Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Voltage-dependent T-type calcium channel subunit alpha-1H

Gene

Cacna1h

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent T-type calcium channel subunit alpha-1HImported
Gene namesi
Name:Cacna1hImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1928842 Cacna1h

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei233 – 256HelicalSequence analysisAdd BLAST24
Transmembranei366 – 387HelicalSequence analysisAdd BLAST22
Transmembranei393 – 418HelicalSequence analysisAdd BLAST26
Transmembranei912 – 934HelicalSequence analysisAdd BLAST23
Transmembranei989 – 1012HelicalSequence analysisAdd BLAST24
Transmembranei1344 – 1365HelicalSequence analysisAdd BLAST22
Transmembranei1377 – 1403HelicalSequence analysisAdd BLAST27
Transmembranei1441 – 1463HelicalSequence analysisAdd BLAST23
Transmembranei1542 – 1566HelicalSequence analysisAdd BLAST25
Transmembranei1622 – 1641HelicalSequence analysisAdd BLAST20
Transmembranei1653 – 1674HelicalSequence analysisAdd BLAST22
Transmembranei1757 – 1777HelicalSequence analysisAdd BLAST21
Transmembranei1789 – 1809HelicalSequence analysisAdd BLAST21
Transmembranei1844 – 1865HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000024112 Expressed in 190 organ(s), highest expression level in heart

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 429Ion_transInterPro annotationAdd BLAST331
Domaini790 – 1018Ion_transInterPro annotationAdd BLAST229
Domaini1304 – 1576Ion_transInterPro annotationAdd BLAST273
Domaini1622 – 1874Ion_transInterPro annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1575 – 1602Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128242
OMAiTEGYPRI
OrthoDBiEOG091G02L1
TreeFamiTF313555

