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Protein

NACHT, LRR and PYD domains-containing protein 12

Gene

Nlrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi217 – 224ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 12
Alternative name(s):
Monarch-1
PYRIN-containing APAF1-like protein 7
Short name:
PYPAF7
Gene namesi
Name:Nlrp12
Synonyms:NALP12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2676630 Nlrp12

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004197581 – 1054NACHT, LRR and PYD domains-containing protein 12Add BLAST1054

Proteomic databases

MaxQBiE9Q5R7
PaxDbiE9Q5R7
PRIDEiE9Q5R7

PTM databases

PhosphoSitePlusiE9Q5R7

Expressioni

Gene expression databases

BgeeiENSMUSG00000078817 Expressed in 21 organ(s), highest expression level in liver
GenevisibleiE9Q5R7 MM

Interactioni

Subunit structurei

Binds to ASC with its pyrin domain. Interacts with FAF1 UBA domain via its pyrin domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104293

Structurei

3D structure databases

ProteinModelPortaliE9Q5R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 95PyrinPROSITE-ProRule annotationAdd BLAST95
Domaini211 – 528NACHTPROSITE-ProRule annotationAdd BLAST318
Repeati821 – 841LRR 1Add BLAST21
Repeati850 – 871LRR 2Add BLAST22
Repeati878 – 899LRR 3Add BLAST22
Repeati907 – 928LRR 4Add BLAST22
Repeati935 – 955LRR 5Add BLAST21
Repeati964 – 985LRR 6Add BLAST22
Repeati992 – 1013LRR 7Add BLAST22
Repeati1021 – 1042LRR 8Add BLAST22

Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IE5X Eukaryota
ENOG4111H3D LUCA
GeneTreeiENSGT00900000140813
HOVERGENiHBG096931
InParanoidiE9Q5R7
KOiK20865
OMAiLCRLSAY
OrthoDBiEOG091G01CG

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR029495 NACHT-assoc
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF14484 FISNA, 1 hit
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01288 FISNA, 1 hit
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS51450 LRR, 6 hits
PS50837 NACHT, 1 hit

Sequencei

Sequence statusi: Complete.

E9Q5R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPSTARDGL YRLSTYLEEL EAGELKKFKL FLGIAEDLSQ DKIPWGRMEK
60 70 80 90 100
AGPLEMAQLM VAHMGTREAW LLALSTFQRI HRKDLWERGQ GEDLVRVTPN
110 120 130 140 150
NGLCLFESQS ACPLDVSPNA PRKDLQTTYK DYVRRKFQLM EDRNARLGEC
160 170 180 190 200
VNLSNRYTRL LLVKEHSNPI WTQQKFVDVE WERSRTRRHQ TSPIQMETLF
210 220 230 240 250
EPDEERPEPP HTVVLQGAAG MGKSMLAHKV MLDWADGRLF QGRFDYVFYI
260 270 280 290 300
SCRELNRSHT QCSVQDLISS CWPERGISLE DLMQAPDRLL FIIDGFDKLH
310 320 330 340 350
PSFHDAQGPW CLCWEEKQPT EVLLGSLIRR LLLPQVSLLI TTRPCALEKL
360 370 380 390 400
HGLLEHPRHV EILGFSEEAR KEYFYRYFHN TGQASRVLSF LMDYEPLFTM
410 420 430 440 450
CFVPMVSWVV CTCLKQQLES GELLRQTPRT TTAVYMFYLL SLMQPKPGTP
460 470 480 490 500
TFKVPANQRG LVSLAAEGLW NQKILFDEQD LGKHGLDGAD VSTFLNVNIF
510 520 530 540 550
QKGIKCEKFY SFIHLSFQEF FAAMYCALNG REAVRRALAE YGFSERNFLA
560 570 580 590 600
LTVHFLFGLL NEEMRCYLER NLGWSISPQV KEEVLAWIQN KAGSEGSTLQ
610 620 630 640 650
HGSLELLSCL YEVQEEDFIQ QALSHFQVVV VRSISTKMEH MVCSFCARYC
660 670 680 690 700
RSTEVLHLHG SAYSTGMEDD PPEPSGVQTQ STYLQERNML PDVYSAYLSA
710 720 730 740 750
AVCTNSNLIE LALYRNALGS QGVRLLCQGL RHASCKLQNL RLKRCQISGS
760 770 780 790 800
ACQDLAAAVI ANRNLIRLDL SDNSIGVPGL ELLCEGLQHP RCRLQMIQLR
810 820 830 840 850
KCLLEAAAGR SLASVLSNNS YLVELDLTGN PLEDSGLKLL CQGLRHPVCR
860 870 880 890 900
LRTLWLKICH LGQASCEDLA STLKMNQSLL ELDLGLNDLG DSGVLLLCEG
910 920 930 940 950
LSHPDCKLQT LRLGICRLGS VACVGIASVL QVNTCLQELD LSFNDLGDRG
960 970 980 990 1000
LQLLGEGLRH QTCRLQKLWL DNCGLTSKAC EDLSSILGIS QTLHELYLTN
1010 1020 1030 1040 1050
NALGDTGVCL LCKRLRHPGC KLRVLWLFGM DLNKKTHRRM AALRVTKPYL

