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Entry version 77 (19 Jan 2022)
Sequence version 1 (05 Apr 2011)
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Protein
Submitted name:

Mucin 5, subtype B, tracheobronchial

Gene

Muc5b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mucin 5, subtype B, tracheobronchialImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc5bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921430, Muc5b

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000066108

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500324575026 – 4800Sequence analysisAdd BLAST4775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi4729 ↔ 4783PROSITE-ProRule annotation
Disulfide bondi4733 ↔ 4785PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E9Q5I3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E9Q5I3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
320363

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E9Q5I3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E9Q5I3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066108, Expressed in cochlea and 42 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
E9Q5I3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000128276

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
E9Q5I3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E9Q5I3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 281VWFDInterPro annotationAdd BLAST202
Domaini428 – 642VWFDInterPro annotationAdd BLAST215
Domaini898 – 1105VWFDInterPro annotationAdd BLAST208
Domaini4121 – 4351VWFDInterPro annotationAdd BLAST231
Domaini4461 – 4531VWFCInterPro annotationAdd BLAST71
Domaini4568 – 4632VWFCInterPro annotationAdd BLAST65
Domaini4698 – 4790CTCKInterPro annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1446 – 1568DisorderedSequence analysisAdd BLAST123
Regioni1673 – 1862DisorderedSequence analysisAdd BLAST190
Regioni1968 – 2179DisorderedSequence analysisAdd BLAST212
Regioni2282 – 2493DisorderedSequence analysisAdd BLAST212
Regioni2598 – 2665DisorderedSequence analysisAdd BLAST68
Regioni2791 – 2835DisorderedSequence analysisAdd BLAST45
Regioni2849 – 2902DisorderedSequence analysisAdd BLAST54
Regioni2947 – 3061DisorderedSequence analysisAdd BLAST115
Regioni3166 – 3375DisorderedSequence analysisAdd BLAST210
Regioni3479 – 3537DisorderedSequence analysisAdd BLAST59
Regioni3743 – 3767DisorderedSequence analysisAdd BLAST25
Regioni3933 – 3954DisorderedSequence analysisAdd BLAST22
Regioni4303 – 4324DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1446 – 1473Polar residuesSequence analysisAdd BLAST28
Compositional biasi1488 – 1568Polar residuesSequence analysisAdd BLAST81

Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1216, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162219

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_223712_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E9Q5I3

