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Protein
Submitted name:

A kinase (PRKA) anchor protein 11

Gene

Akap11

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A kinase (PRKA) anchor protein 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2684060 Akap11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E9Q774

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q774

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q774

PeptideAtlas

More...
PeptideAtlasi
E9Q774

PRoteomics IDEntifications database

More...
PRIDEi
E9Q774

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022016 Expressed in 241 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E9Q774 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q774 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000022593

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEQB Eukaryota
ENOG410ZS5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159558

Database of Orthologous Groups

More...
OrthoDBi
43913at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008382 SPHK1-interactor_AKAP_110

The PANTHER Classification System

More...
PANTHERi
PTHR10226 PTHR10226, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E9Q774-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFQPLRSS HLKSKASVRK SFSEDVFRSV KSLLQSEKEL CSVSGGECLN
60 70 80 90 100
QDEHPQLTEV TFLGFNEETD AAHIQDLAAV SLELPDLLNS LHFCSLSENE
110 120 130 140 150
IICMKDTSKS SNVSSSPLNQ SHHSGMLCVM RVSPTLPGLR IDFIFSLLSK
160 170 180 190 200
YAAGIRHTLD MHAHPQHHLE TTDEDDDDTN QSVSSIEDDF VTAFEQLEEE
210 220 230 240 250
ENAKLYNDEI NIATLRSRCD AASQTTSGHH LESHDLKVLV SYGSPKSLAK
260 270 280 290 300
PSPSVNVLGR KEAASVKTSV TTSVSEPWTQ RSLYRCPSAS DKDKDTQETF
310 320 330 340 350
FPSPVYSSES ECSSPSPVIF LDEEGYQKSL KAKLELPEIP VTKDDVEDSD
360 370 380 390 400
SEVSEFFDSF DQFDELEQTL ETYLLMEDPI IGKSSQKIGH KYEKSCMNPQ
410 420 430 440 450
KFKFERPALP ANVRKPTPRK PESPYGHLSD APDSPRPVMT SEDSGLFSPI
460 470 480 490 500
RTSAFSPPGS CTPAEWFCQT DTSENRNHEN YCTYEDYANN LSCEVLGSVL
510 520 530 540 550
HTQHANTMSD INSIKRGRNH TVTFKYGDSD QKSKCKKSSV ITGSVQKFAA
560 570 580 590 600
DLVGKSLGSA FKDLQKGVSS CTNTLCHLAV KLTSSVFQMA FNELRRQCAF
610 620 630 640 650
SLKERAIGSL ASLLVSDALS NALKDLQYVK KQMFTNTVAR FAADLAEELV
660 670 680 690 700
FEGIMEVCQF SCPQTPASSQ CQSFDFEDKV VKSYAKDLSE SVIQEAFIEL
710 720 730 740 750
SQTNVTFTTK AAVNVSMGNV KYVSAESVSP TQTFTFSSSF SGQAVMMTKP
760 770 780 790 800
MQEHKKEYTV QQALFCTSGI VTSIPVPLAG SALLPYHMSS TLYPSKCLSS
810 820 830 840 850
EPSKASGGST QEHIAIERSA EEVDCLRSTC LPSELNPCNQ NDFKPTNGDI
860 870 880 890 900
DRQSPSKLMS GPVIISNFSA AMVHTIVNET LESMTSFKAT KTIDTNADYL
910 920 930 940 950
TKTIKGKACS PSLCDQAAPQ ENKASSKDMF AEQLSKSIIK HSLDKSKSML
960 970 980 990 1000
PNRDKKPGSK EHVLVLGEES QMTLGETPKF LDFSDNSPHR SLLVGNYCVA
1010 1020 1030 1040 1050
ECKDSVGFGF SLEALPPCSM MTNQKSDLKE VVKDKEVTRH NLNNTALEPM
1060 1070 1080 1090 1100
PFGQESSFRH SQTFSSAVLT CVDGLHEEDK QKIRDRNVIP DTPPSTPLVP
1110 1120 1130 1140 1150
SQTSSEWDIK TLSKQLKGEL AKEFAPATPP STPHNSSVGS LSENEQTTIE
1160 1170 1180 1190 1200
