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UniProtKB - E9Q5I3 (E9Q5I3_MOUSE)

Entry version 77 (19 Jan 2022)
Sequence version 1 (05 Apr 2011)
Previous versions | rss
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Protein
Submitted name:

Mucin 5, subtype B, tracheobronchial

Gene

Muc5b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mucin 5, subtype B, tracheobronchialImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc5bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1921430, Muc5b

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000066108

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324575026 – 4800Sequence analysisAdd BLAST4775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi4729 ↔ 4783PROSITE-ProRule annotation
Disulfide bondi4733 ↔ 4785PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		E9Q5I3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E9Q5I3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		320363

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		E9Q5I3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		E9Q5I3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000066108, Expressed in cochlea and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		E9Q5I3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000128276

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		E9Q5I3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		E9Q5I3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 281VWFDInterPro annotationAdd BLAST202
Domaini428 – 642VWFDInterPro annotationAdd BLAST215
Domaini898 – 1105VWFDInterPro annotationAdd BLAST208
Domaini4121 – 4351VWFDInterPro annotationAdd BLAST231
Domaini4461 – 4531VWFCInterPro annotationAdd BLAST71
Domaini4568 – 4632VWFCInterPro annotationAdd BLAST65
Domaini4698 – 4790CTCKInterPro annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1446 – 1568DisorderedSequence analysisAdd BLAST123
Regioni1673 – 1862DisorderedSequence analysisAdd BLAST190
Regioni1968 – 2179DisorderedSequence analysisAdd BLAST212
Regioni2282 – 2493DisorderedSequence analysisAdd BLAST212
Regioni2598 – 2665DisorderedSequence analysisAdd BLAST68
Regioni2791 – 2835DisorderedSequence analysisAdd BLAST45
Regioni2849 – 2902DisorderedSequence analysisAdd BLAST54
Regioni2947 – 3061DisorderedSequence analysisAdd BLAST115
Regioni3166 – 3375DisorderedSequence analysisAdd BLAST210
Regioni3479 – 3537DisorderedSequence analysisAdd BLAST59
Regioni3743 – 3767DisorderedSequence analysisAdd BLAST25
Regioni3933 – 3954DisorderedSequence analysisAdd BLAST22
Regioni4303 – 4324DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1446 – 1473Polar residuesSequence analysisAdd BLAST28
Compositional biasi1488 – 1568Polar residuesSequence analysisAdd BLAST81

Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1216, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162219

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_223712_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E9Q5I3

Identification of Orthologs from Complete Genome Data

More...OMAi		STWILTE

Database of Orthologous Groups

More...OrthoDBi		12226at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E9Q5I3

