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UniProtKB - E9Q708 (E9Q708_MOUSE)
Protein
Receptor protein-tyrosine kinase
Gene
Fgfr2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 427 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 536 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- fibroblast growth factor-activated receptor activity Source: InterPro
- protein serine/threonine/tyrosine kinase activity Source: RHEA
GO - Biological processi
- animal organ development Source: UniProt
- positive regulation of cell population proliferation Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Fgfr2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95523, Fgfr2 |
VEuPathDBi | HostDB:ENSMUSG00000030849 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003244472 | 22 – 731 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 710 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
jPOSTi | E9Q708 |
MaxQBi | E9Q708 |
ProteomicsDBi | 316632 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030849, Expressed in adrenal gland and 453 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 158 | Ig-likeInterPro annotationAdd BLAST | 94 | |
Domaini | 167 – 267 | Ig-likeInterPro annotationAdd BLAST | 101 | |
Domaini | 391 – 680 | Protein kinaseInterPro annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 63 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 52 | Acidic residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155447 |
HOGENOMi | CLU_000288_74_1_1 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR016248, FGF_rcpt_fam IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000628, FGFR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
E9Q708-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSWGRFICL VLVTMATLSL ARPSFSLVED TTLEPEDAIS SGDDEDDTDS
60 70 80 90 100
SEDVVSENRS NQRAPYWTNT EKMEKRLHAV PAANTVKFRC PAGGNPTPTM
110 120 130 140 150
RWLKNGKEFK QEHRIGGYKV RNQHWSLIME SVVPSDKGNY TCLVENEYGS
160 170 180 190 200
INHTYHLDVV ERSPHRPILQ AGLPANASTV VGGDVEFVCK VYSDAQPHIQ
210 220 230 240 250
WIKHVEKNGS KYGPDGLPYL KVLKHSGINS SNAEVLALFN VTEMDAGEYI
260 270 280 290 300
CKVSNYIGQA NQSAWLTVLP KQQAPVREKE ITASPDYLEI AIYCIGVFLI
310 320 330 340 350
ACMVVTVIFC RMKTTTKKPD FSSQPAVHKL TKRIPLRRQV SAESSSSMNS
360 370 380 390 400
NTPLVRITTR LSSTADTPML AGVSEYELPE DPKWEFPRDK LTLGKPLGEG
410 420 430 440 450
CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM
460 470 480 490 500
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI
510 520 530 540 550
NRVPEEQMTF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM
560 570 580 590 600
KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG
610 620 630 640 650
VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPTNCTN ELYMMMRDCW
660 670 680 690 700
HAVPSQRPTF KQLVEDLDRI LTLTTNEEYL DLTQPLEQYS PSYPDTRSSC
710 720 730
SSGDDSVFSP DPMPYEPCLP QYPHINGSVK T
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP21803 | FGFR2_MOUSE | Fibroblast growth factor receptor 2 | Fgfr2 Bek, Ect1 | 821 | Annotation score: | ||
E9QK53 | E9QK53_MOUSE | Fibroblast growth factor receptor | Fgfr2 | 840 | Annotation score: | ||
E9PXV8 | E9PXV8_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 724 | Annotation score: | ||
D3Z5M8 | D3Z5M8_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 709 | Annotation score: | ||
E9PVU6 | E9PVU6_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 820 | Annotation score: | ||
E9PX67 | E9PX67_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 813 | Annotation score: | ||
E9Q7T0 | E9Q7T0_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 819 | Annotation score: | ||
E9Q7E8 | E9Q7E8_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 822 | Annotation score: | ||
E9PX90 | E9PX90_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 705 | Annotation score: | ||
E9PX60 | E9PX60_MOUSE | Receptor protein-tyrosine kinase | Fgfr2 | 695 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Genome annotation databases
Ensembli | ENSMUST00000120141; ENSMUSP00000113415; ENSMUSG00000030849 |
UCSCi | uc009jzs.1, mouse |
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | E9Q708 |
ModBasei | Search... |
Proteomic databases
jPOSTi | E9Q708 |
MaxQBi | E9Q708 |
ProteomicsDBi | 316632 |
Protocols and materials databases
Antibodypediai | 4393, 1345 antibodies from 47 providers |
Genome annotation databases
Ensembli | ENSMUST00000120141; ENSMUSP00000113415; ENSMUSG00000030849 |
UCSCi | uc009jzs.1, mouse |
Organism-specific databases
MGIi | MGI:95523, Fgfr2 |
VEuPathDBi | HostDB:ENSMUSG00000030849 |
Phylogenomic databases
GeneTreei | ENSGT00940000155447 |
HOGENOMi | CLU_000288_74_1_1 |
Miscellaneous databases
ChiTaRSi | Fgfr2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030849, Expressed in adrenal gland and 453 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR016248, FGF_rcpt_fam IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000628, FGFR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E9Q708_MOUSE | |
Accessioni | E9Q708Primary (citable) accession number: E9Q708 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 5, 2011 |
Last sequence update: | April 5, 2011 | |
Last modified: | January 19, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |