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Protein
Submitted name:

Utrophin

Gene

Utrn

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingUniRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
UtrophinImported
Gene namesi
Name:UtrnImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:104631 Utrn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotation, Cytoplasm, CytoskeletonUniRule annotation, Membrane, Postsynaptic cell membraneUniRule annotation, Synapse

Expressioni

Gene expression databases

BgeeiENSMUSG00000019820 Expressed in 306 organ(s), highest expression level in cochlea
GenevisibleiE9Q6R7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiE9Q6R7, 1 interactor
E9Q6R7, 1 interactor
STRINGi10090.ENSMUSP00000076093

Structurei

3D structure databases

ProteinModelPortaliE9Q6R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 135Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini150 – 255Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini2810 – 2843WWInterPro annotationAdd BLAST34
Domaini3062 – 3109ZZ-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili453 – 476Sequence analysisAdd BLAST24
Coiled coili573 – 593Sequence analysisAdd BLAST21
Coiled coili793 – 813Sequence analysisAdd BLAST21
Coiled coili879 – 906Sequence analysisAdd BLAST28
Coiled coili943 – 977Sequence analysisAdd BLAST35
Coiled coili1099 – 1147Sequence analysisAdd BLAST49
Coiled coili1161 – 1188Sequence analysisAdd BLAST28
Coiled coili1377 – 1397Sequence analysisAdd BLAST21
Coiled coili1683 – 1710Sequence analysisAdd BLAST28
Coiled coili1769 – 1789Sequence analysisAdd BLAST21
Coiled coili1802 – 1822Sequence analysisAdd BLAST21
Coiled coili2257 – 2277Sequence analysisAdd BLAST21
Coiled coili2483 – 2503Sequence analysisAdd BLAST21
Coiled coili2549 – 2583Sequence analysisAdd BLAST35
Coiled coili2684 – 2711Sequence analysisAdd BLAST28
Coiled coili3251 – 3288Sequence analysisAdd BLAST38
Coiled coili3323 – 3353Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237
InParanoidiE9Q6R7
OMAiNFLKWIQ
OrthoDBiEOG091G001Y
TreeFamiTF320178

