Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 5

Gene

Arhgef5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:19713215, PubMed:21525037). Strongly activates RHOA (PubMed:19713215, PubMed:21525037). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (PubMed:19713215). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:21525037). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation (PubMed:21525037). Involved in positive regulation of immature dendritic cell migration (PubMed:19713215).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858952 Arhgef5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Chemotaxis of macrophages, T and B lymphocytes and bone marrow-derived mature dendritic cells from mutant mice is not affected but chemotaxis of immature dendritic cells is abolished.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004351431 – 1581Rho guanine nucleotide exchange factor 5Add BLAST1581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei446PhosphoserineBy similarity1
Modified residuei953PhosphoserineCombined sources1
Modified residuei969PhosphoserineBy similarity1
Modified residuei1029PhosphoserineBy similarity1
Modified residuei1110PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activation of SRC induces tyrosine phosphorylation of ARHGEF5.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q7D5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7D5

PeptideAtlas

More...
PeptideAtlasi
E9Q7D5

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7D5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000033542 Expressed in 225 organ(s), highest expression level in placenta labyrinth

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q7D5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q7D5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SRC (PubMed:21525037). Forms a ternary complex with SRC and the PI3K 85 kDa subunit (PubMed:21525037). Interacts with and is activated by the heterodimer formed by GNB1 and GNG2 (PubMed:19713215). Interacts with ODAM (via C-terminus) (By similarity). Interacts with RHOA (PubMed:19713215).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q7D5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1158 – 1342DHPROSITE-ProRule annotationAdd BLAST185
Domaini1375 – 1488PHSequence analysisAdd BLAST114
Domaini1494 – 1555SH3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 333Glu-richPROSITE-ProRule annotationAdd BLAST172
Compositional biasi775 – 843Pro-richPROSITE-ProRule annotationAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain binds to phosphoinositides and is essential for podosome formation.1 Publication

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3523 Eukaryota
COG5422 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007536

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058673

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q7D5

KEGG Orthology (KO)

More...
KOi
K20684

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKGWNRQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00P4