TreeFam database of animal gene trees

More...TreeFami		TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR025155, WxxW_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08742, C8, 4 hits
PF13330, Mucin2_WxxW, 10 hits
PF01826, TIL, 2 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57567, SSF57567, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS01208, VWFC_1, 2 hits
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q5I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRNWSWAL VWASVALLMV WPAESQGQAE LSSEHLELTG DSQRVYSDSI 
        60         70         80         90        100
SSSTRHVTFI PPITVFPSMS ALHLAHNGRV CSTWGDFHYK TFDGDVFRFP 
       110        120        130        140        150
GLCNYVFSSH CGATYEDFNI QLRRGLEGSR PTVTYVLLRA QGLVIELSNG 
       160        170        180        190        200
SVLVNGHREK LPYSRAGLLM EKSSGYVKIS IRLVLTFLWN EEDSALLELD 
       210        220        230        240        250
SKYINQTCGL CGDFNGLPAV SEFYTHNTRL TPVQFGNLQK LDGPTEQCQD 
       260        270        280        290        300
VLPSAVSNCT DTEDICRRTL LGPAFDKCTA LVDVSMYLDA CVQDLCRCPT 
       310        320        330        340        350
CPCATFAEYS RQCAHAGGYP QNWRHPDLCN WTCPFNMEYR ECSSPCVDTC 
       360        370        380        390        400
SNPQRSQLCE DHCMDGCFCP PGTVLDDVRH LGCLPLEQCH CTHGGRIYAP 
       410        420        430        440        450
GESFNTSCRS CTCFGGLWKC KDLPCPGTCS VQGGSHIFTF DEKLYNVHGD 
       460        470        480        490        500
CSYILTKKCA DSSFTVLVDL RKCGVTDTEN CLKAVTLNLN SGDTVIRIQV 
       510        520        530        540        550
NGAVFLNSIF TQMPLSAGNI TIFKPSSFFI IVQTGMGLQL QVQLVPLMQV 
       560        570        580        590        600
FVRLDRSYQG QMCGLCGNFN QNQADDFTAL SGVVEGTGAA FSNTWKTQAS 
       610        620        630        640        650
CPNSKNTYED PCSYSVENEN FAREWCSMLT ESSGVFSACH ATVSPVPFYS 
       660        670        680        690        700
NCLFDTCNCE NSEDCMCAAL SSYVFACAAK GVLLSGWRDK VCYKYTNNCP 
       710        720        730        740        750
QTKGYFYSVS SCQPTCRSLS EADVTCSVPF VTVDGCTCPE GTFLNDKDHC 
       760        770        780        790        800
VPVEECPCYF HGTVVAPREV VTDNGVVCSC TNGKLTCLGA LMQKSTECQA 
       810        820        830        840        850
PMVYLDCNNA SVGHHGAECL KSCHTLDVEC FSTQCVSGCV CPSGLVADGN 
       860        870        880        890        900
GGCIAEEDCP CIHNEVTYRP GEIIRVDCNN CTCKNRRWEC TNKPCMGACV 
       910        920        930        940        950
AYGDGHFVTF DGERYIFEGS CEYTLAQDYC RGNTSTNGTF RIVTENVPCG 
       960        970        980        990       1000
TTGTTCSKTI KIFVESYELI LHEGNFKVVE QGPSGDPPYK IRFMGIFLVI 
      1010       1020       1030       1040       1050
EIRSGIVVSW DRKTSVFVRL QQHYKGRVCG LCGNFDDNAI NDFTTRSQSV 
      1060       1070       1080       1090       1100
VGDVLEFGNS WKFSPSCPDA PVPKDPCIAN PYRKSWAQKK CSIINSATFA 
      1110       1120       1130       1140       1150
ACHSQVDSTK YYEACVHDVC ACDSGGDCEC FCTAVAAYAQ ACRDVGVCLS 
      1160       1170       1180       1190       1200
WRTPDICPLF CDYYNPHGEC EWHYQPCGAP CLKTCRNPTG HCLVDLPGLE 
      1210       1220       1230       1240       1250
GCYPQCPASQ PFFNEDQMKC VAQCGCYDDN GNYHDIGTQV PTAENCQSCL 
      1260       1270       1280       1290       1300
CTPGGLQCVY NLTACTCTYE GRTYNYNDVV YNTTDGLGAC LVAICKDNGT 
      1310       1320       1330       1340       1350
IARTTEVCHE VPSTTPFTFT TTLAPLATNG SASTVSTVCV HEVCQWSIWY 
      1360       1370       1380       1390       1400
DESHPEAGMS GGDFETFENL RKKGHQVCQT PVGIECRAVK FPSMDLEKLG 
      1410       1420       1430       1440       1450
QKVNCDPSSG LSCFNSEQSP PLCHDYELRV LCCDYVPCGS SLTLGISTTP 
      1460       1470       1480       1490       1500
SQPDTSRRPS SPTLTTHTAS SESQSWTREE KKTSVDKSYS SRQTVPFTSN 
