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Protein
Submitted name:

Chromodomain helicase DNA-binding protein 3

Gene

Chd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • centrosome cycle Source: MGI
  • chromatin assembly or disassembly Source: MGI
  • spindle organization Source: MGI

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6804758 Regulation of TP53 Activity through Acetylation
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Submitted name:
Chromodomain helicase DNA-binding protein 3Imported
Gene namesi
Name:Chd3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1344395 Chd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

MaxQBiE9Q614
PeptideAtlasiE9Q614
PRIDEiE9Q614

Expressioni

Gene expression databases

BgeeiENSMUSG00000018474
ExpressionAtlasiE9Q614 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9Q614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini432 – 479PHD-typeInterPro annotationAdd BLAST48
Domaini508 – 555PHD-typeInterPro annotationAdd BLAST48
Domaini588 – 645ChromoInterPro annotationAdd BLAST58
Domaini683 – 719ChromoInterPro annotationAdd BLAST37
Domaini800 – 984Helicase ATP-bindingInterPro annotationAdd BLAST185
Domaini1116 – 1281Helicase C-terminalInterPro annotationAdd BLAST166

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 41Sequence analysisAdd BLAST37
Coiled coili478 – 505Sequence analysisAdd BLAST28
Coiled coili1344 – 1364Sequence analysisAdd BLAST21
Coiled coili1877 – 1897Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0383 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00760000119067

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.30.40.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR028722 CHD3
IPR012957 CHD_C2
IPR012958 CHD_N
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR009462 DUF1086
IPR009463 DUF1087
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR036910 HMG_box_dom_sf
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10799:SF544 PTHR10799:SF544, 2 hits
PfamiView protein in Pfam
PF08074 CHDCT2, 1 hit
PF08073 CHDNT, 1 hit
PF00385 Chromo, 1 hit
PF06461 DUF1086, 1 hit
PF06465 DUF1087, 1 hit
PF00271 Helicase_C, 1 hit
PF00628 PHD, 2 hits
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01146 DUF1086, 1 hit
SM01147 DUF1087, 1 hit
SM00490 HELICc, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF47095 SSF47095, 1 hit
SSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 3 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50013 CHROMO_2, 2 hits
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

Sequencei

Sequence statusi: Complete.