Identification of Orthologs from Complete Genome Data

More...
OMAi
STWILTE

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E9Q5I3

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR025155, WxxW_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742, C8, 4 hits
PF13330, Mucin2_WxxW, 10 hits
PF01826, TIL, 2 hits
PF00094, VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57567, SSF57567, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS01208, VWFC_1, 2 hits
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E9Q5I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRNWSWAL VWASVALLMV WPAESQGQAE LSSEHLELTG DSQRVYSDSI
60 70 80 90 100
SSSTRHVTFI PPITVFPSMS ALHLAHNGRV CSTWGDFHYK TFDGDVFRFP
110 120 130 140 150
GLCNYVFSSH CGATYEDFNI QLRRGLEGSR PTVTYVLLRA QGLVIELSNG
160 170 180 190 200
SVLVNGHREK LPYSRAGLLM EKSSGYVKIS IRLVLTFLWN EEDSALLELD
210 220 230 240 250
SKYINQTCGL CGDFNGLPAV SEFYTHNTRL TPVQFGNLQK LDGPTEQCQD
260 270 280 290 300
VLPSAVSNCT DTEDICRRTL LGPAFDKCTA LVDVSMYLDA CVQDLCRCPT
310 320 330 340 350
CPCATFAEYS RQCAHAGGYP QNWRHPDLCN WTCPFNMEYR ECSSPCVDTC
360 370 380 390 400
SNPQRSQLCE DHCMDGCFCP PGTVLDDVRH LGCLPLEQCH CTHGGRIYAP
410 420 430 440 450
GESFNTSCRS CTCFGGLWKC KDLPCPGTCS VQGGSHIFTF DEKLYNVHGD
460 470 480 490 500
CSYILTKKCA DSSFTVLVDL RKCGVTDTEN CLKAVTLNLN SGDTVIRIQV
510 520 530 540 550
NGAVFLNSIF TQMPLSAGNI TIFKPSSFFI IVQTGMGLQL QVQLVPLMQV
560 570 580 590 600
FVRLDRSYQG QMCGLCGNFN QNQADDFTAL SGVVEGTGAA FSNTWKTQAS
610 620 630 640 650
CPNSKNTYED PCSYSVENEN FAREWCSMLT ESSGVFSACH ATVSPVPFYS
660 670 680 690 700
NCLFDTCNCE NSEDCMCAAL SSYVFACAAK GVLLSGWRDK VCYKYTNNCP
710 720 730 740 750
QTKGYFYSVS SCQPTCRSLS EADVTCSVPF VTVDGCTCPE GTFLNDKDHC
760 770 780 790 800
VPVEECPCYF HGTVVAPREV VTDNGVVCSC TNGKLTCLGA LMQKSTECQA
810 820 830 840 850
PMVYLDCNNA SVGHHGAECL KSCHTLDVEC FSTQCVSGCV CPSGLVADGN
860 870 880 890 900
GGCIAEEDCP CIHNEVTYRP GEIIRVDCNN CTCKNRRWEC TNKPCMGACV
910 920 930 940 950
AYGDGHFVTF DGERYIFEGS CEYTLAQDYC RGNTSTNGTF RIVTENVPCG
960 970 980 990 1000
TTGTTCSKTI KIFVESYELI LHEGNFKVVE QGPSGDPPYK IRFMGIFLVI
1010 1020 1030 1040 1050
EIRSGIVVSW DRKTSVFVRL QQHYKGRVCG LCGNFDDNAI NDFTTRSQSV
1060 1070 1080 1090 1100
VGDVLEFGNS WKFSPSCPDA PVPKDPCIAN PYRKSWAQKK CSIINSATFA
1110 1120 1130 1140 1150
ACHSQVDSTK YYEACVHDVC ACDSGGDCEC FCTAVAAYAQ ACRDVGVCLS
1160 1170 1180 1190 1200
WRTPDICPLF CDYYNPHGEC EWHYQPCGAP CLKTCRNPTG HCLVDLPGLE
1210 1220 1230 1240 1250
GCYPQCPASQ PFFNEDQMKC VAQCGCYDDN GNYHDIGTQV PTAENCQSCL
1260 1270 1280 1290 1300
CTPGGLQCVY NLTACTCTYE GRTYNYNDVV YNTTDGLGAC LVAICKDNGT
1310 1320 1330 1340 1350
IARTTEVCHE VPSTTPFTFT TTLAPLATNG SASTVSTVCV HEVCQWSIWY
1360 1370 1380 1390 1400
DESHPEAGMS GGDFETFENL RKKGHQVCQT PVGIECRAVK FPSMDLEKLG
1410 1420 1430 1440 1450
QKVNCDPSSG LSCFNSEQSP PLCHDYELRV LCCDYVPCGS SLTLGISTTP
1460 1470 1480 1490 1500
