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Protein
Submitted name:

Integrin alpha-L

Gene

Itgal

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin alpha-LImported
Gene namesi
Name:ItgalImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96606 Itgal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1087 – 1109HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500142427524 – 1162UniRule annotationAdd BLAST1139

Proteomic databases

MaxQBiE9Q5M7
PRIDEiE9Q5M7

Expressioni

Gene expression databases

BgeeiENSMUSG00000030830 Expressed in 93 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiE9Q5M7 baseline and differential
GenevisibleiE9Q5M7 MM

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9Q5M7
SMRiE9Q5M7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 79FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati80 – 138FG-GAPPROSITE-ProRule annotationAdd BLAST59
Domaini153 – 325VWFAInterPro annotationAdd BLAST173
Repeati336 – 387FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati390 – 443FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati444 – 504FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati505 – 561FG-GAPPROSITE-ProRule annotationAdd BLAST57
Repeati565 – 625FG-GAPPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPAP Eukaryota
ENOG410ZJIF LUCA
GeneTreeiENSGT00930000150854
KOiK05718
OMAiPHSQIPV
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E9Q5M7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFRIAGPRL LLLGLQLFAK AWSYNLDTRP TQSFLAQAGR HFGYQVLQIE
60 70 80 90 100
DGVVVGAPGE GDNTGGLYHC RTSSEFCQPV SLHGSNHTSK YLGMTLATDA
110 120 130 140 150
AKGSLLACDP GLSRTCDQNT YLSGLCYLFP QSLEGPMLQN RPAYQECMKG
160 170 180 190 200
KVDLVFLFDG SQSLDRKDFE KILEFMKDVM RKLSNTSYQF AAVQFSTDCR
210 220 230 240 250
TEFTFLDYVK QNKNPDVLLG SVQPMFLLTN TFRAINYVVA HVFKEESGAR
260 270 280 290 300
PDATKVLVII TDGEASDKGN ISAAHDITRY IIGIGKHFVS VQKQKTLHIF
310 320 330 340 350
ASEPVEEFVK ILDTFEKLKD LFTDLQRRIY AIEGTNRQDL TSFNMELSSS
360 370 380 390 400
GISADLSKGH AVVGAVGAKD WAGGFLDLRE DLQGATFVGQ EPLTSDVRGG
410 420 430 440 450
YLGYTVAWMT SRSSRPLLAA GAPRYQHVGQ VLLFQAPEAG GRWNQTQKIE
460 470 480 490 500
GTQIGSYFGG ELCSVDLDQD GEAELLLIGA PLFFGEQRGG RVFTYQRRQS
510 520 530 540 550
LFEMVSELQG DPGYPLGRFG AAITALTDIN GDRLTDVAVG APLEEQGAVY
560 570 580 590 600
IFNGKPGGLS PQPSQRIQGA QVFPGIRWFG RSIHGVKDLG GDRLADVVVG
610 620 630 640 650
AEGRVVVLSS RPVVDVVTEL SFSPEEIPVH EVECSYSARE EQKHGVKLKA
660 670 680 690 700
CFRIKPLTPQ FQGRLLANLS YTLQLDGHRM RSRGLFPDGS HELSGNTSIT
710 720 730 740 750
PDKSCLDFHF HFPICIQDLI SPINVSLNFS LLEEEGTPRD QKVGRAMQPI
760 770 780 790 800
LRPSIHTVTK EIPFEKNCGE DKKCEANLTL SSPARSGPLR LMSSASLAVE
810 820 830 840 850
WTLSNSGEDA YWVRLDLDFP RGLSFRKVEM LQPHSRMPVS CEELTEGSSL
860 870 880 890 900
LTKTLKCNVS SPIFKAGQEV SLQVMFNTLL NSSWEDFVEL NGTVHCENEN
910 920 930 940 950
SSLQEDNSAA THIPVLYPVN ILTKEQENST LYISFTPKGP KTQQVQHVYQ
960 970 980 990 1000
VRIQPSAYDH NMPTLEALVG VPWPHSEDPI TYTWSVQTDP LVTCHSEDLK
1010 1020 1030 1040 1050
RPSSEAEQPC LPGVQFRCPI VFRREILIQV TGTVELSKEI KASSTLSLCS
1060 1070 1080 1090 1100
SLSVSFNSSK HFHLYGSKAS EAQVLVKVDL IHEKEMLHVY VLSGIGGLVL
1110 1120 1130 1140 1150
LFLIFLALYK VGFFKRNLKE KMEADGGVPN GSPPEDTDPL AVPGEETKDM
1160
GCLEPLRESD KD
Length:1,162
Mass (Da):128,314
Last modified:April 5, 2011 - v1
Checksum:iCA2118033958BC44
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P24063ITAL_MOUSE
Integrin alpha-L
Itgal Lfa-1, Ly-15
1,163Annotation score:
E9QNL8E9QNL8_MOUSE
Integrin alpha-L
Itgal
1,161Annotation score:
D3Z627D3Z627_MOUSE
Integrin alpha-L
Itgal
1,201Annotation score:
D3YW95D3YW95_MOUSE
Integrin alpha-L
Itgal
765Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133494 Genomic DNA No translation available.
RefSeqiNP_001240801.1, NM_001253872.1
UniGeneiMm.1618

Genome annotation databases

EnsembliENSMUST00000106306; ENSMUSP00000101913; ENSMUSG00000030830
GeneIDi16408
KEGGimmu:16408
UCSCiuc009jvb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133494 Genomic DNA No translation available.
RefSeqiNP_001240801.1, NM_001253872.1
UniGeneiMm.1618

3D structure databases

ProteinModelPortaliE9Q5M7
SMRiE9Q5M7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE9Q5M7
PRIDEiE9Q5M7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106306; ENSMUSP00000101913; ENSMUSG00000030830
GeneIDi16408
KEGGimmu:16408
UCSCiuc009jvb.2 mouse

Organism-specific databases

CTDi3683
MGIiMGI:96606 Itgal

Phylogenomic databases

eggNOGiENOG410IPAP Eukaryota
ENOG410ZJIF LUCA
GeneTreeiENSGT00930000150854
KOiK05718
OMAiPHSQIPV
TreeFamiTF105391

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030830 Expressed in 93 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiE9Q5M7 baseline and differential
GenevisibleiE9Q5M7 MM

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE9Q5M7_MOUSE
AccessioniPrimary (citable) accession number: E9Q5M7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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