      1510       1520       1530       1540       1550
SRLTSTSMSS ASSLPLSNPT WTTTLKATDE NTMLSSRTTA VFTSQTRSTS 
      1560       1570       1580       1590       1600
RPSTVTQPIS SPETSSTTCQ PQCQWTKWID VDYPSSSING GDIETYENIR 
      1610       1620       1630       1640       1650
ANGEKICEKP QDIRCMAQNH PGVNVDELGQ KVKCDVSSGL VCYNKDQGGT 
      1660       1670       1680       1690       1700
FQMCYNYLIK VLCCSVSHCQ GSTTPEGSVS TTETATSTPQ TLSSKPLPNT 
      1710       1720       1730       1740       1750
SSFETWSPSG PTTSMEASEM PTFWTLRTSV SSPPTTPLTV TSVSTQHPKS 
      1760       1770       1780       1790       1800
LESSGSPSVV TARSTSQGYS LPPSSPHTTN SLSATTSKAS LSSMTTISTS 
      1810       1820       1830       1840       1850
LTTPGPSSPP HGGTTTHPVT TASTTRAVTE TLSSRPHTKT TSELPTVSSA 
      1860       1870       1880       1890       1900
SSTAGPGTQT FSTTCQPQCQ WTKWIDVDYP SSSINGGDIE TYENIRANGE 
      1910       1920       1930       1940       1950
KICEKPQDIR CMAQNYPGVN VDKLGQKVKC DVSSGLVCYN KDQGGTFPMC 
      1960       1970       1980       1990       2000
YNYLIKVLCC SVSHCQGSTT PEGSVSTTET TTATPQTLSS KPLPNTSSIE 
      2010       2020       2030       2040       2050
TWSPSGPTTS MEASEMPTFW TLRTSVSSPP TTPLTVTSVS TQHPKSLESS 
      2060       2070       2080       2090       2100
GSPSVVTARS TSPGHSQPPS SPYATNSLSA TTSKASLSSM TTISTSLTTP 
      2110       2120       2130       2140       2150
GPSSPPHGGT TTHPVTTAST TRAVTETLSS RPHTKTTSEL PTVSSVSSTA 
      2160       2170       2180       2190       2200
GPGTQTGSTS RPNTVTQPAS SPETSSTTCQ PQCQWTKWID VDYPSSSING 
      2210       2220       2230       2240       2250
GDIETYENIR ANGEKICEKP QDIRCMAQNH PGVNVDELGQ KVKCDVSSGL 
      2260       2270       2280       2290       2300
VCYNKDQGGT FQMCYNYLIK VLCCSVSHCQ GSTTPEGSVS TTETTTATPQ 
      2310       2320       2330       2340       2350
TLSSKPLPNT SSIETWSPSG PTTSMEASEM PTFWTLRTSV SSPPTTPLTV 
      2360       2370       2380       2390       2400
TSVSTQHPKS LESSGSPSVV TARSTSPGHS QPPSSPYATN SLSATTSKAS 
      2410       2420       2430       2440       2450
LSSMTTISTS LTTPGPSSPP HGGTTTHPVT TASTTRAVTE TLSSRPHTKT 
      2460       2470       2480       2490       2500
TSELPTVSSV SSTAGPGTQT GSTSRPNTVT QPASSPETSS TTCQPQCQWT 
      2510       2520       2530       2540       2550
KWIDVDYPSS SINGGDIETY ENIRANGEKI CEKPQDIRCM AQNHPGVNVD 
      2560       2570       2580       2590       2600
ELGQKVKCDV SSGLVCYNKD QGGTFQMCYN YLIKVLCCSV SHCQRSTTPA 
      2610       2620       2630       2640       2650
GSAPTTGTAP TATSGTATHT SWPASSMPTS TTESPSSSGK TTILTTASSL 
      2660       2670       2680       2690       2700
ATGTPRETQT SSLLTTGLSS ALTTTGTTST GCKSQCTWTD WLDSDKPQPG 
      2710       2720       2730       2740       2750
QFEGDIETYY HIQNKTGIKI CKKPVDIECE AVLFPNISFQ KLGQEVVCNV 
      2760       2770       2780       2790       2800
DFGLICRNSK QSDNQICFNY HIRVLCCEED TSCISTTGLL STTSTSAPGF 
      2810       2820       2830       2840       2850
PSTVSTSTTS KLPSEEPIPS TSFTTQSRPS TPRTEKIVSI ATARTTGSFP 
      2860       2870       2880       2890       2900
VSSLSTFPAS PTSLLPTSEE PHSGKPSTSS WTASSNVPST AKPTTSTGRQ 
      2910       2920       2930       2940       2950
FPRTKTTLWN SLPSSTPTMA TRSIHPISTT MTTKNPQTLV TSDISKSNSM 
      2960       2970       2980       2990       3000
LPSRPHITAS SVTSTSGSQI SKSYSSTSLT TAGPSSPPHG GTTTHPVTTA 
      3010       3020       3030       3040       3050
STTRAVTETL SSRPHTKTTS ELPTVSSVSS TAGPGTQTGS TSRPSIVTQP 
      3060       3070       3080       3090       3100
VSSPETSSTT CQPQCQWTRW INVDYPSSSI NGGDIETYEN IRANGEKICE 
      3110       3120       3130       3140       3150
KPQDIRCMAQ NYPGVNVDEL GQKVKCDVNS GLVCYNKDQG GTFKMCYNYL 
      3160       3170       3180       3190       3200
IKVLCCSVSH CQGSTTPEGS VSTTETASSI PQTLSSKPLP NTSSFETWSP 
      3210       3220       3230       3240       3250
