UniProtKB - E9Q6I0 (V2116_MOUSE)
Protein
Vomeronasal type-2 receptor 116
Gene
Vmn2r116
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation.3 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- pheromone receptor activity Source: MGI
- signaling receptor activity Source: GO_Central
GO - Biological processi
- positive regulation of female receptivity Source: MGI
- response to pheromone Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Pheromone response |
Names & Taxonomyi
Protein namesi | Recommended name: Vomeronasal type-2 receptor 116ImportedAlternative name(s): Vomeronasal type-2 receptor P51 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3646674, Vmn2r116 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 586 | ExtracellularSequence analysisAdd BLAST | 568 | |
Transmembranei | 587 – 607 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 608 – 622 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 623 – 643 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 644 – 658 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 659 – 679 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 680 – 690 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 691 – 711 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 712 – 745 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 746 – 766 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 767 – 778 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 779 – 799 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 800 – 806 | ExtracellularSequence analysis | 7 | |
Transmembranei | 807 – 827 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 828 – 856 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
No response of neurons in the vomeronasal organ or accessory olfactory bulb to Esp1 and no enhancement of lordosis following exposure to Esp1.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000424696 | 19 – 856 | Vomeronasal type-2 receptor 116Sequence analysisAdd BLAST | 838 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | E9Q6I0 |
PRIDEi | E9Q6I0 |
PTM databases
GlyGeni | E9Q6I0, 1 site |
Expressioni
Tissue specificityi
Expressed in the vomeronasal organ.1 Publication
Gene expression databases
ExpressionAtlasi | E9Q6I0, baseline and differential |
Interactioni
Protein-protein interaction databases
IntActi | E9Q6I0, 1 interactor |
STRINGi | 10090.ENSMUSP00000128106 |
Miscellaneous databases
RNActi | E9Q6I0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Sequence analysis
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00950000183069 |
HOGENOMi | CLU_005389_5_0_1 |
InParanoidi | E9Q6I0 |
OMAi | CEWESEL |
OrthoDBi | 546292at2759 |
PhylomeDBi | E9Q6I0 |
TreeFami | TF340115 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR004073, GPCR_3_vmron_rcpt_2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01535, VOMERONASL2R |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E9Q6I0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFTLIFLFLF LNIPLLVADF ISPRCFWKMK QNEYRDRHHG TGCIFLILAI
60 70 80 90 100
QQPVKKEYFS HILNIQTHTE NHKYALALAF SIYEINRNPD LLPNMSLIFI
110 120 130 140 150
FSADSCEWES ELSLIRFGLQ NSDNLPNYLC EELTKCILAL TNMNWATTVT
160 170 180 190 200
LHTILSNFLS DQLLHITYGT FHPALSDHEK FPYLHQMASD HTSLALALVS
210 220 230 240 250
FIIHFGWNWV GLVISDSDQG IQFLSYLRRE MEKYTLCFAF VNMIPLNINL
260 270 280 290 300
YMSRAEVYYN QIMTSSTNVV IIYGDTDSTL AVSFRMWESL GIQRLWITTS
