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Entry version 56 (17 Jun 2020)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Proline-rich 14-like

Gene

Prr14l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Proline-rich 14-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prr14lImported
Synonyms:C330019G07RikImported, Prl14lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443658 Prr14l

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E9Q7C4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q7C4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q7C4

PeptideAtlas

More...
PeptideAtlasi
E9Q7C4

PRoteomics IDEntifications database

More...
PRIDEi
E9Q7C4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q7C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q7C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054280 Expressed in cardiac ventricle and 236 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q7C4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113259

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q7C4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1838 – 1895TantalusInterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 80DisorderedSequence analysisAdd BLAST46
Regioni443 – 483DisorderedSequence analysisAdd BLAST41
Regioni1798 – 1823DisorderedSequence analysisAdd BLAST26
Regioni1952 – 1971DisorderedSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZ1 Eukaryota
ENOG4111V15 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001409_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q7C4

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFGNTSH

Database of Orthologous Groups

More...
OrthoDBi
20650at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328446

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026320 PRR14
IPR028149 Tantalus-like

The PANTHER Classification System

More...
PANTHERi
PTHR14522 PTHR14522, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15386 Tantalus, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E9Q7C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSGVETQP VPLDSSMSAV VQELYSELSV SVSKELHAEQ EPSKIADVKP
60 70 80 90 100
GASRSPLSHG RASPLGLQRT HAEGCREESS ETLDCRGKNG WCGLVDPTRD
110 120 130 140 150
PMAYEILDRE ERPKSMEPKV FRDQGDQAQV FRDPCEGAKE DPCQHSTATK
160 170 180 190 200
EKICPCQDLL PRQSSKGPVC ADLPGEPQNN GGNVHNTTAA LPELTEERQG
210 220 230 240 250
TCTVSRMSKG KEESCDLDPV WEEADNHQQS LSHCKEKHSS AHNSSITKGS
260 270 280 290 300
IDTVKPSEEN SKILYLTSFL SGPKSLEKCG FECSGLIKAC AEKTQKVDQM
310 320 330 340 350
EDFTCGEERA VESSNHSNCH TEAGCPCTDS CTSMRNSSTE ATEIMFKKTD
360 370 380 390 400
VKITLNLHGN LINSEDHRKT VDVTHPEKRS EESSFSLLVH IEEPEQTTVK
410 420 430 440 450
SSALNGKIYS KDATKSVVSI QRSLGDSLPS TALCNNFLFE RKPPQSLMSE
460 470 480 490 500
DPGSSEHNEI SKPKKGTAKL PSSPGKPVQT SCDSISHFDE PITTCEMSKR
510 520 530 540 550
SPNRALVAHK IEHECVSHQQ VSLSSQDHVT TGSLSINREM PSATCRDVQE
560 570 580 590 600
SHHSLENGVN VTPDTQTIPA ETKMEAMSPQ GDRACGASSF IQTLNNKTRS
610 620 630 640 650
SEGQKEMTAV HSTFFSSVRG AAASSFVTEC QNVQSQDIFS CHCITRDASE
660 670 680 690 700
KNMCSASAAC ELRKDSLKVS NCKIKCGNTS QDGNHCSQRP EGFVEKSTLL
710 720 730 740 750
ESEPAGREVQ SSFLEGKVRS AVAAAVTHTA SLNTATHMET GDEGLLGKKQ
760 770 780 790 800
DQRIDTEIYK HSTSACDTQE LKQSANIPSP ETLVDQSLSI LSSHFKTMYQ
810 820 830 840 850
AAENLHQKAD EVSDCQSNQN ILDKCRCEGK PAGEGLNGDF GETDPEVSHR
860 870 880 890 900
QKDLTVSSGS KVPLSCGGLK IKDPKRAFID IPGSEEFTHS MLDVICPDCT
910 920 930 940 950
DEPPEGVLGV EASSLSGHCT RQDTLAYHET IRSTSLLQGE LNVECQGTEL
960 970 980 990 1000
PNAAASSVDS SEIQKSHEEK VCNSLKDYEM EDCPDSAIDH EVKSVVDHEP
1010 1020 1030 1040 1050
NIRALDRAGV SLNSIHCEHQ GKGGSMIEGL RLEANSEFGK RKTFGLSLKD
1060 1070 1080 1090 1100
SVSPGCQDSV KMVHSCLSSR EHSPAGIFDE MPNSKHHFKP KDDEMLCENV
1110 1120 1130 1140 1150
KDCTVLSDMK AGIPMDLHNP SEGDSTYISV NKKVCKTCHS LKNSIDKHLP
1160 1170 1180 1190 1200
MTMETAIRMN KEETEKHQTG LLGHIPVGKA SEETREGHGG NSQTHLKCQR
1210 1220 1230 1240 1250
VQNVTEAPQN QGPVDSALPK EACTYQKGTH ALLGQHLSSG TVSDEVQDKQ
1260 1270 1280 1290 1300
PVADQDESIL IGAITLRKPS KDRIARQLQW LKYPKEESLC HSLKKDTELC
1310 1320 1330 1340 1350
TGTCLPGASW KEHDPSFAGG DRIHGAFVTL SHQHRLLSVK KQPHRTCKRI
1360 1370 1380 1390 1400
SCQEPVTVRR KISKVRNSDC GKSFSNPIPT KAHRLLSPCT VPAKPLEPET
1410 1420 1430 1440 1450
VASENLRSHI PKPKATLCHS LRSRSCRKPT KESALLSKLS VLASRLTTAT
1460 1470 1480 1490 1500
KPQELRCRRD SSSLVPLAKN YKRLRYKKLL DGFSHNAMQL DPYLAATGWN
1510 1520 1530 1540 1550
RGSNSRPLAL YSLEAVKMSF IDLSNKMPSL LFGTENVPFS FHVKSVSSCM
1560 1570 1580 1590 1600
AESSRTFPEH CAPSRLALTE ASQCSAPAPK WTFSFFLSHG CPGMATFRED
1610 1620 1630 1640 1650
TGLSSQTHTQ APLQEYGGTA IVQTRADRSG LGLHTLLALC SPGCYRIWTK
1660 1670 1680 1690 1700
RRNFSSNMPI MQRLFLTQFT QGLKGLRSPA SIADKVFCSL PYSVGRVLSL
1710 1720 1730 1740 1750
WSQHGPSCTF KLPALHSTPS KQQGSLNALS SHTTIPNVPL PGMGAAHTTN
1760 1770 1780 1790 1800
SSHLRLEPVF PALVPKSCLV TEAAVSTLLL SASELAVPGC DELDGVSAAC
1810 1820 1830 1840 1850
PRPQSSPAQQ KEAEPEKRPK KVSQIRIRKT IPKPDPNLTP MGLPRPKRLK
1860 1870 1880 1890 1900
KKEFSLEEIY TNKNYKSPPA SRCLETIFEE PKERNGTLIS ISQQKRKRVL
1910 1920 1930 1940 1950
EFQDFTVPRK RRARGKVKLA GSFTRAQKAA LQTQELDALL IQKLMELETF
1960 1970
FAKEGEQEHQ PAAENSSGSP L
Length:1,971
Mass (Da):215,824
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2519742BF91C1CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RN94F6RN94_MOUSE
Proline-rich 14-like
Prr14l C330019G07Rik, Prl14l
661Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKZ4H3BKZ4_MOUSE
Proline-rich 14-like
Prr14l C330019G07Rik, Prl14l
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC108773 Genomic DNA No translation available.
AC241622 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_919321.2, NM_194340.2
XP_006503899.1, XM_006503836.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000120129; ENSMUSP00000113259; ENSMUSG00000054280