DIGC
Length:1,054
Mass (Da):119,319
Last modified:April 5, 2011 - v1
Checksum:i3F17BEA78BA38621
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01093162 Genomic DNA No translation available.
CAAA01093166 Genomic DNA No translation available.
CAAA01193276 Genomic DNA No translation available.
AK149454 mRNA Translation: BAE28888.1
CCDSiCCDS51963.1
RefSeqiNP_001028603.1, NM_001033431.1
UniGeneiMm.277152

Genome annotation databases

EnsembliENSMUST00000108653; ENSMUSP00000104293; ENSMUSG00000078817
ENSMUST00000181320; ENSMUSP00000137758; ENSMUSG00000097297
GeneIDi378425
KEGGimmu:378425
UCSCiuc009eul.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01093162 Genomic DNA No translation available.
CAAA01093166 Genomic DNA No translation available.
CAAA01193276 Genomic DNA No translation available.
AK149454 mRNA Translation: BAE28888.1
CCDSiCCDS51963.1
RefSeqiNP_001028603.1, NM_001033431.1
UniGeneiMm.277152

3D structure databases

ProteinModelPortaliE9Q5R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104293

PTM databases

PhosphoSitePlusiE9Q5R7

Proteomic databases

MaxQBiE9Q5R7
PaxDbiE9Q5R7
PRIDEiE9Q5R7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108653; ENSMUSP00000104293; ENSMUSG00000078817
ENSMUST00000181320; ENSMUSP00000137758; ENSMUSG00000097297
GeneIDi378425
KEGGimmu:378425
UCSCiuc009eul.2 mouse

Organism-specific databases

CTDi91662
MGIiMGI:2676630 Nlrp12

Phylogenomic databases

eggNOGiENOG410IE5X Eukaryota
ENOG4111H3D LUCA
GeneTreeiENSGT00900000140813
HOVERGENiHBG096931
InParanoidiE9Q5R7
KOiK20865
OMAiLCRLSAY
OrthoDBiEOG091G01CG

Miscellaneous databases

PROiPR:E9Q5R7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078817 Expressed in 21 organ(s), highest expression level in liver
GenevisibleiE9Q5R7 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR029495 NACHT-assoc
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF14484 FISNA, 1 hit
PF13516 LRR_6, 5 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01288 FISNA, 1 hit
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS51450 LRR, 6 hits
PS50837 NACHT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAL12_MOUSE
AccessioniPrimary (citable) accession number: E9Q5R7
Secondary accession number(s): Q3UEM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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