310 320 330 340 350
QWDVSPSMKD FTFGNKYGTF AFEQHHSEIS GFKHFVQTLN SVKCPDEYLV
360 370 380 390 400
KLEWMHFNCE VSASKCKTLK NCSSNHSLKW LMVHTFDMAF IEESYYIYNA
410 420 430 440 450
VYAFAHVLHQ FTFQKFDNLP KDNGKEHNYS CKKLYSYLRK NHFINPVGDR
460 470 480 490 500
VSMNQRDKLQ EEYDIVYIWN FPQGLGLRVK IGMFSPYFPN GQQVHLSEDM
510 520 530 540 550
LKWARGSTQV PTSMCSADCG PGSRKFRMDG MAACCFHCKP CPENEISNET
560 570 580 590 600
NVDNCVQCPE DQYANTEQNH CIRKAVVFLS YEEPLGVALS LLSLCFSAFT
610 620 630 640 650
TVVLGIFVKH HNTPIVKANN RTLTYLLLIS LIFCFLCPLL FIGHPNSATC
660 670 680 690 700
ILQQLTFGVV FTVSLSTVLA KTITVVLAFK IIASQRMMKY FLISGAINYI
710 720 730 740 750
IPICILIQVI VCAVWLRASP PSVDIDAHSE HGQIIIVCHK GSVNAFYCVL
760 770 780 790 800
GYLAILAFGS FTLAFLSRNL PGAFNEAKSI TFSMLVFCSV WVTFIPVYHS
810 820 830 840 850
TKGKVMVAVE IFSTLASSAG MLGCIFVPKC YTILFRQDQN SLEMIRVKSS
SNVHVS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q4EG82 | A0A3Q4EG82_MOUSE | Vomeronasal type-2 receptor 116 | Vmn2r116 | 816 | Annotation score: | ||
A0A3Q4EH09 | A0A3Q4EH09_MOUSE | Vomeronasal type-2 receptor 116 | Vmn2r116 | 780 | Annotation score: | ||
A0A3Q4EC64 | A0A3Q4EC64_MOUSE | Vomeronasal type-2 receptor 116 | Vmn2r116 | 69 | Annotation score: | ||
A0A3Q4EGR6 | A0A3Q4EGR6_MOUSE | Vomeronasal type-2 receptor 116 | Vmn2r116 | 78 | Annotation score: | ||
A0A3Q4EIK7 | A0A3Q4EIK7_MOUSE | Vomeronasal type-2 receptor 116 | Vmn2r116 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB540947 mRNA Translation: BAJ10472.1 CT485617 Genomic DNA No translation available. |
CCDSi | CCDS50009.1 |
RefSeqi | NP_001098050.1, NM_001104580.1 |
Genome annotation databases
Ensembli | ENSMUST00000164856; ENSMUSP00000128106; ENSMUSG00000090966 |
GeneIDi | 619697 |
KEGGi | mmu:619697 |
UCSCi | uc009vbt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB540947 mRNA Translation: BAJ10472.1 CT485617 Genomic DNA No translation available. |
CCDSi | CCDS50009.1 |
RefSeqi | NP_001098050.1, NM_001104580.1 |
3D structure databases
SMRi | E9Q6I0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E9Q6I0, 1 interactor |
STRINGi | 10090.ENSMUSP00000128106 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | E9Q6I0, 1 site |
Proteomic databases
PaxDbi | E9Q6I0 |
PRIDEi | E9Q6I0 |
Genome annotation databases
Ensembli | ENSMUST00000164856; ENSMUSP00000128106; ENSMUSG00000090966 |
GeneIDi | 619697 |
KEGGi | mmu:619697 |
UCSCi | uc009vbt.1, mouse |
Organism-specific databases
CTDi | 619697 |
MGIi | MGI:3646674, Vmn2r116 |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00950000183069 |
HOGENOMi | CLU_005389_5_0_1 |
InParanoidi | E9Q6I0 |
OMAi | CEWESEL |
OrthoDBi | 546292at2759 |
PhylomeDBi | E9Q6I0 |
TreeFami | TF340115 |
Miscellaneous databases
BioGRID-ORCSi | 619697, 0 hits in 13 CRISPR screens |
ChiTaRSi | Vmn2r116, mouse |
PROi | PR:E9Q6I0 |
RNActi | E9Q6I0, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | E9Q6I0, baseline and differential |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR004073, GPCR_3_vmron_rcpt_2 IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01535, VOMERONASL2R |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | V2116_MOUSE | |
Accessioni | E9Q6I0Primary (citable) accession number: E9Q6I0 Secondary accession number(s): D7URW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 11, 2013 |
Last sequence update: | April 5, 2011 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families