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
215476

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:215476

UCSC genome browser

More...
UCSCi
uc008wzy.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108773 Genomic DNA No translation available.
AC241622 Genomic DNA No translation available.
RefSeqiNP_919321.2, NM_194340.2
XP_006503899.1, XM_006503836.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113259

PTM databases

iPTMnetiE9Q7C4
PhosphoSitePlusiE9Q7C4

Proteomic databases

EPDiE9Q7C4
MaxQBiE9Q7C4
PaxDbiE9Q7C4
PeptideAtlasiE9Q7C4
PRIDEiE9Q7C4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45489 25 antibodies

Genome annotation databases

EnsembliENSMUST00000120129; ENSMUSP00000113259; ENSMUSG00000054280
GeneIDi215476
KEGGimmu:215476
UCSCiuc008wzy.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
253143
MGIiMGI:2443658 Prr14l

Phylogenomic databases

eggNOGiENOG410IDZ1 Eukaryota
ENOG4111V15 LUCA
GeneTreeiENSGT00520000055626
HOGENOMiCLU_001409_0_0_1
InParanoidiE9Q7C4
OMAiAFGNTSH
OrthoDBi20650at2759
TreeFamiTF328446

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
215476 0 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prr14l mouse
RNActiE9Q7C4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054280 Expressed in cardiac ventricle and 236 other tissues
GenevisibleiE9Q7C4 MM

Family and domain databases

InterProiView protein in InterPro
IPR026320 PRR14
IPR028149 Tantalus-like
PANTHERiPTHR14522 PTHR14522, 1 hit
PfamiView protein in Pfam
PF15386 Tantalus, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q7C4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q7C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 17, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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