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Protein

Oogenesin-1

Gene

Oog1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a Ras-mediated signaling protein in early embryogenesis.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Oogenesin-11 Publication
Gene namesi
Name:Oog1Imported
Synonyms:OogImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2679150 Oog1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004370741 – 496Oogenesin-1Add BLAST496

Proteomic databases

PaxDbiE9Q5G7
PRIDEiE9Q5G7

Expressioni

Tissue specificityi

Expressed in the ovary, ovulated oocytes and preimplantation embryos (at protein level). Not detected in testis, liver, kidney, spleen, heart, lung and brain.1 Publication

Developmental stagei

Expressed predominantly in oocytes and one-to four-cell-stage embryos with weak expression in morula/blastocyst-stage embryos (at protein level). Expression increases from oocyte to the one-cell stage and then decreases toward the four-cell stage (at protein level). Highly expressed in oocytes of primary, secondary and antral follicles with low levels in oocytes of primordial follicles (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000096576 Expressed in 8 organ(s), highest expression level in meiotic oocyte (mouse)
ExpressionAtlasiE9Q5G7 baseline
GenevisibleiE9Q5G7 MM

Interactioni

Subunit structurei

Interacts with RALGDS (via Ras-associating domain) (PubMed:16580637). Interacts with HRAS (in GTP-bound form) (PubMed:16580637).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RalgdsQ033855EBI-923698,EBI-923705

Protein-protein interaction databases

IntActiE9Q5G7, 2 interactors
STRINGi10090.ENSMUSP00000093165

Structurei

3D structure databases

ProteinModelPortaliE9Q5G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati115 – 139LRR 1; degenerateBy similarityAdd BLAST25
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 244LRR 3; degenerateBy similarityAdd BLAST26
Repeati245 – 282LRR 4; degenerateBy similarityAdd BLAST38
Repeati283 – 308LRR 5By similarityAdd BLAST26
Repeati309 – 340LRR 6By similarityAdd BLAST32
Repeati341 – 364LRR 7By similarityAdd BLAST24
Repeati365 – 392LRR 8By similarityAdd BLAST28
Repeati393 – 417LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiE9Q5G7
OrthoDBiEOG091G1SOP
TreeFamiTF332708

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

E9Q5G7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVICLHCPDQ DDSLEEVTEE CYSPPTLQNL AIQSLLRDEA LAISALTDLP
60 70 80 90 100
QSLFPVIFEE AFTDGYIGIL KAMIPVWPFP YLSLGKQINN CNLETLKAML
110 120 130 140 150
EGLDILLAQK VQTSRCKLRV INWREDDLKI WAGSHEGEGL PDFRTEKQPI
160 170 180 190 200
ENSAGCEVKK ELKVTTEVLR MKGRLDESTT YLLQWAQQRK DSIHLFCRKL
210 220 230 240 250
LIEGLTKASV IEIFKTVHAD CIQELILRCI CIEELAFLNP YLKLMKSLFT
260 270 280 290 300
LTLDHIIGTF SLGDSEKLDE ETIFSLISQL PTLHCLQKLY VNDVPFIKGN
310 320 330 340 350
LKEYLRCLKK PLETLCISNC DLSQSDLDCL PYCLNICELK HLHISDIYLC
360 370 380 390 400
DLLLEPLGFL LERVGDTLKT LELDSCCIVD FQFSALLPAL SQCSHLREVT
410 420 430 440 450
FYDNDVSLPF LKQLLHHTAL LSQLIYECYP APLECYDDSG VILTHRLESF
460 470 480 490
CPELLDILRA KRQLHSVSFQ TTKCSKCGGC YIYDRHTQCC RFVELL
Length:496
Mass (Da):56,633
Last modified:April 5, 2011 - v1
Checksum:iD80F528860AAF196
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5RJV9Q5RJV9_MOUSE
Oog1 protein
Gm2042 Oog1
496Annotation score:
M0QWA3M0QWA3_MOUSE
Oogenesin-1
Gm2042 Oog1
306Annotation score:
Q8C2W0Q8C2W0_MOUSE
Predicted gene 2042
Gm2042
175Annotation score:
A0A1Y7VJG6A0A1Y7VJG6_MOUSE
Oogenesin-1
Oog1
326Annotation score:
M0QWT2M0QWT2_MOUSE
Predicted gene 2042
Gm2042
199Annotation score:
M0QWU7M0QWU7_MOUSE
Predicted gene 2042
Gm2042
136Annotation score:
M0QWH6M0QWH6_MOUSE
Predicted gene 2042
Gm2042
183Annotation score:
M0QWW9M0QWW9_MOUSE
Predicted gene 2042
Gm2042
189Annotation score:
M0QW82M0QW82_MOUSE
Predicted gene 2042
Gm2042
73Annotation score:
M0QWF7M0QWF7_MOUSE
Predicted gene 2042
Gm2042
47Annotation score:

Sequence cautioni

The sequence BAB91151 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126554 Genomic DNA No translation available.
AB050008 mRNA Translation: BAB91151.3 Different initiation.
CCDSiCCDS49123.1
RefSeqiNP_848772.3, NM_178657.5
UniGeneiMm.208554
Mm.481851

Genome annotation databases

EnsembliENSMUST00000095509; ENSMUSP00000093165; ENSMUSG00000096576
GeneIDi193322
KEGGimmu:193322

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126554 Genomic DNA No translation available.
AB050008 mRNA Translation: BAB91151.3 Different initiation.
CCDSiCCDS49123.1
RefSeqiNP_848772.3, NM_178657.5
UniGeneiMm.208554
Mm.481851

3D structure databases

ProteinModelPortaliE9Q5G7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiE9Q5G7, 2 interactors
STRINGi10090.ENSMUSP00000093165

Proteomic databases

PaxDbiE9Q5G7
PRIDEiE9Q5G7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095509; ENSMUSP00000093165; ENSMUSG00000096576
GeneIDi193322
KEGGimmu:193322

Organism-specific databases

CTDi193322
MGIiMGI:2679150 Oog1

Phylogenomic databases

GeneTreeiENSGT00760000119028
HOGENOMiHOG000231112
HOVERGENiHBG006326
InParanoidiE9Q5G7
OrthoDBiEOG091G1SOP
TreeFamiTF332708

Miscellaneous databases

PROiPR:E9Q5G7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000096576 Expressed in 8 organ(s), highest expression level in meiotic oocyte (mouse)
ExpressionAtlasiE9Q5G7 baseline
GenevisibleiE9Q5G7 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR026271 PRAME_family
PIRSFiPIRSF038286 PRAME, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOOG1_MOUSE
AccessioniPrimary (citable) accession number: E9Q5G7
Secondary accession number(s): Q810D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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