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Protein

AT-rich interactive domain-containing protein 2

Gene

Arid2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.2 PublicationsBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi524 – 603RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST80
Zinc fingeri1626 – 1651C2H2-typeBy similarityAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 2
Short name:
ARID domain-containing protein 2Curated
Alternative name(s):
BRG1-associated factor 200Curated
Short name:
BAF200Curated
Zinc finger protein with activation potentialCurated
Zipzap/p2001 Publication
Gene namesi
Name:Arid2Imported
Synonyms:Baf200Curated
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1924294 Arid2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004424292 – 1828AT-rich interactive domain-containing protein 2Add BLAST1827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei4PhosphoserineBy similarity1
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki555Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei631PhosphoserineBy similarity1
Modified residuei635PhosphoserineBy similarity1
Modified residuei653PhosphothreonineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei692PhosphothreonineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1385PhosphoserineBy similarity1
Modified residuei1491PhosphoserineBy similarity1
Cross-linki1695Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1725Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiE9Q7E2
PaxDbiE9Q7E2
PeptideAtlasiE9Q7E2
PRIDEiE9Q7E2

PTM databases

iPTMnetiE9Q7E2
PhosphoSitePlusiE9Q7E2

Expressioni

Tissue specificityi

Highly expressed in testis, expressed in heart, liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000033237 Expressed in 296 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiE9Q7E2 baseline and differential
GenevisibleiE9Q7E2 MM

Interactioni

Subunit structurei

Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin. Interacts with SRF. Forms complexes with SRF and SRF cofactors MYOCD, NKX2-5 and SRFBP1.2 PublicationsBy similarity

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortaliCPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CORUMiE9Q7E2
STRINGi10090.ENSMUSP00000093969

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 105ARIDPROSITE-ProRule annotationAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi313 – 317LXXLLBy similarity5

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1626 – 1651C2H2-typeBy similarityAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2312 Eukaryota
KOG2744 Eukaryota
ENOG410XT3H LUCA
GeneTreeiENSGT00390000016138
InParanoidiE9Q7E2
KOiK11765
OMAiICDWRNC
OrthoDBiEOG091G169Y
TreeFamiTF106406

