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Entry version 79 (29 Sep 2021)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Leucine-rich repeat-containing protein 7

Gene

Lrrc7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Leucine-rich repeat-containing protein 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrrc7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2676665, Lrrc7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000028176

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q6L9

PeptideAtlas

More...
PeptideAtlasi
E9Q6L9

PRoteomics IDEntifications database

More...
PRIDEi
E9Q6L9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
363681

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
E9Q6L9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028176, Expressed in brain and 158 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1455 – 1540PDZInterPro annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni668 – 709DisorderedSequence analysisAdd BLAST42
Regioni790 – 812DisorderedSequence analysisAdd BLAST23
Regioni827 – 904DisorderedSequence analysisAdd BLAST78
Regioni1139 – 1163DisorderedSequence analysisAdd BLAST25
Regioni1201 – 1223DisorderedSequence analysisAdd BLAST23
Regioni1243 – 1270DisorderedSequence analysisAdd BLAST28
Regioni1337 – 1365DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi681 – 709Polar residuesSequence analysisAdd BLAST29
Compositional biasi837 – 858Polar residuesSequence analysisAdd BLAST22
Compositional biasi1337 – 1357Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeatARBA annotation, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156262

Database of Orthologous Groups

More...
OrthoDBi
40683at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q6L9

TreeFam database of animal gene trees

More...
TreeFami
TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 3 hits
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 11 hits
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 4 hits
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