KEEFMLKLMR SLSEEVESSE GEEHPGMHVK AEHPGKKVQF AEAFATHIIS
1210 1220 1230 1240 1250
LATEAAASHL DHETTQEFKV QNPHLNVPSQ RNVLPALSHS DESIQTCTFA
1260 1270 1280 1290 1300
SDMAADVIAE AEKIANARSC MLFRHERNIC HVEGGRGKAE EKLDVEDVAH
1310 1320 1330 1340 1350
PREVDTCVLS LPSGMPGLTY KYPSCESVTD EYAGHVIQVL QQQGGSGELI
1360 1370 1380 1390 1400
MEQYASRLAY RSVTAAAREA AKTVKMKCGS KLFPLHGCHG KTNKELLVFS
1410 1420 1430 1440 1450
SKERHQEVDR QRKRNGSHLC KYQTCERTQD PCRNELSELY SFSASLASSI
1460 1470 1480 1490 1500
TRDAKKQLTA PKVDLPKSST DGCFFEKSEC VDSSENVTGP ERSKSCQPLQ
1510 1520 1530 1540 1550
SHGFCQNTGY LSGYSCAENA QAIEQYARKV VGDTLELSLG PTVFHNSETT
1560 1570 1580 1590 1600
ASADRITYAE KLSPLINEAC RYCDLKEFHG CTRNSAQLFS KQSPCASAKP
1610 1620 1630 1640 1650
SSRSKLSSIR QKSRIFHLDV PQIHVNLDKR AVLAEKIVAE AIEKAERELS
1660 1670 1680 1690 1700
NTSLAADSGI GQDGISFAES LTTEIMTTAV TNAGHAVSSS REIEDFQSTE
1710 1720 1730 1740 1750
SLGSQQMNLS VGEDSTGSWS NLSFEDDHQD ESSSFHHLSE SSNGNSSSWS
1760 1770 1780 1790 1800
SLGLEGDLYE DNLSFPTSDS DGSDDGDDEQ EDGVEDLQQN GKTLLIMNID
1810 1820 1830 1840 1850
MEPGAVDPQL RIILQWLIAS EAEVAELYFQ DSAKKEFILL SKQLQEKGWK
1860 1870 1880 1890
VGDVLQAVLK YYEVVEKPSR EERCKSLFDW LLENAQNRLQ TSMLV
Length:1,895
Mass (Da):208,848
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34A1AFDC6F7A489F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q777E9Q777_MOUSE
A kinase (PRKA) anchor protein 11
Akap11
1,894Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC161608 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001333713.1, NM_001346784.1
XP_006518961.2, XM_006518898.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.89413

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000022593; ENSMUSP00000022593; ENSMUSG00000022016

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219181

UCSC genome browser

More...
UCSCi
uc007usi.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC161608 Genomic DNA No translation available.
RefSeqiNP_001333713.1, NM_001346784.1
XP_006518961.2, XM_006518898.3
UniGeneiMm.89413

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022593

Proteomic databases

jPOSTiE9Q774
MaxQBiE9Q774
PaxDbiE9Q774
PeptideAtlasiE9Q774
PRIDEiE9Q774

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022593; ENSMUSP00000022593; ENSMUSG00000022016
GeneIDi219181
UCSCiuc007usi.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11215
MGIiMGI:2684060 Akap11

Phylogenomic databases

eggNOGiENOG410IEQB Eukaryota
ENOG410ZS5D LUCA
GeneTreeiENSGT00940000159558
OrthoDBi43913at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022016 Expressed in 241 organ(s), highest expression level in brain
ExpressionAtlasiE9Q774 baseline and differential
GenevisibleiE9Q774 MM

Family and domain databases

InterProiView protein in InterPro
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q774_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q774
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: February 28, 2018
Last modified: January 16, 2019
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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