SQPDTSRRPS SPTLTTHTAS SESQSWTREE KKTSVDKSYS SRQTVPFTSN
1510 1520 1530 1540 1550
SRLTSTSMSS ASSLPLSNPT WTTTLKATDE NTMLSSRTTA VFTSQTRSTS
1560 1570 1580 1590 1600
RPSTVTQPIS SPETSSTTCQ PQCQWTKWID VDYPSSSING GDIETYENIR
1610 1620 1630 1640 1650
ANGEKICEKP QDIRCMAQNH PGVNVDELGQ KVKCDVSSGL VCYNKDQGGT
1660 1670 1680 1690 1700
FQMCYNYLIK VLCCSVSHCQ GSTTPEGSVS TTETATSTPQ TLSSKPLPNT
1710 1720 1730 1740 1750
SSFETWSPSG PTTSMEASEM PTFWTLRTSV SSPPTTPLTV TSVSTQHPKS
1760 1770 1780 1790 1800
LESSGSPSVV TARSTSQGYS LPPSSPHTTN SLSATTSKAS LSSMTTISTS
1810 1820 1830 1840 1850
LTTPGPSSPP HGGTTTHPVT TASTTRAVTE TLSSRPHTKT TSELPTVSSA
1860 1870 1880 1890 1900
SSTAGPGTQT FSTTCQPQCQ WTKWIDVDYP SSSINGGDIE TYENIRANGE
1910 1920 1930 1940 1950
KICEKPQDIR CMAQNYPGVN VDKLGQKVKC DVSSGLVCYN KDQGGTFPMC
1960 1970 1980 1990 2000
YNYLIKVLCC SVSHCQGSTT PEGSVSTTET TTATPQTLSS KPLPNTSSIE
2010 2020 2030 2040 2050
TWSPSGPTTS MEASEMPTFW TLRTSVSSPP TTPLTVTSVS TQHPKSLESS
2060 2070 2080 2090 2100
GSPSVVTARS TSPGHSQPPS SPYATNSLSA TTSKASLSSM TTISTSLTTP
2110 2120 2130 2140 2150
GPSSPPHGGT TTHPVTTAST TRAVTETLSS RPHTKTTSEL PTVSSVSSTA
2160 2170 2180 2190 2200
GPGTQTGSTS RPNTVTQPAS SPETSSTTCQ PQCQWTKWID VDYPSSSING
2210 2220 2230 2240 2250
GDIETYENIR ANGEKICEKP QDIRCMAQNH PGVNVDELGQ KVKCDVSSGL
2260 2270 2280 2290 2300
VCYNKDQGGT FQMCYNYLIK VLCCSVSHCQ GSTTPEGSVS TTETTTATPQ
2310 2320 2330 2340 2350
TLSSKPLPNT SSIETWSPSG PTTSMEASEM PTFWTLRTSV SSPPTTPLTV
2360 2370 2380 2390 2400
TSVSTQHPKS LESSGSPSVV TARSTSPGHS QPPSSPYATN SLSATTSKAS
2410 2420 2430 2440 2450
LSSMTTISTS LTTPGPSSPP HGGTTTHPVT TASTTRAVTE TLSSRPHTKT
2460 2470 2480 2490 2500
TSELPTVSSV SSTAGPGTQT GSTSRPNTVT QPASSPETSS TTCQPQCQWT
2510 2520 2530 2540 2550
KWIDVDYPSS SINGGDIETY ENIRANGEKI CEKPQDIRCM AQNHPGVNVD
2560 2570 2580 2590 2600
ELGQKVKCDV SSGLVCYNKD QGGTFQMCYN YLIKVLCCSV SHCQRSTTPA
2610 2620 2630 2640 2650
GSAPTTGTAP TATSGTATHT SWPASSMPTS TTESPSSSGK TTILTTASSL
2660 2670 2680 2690 2700
ATGTPRETQT SSLLTTGLSS ALTTTGTTST GCKSQCTWTD WLDSDKPQPG
2710 2720 2730 2740 2750
QFEGDIETYY HIQNKTGIKI CKKPVDIECE AVLFPNISFQ KLGQEVVCNV
2760 2770 2780 2790 2800
DFGLICRNSK QSDNQICFNY HIRVLCCEED TSCISTTGLL STTSTSAPGF
2810 2820 2830 2840 2850
PSTVSTSTTS KLPSEEPIPS TSFTTQSRPS TPRTEKIVSI ATARTTGSFP
2860 2870 2880 2890 2900
VSSLSTFPAS PTSLLPTSEE PHSGKPSTSS WTASSNVPST AKPTTSTGRQ
2910 2920 2930 2940 2950
FPRTKTTLWN SLPSSTPTMA TRSIHPISTT MTTKNPQTLV TSDISKSNSM
2960 2970 2980 2990 3000
LPSRPHITAS SVTSTSGSQI SKSYSSTSLT TAGPSSPPHG GTTTHPVTTA
3010 3020 3030 3040 3050
STTRAVTETL SSRPHTKTTS ELPTVSSVSS TAGPGTQTGS TSRPSIVTQP
3060 3070 3080 3090 3100
VSSPETSSTT CQPQCQWTRW INVDYPSSSI NGGDIETYEN IRANGEKICE
3110 3120 3130 3140 3150
KPQDIRCMAQ NYPGVNVDEL GQKVKCDVNS GLVCYNKDQG GTFKMCYNYL
3160 3170 3180 3190 3200
IKVLCCSVSH CQGSTTPEGS VSTTETASSI PQTLSSKPLP NTSSFETWSP
3210 3220 3230 3240 3250
