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Protein

Zinc finger protein 296

Gene

Znf296

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional corepressor with KLF4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 296Imported
Alternative name(s):
Hepatocellular carcinoma-associated antigen MHCA1081 Publication
Gene namesi
Name:Znf296By similarity
Synonyms:Zfp296Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1926956 Zfp296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004367741 – 445Zinc finger protein 296Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiE9Q6W4
PeptideAtlasiE9Q6W4
PRIDEiE9Q6W4

PTM databases

iPTMnetiE9Q6W4
PhosphoSitePlusiE9Q6W4

Expressioni

Tissue specificityi

Strongly expressed in testis and embryonic stem cells.1 Publication

Developmental stagei

In testis, detected in condensing spermatids but not at earlier stages of spermatogenesis (PubMed:11063263). In embryonic stem cells, expressed in undifferentiated cells and down-regulated upon differentiation (PubMed:24161396).2 Publications

Gene expression databases

BgeeiENSMUSG00000011267 Expressed in 71 organ(s), highest expression level in primary oocyte
GenevisibleiE9Q6W4 MM

Interactioni

Subunit structurei

Interacts with KLF4.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104093

Structurei

3D structure databases

ProteinModelPortaliE9Q6W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri138 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri212 – 234C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 441C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063542
HOGENOMiHOG000152395
HOVERGENiHBG071356
InParanoidiE9Q6W4
OMAiLGARNPW
OrthoDBiEOG091G09UH
TreeFamiTF318131

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

E9Q6W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKAGRVP RRVDPDTDTD IEMPDLVMDV KPDLDLRSLA QGPWIARDMP
60 70 80 90 100
ISDVKRQLQT ASRPLGAPST CAPRMPLSSK SSDRQPWTDK HPDLLTCGRC
110 120 130 140 150
GKIFPLGAII AFMDHKKQGC QLLQVSDPIS ESKELKALSC LQCGRQYTSP
160 170 180 190 200
WKLLCHAQWD HGLCIYQTQH LDTPEAPLLG LAEVAAAMSA VAVVAPVESK
210 220 230 240 250
PPPVSSAARR SPTCDVCKKT LSSFSNLKVH MRSHTGERPY SCDQCSYACA
260 270 280 290 300
QSSKLNRHKK THRQLAPGSP STSASSRGVS PAAPPEPAAY AAAPASTLPS
310 320 330 340 350
QTVEKAGAAA TAGVQEPGAP GSGAQGGPGF VGWGAPAKVE RTDPVKIEKT
360 370 380 390 400
APRKSHGPGG KCEFCGKSFT NSSNLTVHRR SHTGERPYTC DQCPYACAQS
410 420 430 440
SKLNRHRRTH GLGTGKTVKC PHCLVPFGLQ ATLDKHLRQK HPEMA
Length:445
Mass (Da):47,821
Last modified:April 5, 2011 - v1
Checksum:i14D51519D2B028AD
GO

Sequence cautioni

The sequence AAN76749 differs from that shown. Reason: Frameshift at position 437.Curated
The sequence BAB25873 differs from that shown. Reason: Frameshift at position 437.Curated
The sequence CAC18551 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EDL23160 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88T → I in AAH99454 (PubMed:15489334).Curated1
Sequence conflicti138L → P in AAN76749 (Ref. 1) Curated1
Sequence conflicti138L → P in BAB25873 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450095 mRNA Translation: AAN76749.1 Frameshift.
AK008748 mRNA Translation: BAB25873.1 Frameshift.
AC149052 Genomic DNA No translation available.
CH466639 Genomic DNA Translation: EDL23160.1 Sequence problems.
BC099454 mRNA Translation: AAH99454.1
AJ278340 mRNA Translation: CAC18551.1 Different initiation.
CCDSiCCDS52060.1
RefSeqiNP_071854.2, NM_022409.2
UniGeneiMm.23310

Genome annotation databases

EnsembliENSMUST00000108453; ENSMUSP00000104093; ENSMUSG00000011267
GeneIDi63872
KEGGimmu:63872
UCSCiuc009fmj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450095 mRNA Translation: AAN76749.1 Frameshift.
AK008748 mRNA Translation: BAB25873.1 Frameshift.
AC149052 Genomic DNA No translation available.
CH466639 Genomic DNA Translation: EDL23160.1 Sequence problems.
BC099454 mRNA Translation: AAH99454.1
AJ278340 mRNA Translation: CAC18551.1 Different initiation.
CCDSiCCDS52060.1
RefSeqiNP_071854.2, NM_022409.2
UniGeneiMm.23310

3D structure databases

ProteinModelPortaliE9Q6W4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104093

PTM databases

iPTMnetiE9Q6W4
PhosphoSitePlusiE9Q6W4

Proteomic databases

PaxDbiE9Q6W4
PeptideAtlasiE9Q6W4
PRIDEiE9Q6W4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108453; ENSMUSP00000104093; ENSMUSG00000011267
GeneIDi63872
KEGGimmu:63872
UCSCiuc009fmj.2 mouse

Organism-specific databases

CTDi63872
MGIiMGI:1926956 Zfp296

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063542
HOGENOMiHOG000152395
HOVERGENiHBG071356
InParanoidiE9Q6W4
OMAiLGARNPW
OrthoDBiEOG091G09UH
TreeFamiTF318131

Miscellaneous databases

PROiPR:E9Q6W4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011267 Expressed in 71 organ(s), highest expression level in primary oocyte
GenevisibleiE9Q6W4 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN296_MOUSE
AccessioniPrimary (citable) accession number: E9Q6W4
Secondary accession number(s): Q4FZI6, Q9D7X0, Q9EPM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 6, 2016
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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