E9Q6L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQCLEMTTKR KLIGRLVPCR CFRGEEEIIS VLDYSHCSLQ QVPKEVFNFE
60 70 80 90 100
RTLEELYLDA NQIEELPKQL FNCQALRKLS IPDNDLSSLP TSIASLVNLK
110 120 130 140 150
ELDISKNGVQ EFPENIKCCK CLTIIEASVN PISKLPDGFT QLLNLTQLYL
160 170 180 190 200
NDAFLEFLPA NFGRLVKLRI LELRENHLKT LPKSMHKLAQ LERLDLGNNE
210 220 230 240 250
FSELPEVLDQ IQNLRELWMD NNALQVLPGS IGKLKMLVYL DMSKNRIETV
260 270 280 290 300
DMDISGCEAL EDLLLSSNML QQLPDSIGLL KKLTTLKVDD NQLTMLPNTI
310 320 330 340 350
GNLSLLEEFD CSCNELESLP PTIGYLHSLR TLAVDENFLP ELPREIGSCK
360 370 380 390 400
NVTVMSLRSN KLEFLPEEIG QMQRLRVLNL SDNRLKNLPF SFTKLKELAA
410 420 430 440 450
LWLSDNQSKA LIPLQTEAHP ETKQRVLTNY MFPQQPRGDE DFQSDSDSFN
460 470 480 490 500
PTLWEEQRQQ RMTVAFEFED KKEDDESAGK VKALSCQAPW DRGQRGITLQ
510 520 530 540 550
PARLSGDCCT PWARCDQQIQ DMPVPQSDPQ LAWGCISGLQ QERSMCAPLP
560 570 580 590 600
VAAQSTTLPS LSGRQVEINL KRYPTPYPED LKNMVKSVQN LVGKPSHGVR
610 620 630 640 650
VENSNPTANT EQTVKEKFEH KWPVAPKEIT VEDSFVHPAN EMRIGELHPS
660 670 680 690 700
LAETPLYPPK LVLLGKDKKE STDESEVDKT HCLNNSVSSG TYSDYSPSQA
710 720 730 740 750
SSASSNTRMK VGSLQATAKD AVHNSLWGNR IAPPFPQPLD AKPLLSQREA
760 770 780 790 800
VPPGNIPQRP DRLPMSDAFP DNWTDGSHYD NTGFVSEEAA GENANNNPLL
810 820 830 840 850
SSKARSVPAH GRRPLIRQER IVGVPLELEQ STHRHTPETE VPPSNPWQNW
860 870 880 890 900
TRTPSPFEDR TAFPSKLETT PTTSPLPERK DHMKEPTETP GPFSPGVPWE
910 920 930 940 950
YHDPTPNRSL GNVFSQIHCR PDSSKGVIAI SKSTERLSPL MKDIKSNKFK
960 970 980 990 1000
KSQSIDEIDV GTYKVYNIPL ENYASGSDHL GSHERPDKFL GPEHGMSSMS
1010 1020 1030 1040 1050
RSQSVPMLDD EMLMYGSSKG PPQQKASMTK KVYQFDQSFN PQGAVEVKAE
1060 1070 1080 1090 1100
KRIPPPFAHN SEYVQQPSKN IAKDLVSPRA YRGYPPMEQM FSFSQPSVNE
1110 1120 1130 1140 1150
DAMVNAQFAS QGPRAGFLRR ADSLASSTEM AMFRRVSEPH ELPPGDRYGR
1160 1170 1180 1190 1200
ATYRGGLEGQ SSISMTDPQF LKRNGRYEDE HPSYQEVKAQ AGSFPAKNLT
1210 1220 1230 1240 1250
QRRPLSARSY STESYGASQT RPVSARPTMA ALLEKIPSDY NLGNYGDKTS
1260 1270 1280 1290 1300
DNSDIKTRPT PVKGEESCGK MPADWRQQLL RHIEARRLDR NAAYKHNTVN
1310 1320 1330 1340 1350
LGMLPYGGIS AMHAGRSMTL NLQTKSKFDL QDLPLQKTPS QQSNILDNGQ
1360 1370 1380 1390 1400
EDVSPSGQWN PYPLGRRDVP PDTITKKAGS HIQTLMGSQS LQHRSREQQP
1410 1420 1430 1440 1450
YEGNINKVTI QQFQSPLPIQ IPSSQATRGP QPGRCLIQTK GQRSMDGYPE
1460 1470 1480 1490 1500
QFCVRIEKNP GLGFSISGGI SGQGNPFKPS DKGIFVTRVQ PDGPASNLLQ
1510 1520 1530 1540
PGDKILQANG HSFVHMEHEK AVLLLKSFQN TVDLVIQREL TV
Length:1,542
Mass (Da):172,662
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52C48DAAD41B933E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TE7LRRC7_MOUSE
Leucine-rich repeat-containing prot...
Lrrc7 Kiaa1365, Lap1
1,490Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDT9A0A0G2JDT9_MOUSE
Leucine-rich repeat-containing prot...
Lrrc7
1,495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFZ5A0A0G2JFZ5_MOUSE
Leucine-rich repeat-containing prot...
Lrrc7
1,531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BEA5A0A571BEA5_MOUSE
Leucine-rich repeat-containing prot...
Lrrc7
1,488Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9EHV0B9EHV0_MOUSE
Leucine-rich repeat-containing prot...
Lrrc7
1,398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001074827.1, NM_001081358.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106044; ENSMUSP00000101659; ENSMUSG00000028176

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
242274

UCSC genome browser

More...
UCSCi
uc008rvw.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001074827.1, NM_001081358.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiE9Q6L9

Proteomic databases

MaxQBiE9Q6L9
PeptideAtlasiE9Q6L9
PRIDEiE9Q6L9
ProteomicsDBi363681

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
939, 60 antibodies

Genome annotation databases

EnsembliENSMUST00000106044; ENSMUSP00000101659; ENSMUSG00000028176
GeneIDi242274
UCSCiuc008rvw.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57554
MGIiMGI:2676665, Lrrc7
VEuPathDBiHostDB:ENSMUSG00000028176

Phylogenomic databases

GeneTreeiENSGT00940000156262
OrthoDBi40683at2759
PhylomeDBiE9Q6L9
TreeFamiTF351429

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
242274, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrrc7, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028176, Expressed in brain and 158 other tissues

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF13855, LRR_8, 3 hits
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 11 hits
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 4 hits
PS50106, PDZ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q6L9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q6L9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 29, 2021
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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