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Entry version 61 (12 Aug 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

URB2 ribosome biogenesis 2 homolog (S. cerevisiae)

Gene

Urb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • ribosome biogenesis Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Urb2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2681124, Urb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9Q7L1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q7L1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7L1

PeptideAtlas

More...
PeptideAtlasi
E9Q7L1

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7L1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031976, Expressed in spermatocyte and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q7L1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q7L1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034457

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q7L1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1322 – 1516Urb2InterPro annotationAdd BLAST195

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWBH, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009258

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_251606_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q7L1

KEGG Orthology (KO)

More...
KOi
K14862

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLDSYCK

Database of Orthologous Groups

More...
OrthoDBi
727255at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q7L1

TreeFam database of animal gene trees

More...
TreeFami
TF328770

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018849, Urb2/Npa2_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10441, Urb2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q7L1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVYSGISF KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ
60 70 80 90 100
SLVAFYKKKL ELQEDIVERL WIYVDNILHS KKLQNLLKDG KTVNLQLSLV
110 120 130 140 150
KIINERIEEF SRSGCQRNIC AVLSCCQGIL SAPALAVIYT AKPELIVALL
160 170 180 190 200
SQLCWSACRQ PEGATTAKLF EVIHLALDHY LRLQQQQANP KRVFGDMTGH
210 220 230 240 250
LFQPCLVLRH LLLGGTWTQA SQGQLWQVLS RDIRSKIDAV LRAGVFRHDL
260 270 280 290 300
LSSYKEELLE QHQESVRMGV LKGLLTPMEA VIARLVEPGY VRSDLHALVV
310 320 330 340 350
ASSVPLLFRL FLEAYLQEES QFLCFQVLPR LFGCLQISHL QEGQIEALSL
360 370 380 390 400
SDWTTELLAI EQLLNSVATS NIYNVATDRI RHAETQFHFY RRVAEVLINH
410 420 430 440 450
SQASVPAWFR CLKILISLNH LILEPDLDDL LSSAWIDAEV TEFRAKKAQE
460 470 480 490 500
VLINTVFQTY AKLRQVPRLF EEVLGVICRP AAEALRQPLL ASGLSVALSA
510 520 530 540 550
CLLELPLSQI LDSWSLVLDK FQSLVMPCLQ SDTDMALKAM SLSSLLHCIM
560 570 580 590 600
FNMQSLDNNM PLPIIRRTQC IMERMLRELV GPLLGLLLDL WSPEPELWQQ
610 620 630 640 650
KVCDSALLLS YTWAQVDATI SLHCSQYYSL GISLARAALD SSNLPLLLPG
660 670 680 690 700
VEMEFWKKVE ECVGQSRSLS RYCLEQLYLQ KVKRTLMRSN SQSKEALQTL
710 720 730 740 750
RFDTAHILDS SRDCLSQKTA AAWDRQVSTM NESIYPVAHW HLIVSNLTVL
760 770 780 790 800
IPYLCLNDVR YVATVLLRTL PASKAQGSLA HGEPHVTLEK ISTALLHSPL
810 820 830 840 850
FPEMQSLYSA FLTCIIAECS STLCSGAHSD LSLVSQQLPW LSGKDDHTIV
860 870 880 890 900
AHWETRLAKV GPEGVEPRGE IAQNFLSMVK SGFPIKLDEE QLKGLLELLE
910 920 930 940 950
VISALRLDSL SPSYHVHMFF LLFSMAVSTL GHCSCPLALQ FLVKCYRLLS
960 970 980 990 1000
SLQRGKNGRT VFRVMYVSDI FEVVLTSLLQ ASAEFQVRED DPAWLQLLQV
1010 1020 1030 1040 1050
SGVFLEQLMQ MLTQVKLSLV LNFGKITAFL SRYRKEASCK EGKIPNLRSR
1060 1070 1080 1090 1100
QLLLVALTKL CQSLGPCVKE RRQLLEAPAE LAELLQQAMM QMGTMLKLCL
1110 1120 1130 1140 1150
VSGTTGRRRL PSVLLAAVPT LLEVDMSQHL RDGQPKIAQV VDTDKTLLSH
1160 1170 1180 1190 1200
GTLYQDVYTQ LLEELPALSG NAQSFQAALQ FLTLFLLAPE LHSKETSVFA
1210 1220 1230 1240 1250
SVFYSVQKVL TGPCIPAPVT QDTELHLGAL LTQMFEAGTT EHFGMVLQSI
1260 1270 1280 1290 1300
LQGLDVTQAW RSDLQVVLCA IRLLKLLLKC PLNGEKASLL WRSCPQIITA
1310 1320 1330 1340 1350
LMLQHREACR EQPVALAVIE PVLEVLAVLL RKGEESISNP HHVSLAFNIL
1360 1370 1380 1390 1400
LTVPLEHLQP REFGSVFLKM HSVLFSILQC HSKVMLKAVP SFLNSFNRLL
1410 1420 1430 1440 1450
VSVMHEGRQK DKGSVDDLTV VLESARLVER MYSHLATRAE EFTAFSPFLV
1460 1470 1480 1490 1500
AQYVTEVQKV TLYPPVKNLL QEGIYLILDL CMERDIQFLR ASLQAGARDV
1510 1520
FKDLHSDYLK YHKAKHEGEK RYTA
Length:1,524
Mass (Da):171,620
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF28A79735B91DDFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UX45G3UX45_MOUSE
URB2 ribosome biogenesis 2 homolog ...
Urb2
1,296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC139575 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001025047.1, NM_001029876.1
XP_006531213.1, XM_006531150.3
XP_006531214.1, XM_006531151.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034457; ENSMUSP00000034457; ENSMUSG00000031976

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
382038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:382038

UCSC genome browser

More...
UCSCi
uc009nwy.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139575 Genomic DNA No translation available.
RefSeqiNP_001025047.1, NM_001029876.1
XP_006531213.1, XM_006531150.3
XP_006531214.1, XM_006531151.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034457

PTM databases

iPTMnetiE9Q7L1
PhosphoSitePlusiE9Q7L1

Proteomic databases

EPDiE9Q7L1
MaxQBiE9Q7L1
PaxDbiE9Q7L1
PeptideAtlasiE9Q7L1
PRIDEiE9Q7L1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1890, 72 antibodies

Genome annotation databases

EnsembliENSMUST00000034457; ENSMUSP00000034457; ENSMUSG00000031976
GeneIDi382038
KEGGimmu:382038
UCSCiuc009nwy.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9816
MGIiMGI:2681124, Urb2

Phylogenomic databases

eggNOGiENOG502QWBH, Eukaryota
GeneTreeiENSGT00390000009258
HOGENOMiCLU_251606_0_0_1
InParanoidiE9Q7L1
KOiK14862
OMAiFLDSYCK
OrthoDBi727255at2759
PhylomeDBiE9Q7L1
TreeFamiTF328770

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
382038, 7 hits in 19 CRISPR screens
RNActiE9Q7L1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031976, Expressed in spermatocyte and 247 other tissues
ExpressionAtlasiE9Q7L1, baseline and differential
GenevisibleiE9Q7L1, MM

Family and domain databases

InterProiView protein in InterPro
IPR018849, Urb2/Npa2_C
PfamiView protein in Pfam
PF10441, Urb2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q7L1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: August 12, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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