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Entry version 65 (08 May 2019)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Ubiquitin-specific peptidase 31

Gene

Usp31

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.071

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin-specific peptidase 31Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp31Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923429 Usp31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
E9Q6Y8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q6Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q6Y8

PeptideAtlas

More...
PeptideAtlasi
E9Q6Y8

PRoteomics IDEntifications database

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PRIDEi
E9Q6Y8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q6Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q6Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063317 Expressed in 223 organ(s), highest expression level in lumbar subsegment of spinal cord

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q6Y8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000040037

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
E9Q6Y8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini123 – 758USPInterPro annotationAdd BLAST636

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1870 Eukaryota
COG5560 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156355

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q6Y8

KEGG Orthology (KO)

More...
KOi
K11852

Identification of Orthologs from Complete Genome Data

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OMAi
KERHHQP

Database of Orthologous Groups

More...
OrthoDBi
1283205at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106278

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q6Y8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVTAPGPG PPVAAGGKEK RSFSKRLFRS GRAGGGGGAG GPGPAAPSSP
60 70 80 90 100
SSARSVGSFM SRVLKTLSTL SHLSSEGAAP DRGGLRSCFP PGPASAPTPP
110 120 130 140 150
PCPPPPASPA PPACASEPVP GVAGLRNHGN TCFMNATLQC LSNTELFAEY
160 170 180 190 200
LALGQYRAGR PEPEPESEQP AGRGPHGQGE VTEQLAHLVR ALWTLEYTPQ
210 220 230 240 250
HSRDFKSIVS KNALQYRGNS QHDAQEFLLW LLDRVHEDLN HAVKQSGQPP
260 270 280 290 300
LKPPSETDMM PEGPFPVCST FVQELFQAQY RSSLTCPHCQ KQSNTFDPFL
310 320 330 340 350
CISLPIPLPH TRPLYVTVVY QGKCSHCMRI GVAVPLSGTV ARLREAVSME
360 370 380 390 400
TKIPTDQIVL TEMYYDGFHR SFSDTDDLET VHESDCIFAF ETPEIFRPEG
410 420 430 440 450
ILSQRGIHLN NNLNHLKFGL DHHRLSSPAP TAAKQGRVDL PTRVASDKIV
460 470 480 490 500
LLVCNRACTG QQGKRFGLPF VLHLEKTVAW DLLQKEILEK MKYFLRPTVS
510 520 530 540 550
IQVCPFSLRV VSVVGITYLL PQEEQPLCHP TVERALKSCG PGGTAHVKLV
560 570 580 590 600
VEWDKETKDF LFVNTEDEYI PDAESVRLQK EQHHQPQTCT LSQCFQLYTK
610 620 630 640 650
EERLAPDDAW RCPHCKQLQQ GSITLSLWTL PDVLIIHLKR FRQEGDRRMK
660 670 680 690 700
LQNMVKFPLT GLDMTPHVVK RSQSSWSLPS HWSPWRRPYG LGRDPEDYIY
710 720 730 740 750
DLYAVCNHHG TMQGGHYTAY CKNSVDGLWY CFDDSDVQQL SEDEVCTQTA
760 770 780 790 800
YILFYQRRTA IPSWSANSSV AGSTSSSLCE HWVSRLPGSK QASVTSAASS
810 820 830 840 850
RRTSLASLSE SVEMTGERSE DDGGFSTRPF VRSVQRQSLS SRSSVTSPLA
860 870 880 890 900
VNENCMRPSW SLSAKLQMRS SSPSRFSGDS PIHGSASTLE RIGEAGDDKV
910 920 930 940 950
SISCFGSLRN LSGSHQEPSD SHNRREHKAV GRAPLAVMEG VFKDDSDPGK
960 970 980 990 1000
LNSSVVDTPS KNRAQGDHLP PVSDPFDNNN QIAYVDQSDS VDSSPVKEVK
1010 1020 1030 1040 1050
PPSHSDSLTK KPESTTKSSP SSKGTSEPEK NMRKGRPALA SQESSLSSPS
1060 1070 1080 1090 1100
PSSPVPVKVS MKPARCRSKA DSSRTSGRHS SSSSTQPKKE SSPRSQESMS
1110 1120 1130 1140 1150
SPSPQKQKSA SAFTYSSSSI SAKKAPSPVT RGPFPSGKSR TSDRSLSREG
1160 1170 1180 1190 1200
SRQSLGSDRA SVTSTSTSKP SSPRVNQARA GDNRVDGKHV RSSSMASLRS
1210 1220 1230 1240 1250
PSTSVRSGLK RDSKSEDKGL SFFKSALRQK ETRRSTDLGK TTLLSKKAGG
1260 1270 1280 1290 1300
SSVKSVSKNT ADDKTEKGHQ PPGSQQPNTN AVGKEQLVSK DPAKHSLLSA
1310 1320 1330 1340
RRSKSSQLDS GAPLSPSSRS TTEKGSKKLS SSMQTSARPS QKPQ
Length:1,344
Mass (Da):146,319
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i200CC34173E82FF7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC134870 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001028345.1, NM_001033173.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046929; ENSMUSP00000040037; ENSMUSG00000063317

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76179

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76179

UCSC genome browser

More...
UCSCi
uc012ftd.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134870 Genomic DNA No translation available.
RefSeqiNP_001028345.1, NM_001033173.1

3D structure databases

SMRiE9Q6Y8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040037

Protein family/group databases

MEROPSiC19.071

PTM databases

iPTMnetiE9Q6Y8
PhosphoSitePlusiE9Q6Y8

Proteomic databases

EPDiE9Q6Y8
MaxQBiE9Q6Y8
PaxDbiE9Q6Y8
PeptideAtlasiE9Q6Y8
PRIDEiE9Q6Y8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046929; ENSMUSP00000040037; ENSMUSG00000063317
GeneIDi76179
KEGGimmu:76179
UCSCiuc012ftd.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57478
MGIiMGI:1923429 Usp31

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00940000156355
InParanoidiE9Q6Y8
KOiK11852
OMAiKERHHQP
OrthoDBi1283205at2759
TreeFamiTF106278

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063317 Expressed in 223 organ(s), highest expression level in lumbar subsegment of spinal cord
GenevisibleiE9Q6Y8 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q6Y8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q6Y8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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