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q6P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEGTLAADE VRVPLGASPS APAAPVRASP ASPGVPGREE QRGSGSSVLA
60 70 80 90 100
PESPGTECGA DLGADEEQPV PYPALAATVF FCLGQTTRPR SWCLRLVCNP
110 120 130 140 150
WFEHISMLVI MLNCVTLGMF RPCEDVECRS ERCSILEAFD DFIFAFFAVE
160 170 180 190 200
MVIKMVALGL FGQKCYLGDT WNRLDFFIVM AGMMEYSLDG HNVSLSAIRT
210 220 230 240 250
VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ
260 270 280 290 300
LWAGLLRNRC FLDSAFVRNN NLTFLRPYYQ TEEGEENPFI CSSRRDNGMQ
310 320 330 340 350
KCSHIPSRRE LRVQCTLGWE AYGQPQAEDG GAGRNACINW NQYYNVCRSG
360 370 380 390 400
EFNPHNGAIN FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI
410 420 430 440 450
LLIIVGSFFM INLCLVVIAT QFSETKQREN QLMREQRARY LSNDSTLASF
460 470 480 490 500
SEPGSCYEEL LKYVGHIFRK VKRRSLRLYA RWQSRWRKKV DPSSTLHGQG
510 520 530 540 550
PRRRPRRAGR RTASVHHLVY HHHHHHHHHY HFSHGGPRRP SPEPGAGDTR
560 570 580 590 600
LVRACVPPSP PSPGHGPPDS ESVHSIYHAD CHVEGPQERA RVAHTIATAA
610 620 630 640 650
SLKLASGLGT MNYPTILPSG AVNSKGSTSS RPKGLRSAGT PGATAHSPLS
660 670 680 690 700
LGSPSPYEKI QHVVGEQGLG RASSHLSGLS VPCPLPSPQA GTLTCELKSC
710 720 730 740 750
PYCASALEDP EFEFSGSESG DSDAHGVYEF TQDVRHGDCR DPVQQPHEGG
760 770 780 790 800
TPGHGNERWR PPLRTASQPG GLGRLWASFS SKLRRIVDSK YFNRGIMAAI
810 820 830 840 850
LVNTLSMGVE YHEQPDELTN ALEISNIVFT SMFALEMLLK LLACGPLGYI
860 870 880 890 900
RNPYNIFDGI VVIISVWEIV GQADGGLSVL RTFRLLRVLK LVRFLPALRR
910 920 930 940 950
QLVVLMRTMD NVATFCMLLM LFIFIFSILG MHLFGCKFSL KTDSGDTVPD
960 970 980 990 1000
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSSWAAL YFVALMTFGN
1010 1020 1030 1040 1050
YVLFNLLVAI LVEGFQAEGD ATRSDTDEDK TSTHLEEDFD KLRDVQATEM
1060 1070 1080 1090 1100
KMYSLAVTPN GHLEGRGSLP PPLITHTAAT PMPTPKSSPH LDMAHTLLDS
1110 1120 1130 1140 1150
RRSSSGSVDP QLGDQKSLAS LRSSPCAPWG PNSAGSSRRS SWNSLGRAPS
1160 1170 1180 1190 1200
LKRRSQCGER ESLLSGEGKG STDDEAEDSR PNSGTHPGAS PGPRATPLRR
1210 1220 1230 1240 1250
AESLGHRSTM DLCPPRPATL LPTKFRDCNG QMVALPSEFF LRIDSHKEDA
1260 1270 1280 1290 1300
AEFDDDIEDS CCFRLHKVLE PYAPQWCSSR ESWALYLFPP QNRLRVSCQK
1310 1320 1330 1340 1350
VIAHKMFDHV VLVFIFLNCI TIALERPDID PGSTERAFLS VSNYIFTAIF
1360 1370 1380 1390 1400
VVEMMVKVVA LGLLWGEHAY LQSSWNVLDG LLVLVSLVDI IVAVASAGGA
1410 1420 1430 1440 1450
KILGVLRVLR LLRTLRPLRV ISRAPGLKLV VETLISSLRP IGNIVLICCA
1460 1470 1480 1490 1500
FFIIFGILGV QLFKGKFYYC EGTDTRNITT KAECHAAHYR WVRRKYNFDN
1510 1520 1530 1540 1550
LGQALMSLFV LSSKDGWVNI MYDGLDAVGI DQQPVQNHNP WMLLYFISFL
1560 1570 1580 1590 1600
LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLERRRRKAQ
1610 1620 1630 1640 1650
RRPYYADYSH TRRSIHSLCT SHYLDLFITF IICLNVITMS MEHYNQPKSL
1660 1670 1680 1690 1700
DEALKYCNYV FTIVFVFEAA LKLVAFGFRR FFKDRWNQLD LAIVLLSIMG
1710 1720 1730 1740 1750
IALEEIEMNA ALPINPTIIR IMRVLRIARV LKLLKMATGM RALLDTVVQA
1760 1770 1780 1790 1800
LPQVGNLGLL FMLLFFIYAA LGVELFGRLE CSEDNPCEGL SRHATFTNFG
1810 1820 1830 1840 1850
MAFLTLFRVS TGDNWNGIMK DTLRECTRED KHCLSYLPAL SPVYFVTFVL
1860 1870 1880 1890 1900
VAQFVLVNVV VAVLMKHLEE SNKEAREDAE MDAEIELEIA QGSTAQPPST
1910 1920 1930 1940 1950
AQESQGTEPD TPNLLVVRKV SVSRMLSLPN DSYMFRPVAP AAAPHSHPLQ
1960 1970 1980 1990 2000
EVEMETYTGP VTSAHSPSLE PRTSFQVPSA ASSPARVSDP LCALSPRDTP
2010 2020 2030 2040 2050
RSLSLSRILC RQEAMHAESL EGQIDDAGED SIPDYTEPAE NISMSQAPLG
2060 2070 2080 2090 2100
TLRSPPCSPR PASVRTRKHT FGQHCISSRP PTLGGDDAEA ADPADEEVSH
2110 2120 2130 2140 2150
ITSSAHPWPA TEPHSPEASP TASPAKGTVG SGRDPHRFCS VDAQSFLDKP
2160 2170 2180 2190 2200
GRPDAQRWSS VELDNGDGHL ESGEVRARAS ELEPALGARR KKKMSPPCIS
2210 2220 2230 2240 2250
IDPPTEDEGS SRPPAAEGGN TTLRRRTPSC EAALHRDCPE STEGPGTGGD
2260 2270 2280 2290 2300
PVAKGERWGQ ASCRAEHLTV PNFAFEPLDM GGPGGDCFLD SDQSVTPEPR
2310 2320 2330 2340 2350
VSSLGAIVPL ILETELSMPS GDPPEKEQGL YLTVPQTPLK KPGSPPATPA

PDDSGDEPV
Length:2,359
Mass (Da):261,300
Last modified:April 5, 2011 - v1
Checksum:iEA595B7F2619EF9F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88427CAC1H_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h Kiaa1120
2,365Annotation score:
F6USE5F6USE5_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
293Annotation score:
E0CYZ3E0CYZ3_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
1,901Annotation score:
F6U5P7F6U5P7_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
49Annotation score:
E9Q6E4E9Q6E4_MOUSE
Voltage-dependent T-type calcium ch...
Cacna1h
147Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
RefSeqiNP_067390.4, NM_021415.4
UniGeneiMm.268378

Genome annotation databases

EnsembliENSMUST00000078496; ENSMUSP00000077586; ENSMUSG00000024112
ENSMUST00000159610; ENSMUSP00000125541; ENSMUSG00000024112
GeneIDi58226
UCSCiuc008bav.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122454 Genomic DNA No translation available.
AC131323 Genomic DNA No translation available.
RefSeqiNP_067390.4, NM_021415.4
UniGeneiMm.268378

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078496; ENSMUSP00000077586; ENSMUSG00000024112
ENSMUST00000159610; ENSMUSP00000125541; ENSMUSG00000024112
GeneIDi58226
UCSCiuc008bav.2 mouse

Organism-specific databases

CTDi8912
MGIiMGI:1928842 Cacna1h

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128242
OMAiTEGYPRI
OrthoDBiEOG091G02L1
TreeFamiTF313555

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024112 Expressed in 190 organ(s), highest expression level in heart

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q6P9_MOUSE
AccessioniPrimary (citable) accession number: E9Q6P9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again