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Entry version 51 (16 Jan 2019)
Sequence version 1 (05 Apr 2011)
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Protein

Jhy protein

Gene

Jhy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • axoneme assembly Source: MGI
  • brain development Source: MGI
  • cerebrospinal fluid secretion Source: MGI
  • ciliary basal body organization Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Jhy protein1 Publication
Alternative name(s):
Juvenile hydrocephalus protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Jhy1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918239 Jhy

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004422611 – 770Jhy proteinAdd BLAST770

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
E9Q793

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q793

PRoteomics IDEntifications database

More...
PRIDEi
E9Q793

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, specifically in hypothalamus, pineal gland, and ependymal cells of the aqueduct of Sylvius, as well as in the choroid plexus of the third ventricle. Expressed in the ependymal cells lining the lateral ventricles (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000032023 Expressed in 24 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
E9Q793 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH42 Eukaryota
ENOG410XX5X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002823

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000013118

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG081220

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
E9Q793

Identification of Orthologs from Complete Genome Data

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OMAi
TQIMEQH

Database of Orthologous Groups

More...
OrthoDBi
1114555at2759

TreeFam database of animal gene trees

More...
TreeFami
TF335473

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027968 JHY

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15261 JHY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q793-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKYKPVPKL SSQSPVHHTN LRIPPSGRPF KKEDFLNLIS KDSLESDSES
60 70 80 90 100
LPQEAKSWSD IKDQIQDKDM EPDSLEEDSP SETEEAVNRK AAHNTNREDL
110 120 130 140 150
SAHDAGVNHS QHQVEDKYSD LRYDPNWKNK REEGQPLAGE ALPGSADSSS
160 170 180 190 200
ENLPLAPLYP SREPSMGLSA GKGKEKKSPQ SEASLLGSEF LSPKYERSTR
210 220 230 240 250
QNGFFSELSD SDQEEKSSGL SQYLKSSSSH NDVFLPGSRG PRRRKSKQYF
260 270 280 290 300
VEKNKLTLGL PMPKTDSYLQ LHNKKRGETR LEQISYPVRD TDKMTVQNDK
310 320 330 340 350
EVENTFMDPE DKWHQRAKQL KNYQEHLSQY EDTKSGNVPR GQSSDAANGQ
360 370 380 390 400
QPSRRTAKAR VRKQRKHQKG LKSLGTKELV VSQNNQNNPF QQPQNQRQTA
410 420 430 440 450
DASAKHELAA QTNASNPNLQ DARTLTHNPK VTSDSFVSPK QALDRALYKN
460 470 480 490 500
SISGLNANKR RGHRREEERI LYQPQPIYVF SDTHLQDFNE LPHRHESPSQ
510 520 530 540 550
RAPQSDHHMN THRSTKTKKP AKQPQAETKY KNIEMLWKFH SSSDMEPASA
560 570 580 590 600
SPDSRLAQIM EQHQQALMQL AEVQPSEGSL ASIILPPILS RVESESQLNS
610 620 630 640 650
ERSHRHQVKM ARSNSEGYLL QLERGKRHRK RSSTKSSKLK GYQKRDVKLG
660 670 680 690 700
GLGPDFASVR DKMQMLMQQK EYAQQVKDYN MKALSILSKP QTSKTESKSA
710 720 730 740 750
ISRKKALDYA KTIPKPKPPN LPDQTAKKTK NSRHSEKEGG LPEISLLEIL
760 770
QSRHEREKQA VAAFKVLHIV
Length:770
Mass (Da):87,417
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2477A2667C344485
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC159820 Genomic DNA No translation available.
AK016487 mRNA Translation: BAB30266.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40592.1

NCBI Reference Sequences

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RefSeqi
NP_001074590.1, NM_001081121.1
XP_006510662.1, XM_006510599.3
XP_006510663.1, XM_006510600.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.335087

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034521; ENSMUSP00000034521; ENSMUSG00000032023

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70989

UCSC genome browser

More...
UCSCi
uc009pac.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159820 Genomic DNA No translation available.
AK016487 mRNA Translation: BAB30266.1
CCDSiCCDS40592.1
RefSeqiNP_001074590.1, NM_001081121.1
XP_006510662.1, XM_006510599.3
XP_006510663.1, XM_006510600.3
UniGeneiMm.335087

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

MaxQBiE9Q793
PaxDbiE9Q793
PRIDEiE9Q793

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034521; ENSMUSP00000034521; ENSMUSG00000032023
GeneIDi70989
KEGGimmu:70989
UCSCiuc009pac.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79864
MGIiMGI:1918239 Jhy

Phylogenomic databases

eggNOGiENOG410IH42 Eukaryota
ENOG410XX5X LUCA
GeneTreeiENSGT00390000002823
HOGENOMiHOG000013118
HOVERGENiHBG081220
InParanoidiE9Q793
OMAiTQIMEQH
OrthoDBi1114555at2759
TreeFamiTF335473

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E9Q793

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032023 Expressed in 24 organ(s), highest expression level in testis
GenevisibleiE9Q793 MM

Family and domain databases

InterProiView protein in InterPro
IPR027968 JHY
PfamiView protein in Pfam
PF15261 JHY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJHY_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q793
Secondary accession number(s): E0CX29, Q9CUE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: April 5, 2011
Last modified: January 16, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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