TreeFam database of animal gene trees

More...
TreeFami
TF342609

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029212 ARHGEF5/35_N
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15441 ARHGEF5_35, 1 hit
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q7D5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEEPEYGV STEVPDIEEL KTIPEGIMRS SQIPALDPEA QEDRDPSYKW
60 70 80 90 100
TDGHRPVMNQ SKVLRDMGDH TPNSMAIFFK KESSDMETSQ EILLAEACNT
110 120 130 140 150
PDQQEAVIQS LKDRLSRTIA APELLACAVQ EEWLDIPSKL DNRVGAELQS
160 170 180 190 200
ELMSLTLAVS KEKEEEETSP DTSIPRGSWP PCKTHPGETE QTQGSGSELL
210 220 230 240 250
RQGKQLQLEA TQENQGQEGF LQSQEAQGLE EQEGQEVEIQ EEGTLNEGIC
260 270 280 290 300
FGGLLGEQEE VEEGFNGNEE EQKQGQIQSY MLLGGQWENE GLSGELEGLN
310 320 330 340 350
YSERGQENRE RRVWVLRDSE EEGQDQESRE VEERRVATQY TENQRLVEKS
360 370 380 390 400
EIVKRKQRDH DQTGKVMPVR DQKEVVDSGD RVQGNGDSGG QTAVEGSRPG
410 420 430 440 450
EDSKPSLPVA SVDPEVLSPG TLFPGISSSV ADIPQIQKEP VCEELSPQAP
460 470 480 490 500
ALEPTEWSHQ PISPPASFAP EESLDNRTHN SQQEEFRLRK GIEVVSASTS
510 520 530 540 550
VAPSGTRDSP PFSPPNVFSS TATLSPVSSS VILPEETPTA SASADTPHHC
560 570 580 590 600
GPCETPPLPA KSSRYPCATS DTANPHSPLS SYTGVTQHLR SNSFPGSHRT
610 620 630 640 650
EQTPDSLGMS LSFSHLELPQ RPPKPAIYGS LTPRRNRRSR DGIVFSDSST
660 670 680 690 700
ALFALKQDSE EFTSNPERPS SPHGSPTWGS PQNSAFAIGS PANVSSPPTV
710 720 730 740 750
SMDMTIREAL LPIPPEKRHS YSHIVERDGL LHEVASTLKR HSHPPPLTLS
760 770 780 790 800
SGLHRSSKGS FSLVPDSTVA RQHRPLPSTP ESPNHTQTSI PSRLRYNKPL
810 820 830 840 850
PPTPDMPEFY HPSISSSYIS RMYRPLPPVP IIDPSSEPPP LPPKSRGRSK
860 870 880 890 900
SIQGGVIHSG GQAKPRPNNQ DWTASTLSVG RTSWPPATGR STESLPLTSR
910 920 930 940 950
CNNEVSPGLA FSNMTNLLSP SSPTTPWIPD LQRPTTKDES GLTEESEPPV
960 970 980 990 1000
RGSFRRSAPQ EEFNNTRRSA LGSRKNSEKP LHHQLEKASS WPHRRDPART
1010 1020 1030 1040 1050
SESSSEQVVL GQVPNKQKGW NRQGLRRPSI LPESSSDLRN PAAGRLPGSS
1060 1070 1080 1090 1100
DSVVFREKKP KEGMGGFSRR CSKLISSQLL YQEYSDVVLN KEIQSQQRLD
1110 1120 1130 1140 1150
SLAEPHGLSS PRHRRKALVS SDSYLQRLSM ASSGSLWQEI PVVRNSTVLL
1160 1170 1180 1190 1200
SMTHEDQKLQ EAKFELIVSE ASYLRSLNIA VDHFQHSAQL RGTLSNQDHQ
1210 1220 1230 1240 1250
WLFSRLQDVR DVSTTFLSDL EENFENNIFS FQVCDVVLNH AADFHRVYLP
1260 1270 1280 1290 1300
YVTNQTYQER TFQSLMNSNS SFREVLEKLE SDPICQRLSL KSFLILPFQR
1310 1320 1330 1340 1350
ITRLKLLLQN ILKRTQPGSS EEAEATKAHH ALEKLIRDCN SNVQRMRRTE
1360 1370 1380 1390 1400
ELIYLSQKIE FECKIFPLIS QSRWLVKSGE LTALEFSVSP GLRRKLTTRP
1410 1420 1430 1440 1450
VHLHLFNDCL LLSRPREGSR FLVFDHAPFS SIRGEKCEMK LHGPHKNLFR
1460 1470 1480 1490 1500
LFLLHNAQGT QVEFLFRTET QSEKLRWISA LAMPREELDL LECYDSPQVQ
1510 1520 1530 1540 1550
CLRAYKPREN DELALEKADV VMVTQQSSDG WLEGVRLSDG EQGWFPVQQV
1560 1570 1580
EFISNPEVRA QNLKEAHRVK TAKLQLVEQQ V
Length:1,581
Mass (Da):176,664
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE61F8807C1C4102
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1F1S4R1F1_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef5
796Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC153885 Genomic DNA No translation available.
AC158671 Genomic DNA No translation available.
BC006829 mRNA Translation: AAH06829.1
BC025127 mRNA Translation: AAH25127.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51759.1

NCBI Reference Sequences

More...
RefSeqi
NP_598435.1, NM_133674.1
XP_006506450.1, XM_006506387.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.320978

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000031750; ENSMUSP00000031750; ENSMUSG00000033542

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:54324

UCSC genome browser

More...
UCSCi
uc009bsn.1 mouse
uc009bso.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153885 Genomic DNA No translation available.
AC158671 Genomic DNA No translation available.
BC006829 mRNA Translation: AAH06829.1
BC025127 mRNA Translation: AAH25127.1
CCDSiCCDS51759.1
RefSeqiNP_598435.1, NM_133674.1
XP_006506450.1, XM_006506387.2
UniGeneiMm.320978

3D structure databases

SMRiE9Q7D5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031750

PTM databases

iPTMnetiE9Q7D5
PhosphoSitePlusiE9Q7D5

Proteomic databases

MaxQBiE9Q7D5
PaxDbiE9Q7D5
PeptideAtlasiE9Q7D5
PRIDEiE9Q7D5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031750; ENSMUSP00000031750; ENSMUSG00000033542
GeneIDi54324
KEGGimmu:54324
UCSCiuc009bsn.1 mouse
uc009bso.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7984
MGIiMGI:1858952 Arhgef5

Phylogenomic databases

eggNOGiKOG3523 Eukaryota
COG5422 LUCA
GeneTreeiENSGT00940000157968
HOGENOMiHOG000007536
HOVERGENiHBG058673
InParanoidiE9Q7D5
KOiK20684
OMAiHKGWNRQ
OrthoDBiEOG091G00P4
TreeFamiTF342609

Enzyme and pathway databases

ReactomeiR-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9Q7D5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000033542 Expressed in 225 organ(s), highest expression level in placenta labyrinth
ExpressionAtlasiE9Q7D5 baseline and differential
GenevisibleiE9Q7D5 MM

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR029212 ARHGEF5/35_N
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF15441 ARHGEF5_35, 1 hit
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHG5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7D5
Secondary accession number(s): Q8R172, Q922T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: April 5, 2011
Last modified: December 5, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again