SGPTTSMEAS EMPTFWTLRT SVSSPPTTPL TVTSVSTQHP KSLESSGSPS 
      3260       3270       3280       3290       3300
VVTARSTSQG HSLPPSSPHT TNSLSATTSK ASLSSMTTIS TSLTTSEPSS 
      3310       3320       3330       3340       3350
PPHGGTTTHP VTAASTTRAV TETLSSRPHT KTTSELPTVP SASSTAGPGT 
      3360       3370       3380       3390       3400
QTGSTSRPST VTQPASSPET SSTTCQPQCQ WTKWIDVDYP SSSINGGDIE 
      3410       3420       3430       3440       3450
TYENIRTNGE KICEKPQDIR CMAQNHPGVN VDELGQKVKC DVNSGLVCYN 
      3460       3470       3480       3490       3500
KDQGGTFQMC YNYLIKVLCC SVSHCQGSTT TPGSAPMTGS ATTATQTLSS 
      3510       3520       3530       3540       3550
MPLPNTSLTV TSPHSASTTA ATSITETSSP RSVSSIHTTP KIFPETLQST 
      3560       3570       3580       3590       3600
TGLTTQQTSS TGIWTSMLTG TAGTVSSTSL STSLESTTGI TEVSTSMPMT 
      3610       3620       3630       3640       3650
STLPVTVTNA TTPQGTTLCQ PKCKWTEWFD VDSPTSGSVK GDMETYENIR 
      3660       3670       3680       3690       3700
ASGKTLCQAP EKIECRAENY PAVSIDKVGQ VVSCNLETGL VCKNEDQKDD 
      3710       3720       3730       3740       3750
FKMCFNYNIR VLCCDDYSHC PTTTYTTIKS PLAPFTTSVS SSMESTFQTN 
      3760       3770       3780       3790       3800
RPASPSGPST QASTWSTLPD SGCTPRCKWT EWFDADYPNP GPRGGDFEVY 
      3810       3820       3830       3840       3850
AVFREVGYIF CDQPKDIECR SEKEPDRPLE TLEQVVQCDV RFGLICKNIN 
      3860       3870       3880       3890       3900
QSGPLQYCDN YHVRLLCCDN YSHCTSSPMA TMSTALSSSH LPSTHTSLAL 
      3910       3920       3930       3940       3950
NTTTFFPGLS SSSEPHSSSL MSTHTSTMLT TETSPIATGP TVAPSSTSGT 
      3960       3970       3980       3990       4000
PYTPKVSPSS QVTFSVSTAF SSVFSTPRPV FSSHASSPSP CFCQAFGQLF 
      4010       4020       4030       4040       4050
LPGDIIYNKT DGAGCQFYAI CNQYCDVDRF QGTCPSSSPP MSSTTVPLPP 
      4060       4070       4080       4090       4100
LLPGCDNAIP PRQVNESWTL ENCTVARCQG NNQIILLEPE PVDNVTCANR 
      4110       4120       4130       4140       4150
HLPIKVWDQE PCHFHYECEC FCSGWGHSHY LTFDGTSYTF LDNCTSVLMR 
      4160       4170       4180       4190       4200
EIHPRHGNLS ILAHSYYCGA TTNVTSCPRA LSVYYNSMEI ILTISTTESG 
      4210       4220       4230       4240       4250
KDESLIIWDQ MWIRSGFSKN GVTVSLSGAT TMSVNISTIG TIITFDGNIF 
      4260       4270       4280       4290       4300
QIWLPYRYFS SNTEGQCGTC TNSQIDDCRR PDGTIASDCQ DMAKEWLVPG 
      4310       4320       4330       4340       4350
NSSSSCLAQP SPLPSTTPQT PVSSTLTSTP CPSAPLCELM LSQVFAECHR 
      4360       4370       4380       4390       4400
LIPPDAFFRS CVSDHCNANI TDMLCQSLEA YAALCRAQGV CTNWRNATGG 
      4410       4420       4430       4440       4450
LCDLSCPPTK EYRPCGPLHP ASCNSRTQDS TTGMLAEGCF CPENQLLFNS 
      4460       4470       4480       4490       4500
RMDICVSECP CVGPDGLPKF PGEHWISNCQ ACVCEPGSVS VQCEPVKCES 
      4510       4520       4530       4540       4550
QDKPPQCTEA GFVTVTWPSA DNPCCPETLC VCNSTTCPKS LPTCEPGYEL 
      4560       4570       4580       4590       4600
VQTHENSSCC PSYSCRPKLC TYNDTIYGVG TTFPGGPCHT CTCLSDGDQE 
      4610       4620       4630       4640       4650
PKVECKETNC TTSCPQGFKY TLVPEQCCGE CLQNACLTPE GHAVQPNETW 
      4660       4670       4680       4690       4700
VNSPVDNCTA YHCMAENGVY VLTPIPTSCP DVSNCTGTLR KTGCCYSCEK 
      4710       4720       4730       4740       4750
EDSSTCQVHV NATVLRYKGC ETEVNITFCE GSCSGISKYS MEAQAMERQC 
      4760       4770       4780       4790       4800
TCCQESKVHD VAVTMQCPDG TVIQHTYTHI DECNCAPACS SLPGTSMIAS
Length:4,800
Mass (Da):515,441
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9751153D83BFF55
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		NP_083077.2, NM_028801.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000165147; ENSMUSP00000128276; ENSMUSG00000066108