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 7 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 20 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E9Q6R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKYGDLEAR PDDGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
60 70 80 90 100
PPISDMFSDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
110 120 130 140 150
HQNNVDLVNI GGTDIVDGNP KLTLGLLWSI ILHWQVKDVM KDIMSDLQQT
160 170 180 190 200
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
210 220 230 240 250
RVVKMSPIER LEHAFSKAHT YLGIEKLLDP EDVAVHLPDK KSIIMYLTSL
260 270 280 290 300
FEVLPQQVTI DAIREVETLP RKYKKECEEE EIHIQSAVLA EEGQSPRAET
310 320 330 340 350
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKEQFA
360 370 380 390 400
THETFMMELT AHQSSVGSVL QAGNQLMTQG TLSEEEEFEI QEQMTLLNAR
410 420 430 440 450
WEALRVESME RQSRLHDALM ELQKKQLQQL SSWLALTEER IQKMESLPLG
460 470 480 490 500
DDLPSLQKLL QEHKSLQNDL EAEQVKVNSL THMVVIVDEN SGESATALLE
510 520 530 540 550
DQLQKLGERW TAVCRWTEER WNRLQEISIL WQELLEEQCL LEAWLTEKEE
560 570 580 590 600
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
610 620 630 640 650
LSNPKASKKM NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
660 670 680 690 700
DLLETVHVRE QGMVKKPKQE LPPPPPPKKR QIHVDVEAKK KFDAISTELL
710 720 730 740 750
NWILKSKTAI QNTEMKEYKK SQETSGMKKK LKGLEKEQKE NLPRLDELNQ
760 770 780 790 800
TGQTLREQMG KEGLSTEEVN DVLERVSLEW KMISQQLEDL GRKIQLQEDI
810 820 830 840 850
NAYFKQLDAI EETIKEKEEW LRGTPISESP RQPLPGLKDS CQRELTDLLG
860 870 880 890 900
LHPRIETLCA SCSALKSQPC VPGFVQQGFD DLRHHYQAVR KALEEYQQQL
910 920 930 940 950
ENELKSQPGP AYLDTLNTLK KMLSESEKAA QASLNALNDP IAVEQALQEK
960 970 980 990 1000
KALDETLENQ KHTLHKLSEE TKTLEKNMLP DVGKMYKQEF DDVQGRWNKV
1010 1020 1030 1040 1050
KTKVSRDLHL LEEITPRLRD FEADSEVIEK WVSGIKDFLM KEQAAQGDAA
1060 1070 1080 1090 1100
ALQSQLDQCA TFANEIETIE SSLKNMREVE TSLQRCPVTG VKTWVQARLV
1110 1120 1130 1140 1150
DYQSQLEKFS KEIAIQKSRL SDSQEKALNL KKDLAEMQEW MAQAEEDYLE
1160 1170 1180 1190 1200
RDFEYKSPEE LESAVEEMKR AKEEVLQKEV RVKILKDSIK LVAAKVPSGG
1210 1220 1230 1240 1250
QELTSEFNEV LESYQLLCNR IRGKCHTLEE VWSCWVELLH YLDLETTWLN
1260 1270 1280 1290 1300
TLEERVRSTE ALPERAEAVH EALESLESVL RHPADNRTQI RELGQTLIDG
1310 1320 1330 1340 1350
GILDDIISEK LEAFNSRYEE LSHLAESKQI SLEKQLQVLR ETDHMLQVLK
1360 1370 1380 1390 1400
ESLGELDKQL TTYLTDRIDA FQLPQEAQKI QAEISAHELT LEELRKNVRS
1410 1420 1430 1440 1450
QPPTSPEGRA TRGGSQMDML QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1460 1470 1480 1490 1500
LEGVKAELHV LDVRDVDPDV IQAHLDKCMK LYKTLSEVKL EVETVIKTGR
1510 1520 1530 1540 1550
HIVQKQQTDN PKSMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLSRKMK
1560 1570 1580 1590 1600
KEAAVLSEWL SATEAELVQK STSEGVIGDL DTEISWAKSI LKDLEKRKVD
1610 1620 1630 1640 1650
LNGITESSAA LQHLVLGSES VLEENLCVLN AGWSRVRTWT EDWCNTLLNH
1660 1670 1680 1690 1700
QNQLELFDGH VAHISTWLYQ AEALLDEIEK KPASKQEEIV KRLLSELDDA
1710 1720 1730 1740 1750
SLQVENVREQ AIILVNARGS ASRELVEPKL AELSRNFEKV SQHIKSARML
1760 1770 1780 1790 1800
IGQDPSSYQG LDPAGTVQAA ESFSDLENLE QDIENMLKVV EKHLDPNNDE
1810 1820 1830 1840 1850
KMDEEQAQIE EVLQRGEHLL HEPMEDSKKE KIRLQLLLLH TRYNKIKTIP
1860 1870 1880 1890 1900
IQQRKTIPVS SGITSSALPA DYLVEINKIL LTLDDIELSL NMPELNTTVY
1910 1920 1930 1940 1950
KDFSFQEDSL KSIKGQLDRL GEQIAVVHEK QPDVIVEASG PEAIQIRDML
1960 1970 1980 1990 2000
AQLNAKWDRV NRVYSDRRGS FARAVEEWRQ FHHDLDDLTQ WLSEAEDLLV
2010 2020 2030 2040 2050
DTCAPDGSLD LEKARAQQLE LEEGLSSHQP SLIKVNRKGE DLVQRLRPSE
2060 2070 2080 2090 2100
ASFLKEKLAG FNQRWSTLVA EVEALQPRLK GESQQVLGYK RRLDEVTCWL
2110 2120 2130 2140 2150
TKVESAVQKR STPDPEESPQ ELTDLAQETE VQAENIKWLN RAELEMLSDK
2160 2170 2180 2190 2200
NLSLREREKL SESLRNVNTT WTKVCREVPS LLKTRTQDPC SAPQMRMAAH
2210 2220 2230 2240 2250
PNVQKVVLVS SASDAPLRGG LEISVPADLD KTITELADWL VLIDQMLKSN
2260 2270 2280 2290 2300
IVTVGDVKEI NKTVSRMKIT KADLEQRHPQ LDCVFTLAQN LKNKASSSDV
2310 2320 2330 2340 2350
RTAITEKLEK LKTQWESTQH GVELRRQQLE DMVVDSLQWD DHREETEELM
2360 2370 2380 2390 2400
RKYEARFYML QQARRDPLSK QVSDNQLLLQ ELGSGDGVIM AFDNVLQKLL
2410 2420 2430 2440 2450
EEYSGDDTRN VEETTEYLKT SWVNLKQSIA DRQSALEAEL QTVQTSRRDL
2460 2470 2480 2490 2500
ENFVKWLQEA ETTANVLADA SQRENALQDS VLARQLRQQM LDIQAEIDAH
2510 2520 2530 2540 2550
NDIFKSIDGN RQKMVKALGN SEEATMLQHR LDDMNQRWND LKAKSASIRA
2560 2570 2580 2590 2600
HLEASAEKWN RLLASLEELI KWLNMKDEEL KKQMPIGGDV PALQLQYDHC
2610 2620 2630 2640 2650
KVLRRELKEK EYSVLNAVDQ ARVFLADQPI EAPEEPRRNP QSKTELTPEE
2660 2670 2680 2690 2700
RAQKIAKAMR KQSSEVREKW ENLNAVTSNW QKQVGKALEK LRDLQGAMDD
2710 2720 2730 2740 2750
LDADMKEVEA VRNGWKPVGD LLIDSLQDHI EKTLAFREEI APINLKVKTM
2760 2770 2780 2790 2800
NDLSSQLSPL DLHPSLKMSR QLDDLNMRWK LLQVSVDDRL KQLQEAHRDF
2810 2820 2830 2840 2850
GPSSQHFLST SVQLPWQRSI SHNKVPYYIN HQTQTTCWDH PKMTELFQSL
2860 2870 2880 2890 2900
ADLNNVRFSA YRTAIKIRRL QKALCLDLLE LNTTNEVFKQ HKLNQNDQLL
2910 2920 2930 2940 2950
SVPDVINCLT TTYDGLEQLH KDLVNVPLCV DMCLNWLLNV YDTGRTGKIR
2960 2970 2980 2990 3000
VQSLKIGLMS LSKGLLEEKY RCLFKEVAGP TEMCDQRQLG LLLHDAIQIP
3010 3020 3030 3040 3050
RQLGEVAAFG GSNIEPSVRS CFQQNNNKPE ISVKEFIDWM HLEPQSMVWL
3060 3070 3080 3090 3100
PVLHRVAAAE TAKHQAKCNI CKECPIVGFR YRSLKHFNYD VCQSCFFSGR
3110 3120 3130 3140 3150
TAKGHKLHYP MVEYCIPTTS GEDVRDFTKV LKNKFRSKKY FAKHPRLGYL
3160 3170 3180 3190 3200
PVQTVLEGDN LETPITLISM WPEHYDPSQS PQLFHDDTHS RIEQYATRLA
3210 3220 3230 3240 3250
QMERTNGSFL TDSSSTTGSV EDEHALIQQY CQTLGGESPV SQPQSPAQIL
3260 3270 3280 3290 3300
KSVEREERGE LERIIADLEE EQRNLQVEYE QLKEQHLRRG LPVGSPPDSI
3310 3320 3330 3340 3350
VSPHHTSEDS ELIAEAKLLR QHKGRLEARM QILEDHNKQL ESQLHRLRQL
3360 3370 3380 3390 3400
LEQPDSDSRI NGVSPWASPQ HSALSYSLDT DPGPQFHQAA SEDLLAPPHD
3410 3420 3430
TSTDLTDVME QINSTFPSCS SNVPSRPQAM
Length:3,430
Mass (Da):392,706
Last modified:April 5, 2011 - v1
Checksum:iEBC824263FCB72E2
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q61636Q61636_MOUSE
G-utrophin (Predicted protein)
Utrn G-utrophin
987Annotation score:
A0A1W2P7C0A0A1W2P7C0_MOUSE
Utrophin
Utrn
956Annotation score:
A0A1W2P8A5A0A1W2P8A5_MOUSE
Utrophin
Utrn
732Annotation score:
A0A1W2P8G5A0A1W2P8G5_MOUSE
Utrophin
Utrn
730Annotation score:
A0A1W2P6L4A0A1W2P6L4_MOUSE
Utrophin
Utrn
186Annotation score:
A0A1W2P6H3A0A1W2P6H3_MOUSE
Utrophin
Utrn
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122734 Genomic DNA No translation available.
AC153565 Genomic DNA No translation available.
AC153893 Genomic DNA No translation available.
AC156952 Genomic DNA No translation available.
RefSeqiNP_035812.3, NM_011682.4
XP_006512770.1, XM_006512707.3
XP_006512771.1, XM_006512708.3
XP_006512772.1, XM_006512709.3
XP_006512773.1, XM_006512710.3
UniGeneiMm.331784
Mm.418026

