPSTAFYQ
660 670 680 690 700
AFHLNTCQES KSLWDSASGG GVVAIDNKIE QAMDLVKSHL MYAVREEVEV
710 720 730 740 750
LKEQIKELVE RNSLLERENA LLKSLSNNDQ LSQLPAQQAN PGSTSQQQAM
760
IAQPPQPTQP PQQPNVSSA
Length:769
Mass (Da):78,197
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37B9E141AEE848E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFZ4A0A0G2JFZ4_MOUSE
TSC22 domain family, member 2
Tsc22d2
745Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFL0A0A0G2JFL0_MOUSE
TSC22 domain family, member 2
Tsc22d2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC121794 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074698.1, NM_001081229.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000099090; ENSMUSP00000096688; ENSMUSG00000027806

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72033

UCSC genome browser

More...
UCSCi
uc008php.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121794 Genomic DNA No translation available.
RefSeqiNP_001074698.1, NM_001081229.2

3D structure databases

SMRiE9Q7M2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096688

PTM databases

iPTMnetiE9Q7M2
PhosphoSitePlusiE9Q7M2

Proteomic databases

jPOSTiE9Q7M2
MaxQBiE9Q7M2
PaxDbiE9Q7M2
PeptideAtlasiE9Q7M2
PRIDEiE9Q7M2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1698 146 antibodies

Genome annotation databases

EnsembliENSMUST00000099090; ENSMUSP00000096688; ENSMUSG00000027806
GeneIDi72033
KEGGimmu:72033
UCSCiuc008php.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9819
MGIiMGI:1919283 Tsc22d2

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG410YCNM LUCA
GeneTreeiENSGT00940000160465
HOGENOMiCLU_020315_0_0_1
InParanoidiE9Q7M2
OrthoDBi1602203at2759
TreeFamiTF318837

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tsc22d2 mouse
RNActiE9Q7M2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000027806 Expressed in cleaving embryo and 239 other tissues
ExpressionAtlasiE9Q7M2 baseline and differential
GenevisibleiE9Q7M2 MM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q7M2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7M2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 22, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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