Database of genes from NCBI RefSeq genomes

More...GeneIDi		74180

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:74180

UCSC genome browser

More...UCSCi		uc009kmc.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_083077.2, NM_028801.2

3D structure databases

SMRiE9Q5I3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128276

PTM databases

iPTMnetiE9Q5I3
PhosphoSitePlusiE9Q5I3

Proteomic databases

MaxQBiE9Q5I3
PaxDbiE9Q5I3
ProteomicsDBi320363

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1456, 340 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		74180

Genome annotation databases

EnsembliENSMUST00000165147; ENSMUSP00000128276; ENSMUSG00000066108
GeneIDi74180
KEGGimmu:74180
UCSCiuc009kmc.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		727897
MGIiMGI:1921430, Muc5b
VEuPathDBiHostDB:ENSMUSG00000066108

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
GeneTreeiENSGT00940000162219
HOGENOMiCLU_223712_0_0_1
InParanoidiE9Q5I3
OMAiSTWILTE
OrthoDBi12226at2759
PhylomeDBiE9Q5I3
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		74180, 3 hits in 63 CRISPR screens
RNActiE9Q5I3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000066108, Expressed in cochlea and 42 other tissues
GenevisibleiE9Q5I3, MM

Family and domain databases

InterProiView protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR025155, WxxW_domain
PfamiView protein in Pfam
PF08742, C8, 4 hits
PF13330, Mucin2_WxxW, 10 hits
PF01826, TIL, 2 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SUPFAMiSSF57567, SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS01208, VWFC_1, 2 hits
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q5I3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q5I3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 19, 2022
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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