SGPTTSMEAS EMPTFWTLRT SVSSPPTTPL TVTSVSTQHP KSLESSGSPS
3260 3270 3280 3290 3300
VVTARSTSQG HSLPPSSPHT TNSLSATTSK ASLSSMTTIS TSLTTSEPSS
3310 3320 3330 3340 3350
PPHGGTTTHP VTAASTTRAV TETLSSRPHT KTTSELPTVP SASSTAGPGT
3360 3370 3380 3390 3400
QTGSTSRPST VTQPASSPET SSTTCQPQCQ WTKWIDVDYP SSSINGGDIE
3410 3420 3430 3440 3450
TYENIRTNGE KICEKPQDIR CMAQNHPGVN VDELGQKVKC DVNSGLVCYN
3460 3470 3480 3490 3500
KDQGGTFQMC YNYLIKVLCC SVSHCQGSTT TPGSAPMTGS ATTATQTLSS
3510 3520 3530 3540 3550
MPLPNTSLTV TSPHSASTTA ATSITETSSP RSVSSIHTTP KIFPETLQST
3560 3570 3580 3590 3600
TGLTTQQTSS TGIWTSMLTG TAGTVSSTSL STSLESTTGI TEVSTSMPMT
3610 3620 3630 3640 3650
STLPVTVTNA TTPQGTTLCQ PKCKWTEWFD VDSPTSGSVK GDMETYENIR
3660 3670 3680 3690 3700
ASGKTLCQAP EKIECRAENY PAVSIDKVGQ VVSCNLETGL VCKNEDQKDD
3710 3720 3730 3740 3750
FKMCFNYNIR VLCCDDYSHC PTTTYTTIKS PLAPFTTSVS SSMESTFQTN
3760 3770 3780 3790 3800
RPASPSGPST QASTWSTLPD SGCTPRCKWT EWFDADYPNP GPRGGDFEVY
3810 3820 3830 3840 3850
AVFREVGYIF CDQPKDIECR SEKEPDRPLE TLEQVVQCDV RFGLICKNIN
3860 3870 3880 3890 3900
QSGPLQYCDN YHVRLLCCDN YSHCTSSPMA TMSTALSSSH LPSTHTSLAL
3910 3920 3930 3940 3950
NTTTFFPGLS SSSEPHSSSL MSTHTSTMLT TETSPIATGP TVAPSSTSGT
3960 3970 3980 3990 4000
PYTPKVSPSS QVTFSVSTAF SSVFSTPRPV FSSHASSPSP CFCQAFGQLF
4010 4020 4030 4040 4050
LPGDIIYNKT DGAGCQFYAI CNQYCDVDRF QGTCPSSSPP MSSTTVPLPP
4060 4070 4080 4090 4100
LLPGCDNAIP PRQVNESWTL ENCTVARCQG NNQIILLEPE PVDNVTCANR
4110 4120 4130 4140 4150
HLPIKVWDQE PCHFHYECEC FCSGWGHSHY LTFDGTSYTF LDNCTSVLMR
4160 4170 4180 4190 4200
EIHPRHGNLS ILAHSYYCGA TTNVTSCPRA LSVYYNSMEI ILTISTTESG
4210 4220 4230 4240 4250
KDESLIIWDQ MWIRSGFSKN GVTVSLSGAT TMSVNISTIG TIITFDGNIF
4260 4270 4280 4290 4300
QIWLPYRYFS SNTEGQCGTC TNSQIDDCRR PDGTIASDCQ DMAKEWLVPG
4310 4320 4330 4340 4350
NSSSSCLAQP SPLPSTTPQT PVSSTLTSTP CPSAPLCELM LSQVFAECHR
4360 4370 4380 4390 4400
LIPPDAFFRS CVSDHCNANI TDMLCQSLEA YAALCRAQGV CTNWRNATGG
4410 4420 4430 4440 4450
LCDLSCPPTK EYRPCGPLHP ASCNSRTQDS TTGMLAEGCF CPENQLLFNS
4460 4470 4480 4490 4500
RMDICVSECP CVGPDGLPKF PGEHWISNCQ ACVCEPGSVS VQCEPVKCES
4510 4520 4530 4540 4550
QDKPPQCTEA GFVTVTWPSA DNPCCPETLC VCNSTTCPKS LPTCEPGYEL
4560 4570 4580 4590 4600
VQTHENSSCC PSYSCRPKLC TYNDTIYGVG TTFPGGPCHT CTCLSDGDQE
4610 4620 4630 4640 4650
PKVECKETNC TTSCPQGFKY TLVPEQCCGE CLQNACLTPE GHAVQPNETW
4660 4670 4680 4690 4700
VNSPVDNCTA YHCMAENGVY VLTPIPTSCP DVSNCTGTLR KTGCCYSCEK
4710 4720 4730 4740 4750
EDSSTCQVHV NATVLRYKGC ETEVNITFCE GSCSGISKYS MEAQAMERQC
4760 4770 4780 4790 4800
TCCQESKVHD VAVTMQCPDG TVIQHTYTHI DECNCAPACS SLPGTSMIAS
Length:4,800
Mass (Da):515,441
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9751153D83BFF55
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
NP_083077.2, NM_028801.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000165147; ENSMUSP00000128276; ENSMUSG00000066108