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR003150 DNA-bd_RFX
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02257 RFX_DNA_binding, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF46785 SSF46785, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51526 RFX_DBD, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q7E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL
60 70 80 90 100
YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFALK QYYLRYLEKY
110 120 130 140 150
EKVHHFGEDD DEVPPGNPKP QLPIGAIPSS YNYQQHSVSD YLRQSYGLSM
160 170 180 190 200
DFNSPNDYNK LVLSLLSGLP NEVDFAINVC TLLSNESKHV MQLEKDPKII
210 220 230 240 250
TLLLANAGVF DDTLGSFSSV FGEEWREKTD RDFVKFWKDI VDDNEVRDLI
260 270 280 290 300
SDRNKAHEDT PGEWIWESLF HPPRKLGIND IEGQRVLQIA VILRNLSFEE
310 320 330 340 350
SNVKLLAANR TCLRFLLLSA HSHFISLRQL GLDTLGNIAA ELLLDPVDFR
360 370 380 390 400
TTHLMFHTVT KCLMSRDRFL KMRGMEILGN LCKAEDNGVL ICEYVDQDSY
410 420 430 440 450
REIICHLTLP DVLLVTSTLE VLYMLTEMGD VACTKIAKVE KSIDVLVCLV
460 470 480 490 500
SMDAQMFGPD ALAAVKLIEH PSSSHQVLSE IRPQAIEQVQ TQTHIASGPA
510 520 530 540 550
SRAVVAQHAA PPPGIVEIDS EKFACQWLNA HFEVNPDCSV SRAEMYSEYL
560 570 580 590 600
STCSKLARGG ILTSTGFYKC LRTVFPNHTV KRVEDSTSSG QAHIHVIGVK
610 620 630 640 650
RRALPLPIQM YYQQQPISTP VVRVDAVADL SPTPSPAGIP HGPQAAGNHF
660 670 680 690 700
QRTPVTNQSS NLTATQMSFP VQGIHTVAQT VSRIPPNPSV HTHQQQNSPV
710 720 730 740 750
TVIQNKAPIP CEVVKATVIQ NSVPQTAVPV SISVGGAPAQ NSVGQNHSAG
760 770 780 790 800
PQPVTVVNSQ TLLHHPSVMP QPSPLHTVVP GQVPSGTPVT VIQQTVPQSR
810 820 830 840 850
MFGRVQSIPA CTSTVSQGQQ LITTSPQPMH TSSQQTAAGS QPQDTVIIAP
860 870 880 890 900
PQYVTTSASN IVSATSVQNF QVATGQVVTI AGVPSPQPSR VGFQNIAPKP
910 920 930 940 950
LPSQQVSPSV VQQPIQQPQQ PAQQSVVIVS QPAQQGQAYA PAIHQIVLAN
960 970 980 990 1000
PAALPAGQTV QLTGQPNITP SSSPSPVPPT NNQVPTAMSS SSTLQSQGPP
1010 1020 1030 1040 1050
PTVSQMLSVK RQQQQQHSPA APAQQVQVQV QQPQQVQVQV QPQQPSAGVG
1060 1070 1080 1090 1100
QPAPNESSLI KQLLLPKRGP STPGGKLILP APQIPPPNNA RAPSPQVVYQ
1110 1120 1130 1140 1150
VANNQAAGFG VQGQTPAQQL LVGQQNVQLV QSAMPPAGGV QTVPISNLQI
1160 1170 1180 1190 1200
LPGPLISNSP ATIFQGTSGN QVTITVVPNT SFATATVSQG NAAQLIAPAG
1210 1220 1230 1240 1250
LSMSGAQASA GLQVQTLPAG QSACTTAPLP FKGDKIICQK EEEAKEATGL
1260 1270 1280 1290 1300
HVHERKIEVM ENPSCRRGTT NTSNGDTSES ELQVGSLLNG RKYSDSSLPP
1310 1320 1330 1340 1350
SNSGKLQSET SQCSLISNGP SLELGENGAP GKQNSEPVDM QDVKGDLKKA
1360 1370 1380 1390 1400
LVNGICDFDK GDGSHLSKNI PNHKTSNHVG NGEISPVEPQ GTSGATQQDT
1410 1420 1430 1440 1450
AKGDQLERVS NGPVLTLGGS PSTSSMQEAP SVATPPLSGT DLPNGPLASS
1460 1470 1480 1490 1500
LNSDVPQQRP SVVVSPHSTA PVIQGHQVIA VPHSGPRVTP SALSSDARST
1510 1520 1530 1540 1550
NGTAECKTVK RPAEDNDRDT VPGIPNKVGV RIVTISDPNN AGCSATMVAV
1560 1570 1580 1590 1600
PAGADPSTVA KVAIESAAQQ KQQHPPTYMQ SVAPQNTPMP PSPAVQVQGQ
1610 1620 1630 1640 1650
PSSSQPSPVS ASSQHADPVR KPGQNFMCLW QSCKKWFQTP SQVFYHAATE
1660 1670 1680 1690 1700
HGGKDVYPGQ CLWEGCEPFQ RQRFSFITHL QDKHCSKDAL LAGLKQDEPG
1710 1720 1730 1740 1750
QVANQKSSTK QPTVGGTGSA PRAQKAIASH PSAALMALRR GSRNLVFRDF
1760 1770 1780 1790 1800
TDEKEGPITK HIRLTAALIL KNIGKYSECG RRLLKRHENN LSVLAISNME
1810 1820
ASSTLAKCLY ELNFTVQSKE QEKDSEML
Length:1,828
Mass (Da):195,988
Last modified:April 5, 2011 - v1
Checksum:i1BC23646CFA2F68D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D982Q9D982_MOUSE
AT-rich interactive domain-containi...
Arid2 mCG_141061
145Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133578 Genomic DNA No translation available.
CCDSiCCDS37185.2
RefSeqiNP_780460.3, NM_175251.4
UniGeneiMm.17166

Genome annotation databases

EnsembliENSMUST00000096250; ENSMUSP00000093969; ENSMUSG00000033237
GeneIDi77044
KEGGimmu:77044
UCSCiuc007xkd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133578 Genomic DNA No translation available.
CCDSiCCDS37185.2
RefSeqiNP_780460.3, NM_175251.4
UniGeneiMm.17166

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CORUMiE9Q7E2
STRINGi10090.ENSMUSP00000093969

PTM databases

iPTMnetiE9Q7E2
PhosphoSitePlusiE9Q7E2

Proteomic databases

MaxQBiE9Q7E2
PaxDbiE9Q7E2
PeptideAtlasiE9Q7E2
PRIDEiE9Q7E2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096250; ENSMUSP00000093969; ENSMUSG00000033237
GeneIDi77044
KEGGimmu:77044
UCSCiuc007xkd.2 mouse

Organism-specific databases

CTDi196528
MGIiMGI:1924294 Arid2

Phylogenomic databases

eggNOGiKOG2312 Eukaryota
KOG2744 Eukaryota
ENOG410XT3H LUCA
GeneTreeiENSGT00390000016138
InParanoidiE9Q7E2
KOiK11765
OMAiICDWRNC
OrthoDBiEOG091G169Y
TreeFamiTF106406

Enzyme and pathway databases

ReactomeiR-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

PROiPR:E9Q7E2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033237 Expressed in 296 organ(s), highest expression level in olfactory bulb
ExpressionAtlasiE9Q7E2 baseline and differential
GenevisibleiE9Q7E2 MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016024 ARM-type_fold
IPR003150 DNA-bd_RFX
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02257 RFX_DNA_binding, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
SSF46785 SSF46785, 1 hit
SSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51526 RFX_DBD, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARID2_MOUSE
AccessioniPrimary (citable) accession number: E9Q7E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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