E9Q614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPLRDEEE EEEEMVVSEE EEEEEEEGDE EEEEVEAADE DDEEEDEEGV
60 70 80 90 100
LGRGPGHDRS RDRHSPPSCH LFPPPPPPLP PPPPPDKDDI RLLPSALGVK
110 120 130 140 150
KRKRGPKKQK ENKPGKPRKR KKLDSEEEFG SERDEYREKS ESGGSEYGTG
160 170 180 190 200
PGRKRRRKHR EKKEKKTKRR KRGEGDGGHK QVEQKSSATL LLTWGLEDVE
210 220 230 240 250
HVFSEEDYHT LTNYKAFSQF MRPLIAKKNP KIPMSKMMTI LGAKWREFSA
260 270 280 290 300
NNPFKGSAAA VAAAAAAAAA AVAEQVSAAV SSATPIAPSG PPPALPPPPA
310 320 330 340 350
PEIQPPPIRR AKTKEGKGPG HKRRNKSPRV PDGRKKLRGK KMAPLKIKLG
360 370 380 390 400
LLGGKRKKAG SCAFQSEEGH EPEAEESDLD SGSVHSASGW PDGPVRAKKL
410 420 430 440 450
KRGRPGRKKK KVLGCPAVTG EEEVDGYETD HQDYCEVCQQ GGEIILCDTC
460 470 480 490 500
PRAYHLVCLD PELDRAPEGK WSCPHCEKEG VQWEAKEEEE EYEEEGEEGE
510 520 530 540 550
KEEEDDHMEY CRVCKDGGEL LCCDACISSY HIHCLNPPLP DIPNGEWLCP
560 570 580 590 600
RCTCPVLKGR VQKILHWRWG EPPVAVPAPQ QADGNPDVPP PRPLQGRSER
610 620 630 640 650
EFFVKWVGLS YWHCSWAKEL QLEIFHLVMY RNYQRKNDMD EPPPLDYGSG
660 670 680 690 700
EDDGKSDKRK VKDPHYAEME EKYYRFGIKP EWMTVHRIIN HSMDKKGNYH
710 720 730 740 750
YLVKWKDLPY DQSTWEEDEM NIPEYDDHKQ SYWRHRELIM GEDPAQPRKY
760 770 780 790 800
KKKKKELQGD GPPSSPTNDP TVKYETQPRF ITATGGTLHM YQLEGLNWLR
810 820 830 840 850
FSWAQGTDTI LADEMGLGKT IQTIVFLYSL YKEGHTKGPF LVSAPLSTII
860 870 880 890 900
NWEREFQMWA PKFYVVTYTG DKDSRAIIRE NEFSFEDNAI KGGKKAFKMK
910 920 930 940 950
REAQVKFHVL LTSYELITID QAALGSIRWA CLVVDEAHRL KNNQSKFFRV
960 970 980 990 1000
LNGYKIDHKL LLTGTPLQNN LEELFHLLNF LTPERFNNLE GFLEEFADIS
1010 1020 1030 1040 1050
KEDQIKKLHD LLGPHMLRRL KADVFKNMPA KTELIVRVEL SPMQKKYYKY
1060 1070 1080 1090 1100
ILTRNFEALN SRGGGNQVSL LNIMMDLKKC CNHPYLFPVA AMESPKLPSG
1110 1120 1130 1140 1150
AYEGGALIKS SGKLLLLQKM LRKLKEQGHR VLIFSQMTKM LDLLEDFLDY
1160 1170 1180 1190 1200
EGYKYERIDG GITGALRQEA IDRFNAPGAQ QFCFLLSTRA GGLGINLATA
1210 1220 1230 1240 1250
DTVIIFDSDW NPHNDIQAFS RAHRIGQANK VMIYRFVTRA SVEERITQVA
1260 1270 1280 1290 1300
KRKMMLTHLV VRPGLGSKAG SMSKQELDDI LKFGTEELFK DENEGENKEE
1310 1320 1330 1340 1350
DSSVIHYDNE AIARLLDRNQ DATEDTDVQN MNEYLSSFKV AQYVVREEDK
1360 1370 1380 1390 1400
IEEIEREIIK QEENVDPDYW EKLLRHHYEQ QQEDLARNLG KGKRVRKQVN
1410 1420 1430 1440 1450
YNDAAQEDQD NQSEYSVGSE EEDEDFDERP EGRRQSKRQL RNEKDKPLPP
1460 1470 1480 1490 1500
LLARVGGNIE VLGFNTRQRK AFLNAVMRWG MPPQDAFTTQ WLVRDLRGKT
1510 1520 1530 1540 1550
EKEFKAYVSL FMRHLCEPGA DGSETFADGV PREGLSRQQV LTRIGVMSLV
1560 1570 1580 1590 1600
KKKVQEFEHI NGRWSMPELM PDPSAESKRS SRASSPTKTS PTTPEASTTN
1610 1620 1630 1640 1650
SPCTSKPATP APSEKGDGVR TPLDKDDTEN QEEKPEKNSK VGEKMEAEVD
1660 1670 1680 1690 1700
SPSPAPSLGE RLEHRKILLE DEAPGVPGET EPEPGYRGDR EKSEDVKADR
1710 1720 1730 1740 1750
ELRLGPPRDE PRPNGRREEK VEKPRFMFNI ADGGFTELHT LWQNEERAAI
1760 1770 1780 1790 1800
SSGKLNEIWH RRHDYWLLAG IVLHGYARWQ DIQNDAQFAI INEPFKTEAN
1810 1820 1830 1840 1850
KGNFLEMKNK FLARRFKLLE QALVIEEQLR RAAYLNLSQE PAHPAMALHA
1860 1870 1880 1890 1900
RFAEAECLAE SHQHLSKESL AGNKPANAVL HKVLNQLEEL LSDMKADVTR
1910 1920 1930 1940 1950
LPATLSRIPP IAARLQMSER SILSRLASKG TEPHPTPAFP PGPYATPPGY
1960 1970 1980 1990 2000
GAAFSAAPVG ALAAAGANYS QMPAGSFITA TTNGPPVLVK KEKEMVGALV
2010 2020
SDGLGLDRKE PRAGEVICID D
Length:2,021
Mass (Da):228,973
Last modified:April 5, 2011 - v1
Checksum:i5E06C5E2065FDB92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596125 Genomic DNA No translation available.
AL645527 Genomic DNA No translation available.
RefSeqiXP_006532951.1, XM_006532888.1
UniGeneiMm.178246

Genome annotation databases

EnsembliENSMUST00000092971; ENSMUSP00000090649; ENSMUSG00000018474
GeneIDi216848

Similar proteinsi

Entry informationi

Entry nameiE9Q614_MOUSE
AccessioniPrimary (citable) accession number: E9Q614
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 18, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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