Database of genes from NCBI RefSeq genomes

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GeneIDi
74180

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:74180

UCSC genome browser

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UCSCi
uc009kmc.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_083077.2, NM_028801.2

3D structure databases

SMRiE9Q5I3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128276

PTM databases

iPTMnetiE9Q5I3
PhosphoSitePlusiE9Q5I3

Proteomic databases

MaxQBiE9Q5I3
PaxDbiE9Q5I3
ProteomicsDBi320363

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1456, 340 antibodies from 33 providers

The DNASU plasmid repository

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DNASUi
74180

Genome annotation databases

EnsembliENSMUST00000165147; ENSMUSP00000128276; ENSMUSG00000066108
GeneIDi74180
KEGGimmu:74180
UCSCiuc009kmc.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
727897
MGIiMGI:1921430, Muc5b
VEuPathDBiHostDB:ENSMUSG00000066108

Phylogenomic databases

eggNOGiKOG1216, Eukaryota
GeneTreeiENSGT00940000162219
HOGENOMiCLU_223712_0_0_1
InParanoidiE9Q5I3
OMAiSTWILTE
OrthoDBi12226at2759
PhylomeDBiE9Q5I3
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
74180, 3 hits in 63 CRISPR screens
RNActiE9Q5I3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066108, Expressed in cochlea and 42 other tissues
GenevisibleiE9Q5I3, MM

Family and domain databases

InterProiView protein in InterPro
IPR006207, Cys_knot_C
IPR036084, Ser_inhib-like_sf
IPR002919, TIL_dom
IPR014853, Unchr_dom_Cys-rich
IPR001007, VWF_dom
IPR001846, VWF_type-D
IPR025155, WxxW_domain
PfamiView protein in Pfam
PF08742, C8, 4 hits
PF13330, Mucin2_WxxW, 10 hits
PF01826, TIL, 2 hits
PF00094, VWD, 4 hits
SMARTiView protein in SMART
SM00832, C8, 4 hits
SM00041, CT, 1 hit
SM00214, VWC, 5 hits
SM00215, VWC_out, 2 hits
SM00216, VWD, 4 hits
SUPFAMiSSF57567, SSF57567, 4 hits
PROSITEiView protein in PROSITE
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS01208, VWFC_1, 2 hits
PS50184, VWFC_2, 2 hits
PS51233, VWFD, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE9Q5I3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E9Q5I3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 19, 2022
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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