Genome annotation databases

EnsembliENSMUST00000076817; ENSMUSP00000076093; ENSMUSG00000019820
ENSMUST00000218635; ENSMUSP00000151431; ENSMUSG00000019820
GeneIDi22288
KEGGimmu:22288
UCSCiuc007ejw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122734 Genomic DNA No translation available.
AC153565 Genomic DNA No translation available.
AC153893 Genomic DNA No translation available.
AC156952 Genomic DNA No translation available.
RefSeqiNP_035812.3, NM_011682.4
XP_006512770.1, XM_006512707.3
XP_006512771.1, XM_006512708.3
XP_006512772.1, XM_006512709.3
XP_006512773.1, XM_006512710.3
UniGeneiMm.331784
Mm.418026

3D structure databases

ProteinModelPortaliE9Q6R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q6R7, 1 interactor
E9Q6R7, 1 interactor
STRINGi10090.ENSMUSP00000076093

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076817; ENSMUSP00000076093; ENSMUSG00000019820
ENSMUST00000218635; ENSMUSP00000151431; ENSMUSG00000019820
GeneIDi22288
KEGGimmu:22288
UCSCiuc007ejw.1 mouse

Organism-specific databases

CTDi7402
MGIiMGI:104631 Utrn

Phylogenomic databases

eggNOGiKOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000119237
InParanoidiE9Q6R7
OMAiNFLKWIQ
OrthoDBiEOG091G001Y
TreeFamiTF320178

Miscellaneous databases

ChiTaRSiUtrn mouse
PROiPR:E9Q6R7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019820 Expressed in 306 organ(s), highest expression level in cochlea
GenevisibleiE9Q6R7 MM

Family and domain databases

CDDicd00014 CH, 2 hits
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035436 Dystrophin/utrophin
IPR011992 EF-hand-dom_pair
IPR015153 EF-hand_dom_typ1
IPR015154 EF-hand_dom_typ2
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR001202 WW_dom
IPR036020 WW_dom_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF09068 EF-hand_2, 1 hit
PF09069 EF-hand_3, 1 hit
PF00435 Spectrin, 7 hits
PF00397 WW, 1 hit
PF00569 ZZ, 1 hit
PIRSFiPIRSF002341 Dystrophin/utrophin, 3 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00150 SPEC, 20 hits
SM00456 WW, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
SSF47576 SSF47576, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q6R7_MOUSE
AccessioniPrimary (citable) accession number: E9Q6R7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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